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The map label for this gene is purK

Identifier: 52840472

GI number: 52840472

Start: 249089

End: 250168

Strand: Reverse

Name: purK

Synonym: lpg0217

Alternate gene names: 52840472

Gene position: 250168-249089 (Counterclockwise)

Preceding gene: 52840473

Following gene: 52840469

Centisome position: 7.36

GC content: 41.11

Gene sequence:

>1080_bases
ATGAAACTTGGTATTCTAGGTGGTGGCCAACTTGCAAGAATGTTGGCATTAGCAGCATATCCCTTAGGGATTAACACTGT
CTGCCTGGATCCCAGCCCTGATGCTTGTGCTGGCCAACTCACCAGGCTGATAGTCTCTGATTTTAATGATGAATTGGCTT
TAAAACAATTTTTGTCAGAAGTGGATTGCGTCACAATAGAAACCGAAAATATACCATTTTCTTGTGCCGAATTAATTGCC
CAAATAAAGCCTTTTTATCCATCAACCCAAGCTTTGAAAATTACGCAAGACAGATTATATGAAAAAAATTTTTTCAGGTC
TCTGAATATTCCTACTCCAGAATTTTTACCAGTTGAATCTGAAGGTGAATTGATGCAGGCTATTACGGACATAGGAATGC
CTGCCGTGTTAAAAACAAGAAGGTTTGGCTATGATGGCAAGGGCCAATTTGTTTTGCGAGCCCAATCAGATATTTCAAAA
AGTTGGGGCCTGTTAGGCAGTCAGCCTCTCATTCTCGAAGAGTTAATTTCCTTTGAAAGTGAATTTTCGCTAATTGCTGT
TCGCAATAAGAGTGGTGAAACAAGTTTCTACCCATTGATTAAAAATCATCACAGGAAGGGCATTTTACATTTCTCAGAAG
CCCCTGTTCATCAGGACACCTTACAACAGGAGGCGCAAACTCATGCATTCAAAATTTTAGAAGCCCTGAATTATGTTGGT
GTACTTACCATTGAGTTTTTTTATCAAGGCAACCAATTGATTGCGAATGAGATAGCACCACGCGTTCATAATTCTGGCCA
CTGGACTATCGAGGGAGCACATACTAGCCAATTCGAAAATCATCTGCGCGCTCTTTTTGATTTGCCCTTGGGAAGCACTG
AAGTAAGCGGCTCTTGTTTTTTATTAAATTGCATTGGCAATCTGCTGCCATTGGAGCCCTGTTTATCGATCCCGGGTGTT
CATTATCACGCTTATGGAAAAGCCCCCCGGCCAGATCGCAAGGTAGGTCATGTTACCCTTATCGATACTCATTTGGAACG
TTATGCAAAAAGCAAAGACTTACTTCTTGACATTTCATGA

Upstream 100 bases:

>100_bases
TTGCTAATAAATATCCTGATATTCGAGCTGCCTTAAAACACTATAGAGAACAACAAACACAAAAAGTGCTCGACAATCCA
AACCCTAAAGAGGAAAAGTC

Downstream 100 bases:

>100_bases
GTAGCAGATAGTTAGAAAGCGAGCAATAGGAGTCAGCGCATAATATTGTTCGCAATTTGGAAAGCTGAGCGTTGGATTCT
GTTGCCTACTGCTCATCCAC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPDACAGQLTRLIVSDFNDELALKQFLSEVDCVTIETENIPFSCAELIA
QIKPFYPSTQALKITQDRLYEKNFFRSLNIPTPEFLPVESEGELMQAITDIGMPAVLKTRRFGYDGKGQFVLRAQSDISK
SWGLLGSQPLILEELISFESEFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQTHAFKILEALNYVG
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSGSCFLLNCIGNLLPLEPCLSIPGV
HYHAYGKAPRPDRKVGHVTLIDTHLERYAKSKDLLLDIS

Sequences:

>Translated_359_residues
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPDACAGQLTRLIVSDFNDELALKQFLSEVDCVTIETENIPFSCAELIA
QIKPFYPSTQALKITQDRLYEKNFFRSLNIPTPEFLPVESEGELMQAITDIGMPAVLKTRRFGYDGKGQFVLRAQSDISK
SWGLLGSQPLILEELISFESEFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQTHAFKILEALNYVG
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSGSCFLLNCIGNLLPLEPCLSIPGV
HYHAYGKAPRPDRKVGHVTLIDTHLERYAKSKDLLLDIS
>Mature_359_residues
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPDACAGQLTRLIVSDFNDELALKQFLSEVDCVTIETENIPFSCAELIA
QIKPFYPSTQALKITQDRLYEKNFFRSLNIPTPEFLPVESEGELMQAITDIGMPAVLKTRRFGYDGKGQFVLRAQSDISK
SWGLLGSQPLILEELISFESEFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQTHAFKILEALNYVG
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSGSCFLLNCIGNLLPLEPCLSIPGV
HYHAYGKAPRPDRKVGHVTLIDTHLERYAKSKDLLLDIS

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=357, Percent_Identity=36.1344537815126, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1788155, Length=311, Percent_Identity=27.0096463022508, Blast_Score=102, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324702, Length=364, Percent_Identity=33.5164835164835, Blast_Score=205, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 39918; Mature: 39918

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPDACAGQLTRLIVSDFNDELALKQFLSE
CEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
VDCVTIETENIPFSCAELIAQIKPFYPSTQALKITQDRLYEKNFFRSLNIPTPEFLPVES
CCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCEEECCC
EGELMQAITDIGMPAVLKTRRFGYDGKGQFVLRAQSDISKSWGLLGSQPLILEELISFES
CCHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEECHHHHHHCCCCCCCCHHHHHHHCCCC
EFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQTHAFKILEALNYVG
CCEEEEEECCCCCCEEEHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHE
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSGSCF
EEEEEEEECCCEEEHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCEE
LLNCIGNLLPLEPCLSIPGVHYHAYGKAPRPDRKVGHVTLIDTHLERYAKSKDLLLDIS
EHHHHHCCCCCCHHHCCCCCEEEECCCCCCCCCCCCEEEEEHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPDACAGQLTRLIVSDFNDELALKQFLSE
CEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
VDCVTIETENIPFSCAELIAQIKPFYPSTQALKITQDRLYEKNFFRSLNIPTPEFLPVES
CCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCEEECCC
EGELMQAITDIGMPAVLKTRRFGYDGKGQFVLRAQSDISKSWGLLGSQPLILEELISFES
CCHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEECHHHHHHCCCCCCCCHHHHHHHCCCC
EFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQTHAFKILEALNYVG
CCEEEEEECCCCCCEEEHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHE
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSGSCF
EEEEEEEECCCEEEHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCEE
LLNCIGNLLPLEPCLSIPGVHYHAYGKAPRPDRKVGHVTLIDTHLERYAKSKDLLLDIS
EHHHHHCCCCCCHHHCCCCCEEEECCCCCCCCCCCCEEEEEHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]