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The map label for this gene is pntAa

Identifier: 52841112

GI number: 52841112

Start: 950384

End: 951517

Strand: Reverse

Name: pntAa

Synonym: lpg0876

Alternate gene names: 52841112

Gene position: 951517-950384 (Counterclockwise)

Preceding gene: 52841113

Following gene: 52841111

Centisome position: 28.0

GC content: 41.71

Gene sequence:

>1134_bases
ATGATGATTGCAACCTTAATGGAATCAGCCCAGGAAACGCGAGTAGCCATTACTCCCAACTCGGCCAAACAATACATAAA
ACTAGGCTATGATGTAGGGATTGAAAAAAACGCGGGGCTTAGCTCAGATTTTGCTAACGAAGAATTTGAAAAAGCTGGCG
CAATAATATTCGATAGTAAAAGTACATTACTCAAAAAAACACAAATTCTTTTATGTGTTAACGAACCCGATCCCAAAAAC
CTGAATGGCTTACCTCCAGATTCTCTAATAATCGGACATATAGACAATAACCCACTTAGCCCGCTTGTTAAGTGGTGTCT
GGATCAAAAAATGACATTATTTTCAATGAATCTCATTCCCAGGATAAGTCGTGCTCAAAGCATGGACAGCCTATCGTCTC
AGGCTAACCTAGCTGGTTACAGGGCAGTTTTGGAAGCTGCGGCAACATTTCATAGAGCTATACCTATGATGATGACAGCA
GCAGGCATGATACAACCGGCCAAAGCACTTATTCTTGGTGCCGGAGTTGCAGGCTTGCAAGCCATAGCTACTGCGAAACG
TTTAGGTGCAGTGGTTTATGCCTTTGACGTAAGAAAGGCAGCCAAAGAACAGGTTGAAAGTTTAGGCGCTGAATTCATAG
AGGTAATGCAGGAGCAAGATAGTGAAACAGCTGGGGGATATGCCACAGAAACAAGCGAAGAATATAAAAAACTTCAGGCT
GAACTCATTGATCAATATGCAAAAACTGCAGACATTGTAATTTCTACTGCCTTGATACCAGGGCGTCAAGCTCCGGTTTT
ACTTTATAAAAAAACTGTCGAGCAAATGAAACCAGGTTCTGTCATTGTTGATCTCGCAACGTCTCGAGGTGGAAATTGTG
AACTCAGTGTTGCCGATAAAATCATCAAGCATGGTGAGATTACTATAGTGGGATTAAGTAATATGGCAGGTCTCGTCCCT
GCTACGGCAAGTGACCTTTATTCTAATAATCTGGTTCATCTTATAAACATTTTGGCGAAAAATCCGGCTGAACTTAACTT
AAATCCTGATGATGAGATTATCCAGCAAGCCGTTCTTTGCCATAAAGGAACTTACCTGCCCTTTCAAGGAGTAAAGGAGA
AGCAAAATGCCTGA

Upstream 100 bases:

>100_bases
GCTTGTCCGGATCCAAAGATCCAAAATTGGTATTTTATGCTGTAGAAAATTATTCTAAATTACAATAGGATAGAATAATA
ACGGTAATAAGGATTTTCCC

Downstream 100 bases:

>100_bases
AATTCATACACTTGATAATCCTTATATTACAATATTAACCATTTTCGTACTGGCCTGTTTTGTAGGTTATTATGTGGTTT
GGAAAGTAACACCGGCTTTA

Product: pyridine nucleotide transhydrogenase, alpha subunit

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MMIATLMESAQETRVAITPNSAKQYIKLGYDVGIEKNAGLSSDFANEEFEKAGAIIFDSKSTLLKKTQILLCVNEPDPKN
LNGLPPDSLIIGHIDNNPLSPLVKWCLDQKMTLFSMNLIPRISRAQSMDSLSSQANLAGYRAVLEAAATFHRAIPMMMTA
AGMIQPAKALILGAGVAGLQAIATAKRLGAVVYAFDVRKAAKEQVESLGAEFIEVMQEQDSETAGGYATETSEEYKKLQA
ELIDQYAKTADIVISTALIPGRQAPVLLYKKTVEQMKPGSVIVDLATSRGGNCELSVADKIIKHGEITIVGLSNMAGLVP
ATASDLYSNNLVHLINILAKNPAELNLNPDDEIIQQAVLCHKGTYLPFQGVKEKQNA

