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The map label for this gene is nadB1

Identifier: 52841036

GI number: 52841036

Start: 873669

End: 875318

Strand: Reverse

Name: nadB1

Synonym: lpg0800

Alternate gene names: 52841036

Gene position: 875318-873669 (Counterclockwise)

Preceding gene: 52841037

Following gene: 52841035

Centisome position: 25.76

GC content: 44.42

Gene sequence:

>1650_bases
ATGAGTGATCAGCTATCACAACAAGGCCAATCGTTCGAATTCGATGTTCTCGTCATTGGAACAGGATTAGCCGGGTTACA
TTATTGTTTGCAGCTTTTAGCTATCCAACCCAAGCTAAACATTGCGTTAATCAGCAAAGCAGAGTCCATTGAGTGTAACA
GCCGCTATGCTCAAGGGGGGATTGCTGCCGCCATTTCGCCAGAAGATTCCCTGGAGTCTCATATATCTGATACTGTATTG
GCTGGAGATGGGCTATGCTACTTACCTGCGGTGGAATTTATTATCCGCCAAGGGCCAGATATTATAAAACAACTTGATCA
GTATAAAGTTCAATTTAAAAGAGAAAATGATGGTCGCTTTCATCTTGCCAAAGAAGGTGGCCATTCACACCGGCGCATTT
TTAATTGTGGCGATCAAACGGGATTAACGCTAACACAAACTCTCAATCATTTGGCAAGGCAACATCAACAGATCCAGTTT
TTTGAACATCACGTGGCGGTTAACCTGATTACTCAATATCATCCTCACCGGACAGATAACCAGGGTGAGGTATTAGGAGC
CTATATACTCGACTGCCAACATAATCGCATTCACACCTTTCTTGCGAAATGCGTCATTTTAGCGACCGGTGGCGCCGGCA
AAACCTACAGGTATACGACTAACCCTATGGTTGCAACAGGTGATGGTGTCGCGATGGCATACAGGGCTGGAGCTCGTGTG
GGCAACATGGAATTTTATCAATTTCACCCTACCCTCTTGCACCATCACACCATTAACAATTTTTTAATTTCCGAAGCAGT
TCGAGGCGAAGGCGCTTTGCTTAAAAACCCTGAAACAGGCGAGCGTTTTATGAAACGATACGCACCTGACCAACTTGAGT
TAGCAACCAGAGACGTCGTGGCAAGAGCTATTTTTAGTGAAATTGAGCAAGGCCAGGCTGGATATGTGCATCTGGATATT
TCTCATCAAAGCAAATCTTTCCTGAAAAAACGTTTCCCACAAATTTATTCCACATTGTTATCTATTGGAATTGATATGAG
CCAGGATTTGATTCCTGTCGTTCCGGCCGCTCATTACCAATGCGGTGGGGTTCTTACTGATGTGGACGGCCGCACCGATC
TGGCACGATTATACGCTATCGGTGAAGTGGCTTTTACTGGGCTGCATGGTGCGAACAGGCTGGCAAGCAATTCCCTACTT
GAAGCCTTGGTCATGGGTTCCAATGCGGCACGCTGTACACTTAAAGACATTGCTACTCCGTTAAAACTTATCGATCATAT
CCCCAGCTGGAGCTCTCCAGGAGAAGTCAATGCAAGAAGAGCCAGTCAAATCAACGCCCAATGGAGAGGCTTAAGAGGGG
AAATGACTTCCTATGCAGGCATTGTGCGCACTGAAGCAGGCCTTGAAGATCTACTACAATTAATATTGAAGCGTAAGAAA
ATTATTGAAGAGTATTACTGGAAACATTGCATTACCAGAGATTTTATTGAGTTAAGGAACATTATCCTTAATGCAGAATT
GATTGTTAGAGCAGCCCTTTCCAGAAGGGAATCACGTGGTGGACATTTTCGTGAAGATTTCCCCAATAAAAATTTCAAAG
CCCAGGAAAGTATTGCAAAACTGGGACAGGCAGACAGTTCATTAGGATAG

Upstream 100 bases:

>100_bases
TTAAAACCCTGTCTATTCCCGAAGAAGCAAAAGCAGAGTTAATGAAATTAACTCCAGAGACTTACACAGGTCTTGCAACC
CAATTGGTCAAGGCTTTTTC

Downstream 100 bases:

