Click here to switch to the map view.

The map label for this gene is neuB

Identifier: 52840989

GI number: 52840989

Start: 822797

End: 823867

Strand: Direct

Name: neuB

Synonym: lpg0752

Alternate gene names: NA

Gene position: 822797-823867 (Clockwise)

Preceding gene: 52840988

Following gene: 52840990

Centisome position: 24.22

GC content: 38.28

Gene sequence:

>1071_bases
TTGGGCTCTAACAGAAAAATTAATGGAATTAAACCAAGAGGCTCTAGTATGACTTGTTTTATTATTGCTGAAGCAGGAGT
AAACCATAATGGTGATCTTCAACTGGCTAAAGAATTAGTTTATGCAGCCAAAGAGTCAGGAGCTGATGCAGTAAAGTTTC
AGACTTTCAAAGCGGACACCTTGGTTAATAAAACAGTAGAAAAAGCGGAATACCAAAAAAATAATGCCCCGGAATCCTCT
ACTCAGTATGAGATGCTCAAGGCACTGGAACTTTCAGAAGAGGACCATTATTTACTAAGTGAATTAGCCAATTCACTCGG
CATTGAATTTATGTCAACTGGTTTTGATGAACAAAGCATCGATTTTCTTATTTCCCTAGGGGTAAAGCGATTAAAAATCC
CTTCTGGCGAAATTACTAATGTACCTTATTTACAACATTGTGCCAGTAAGAAGTTACCTTTAATCATCTCAACAGGGATG
TGCGATCTACAAGAAGTAAGAGTAGCCATAGATACAGTAAAACCCTACTATGGAAACTCTTTATCCGATTATTTGGTTTT
GTTGCATTGCACTTCTAATTATCCGGCATCTTATCAAGACGTGAATCTGAAAGCCATGCAGACTTTAGCTGACGAATTTC
AATTGCCAGTAGGTTATTCTGATCATACTTTAGGTATTTTGGTGCCAACATTAGCAGTAGGAATGGGGGCGTGTGTTATC
GAAAAGCATTTTACAATGGATAAATCTCTTCCTGGTCCAGATCATCTGGCTTCTATGGATCCAGAGGAAATGAAGAATTT
AGTACAATCCATTAGAGACGCTGAAACTGTTTTGGGAAGTGGTGAAAAAAAACCGTCGGATAATGAGCTGCCGATAAGAG
CTCTGGTTAGAAGAAGTATTACTTTAAGACGTGATTTGGTGAAAGGAGCACAAATCAGTAAAGAAGATTTGATCTTGCTA
AGACCTGGTACTGGGATAGCGCCCTCTGAAATATCAAATATTGTAGGCTCTCGATTAAGTATGAATTTGTCTGCGGGTAC
TACTTTGTTATGGGAACATATTGAAGCGTAA

Upstream 100 bases:

>100_bases
CTAAACAAATTATTGAAAATAAGAGTTTTTATAGCGAACCAACCAAACCTTTATTGTTAAATAGTATTAGTGAATCCATC
GACATCGATACGCCAATCGA

Downstream 100 bases:

>100_bases
TGATCAGAAAAATAATTTATGTTACAGGTACTCGTGCCGATTATGGACTGATGAGAGAAGTACTAAAAAGATTACACCAG
TCAGAAGACATTGACTTATC

Product: N-acetylneuraminic acid synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MGSNRKINGIKPRGSSMTCFIIAEAGVNHNGDLQLAKELVYAAKESGADAVKFQTFKADTLVNKTVEKAEYQKNNAPESS
TQYEMLKALELSEEDHYLLSELANSLGIEFMSTGFDEQSIDFLISLGVKRLKIPSGEITNVPYLQHCASKKLPLIISTGM
CDLQEVRVAIDTVKPYYGNSLSDYLVLLHCTSNYPASYQDVNLKAMQTLADEFQLPVGYSDHTLGILVPTLAVGMGACVI
EKHFTMDKSLPGPDHLASMDPEEMKNLVQSIRDAETVLGSGEKKPSDNELPIRALVRRSITLRRDLVKGAQISKEDLILL
RPGTGIAPSEISNIVGSRLSMNLSAGTTLLWEHIEA

