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The map label for this gene is pacS [H]

Identifier: 52840486

GI number: 52840486

Start: 267234

End: 269792

Strand: Reverse

Name: pacS [H]

Synonym: lpg0231

Alternate gene names: 52840486

Gene position: 269792-267234 (Counterclockwise)

Preceding gene: 52840488

Following gene: 52840485

Centisome position: 7.94

GC content: 40.48

Gene sequence:

>2559_bases
ATGCTGTATAGTAATTATCGATTCTACCTTGCAAAAGATGCCCAACTTCTCAACCCGGAAGAATCCAGAGAAGCAATTGA
GCAGATTTTAGCTAAAACTAAAGAGTTGGAGTTAATAAGAGTAGCTGTCGATTTGACTAGTTCAAATAAAAGCATCAGCT
TATTGAGCGCATCCAAAGAGAATCATGTCATAAAAACCAAAGTGACCCAGATTTTAAAGGAGCAGGGCCTTTCTGTAATA
GACATGATGGAAGTGGAAGTGCTCCAGGATATTGAAAAAATAGAGCATCACCATCCTACTCATAAGTCTAAGAACACACA
TCTTCATCCCGTTAAAAAGCACCAAAAAAAAGCAAAACATGACCATTCTCATGGGCATGGGCACCACCATGGACATCATC
ATGAAAATCATTGGATCAAAGCAGCATTAGGTTTGATTTGGGGAATTGGATTACTTGTTCTTTCTATTGGGACTTTTAAT
ATTCCCTTGGTTGCTTACTATGTCATTACAGGACTTACCTCTTTGATGACTTTGTATTTGGGCCACACAGTTTATCAATC
AGCCTGGCAAGCATTGAAAGAAAAAAAATGGGACACCACTACTTTATACTCAATTAGCACTCTAACTATTCTTGCTGTTT
CTATTGCGAGCGTTTTTGTCCCTGGCCTACCCATGATGTTTGAGGCAGCCCCTCTGGTTTTAGGCTTTTGGCATTTAGGT
GAAGGAATTGAACATACTCTGGTCGGTAAAATCAATAAAAAATTGGATGTCCGGGATTGTGTACCACCATTAGTCCTGTT
AAAAGGTAATCCGGATAAAGAGATTTCAGTCAAGACATTAATTCCTAACGACATGATTATCGTTAAAAAAGGACAGGTCA
TTCCTGTTGATGGTGTCTTAACGCAAAAAGCGCTCCTTTATACCACAAGAATTGATGGCTCGCCCAAACTCAAAGAATTT
CACCCTGGGGATGTTGTAAAAGCTGGCATGCAATTGGCAGATCATATTCCTTCTCTGGAAATGCAGGTTACCAAAACTTA
TCAAAATTCTTATTTGTCATTGATTGCCGAAAACATTAATAAAGCGAATGATGAGAAAGCGCCTATCGAAATGTTTGCAG
ACAAGGTATTGAAATATTTTATTCCTGGTTTGATTGCGGTAGCGCTCCTATCGGGGATTGTGATCGGTTCGTTGTTTAAT
CCAGCACTGGCTATTCAATGCGTCGTGTCTGTTCTGGTAAGTGCCTGCCCGTGCGCTTTGAGTTTAATTACCCCAATGGC
AGTTAAAATCGGTATGAAAAAAGCCTCTGAAAACGGCATCCACTTTAACAACGGTAAAGCCTTGCAAGCAGCAGCCGACA
TCGATACCGTTGTTTTTGATTTGAATGGCACTCTGACTCAGGGCAAAATGGTGGTGAAATCATTGCATATTACTGATAAA
AAGTATTTGCGCCCTATTGCATTACTGGAAAGCCAGTCGGATCATCCAGTAGCGAAAATTATTAAATCTTACATGGAACA
GCAAGATACGGCTTCAACCGAACCATTAGAAATAACGTCAATTGATAAGAGTCATCATTCCGGCATGAAAGGTATTATTA
ATGGTGAGGTCTTTATTATAGGGAATAAAGACATGCTTGCCGCCAATGGAATTACCTCTATCGACAAACCCTATGATAAT
CCTGAAAAAGGTTCTGTTTATATTGTGCGTGGGACAACGGTGATAGGTCAAATTGCCTTAATTGATCCATTGCGAGAGGA
TGCCATTGCTACAGTGAAACAATTGAAACGTCTTGGAAAATCCGTACATATTTGCACCGGGGCAGATCAAGCTACTGCAG
AAAAATATGCGGCATTATTAGGCATTCCCAAGGATAATATCTGTGCGAACACTGTGGGGGCTGTCACGAAAAAGGGGGAA
GTATCCAAAACCAGTTATATTCAACAATTAAAGCAAAAAGGCTTTAAAGTAGCTATGGTTGGTGATGCCGCTAATGACGC
TACGGCAATTGCCTATTCCGATATAGGCATTGCTGTTAAATCAAGTATCGGTGACTCCATAACCGAACAACATGCCGGCA
TAGTCGTACAACAAGGCTTATTATTTCCTATAGCAACAGCATTTGATGTAGCCCAAAAAACCAAACAAAATATTTTCCAA
AACCTGTTCGTGAGCCTAAGCTATAACTCAATAATTACGCTTGTGGCGGCGGGGTTGTTTGTGGCATTAGGTTTTGCACT
AAATCCTGTGCTGGGTGTCGCATTGATGGTGCTTGAATCCACTATTGTTTTGACGAACTTATATCTTTTCAAGCAACAAG
ATATTGTGTCCTCAACATCATCCAATGCCAATAATGCTGTAGAGATCGAGCCCGCTGCAAATACAACCTCAAAGGTCTTG
CATGCTTTAGGGCATCGTTCCCAGCCTCAAGAAAATTTAGCAGTTGTGACAGAGTCTAAACCAGTCAATCCCAAAGTAAT
AAATTTGTTTGCACCTAAAGAACATTCTTCGTATAGGCCTGATGCCACTCAACAAAAATTGGGGTGCGGCATCTGTTGA