>100_bases
CCTGGCAAAGCTATCCCATTAACAATAATGAAAGAACCCTTCCCACAAATCCCTAATGACTAGAGGTAGATTTAATGTTT
AAAAATTCAACTACGTACCA

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MSDQLSQQGQSFEFDVLVIGTGLAGLHYCLQLLAIQPKLNIALISKAESIECNSRYAQGGIAAAISPEDSLESHISDTVL
AGDGLCYLPAVEFIIRQGPDIIKQLDQYKVQFKRENDGRFHLAKEGGHSHRRIFNCGDQTGLTLTQTLNHLARQHQQIQF
FEHHVAVNLITQYHPHRTDNQGEVLGAYILDCQHNRIHTFLAKCVILATGGAGKTYRYTTNPMVATGDGVAMAYRAGARV
GNMEFYQFHPTLLHHHTINNFLISEAVRGEGALLKNPETGERFMKRYAPDQLELATRDVVARAIFSEIEQGQAGYVHLDI
SHQSKSFLKKRFPQIYSTLLSIGIDMSQDLIPVVPAAHYQCGGVLTDVDGRTDLARLYAIGEVAFTGLHGANRLASNSLL
EALVMGSNAARCTLKDIATPLKLIDHIPSWSSPGEVNARRASQINAQWRGLRGEMTSYAGIVRTEAGLEDLLQLILKRKK
IIEEYYWKHCITRDFIELRNIILNAELIVRAALSRRESRGGHFREDFPNKNFKAQESIAKLGQADSSLG

Sequences:

>Translated_549_residues
MSDQLSQQGQSFEFDVLVIGTGLAGLHYCLQLLAIQPKLNIALISKAESIECNSRYAQGGIAAAISPEDSLESHISDTVL
AGDGLCYLPAVEFIIRQGPDIIKQLDQYKVQFKRENDGRFHLAKEGGHSHRRIFNCGDQTGLTLTQTLNHLARQHQQIQF
FEHHVAVNLITQYHPHRTDNQGEVLGAYILDCQHNRIHTFLAKCVILATGGAGKTYRYTTNPMVATGDGVAMAYRAGARV
GNMEFYQFHPTLLHHHTINNFLISEAVRGEGALLKNPETGERFMKRYAPDQLELATRDVVARAIFSEIEQGQAGYVHLDI
SHQSKSFLKKRFPQIYSTLLSIGIDMSQDLIPVVPAAHYQCGGVLTDVDGRTDLARLYAIGEVAFTGLHGANRLASNSLL
EALVMGSNAARCTLKDIATPLKLIDHIPSWSSPGEVNARRASQINAQWRGLRGEMTSYAGIVRTEAGLEDLLQLILKRKK
IIEEYYWKHCITRDFIELRNIILNAELIVRAALSRRESRGGHFREDFPNKNFKAQESIAKLGQADSSLG
>Mature_548_residues
SDQLSQQGQSFEFDVLVIGTGLAGLHYCLQLLAIQPKLNIALISKAESIECNSRYAQGGIAAAISPEDSLESHISDTVLA
GDGLCYLPAVEFIIRQGPDIIKQLDQYKVQFKRENDGRFHLAKEGGHSHRRIFNCGDQTGLTLTQTLNHLARQHQQIQFF
EHHVAVNLITQYHPHRTDNQGEVLGAYILDCQHNRIHTFLAKCVILATGGAGKTYRYTTNPMVATGDGVAMAYRAGARVG
NMEFYQFHPTLLHHHTINNFLISEAVRGEGALLKNPETGERFMKRYAPDQLELATRDVVARAIFSEIEQGQAGYVHLDIS
HQSKSFLKKRFPQIYSTLLSIGIDMSQDLIPVVPAAHYQCGGVLTDVDGRTDLARLYAIGEVAFTGLHGANRLASNSLLE
ALVMGSNAARCTLKDIATPLKLIDHIPSWSSPGEVNARRASQINAQWRGLRGEMTSYAGIVRTEAGLEDLLQLILKRKKI
IEEYYWKHCITRDFIELRNIILNAELIVRAALSRRESRGGHFREDFPNKNFKAQESIAKLGQADSSLG

