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The map label for this gene is tktA

Identifier: 52840394

GI number: 52840394

Start: 167051

End: 169129

Strand: Reverse

Name: tktA

Synonym: lpg0139

Alternate gene names: 52840394

Gene position: 169129-167051 (Counterclockwise)

Preceding gene: 52840398

Following gene: 52840393

Centisome position: 4.98

GC content: 45.45

Gene sequence:

>2079_bases
ATGAATGGTCTTCTTGCCGATTTATGCCTTCTGAGCGACAATAGTGCCTCAGTTAAATGCAAAAGAGTAGGCATGAACAG
TTTTACAGAATTAGCTAATGCAGTACGCATGTTAAGCATCGATGCAGTAAACCAAGCTCAATCAGGCCACCCTGGCATGC
CCTTGGGTATGGCTGATATTGCCACCGTTTTATGGAAAAAATTTCTAAAATTCAACCCCAAAAACCCGCACTGGTTTAAC
AGAGACCGTTTTGTATTATCTAATGGCCATGGTTCCATGCTTCTCTATTCTTTACTGCATTTGACCGGATACAACTTGGA
TATTAGCGAGCTTAAAAACTTCCGCCAATTGCACTCAAAAACACCAGGGCATCCGGAACATGGGCACACTCCTGGTGTCG
AAACAACAACAGGGCCATTAGGTCAGGGTTTAGCCAATTCAGTCGGGATGGCCTTAGCGGAGCGTGTGCTGGCTAGTACC
TTTAACCACGATCACTTTAACCTGGTTGATCATTATACATATACTTTTGCCGGTGATGGTTGCCTGATGGAAGGCATTTC
TCATGAGGCGTGTTCTTTAGCTGGCACTCTTGGTTTGGGAAAGCTCATTGTATTTTATGACGACAATGGGATATCTATTG
ATGGTAAGGTAGAATCCTGGTTTACGGACGATACTACGTCTCGCTTTAAAGCCTACAACTGGCAAGTCATAGGCCCCATC
GATGGCCACGACGCAGATCAAATTGAGCAAGCCATATCAGCAGCACGCGAGAACACGACTCAACCTTCATTAATTATCTG
TAAAACCGTCATAGGACTGGGCTCCTCTGTAGCCGGTAGCGAAAAAGCGCACGGCTCTCCATTGAGTGCCCAAGACATAA
ATAATGTCCGTGAATTTTTTAATTGGAAACATGCTCCCTTTGAAATTCCAGATTCGATATACAAGCAATGGGATCATAGA
GAGCAAGGAGAAAAAGAAGAGCAACAATGGCTGCAGCTCCTGCATGAATACCGGCAACAACATCCATCGGAACACGATGA
GTTTTTGCGTCGTGCCAATGGCGACCTGCCCGATGATTGGCAAGAAATATCGGCTGGATTCCTAAAACAATGCCTGAACA
ATGAGAAAGCCATAGCAACGCGTAAGGCGTCGCAGCAATGCATAGAGTTTTTCGCGCCAATATTACCGGAAATGTTTGGC
GGCTCAGCGGATTTGACTGGTTCCAATAATACCGACTGGTCAGGCAGCAAAGCCATCACGGCCCATAATTTTTCCGGAAA
TTACCTTTATTATGGAGTGAGGGAATTTGCCATGGCAGCCATCATGAATGGACTTGCTGTGCATGGGGGATTCATTCCCT
ACGGCGGAACATTCCTTGTTTTCGCAGATTATGCAAGAAATGCCATCCGTTTAAGCGCTTTAATGAAACAAAGAGTGATA
TACGTATTGACTCATGATTCTATCGGTTTAGGGGAAGATGGCCCGACACACCAACCTATAGAACATATCGCTATGTTAAG
AATGACCCCTGGCATGACGGTCTGGCGCCCTGCTGATTTGATGGAAACCGCTGTTGCATGGCAACAATCGTTAGAACATC
ATAATGGCCCGTCTGCCTTATTACTCTCAAGACAAAATCTGCCCGCTTTAGCCCATGGCACCGATGCGGCTGACTTGATT
AAGAAAGGCGGATATATTATTGCCGATTGTGAAGGGAAACCTGATGCTATCCTGATAGCCACTGGTTCAGAAGTTCAACT
GGCTATAACCGCAGCAGAAAAGGCAAAAGCAAGAGGTCTCCAGGTCAGGGTGGTATCCATGCCCTGTGCTGAGCGATTCC
TTGCCCAGAGTGATGATTACAAAAACCAGGTATTACCTGGTCAGGTTCGCACACGTATTGCGATAGAAGCAGCTAGCAGT
GCCTATTGGCACCAATTTGTTGGCTTTGACGGCGCTGTCATTGGGCTGGATTGTTTTGGGGTATCAGCTCCTGCTACAGA
TGCTTTTAATTACCTTGGAATTACAGTAGAAAAAATTATCAATACTCTAGATACATTAACCAAACAAACAATGGTGTAA