Upstream 100 bases:

>100_bases
ACCGCTGGCTCTATTGTGCAGACCCAGTTTCAAAATAGGCATTTGCAGAAAATTAACCTTTCTCTATAGCAACCAGAACC
CCTTTAAATAGAGGAAAGCC

Downstream 100 bases:

>100_bases
TCAAGCAGTACTGGAAATTGCCTTGATTTTCTACTTCAAGGCAGTTGTTACGATAGCCATCATTTCGTTAATAACTGTTT
TTTGGACTATACTCTTATCA

Product: heavy metal transporting P-type ATPase, cation transporting

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 852; Mature: 852

Protein sequence:

>852_residues
MLYSNYRFYLAKDAQLLNPEESREAIEQILAKTKELELIRVAVDLTSSNKSISLLSASKENHVIKTKVTQILKEQGLSVI
DMMEVEVLQDIEKIEHHHPTHKSKNTHLHPVKKHQKKAKHDHSHGHGHHHGHHHENHWIKAALGLIWGIGLLVLSIGTFN
IPLVAYYVITGLTSLMTLYLGHTVYQSAWQALKEKKWDTTTLYSISTLTILAVSIASVFVPGLPMMFEAAPLVLGFWHLG
EGIEHTLVGKINKKLDVRDCVPPLVLLKGNPDKEISVKTLIPNDMIIVKKGQVIPVDGVLTQKALLYTTRIDGSPKLKEF
HPGDVVKAGMQLADHIPSLEMQVTKTYQNSYLSLIAENINKANDEKAPIEMFADKVLKYFIPGLIAVALLSGIVIGSLFN
PALAIQCVVSVLVSACPCALSLITPMAVKIGMKKASENGIHFNNGKALQAAADIDTVVFDLNGTLTQGKMVVKSLHITDK
KYLRPIALLESQSDHPVAKIIKSYMEQQDTASTEPLEITSIDKSHHSGMKGIINGEVFIIGNKDMLAANGITSIDKPYDN
PEKGSVYIVRGTTVIGQIALIDPLREDAIATVKQLKRLGKSVHICTGADQATAEKYAALLGIPKDNICANTVGAVTKKGE
VSKTSYIQQLKQKGFKVAMVGDAANDATAIAYSDIGIAVKSSIGDSITEQHAGIVVQQGLLFPIATAFDVAQKTKQNIFQ
NLFVSLSYNSIITLVAAGLFVALGFALNPVLGVALMVLESTIVLTNLYLFKQQDIVSSTSSNANNAVEIEPAANTTSKVL
HALGHRSQPQENLAVVTESKPVNPKVINLFAPKEHSSYRPDATQQKLGCGIC

Sequences:

>Translated_852_residues
MLYSNYRFYLAKDAQLLNPEESREAIEQILAKTKELELIRVAVDLTSSNKSISLLSASKENHVIKTKVTQILKEQGLSVI
DMMEVEVLQDIEKIEHHHPTHKSKNTHLHPVKKHQKKAKHDHSHGHGHHHGHHHENHWIKAALGLIWGIGLLVLSIGTFN
IPLVAYYVITGLTSLMTLYLGHTVYQSAWQALKEKKWDTTTLYSISTLTILAVSIASVFVPGLPMMFEAAPLVLGFWHLG
EGIEHTLVGKINKKLDVRDCVPPLVLLKGNPDKEISVKTLIPNDMIIVKKGQVIPVDGVLTQKALLYTTRIDGSPKLKEF
HPGDVVKAGMQLADHIPSLEMQVTKTYQNSYLSLIAENINKANDEKAPIEMFADKVLKYFIPGLIAVALLSGIVIGSLFN
PALAIQCVVSVLVSACPCALSLITPMAVKIGMKKASENGIHFNNGKALQAAADIDTVVFDLNGTLTQGKMVVKSLHITDK
KYLRPIALLESQSDHPVAKIIKSYMEQQDTASTEPLEITSIDKSHHSGMKGIINGEVFIIGNKDMLAANGITSIDKPYDN
PEKGSVYIVRGTTVIGQIALIDPLREDAIATVKQLKRLGKSVHICTGADQATAEKYAALLGIPKDNICANTVGAVTKKGE
VSKTSYIQQLKQKGFKVAMVGDAANDATAIAYSDIGIAVKSSIGDSITEQHAGIVVQQGLLFPIATAFDVAQKTKQNIFQ
NLFVSLSYNSIITLVAAGLFVALGFALNPVLGVALMVLESTIVLTNLYLFKQQDIVSSTSSNANNAVEIEPAANTTSKVL
HALGHRSQPQENLAVVTESKPVNPKVINLFAPKEHSSYRPDATQQKLGCGIC
>Mature_852_residues
MLYSNYRFYLAKDAQLLNPEESREAIEQILAKTKELELIRVAVDLTSSNKSISLLSASKENHVIKTKVTQILKEQGLSVI
DMMEVEVLQDIEKIEHHHPTHKSKNTHLHPVKKHQKKAKHDHSHGHGHHHGHHHENHWIKAALGLIWGIGLLVLSIGTFN
IPLVAYYVITGLTSLMTLYLGHTVYQSAWQALKEKKWDTTTLYSISTLTILAVSIASVFVPGLPMMFEAAPLVLGFWHLG
EGIEHTLVGKINKKLDVRDCVPPLVLLKGNPDKEISVKTLIPNDMIIVKKGQVIPVDGVLTQKALLYTTRIDGSPKLKEF
HPGDVVKAGMQLADHIPSLEMQVTKTYQNSYLSLIAENINKANDEKAPIEMFADKVLKYFIPGLIAVALLSGIVIGSLFN
PALAIQCVVSVLVSACPCALSLITPMAVKIGMKKASENGIHFNNGKALQAAADIDTVVFDLNGTLTQGKMVVKSLHITDK
KYLRPIALLESQSDHPVAKIIKSYMEQQDTASTEPLEITSIDKSHHSGMKGIINGEVFIIGNKDMLAANGITSIDKPYDN
PEKGSVYIVRGTTVIGQIALIDPLREDAIATVKQLKRLGKSVHICTGADQATAEKYAALLGIPKDNICANTVGAVTKKGE
VSKTSYIQQLKQKGFKVAMVGDAANDATAIAYSDIGIAVKSSIGDSITEQHAGIVVQQGLLFPIATAFDVAQKTKQNIFQ
NLFVSLSYNSIITLVAAGLFVALGFALNPVLGVALMVLESTIVLTNLYLFKQQDIVSSTSSNANNAVEIEPAANTTSKVL
HALGHRSQPQENLAVVTESKPVNPKVINLFAPKEHSSYRPDATQQKLGCGIC

Specific function: May play a role in the osmotic adaptation [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=734, Percent_Identity=26.4305177111717, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI115529486, Length=678, Percent_Identity=25.811209439528, Blast_Score=188, Evalue=2e-47,
Organism=Homo sapiens, GI55743073, Length=532, Percent_Identity=26.8796992481203, Blast_Score=147, Evalue=3e-35,
Organism=Escherichia coli, GI1786691, Length=670, Percent_Identity=30.1492537313433, Blast_Score=212, Evalue=8e-56,
Organism=Escherichia coli, GI1789879, Length=615, Percent_Identity=28.780487804878, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI1786914, Length=440, Percent_Identity=25.9090909090909, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17556548, Length=680, Percent_Identity=26.1764705882353, Blast_Score=166, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6320475, Length=640, Percent_Identity=28.90625, Blast_Score=201, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6319772, Length=647, Percent_Identity=25.8114374034003, Blast_Score=157, Evalue=5e-39,
Organism=Drosophila melanogaster, GI221329854, Length=407, Percent_Identity=29.4840294840295, Blast_Score=109, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 92672; Mature: 92672

