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The map label for this gene is map-1

Identifier: 52840412

GI number: 52840412

Start: 190331

End: 191104

Strand: Reverse

Name: map-1

Synonym: lpg0157

Alternate gene names: 52840412

Gene position: 191104-190331 (Counterclockwise)

Preceding gene: 52840413

Following gene: 52840411

Centisome position: 5.62

GC content: 41.99

Gene sequence:

>774_bases
GTGAAATATACGATGTTAGTGAAGACGCCTGAAGAAATAAAAAAAATGCGCGTTGCTGGGCAGTTGGCCGCATCTGTACT
TGAAATGATAGAGCCTTATGTCATTGCAGGTACCAGTACAAAGGAGCTTGAACAAATTTGTCGTCAGTATATTGTCGAGG
ATTTGAAAGCGATTCCCTCGACGTTAAACCACTATGGGTTTCCCGCATGCATTTGCACTTCGATAAATCACGTGGTATGC
CATGGCATCCCCTCAGAGAAAAAACTTAAAAATGGCGACATCATTAATATTGATGTGACTGTGCAAAAGGACGGTTATAT
TGGGGATACCAGCAAAATGTTTCTCGTCGGCAACATCAAGCCATTTGCTAAAAAGTTAGTGGAAGTTACCCAGGAATGCC
TATACAAAGCTATTTCAATAGTTCGCCCAGGGGCTCATCTTGGAGACATCGGAAACATAATCCAGACACATGCAGAACAA
CATGGATATTCAATAGTACGAGAGTTTGGTGGGCATGGAATTGGTAAATCCATGTGGGAAGATCCTCACATTATGCACTT
CGGTAAACCAAATACCGGATTACGATTACAAGCAGGAATGACTTTCACTATTGAGCCAATGCTCAATTTGGGCCGTAAAG
AAGTCAAGACTTTAGGGGATGGTTGGACTGTTGTCACAAAAGACCATAAATTATCTGCACAATGGGAGCATACCATTTTA
GTGACCGATAATGGACATGAAATACTGACCTTAAGAGCAGACGAGCACCTATAG

Upstream 100 bases:

>100_bases
CAAGCAGAATATTGGATTAGAATAGGGAAATTGGCAGAAGAAAATCCCTCCATTACCTATACTGACATTCTTAAAATTTT
AGTCCATCAAGCTTCACTAG

Downstream 100 bases:

>100_bases
ACATATCTCCTCTTGCTTGGTAATTACTGTTCCTCCAAGCCTCGCGACGGAAAACATATACTATAATCAAACTAAAGGAA
ACCCAGTCAATCAAGGGAAA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKYTMLVKTPEEIKKMRVAGQLAASVLEMIEPYVIAGTSTKELEQICRQYIVEDLKAIPSTLNHYGFPACICTSINHVVC
HGIPSEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAKKLVEVTQECLYKAISIVRPGAHLGDIGNIIQTHAEQ
HGYSIVREFGGHGIGKSMWEDPHIMHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTIL
VTDNGHEILTLRADEHL

Sequences:

>Translated_257_residues
MKYTMLVKTPEEIKKMRVAGQLAASVLEMIEPYVIAGTSTKELEQICRQYIVEDLKAIPSTLNHYGFPACICTSINHVVC
HGIPSEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAKKLVEVTQECLYKAISIVRPGAHLGDIGNIIQTHAEQ
HGYSIVREFGGHGIGKSMWEDPHIMHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTIL
VTDNGHEILTLRADEHL
>Mature_257_residues
MKYTMLVKTPEEIKKMRVAGQLAASVLEMIEPYVIAGTSTKELEQICRQYIVEDLKAIPSTLNHYGFPACICTSINHVVC
HGIPSEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAKKLVEVTQECLYKAISIVRPGAHLGDIGNIIQTHAEQ
HGYSIVREFGGHGIGKSMWEDPHIMHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTIL
VTDNGHEILTLRADEHL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=246, Percent_Identity=43.9024390243902, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=43.7246963562753, Blast_Score=203, Evalue=1e-52,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=58, Blast_Score=305, Evalue=2e-84,
Organism=Escherichia coli, GI1788728, Length=256, Percent_Identity=26.5625, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=43.7246963562753, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6323273, Length=243, Percent_Identity=42.798353909465, Blast_Score=200, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=45.0819672131148, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=44.7154471544715, Blast_Score=216, Evalue=9e-57,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28626; Mature: 28626

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTMLVKTPEEIKKMRVAGQLAASVLEMIEPYVIAGTSTKELEQICRQYIVEDLKAIPS
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
TLNHYGFPACICTSINHVVCHGIPSEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIK
HHHHCCCHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEECCC
PFAKKLVEVTQECLYKAISIVRPGAHLGDIGNIIQTHAEQHGYSIVREFGGHGIGKSMWE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
DPHIMHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTIL
CCCEEEECCCCCCEEEECCCEEEEHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCEEEE
VTDNGHEILTLRADEHL
EECCCCEEEEEECCCCC
>Mature Secondary Structure
MKYTMLVKTPEEIKKMRVAGQLAASVLEMIEPYVIAGTSTKELEQICRQYIVEDLKAIPS
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
TLNHYGFPACICTSINHVVCHGIPSEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIK
HHHHCCCHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEECCC
PFAKKLVEVTQECLYKAISIVRPGAHLGDIGNIIQTHAEQHGYSIVREFGGHGIGKSMWE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
DPHIMHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTIL
CCCEEEECCCCCCEEEECCCEEEEHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCEEEE
VTDNGHEILTLRADEHL
EECCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]