Sequences:

>Translated_377_residues
MMIATLMESAQETRVAITPNSAKQYIKLGYDVGIEKNAGLSSDFANEEFEKAGAIIFDSKSTLLKKTQILLCVNEPDPKN
LNGLPPDSLIIGHIDNNPLSPLVKWCLDQKMTLFSMNLIPRISRAQSMDSLSSQANLAGYRAVLEAAATFHRAIPMMMTA
AGMIQPAKALILGAGVAGLQAIATAKRLGAVVYAFDVRKAAKEQVESLGAEFIEVMQEQDSETAGGYATETSEEYKKLQA
ELIDQYAKTADIVISTALIPGRQAPVLLYKKTVEQMKPGSVIVDLATSRGGNCELSVADKIIKHGEITIVGLSNMAGLVP
ATASDLYSNNLVHLINILAKNPAELNLNPDDEIIQQAVLCHKGTYLPFQGVKEKQNA
>Mature_377_residues
MMIATLMESAQETRVAITPNSAKQYIKLGYDVGIEKNAGLSSDFANEEFEKAGAIIFDSKSTLLKKTQILLCVNEPDPKN
LNGLPPDSLIIGHIDNNPLSPLVKWCLDQKMTLFSMNLIPRISRAQSMDSLSSQANLAGYRAVLEAAATFHRAIPMMMTA
AGMIQPAKALILGAGVAGLQAIATAKRLGAVVYAFDVRKAAKEQVESLGAEFIEVMQEQDSETAGGYATETSEEYKKLQA
ELIDQYAKTADIVISTALIPGRQAPVLLYKKTVEQMKPGSVIVDLATSRGGNCELSVADKIIKHGEITIVGLSNMAGLVP
ATASDLYSNNLVHLINILAKNPAELNLNPDDEIIQQAVLCHKGTYLPFQGVKEKQNA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=352, Percent_Identity=38.6363636363636, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI122939153, Length=352, Percent_Identity=38.6363636363636, Blast_Score=227, Evalue=2e-59,
Organism=Escherichia coli, GI1787887, Length=354, Percent_Identity=41.2429378531073, Blast_Score=270, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17550456, Length=353, Percent_Identity=41.0764872521246, Blast_Score=264, Evalue=5e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 40616; Mature: 40616

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIATLMESAQETRVAITPNSAKQYIKLGYDVGIEKNAGLSSDFANEEFEKAGAIIFDSK
CCHHHHHHHHHHCEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCEEECCC
STLLKKTQILLCVNEPDPKNLNGLPPDSLIIGHIDNNPLSPLVKWCLDQKMTLFSMNLIP
HHHHEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHH
RISRAQSMDSLSSQANLAGYRAVLEAAATFHRAIPMMMTAAGMIQPAKALILGAGVAGLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCHHHHH
AIATAKRLGAVVYAFDVRKAAKEQVESLGAEFIEVMQEQDSETAGGYATETSEEYKKLQA
HHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
ELIDQYAKTADIVISTALIPGRQAPVLLYKKTVEQMKPGSVIVDLATSRGGNCELSVADK
HHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHH
IIKHGEITIVGLSNMAGLVPATASDLYSNNLVHLINILAKNPAELNLNPDDEIIQQAVLC
HHHCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCEECCCCCHHHHHHHHHH
HKGTYLPFQGVKEKQNA
HCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMIATLMESAQETRVAITPNSAKQYIKLGYDVGIEKNAGLSSDFANEEFEKAGAIIFDSK
CCHHHHHHHHHHCEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCEEECCC
STLLKKTQILLCVNEPDPKNLNGLPPDSLIIGHIDNNPLSPLVKWCLDQKMTLFSMNLIP
HHHHEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHH
RISRAQSMDSLSSQANLAGYRAVLEAAATFHRAIPMMMTAAGMIQPAKALILGAGVAGLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCHHHHH
AIATAKRLGAVVYAFDVRKAAKEQVESLGAEFIEVMQEQDSETAGGYATETSEEYKKLQA
HHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
ELIDQYAKTADIVISTALIPGRQAPVLLYKKTVEQMKPGSVIVDLATSRGGNCELSVADK
HHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHH
IIKHGEITIVGLSNMAGLVPATASDLYSNNLVHLINILAKNPAELNLNPDDEIIQQAVLC
HHHCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCEECCCCCHHHHHHHHHH
HKGTYLPFQGVKEKQNA
HCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]