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=531, Percent_Identity=32.015065913371, Blast_Score=230, Evalue=2e-60,
Organism=Escherichia coli, GI1788928, Length=541, Percent_Identity=44.731977818854, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1790597, Length=553, Percent_Identity=32.368896925859, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1786942, Length=565, Percent_Identity=33.2743362831858, Blast_Score=224, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17505833, Length=530, Percent_Identity=32.8301886792453, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17550100, Length=534, Percent_Identity=31.2734082397004, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71986328, Length=458, Percent_Identity=27.292576419214, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322701, Length=533, Percent_Identity=33.0206378986867, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6322416, Length=534, Percent_Identity=33.5205992509363, Blast_Score=240, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6320788, Length=488, Percent_Identity=28.6885245901639, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322511, Length=484, Percent_Identity=26.6528925619835, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17137288, Length=568, Percent_Identity=32.3943661971831, Blast_Score=236, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24655642, Length=568, Percent_Identity=32.3943661971831, Blast_Score=236, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24655647, Length=568, Percent_Identity=32.3943661971831, Blast_Score=236, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24663005, Length=545, Percent_Identity=31.743119266055, Blast_Score=229, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 61064; Mature: 60933

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQLSQQGQSFEFDVLVIGTGLAGLHYCLQLLAIQPKLNIALISKAESIECNSRYAQGG
CCCCHHHCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCC
IAAAISPEDSLESHISDTVLAGDGLCYLPAVEFIIRQGPDIIKQLDQYKVQFKRENDGRF
EEEEECCHHHHHHHHCCCEECCCCEEHHHHHHHHHHCCHHHHHHHHHHHEEEEECCCCEE
HLAKEGGHSHRRIFNCGDQTGLTLTQTLNHLARQHQQIQFFEHHVAVNLITQYHPHRTDN
EEECCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
QGEVLGAYILDCQHNRIHTFLAKCVILATGGAGKTYRYTTNPMVATGDGVAMAYRAGARV
CCCEEEEEEEECCCCHHHHHHHHHHHEEECCCCCEEEEECCCEEECCCCEEEHHHCCCCC
GNMEFYQFHPTLLHHHTINNFLISEAVRGEGALLKNPETGERFMKRYAPDQLELATRDVV
CCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHCCCCHHHHHHHHHH
ARAIFSEIEQGQAGYVHLDISHQSKSFLKKRFPQIYSTLLSIGIDMSQDLIPVVPAAHYQ
HHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
CGGVLTDVDGRTDLARLYAIGEVAFTGLHGANRLASNSLLEALVMGSNAARCTLKDIATP
CCCEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHH
LKLIDHIPSWSSPGEVNARRASQINAQWRGLRGEMTSYAGIVRTEAGLEDLLQLILKRKK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
IIEEYYWKHCITRDFIELRNIILNAELIVRAALSRRESRGGHFREDFPNKNFKAQESIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHH
LGQADSSLG
HCCCCCCCC
>Mature Secondary Structure 
SDQLSQQGQSFEFDVLVIGTGLAGLHYCLQLLAIQPKLNIALISKAESIECNSRYAQGG
CCCHHHCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCC
IAAAISPEDSLESHISDTVLAGDGLCYLPAVEFIIRQGPDIIKQLDQYKVQFKRENDGRF
EEEEECCHHHHHHHHCCCEECCCCEEHHHHHHHHHHCCHHHHHHHHHHHEEEEECCCCEE
HLAKEGGHSHRRIFNCGDQTGLTLTQTLNHLARQHQQIQFFEHHVAVNLITQYHPHRTDN
EEECCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
QGEVLGAYILDCQHNRIHTFLAKCVILATGGAGKTYRYTTNPMVATGDGVAMAYRAGARV
CCCEEEEEEEECCCCHHHHHHHHHHHEEECCCCCEEEEECCCEEECCCCEEEHHHCCCCC
GNMEFYQFHPTLLHHHTINNFLISEAVRGEGALLKNPETGERFMKRYAPDQLELATRDVV
CCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHCCCCHHHHHHHHHH
ARAIFSEIEQGQAGYVHLDISHQSKSFLKKRFPQIYSTLLSIGIDMSQDLIPVVPAAHYQ
HHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
CGGVLTDVDGRTDLARLYAIGEVAFTGLHGANRLASNSLLEALVMGSNAARCTLKDIATP
CCCEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHH
LKLIDHIPSWSSPGEVNARRASQINAQWRGLRGEMTSYAGIVRTEAGLEDLLQLILKRKK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
IIEEYYWKHCITRDFIELRNIILNAELIVRAALSRRESRGGHFREDFPNKNFKAQESIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHH
LGQADSSLG
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]