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The map label for this gene is cidA1 [H]

Identifier: 52840469

GI number: 52840469

Start: 247292

End: 247900

Strand: Reverse

Name: cidA1 [H]

Synonym: lpg0214

Alternate gene names: 52840469

Gene position: 247900-247292 (Counterclockwise)

Preceding gene: 52840472

Following gene: 52840468

Centisome position: 7.3

GC content: 37.77

Gene sequence:

>609_bases
CTGTTTTATGGCTTTACTGACTGTAGACTGGGTCGTAAAGAGATTTTCAGCCGCTTTGGAAAAACTACCCTGCCGTACAA
CCTCTATGAAAGTCTGAAGCAGTTTAAATTCCATAATTATTCCATATTGGAAAGGTTATTAGTCTATAAATTCATTTTAT
TCATCTTAATTAAAAGTGTAAACTTAAATGAAAAAATAATATCCACCATGAGCACATATATGGCAAATAAAATTCAGCAA
AATTCATTTTTTCAGATAGTATTGGTTGGCTTATTTTGGTTAGCTAGTGAGTTATTGCTCAAACTGGTCAAGCTTCCTTT
GTCCGGAGGAATCCTTGGCTTGGGAATTGTTTTACTGCTTTTGGCGACGAATTGCTTAAAATTAAATCGTATAAGGCGGG
GAGCTGAATTACTCCTTGCCAATATGTTACTTTTTTTTATCCCTGGCGTCCTTGCAATACTGGAGCACCGGGAATTTATC
GGTCTTTTAGGCCTTAAAATTCTCTTCATTATTCTGCTCAGCACAATCACGGTGATGCTAGTCACTGCCCTTGTTGTAGA
TTATTGCTACCGTTGGAGGACGCATCATGCCAAGCAGCATTCTCTCTGA

Upstream 100 bases:

>100_bases
ATAATTTTGTTCCTCGTTGATAAACAATTTCACCTGCGGTTGTTGGTACATTACGCTTTTTAAACCGCTCAATCAGAGTG
ATACCTAACTCCTCTTCAAG

Downstream 100 bases:

>100_bases
ATCCATGATCCAGGCATTTTTCTGGTCACTTATCACAATAGGTATGTATTTTATTACGCAAAAACTATATAGAAGATGGC
CCTTTTGGTGGCTAATGCCA

Product: murein hydrolase exporter, LrgA family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MFYGFTDCRLGRKEIFSRFGKTTLPYNLYESLKQFKFHNYSILERLLVYKFILFILIKSVNLNEKIISTMSTYMANKIQQ
NSFFQIVLVGLFWLASELLLKLVKLPLSGGILGLGIVLLLLATNCLKLNRIRRGAELLLANMLLFFIPGVLAILEHREFI
GLLGLKILFIILLSTITVMLVTALVVDYCYRWRTHHAKQHSL

Sequences:

>Translated_202_residues
MFYGFTDCRLGRKEIFSRFGKTTLPYNLYESLKQFKFHNYSILERLLVYKFILFILIKSVNLNEKIISTMSTYMANKIQQ
NSFFQIVLVGLFWLASELLLKLVKLPLSGGILGLGIVLLLLATNCLKLNRIRRGAELLLANMLLFFIPGVLAILEHREFI
GLLGLKILFIILLSTITVMLVTALVVDYCYRWRTHHAKQHSL
>Mature_202_residues
MFYGFTDCRLGRKEIFSRFGKTTLPYNLYESLKQFKFHNYSILERLLVYKFILFILIKSVNLNEKIISTMSTYMANKIQQ
NSFFQIVLVGLFWLASELLLKLVKLPLSGGILGLGIVLLLLATNCLKLNRIRRGAELLLANMLLFFIPGVLAILEHREFI
GLLGLKILFIILLSTITVMLVTALVVDYCYRWRTHHAKQHSL

Specific function: Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. W

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. CidA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005538 [H]

Pfam domain/function: PF03788 LrgA [H]

EC number: NA

Molecular weight: Translated: 23334; Mature: 23334

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYGFTDCRLGRKEIFSRFGKTTLPYNLYESLKQFKFHNYSILERLLVYKFILFILIKSV
CCCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
NLNEKIISTMSTYMANKIQQNSFFQIVLVGLFWLASELLLKLVKLPLSGGILGLGIVLLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LATNCLKLNRIRRGAELLLANMLLFFIPGVLAILEHREFIGLLGLKILFIILLSTITVML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTALVVDYCYRWRTHHAKQHSL
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFYGFTDCRLGRKEIFSRFGKTTLPYNLYESLKQFKFHNYSILERLLVYKFILFILIKSV
CCCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
NLNEKIISTMSTYMANKIQQNSFFQIVLVGLFWLASELLLKLVKLPLSGGILGLGIVLLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LATNCLKLNRIRRGAELLLANMLLFFIPGVLAILEHREFIGLLGLKILFIILLSTITVML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTALVVDYCYRWRTHHAKQHSL
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]