Sequences:

>Translated_356_residues
MGSNRKINGIKPRGSSMTCFIIAEAGVNHNGDLQLAKELVYAAKESGADAVKFQTFKADTLVNKTVEKAEYQKNNAPESS
TQYEMLKALELSEEDHYLLSELANSLGIEFMSTGFDEQSIDFLISLGVKRLKIPSGEITNVPYLQHCASKKLPLIISTGM
CDLQEVRVAIDTVKPYYGNSLSDYLVLLHCTSNYPASYQDVNLKAMQTLADEFQLPVGYSDHTLGILVPTLAVGMGACVI
EKHFTMDKSLPGPDHLASMDPEEMKNLVQSIRDAETVLGSGEKKPSDNELPIRALVRRSITLRRDLVKGAQISKEDLILL
RPGTGIAPSEISNIVGSRLSMNLSAGTTLLWEHIEA
>Mature_355_residues
GSNRKINGIKPRGSSMTCFIIAEAGVNHNGDLQLAKELVYAAKESGADAVKFQTFKADTLVNKTVEKAEYQKNNAPESST
QYEMLKALELSEEDHYLLSELANSLGIEFMSTGFDEQSIDFLISLGVKRLKIPSGEITNVPYLQHCASKKLPLIISTGMC
DLQEVRVAIDTVKPYYGNSLSDYLVLLHCTSNYPASYQDVNLKAMQTLADEFQLPVGYSDHTLGILVPTLAVGMGACVIE
KHFTMDKSLPGPDHLASMDPEEMKNLVQSIRDAETVLGSGEKKPSDNELPIRALVRRSITLRRDLVKGAQISKEDLILLR
PGTGIAPSEISNIVGSRLSMNLSAGTTLLWEHIEA

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=345, Percent_Identity=34.2028985507246, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21357081, Length=364, Percent_Identity=31.8681318681319, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 38991; Mature: 38860

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSNRKINGIKPRGSSMTCFIIAEAGVNHNGDLQLAKELVYAAKESGADAVKFQTFKADT
CCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHH
LVNKTVEKAEYQKNNAPESSTQYEMLKALELSEEDHYLLSELANSLGIEFMSTGFDEQSI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCCCCHHHH
DFLISLGVKRLKIPSGEITNVPYLQHCASKKLPLIISTGMCDLQEVRVAIDTVKPYYGNS
HHHHHCCHHEEECCCCCCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCC
LSDYLVLLHCTSNYPASYQDVNLKAMQTLADEFQLPVGYSDHTLGILVPTLAVGMGACVI
HHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHH
EKHFTMDKSLPGPDHLASMDPEEMKNLVQSIRDAETVLGSGEKKPSDNELPIRALVRRSI
HHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
TLRRDLVKGAQISKEDLILLRPGTGIAPSEISNIVGSRLSMNLSAGTTLLWEHIEA
HHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHCC
>Mature Secondary Structure 
GSNRKINGIKPRGSSMTCFIIAEAGVNHNGDLQLAKELVYAAKESGADAVKFQTFKADT
CCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHH
LVNKTVEKAEYQKNNAPESSTQYEMLKALELSEEDHYLLSELANSLGIEFMSTGFDEQSI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCCCCHHHH
DFLISLGVKRLKIPSGEITNVPYLQHCASKKLPLIISTGMCDLQEVRVAIDTVKPYYGNS
HHHHHCCHHEEECCCCCCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCC
LSDYLVLLHCTSNYPASYQDVNLKAMQTLADEFQLPVGYSDHTLGILVPTLAVGMGACVI
HHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHH
EKHFTMDKSLPGPDHLASMDPEEMKNLVQSIRDAETVLGSGEKKPSDNELPIRALVRRSI
HHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
TLRRDLVKGAQISKEDLILLRPGTGIAPSEISNIVGSRLSMNLSAGTTLLWEHIEA
HHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]