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYSNYRFYLAKDAQLLNPEESREAIEQILAKTKELELIRVAVDLTSSNKSISLLSASKE
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCEEEEEECCCC
NHVIKTKVTQILKEQGLSVIDMMEVEVLQDIEKIEHHHPTHKSKNTHLHPVKKHQKKAKH
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHC
DHSHGHGHHHGHHHENHWIKAALGLIWGIGLLVLSIGTFNIPLVAYYVITGLTSLMTLYL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GHTVYQSAWQALKEKKWDTTTLYSISTLTILAVSIASVFVPGLPMMFEAAPLVLGFWHLG
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
EGIEHTLVGKINKKLDVRDCVPPLVLLKGNPDKEISVKTLIPNDMIIVKKGQVIPVDGVL
CCCCHHHHHHHCCCCCHHHCCCCEEEEECCCCCCEEEEEECCCCEEEEECCCEEECCCHH
TQKALLYTTRIDGSPKLKEFHPGDVVKAGMQLADHIPSLEMQVTKTYQNSYLSLIAENIN
HCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHH
KANDEKAPIEMFADKVLKYFIPGLIAVALLSGIVIGSLFNPALAIQCVVSVLVSACPCAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLITPMAVKIGMKKASENGIHFNNGKALQAAADIDTVVFDLNGTLTQGKMVVKSLHITDK
HHHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCH
KYLRPIALLESQSDHPVAKIIKSYMEQQDTASTEPLEITSIDKSHHSGMKGIINGEVFII
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHCCCCCEEECCEEEEE
GNKDMLAANGITSIDKPYDNPEKGSVYIVRGTTVIGQIALIDPLREDAIATVKQLKRLGK
ECCCEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEHHHHHCHHHHHHHHHHHHHHHHCC
SVHICTGADQATAEKYAALLGIPKDNICANTVGAVTKKGEVSKTSYIQQLKQKGFKVAMV
EEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEE
GDAANDATAIAYSDIGIAVKSSIGDSITEQHAGIVVQQGLLFPIATAFDVAQKTKQNIFQ
ECCCCCCEEEEEECCCEEEHHHCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHH
NLFVSLSYNSIITLVAAGLFVALGFALNPVLGVALMVLESTIVLTNLYLFKQQDIVSSTS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SNANNAVEIEPAANTTSKVLHALGHRSQPQENLAVVTESKPVNPKVINLFAPKEHSSYRP
CCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCC
DATQQKLGCGIC
CCHHHHCCCCCC
>Mature Secondary Structure
MLYSNYRFYLAKDAQLLNPEESREAIEQILAKTKELELIRVAVDLTSSNKSISLLSASKE
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCEEEEEECCCC
NHVIKTKVTQILKEQGLSVIDMMEVEVLQDIEKIEHHHPTHKSKNTHLHPVKKHQKKAKH
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHC
DHSHGHGHHHGHHHENHWIKAALGLIWGIGLLVLSIGTFNIPLVAYYVITGLTSLMTLYL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GHTVYQSAWQALKEKKWDTTTLYSISTLTILAVSIASVFVPGLPMMFEAAPLVLGFWHLG
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
EGIEHTLVGKINKKLDVRDCVPPLVLLKGNPDKEISVKTLIPNDMIIVKKGQVIPVDGVL
CCCCHHHHHHHCCCCCHHHCCCCEEEEECCCCCCEEEEEECCCCEEEEECCCEEECCCHH
TQKALLYTTRIDGSPKLKEFHPGDVVKAGMQLADHIPSLEMQVTKTYQNSYLSLIAENIN
HCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHH
KANDEKAPIEMFADKVLKYFIPGLIAVALLSGIVIGSLFNPALAIQCVVSVLVSACPCAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLITPMAVKIGMKKASENGIHFNNGKALQAAADIDTVVFDLNGTLTQGKMVVKSLHITDK
HHHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCH
KYLRPIALLESQSDHPVAKIIKSYMEQQDTASTEPLEITSIDKSHHSGMKGIINGEVFII
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHCCCCCEEECCEEEEE
GNKDMLAANGITSIDKPYDNPEKGSVYIVRGTTVIGQIALIDPLREDAIATVKQLKRLGK
ECCCEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEHHHHHCHHHHHHHHHHHHHHHHCC
SVHICTGADQATAEKYAALLGIPKDNICANTVGAVTKKGEVSKTSYIQQLKQKGFKVAMV
EEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEE
GDAANDATAIAYSDIGIAVKSSIGDSITEQHAGIVVQQGLLFPIATAFDVAQKTKQNIFQ
ECCCCCCEEEEEECCCEEEHHHCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHH
NLFVSLSYNSIITLVAAGLFVALGFALNPVLGVALMVLESTIVLTNLYLFKQQDIVSSTS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SNANNAVEIEPAANTTSKVLHALGHRSQPQENLAVVTESKPVNPKVINLFAPKEHSSYRP
CCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCC
DATQQKLGCGIC
CCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]