Click here to switch to the map view.

The map label for this gene is neuA

Identifier: 52840988

GI number: 52840988

Start: 822150

End: 822848

Strand: Direct

Name: neuA

Synonym: lpg0751

Alternate gene names: 52840988

Gene position: 822150-822848 (Clockwise)

Preceding gene: 52840987

Following gene: 52840989

Centisome position: 24.2

GC content: 38.48

Gene sequence:

>699_bases
ATGAGAATATTGGCAGTAATCCCGGCAAGGGCTGGCTCAAAGAGGCTGCCCGGTAAAAATACCAGATTACTTGCCGGAAA
GCCATTAATTGCACATACTATTGTTGCTGCCTTGCAGTCGTCTTGTTGTGAAGAAATCGTTGTTTCAACCGATAGTAAAC
AAATAGCAGACGTCGCCGTTCAATATGGGGCTTCAGTACCCTGGCTAAGATCGGAAGATTTAGCCACGGATACTTCGGAT
GTGATTCATACTGTTATTGACCTCCTGTTTAAGTTTCAGCAAATGGATGTTTTTTTTGACAGTGTATTGCTGTTACAACC
AACTTCTCCATTTAGGAAGCCAGAAACCATAAGACATGCTGTTGAAATACATAAAGTAACGGGGAAAAGTGTCGTTTCAG
TTAGTCCCATCTCTTTAAAGCCTTCTTGGTGTAGAAGCATTGATAGCCAAGGCAATTTGGTTAAGCCAGAACTTTTTCAG
GATCTGGAAATTTATTGCAACGAGAATCCAATTTATAAATTAAATGGGTCAATTTATATTGCAACAGCTAAACAAATTAT
TGAAAATAAGAGTTTTTATAGCGAACCAACCAAACCTTTATTGTTAAATAGTATTAGTGAATCCATCGACATCGATACGC
CAATCGATTGGGCTCTAACAGAAAAATTAATGGAATTAAACCAAGAGGCTCTAGTATGA

Upstream 100 bases:

>100_bases
AGATGAAAATATGTACGGATGCCAATTTCATCCTGAAAAAAGCGGGGAAGTAGGTTTAAGCATCATTCAACAGTTTTTGC
AGATTTAGGGTGAATTAAAA

Downstream 100 bases:

>100_bases
CTTGTTTTATTATTGCTGAAGCAGGAGTAAACCATAATGGTGATCTTCAACTGGCTAAAGAATTAGTTTATGCAGCCAAA
GAGTCAGGAGCTGATGCAGT

Product: CMP-N-acetylneuraminic acid synthetase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MRILAVIPARAGSKRLPGKNTRLLAGKPLIAHTIVAALQSSCCEEIVVSTDSKQIADVAVQYGASVPWLRSEDLATDTSD
VIHTVIDLLFKFQQMDVFFDSVLLLQPTSPFRKPETIRHAVEIHKVTGKSVVSVSPISLKPSWCRSIDSQGNLVKPELFQ
DLEIYCNENPIYKLNGSIYIATAKQIIENKSFYSEPTKPLLLNSISESIDIDTPIDWALTEKLMELNQEALV

Sequences:

>Translated_232_residues
MRILAVIPARAGSKRLPGKNTRLLAGKPLIAHTIVAALQSSCCEEIVVSTDSKQIADVAVQYGASVPWLRSEDLATDTSD
VIHTVIDLLFKFQQMDVFFDSVLLLQPTSPFRKPETIRHAVEIHKVTGKSVVSVSPISLKPSWCRSIDSQGNLVKPELFQ
DLEIYCNENPIYKLNGSIYIATAKQIIENKSFYSEPTKPLLLNSISESIDIDTPIDWALTEKLMELNQEALV
>Mature_232_residues
MRILAVIPARAGSKRLPGKNTRLLAGKPLIAHTIVAALQSSCCEEIVVSTDSKQIADVAVQYGASVPWLRSEDLATDTSD
VIHTVIDLLFKFQQMDVFFDSVLLLQPTSPFRKPETIRHAVEIHKVTGKSVVSVSPISLKPSWCRSIDSQGNLVKPELFQ
DLEIYCNENPIYKLNGSIYIATAKQIIENKSFYSEPTKPLLLNSISESIDIDTPIDWALTEKLMELNQEALV

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=241, Percent_Identity=30.7053941908714, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329
- InterPro:   IPR013830
- InterPro:   IPR013831 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 25764; Mature: 25764

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILAVIPARAGSKRLPGKNTRLLAGKPLIAHTIVAALQSSCCEEIVVSTDSKQIADVAV
CEEEEEECCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QYGASVPWLRSEDLATDTSDVIHTVIDLLFKFQQMDVFFDSVLLLQPTSPFRKPETIRHA
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCHHHHHHH
VEIHKVTGKSVVSVSPISLKPSWCRSIDSQGNLVKPELFQDLEIYCNENPIYKLNGSIYI
HHHHHHCCCCEEEECCCCCCHHHHHHCCCCCCEECHHHHHHHHEEECCCCEEEECCCEEE
ATAKQIIENKSFYSEPTKPLLLNSISESIDIDTPIDWALTEKLMELNQEALV
EEHHHHHHCCHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRILAVIPARAGSKRLPGKNTRLLAGKPLIAHTIVAALQSSCCEEIVVSTDSKQIADVAV
CEEEEEECCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QYGASVPWLRSEDLATDTSDVIHTVIDLLFKFQQMDVFFDSVLLLQPTSPFRKPETIRHA
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCHHHHHHH
VEIHKVTGKSVVSVSPISLKPSWCRSIDSQGNLVKPELFQDLEIYCNENPIYKLNGSIYI
HHHHHHCCCCEEEECCCCCCHHHHHHCCCCCCEECHHHHHHHHEEECCCCEEEECCCEEE
ATAKQIIENKSFYSEPTKPLLLNSISESIDIDTPIDWALTEKLMELNQEALV
EEHHHHHHCCHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2549035 [H]