Upstream 100 bases:

>100_bases
TGCAAAAATTAATCAAACTCCATCATTATGTCAAAAATTAGGAAAAATTTAAACTTAAATTTACATTTTGCTCTAATATT
GTCATTATTTTCAACTAAAA

Downstream 100 bases:

>100_bases
CCCATACCCCTTCTGAAGTTTCAAGAAGGCCTGTATTCAGTATAACTGAGTATGGAGGTTACCCTAACTCGGAGAAGTAG
TATGACAATACGAGTCGCGA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 692; Mature: 692

Protein sequence:

>692_residues
MNGLLADLCLLSDNSASVKCKRVGMNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPKNPHWFN
RDRFVLSNGHGSMLLYSLLHLTGYNLDISELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGLANSVGMALAERVLAST
FNHDHFNLVDHYTYTFAGDGCLMEGISHEACSLAGTLGLGKLIVFYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPI
DGHDADQIEQAISAARENTTQPSLIICKTVIGLGSSVAGSEKAHGSPLSAQDINNVREFFNWKHAPFEIPDSIYKQWDHR
EQGEKEEQQWLQLLHEYRQQHPSEHDEFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKASQQCIEFFAPILPEMFG
GSADLTGSNNTDWSGSKAITAHNFSGNYLYYGVREFAMAAIMNGLAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVI
YVLTHDSIGLGEDGPTHQPIEHIAMLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGTDAADLI
KKGGYIIADCEGKPDAILIATGSEVQLAITAAEKAKARGLQVRVVSMPCAERFLAQSDDYKNQVLPGQVRTRIAIEAASS
AYWHQFVGFDGAVIGLDCFGVSAPATDAFNYLGITVEKIINTLDTLTKQTMV

Sequences:

>Translated_692_residues
MNGLLADLCLLSDNSASVKCKRVGMNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPKNPHWFN
RDRFVLSNGHGSMLLYSLLHLTGYNLDISELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGLANSVGMALAERVLAST
FNHDHFNLVDHYTYTFAGDGCLMEGISHEACSLAGTLGLGKLIVFYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPI
DGHDADQIEQAISAARENTTQPSLIICKTVIGLGSSVAGSEKAHGSPLSAQDINNVREFFNWKHAPFEIPDSIYKQWDHR
EQGEKEEQQWLQLLHEYRQQHPSEHDEFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKASQQCIEFFAPILPEMFG
GSADLTGSNNTDWSGSKAITAHNFSGNYLYYGVREFAMAAIMNGLAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVI
YVLTHDSIGLGEDGPTHQPIEHIAMLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGTDAADLI
KKGGYIIADCEGKPDAILIATGSEVQLAITAAEKAKARGLQVRVVSMPCAERFLAQSDDYKNQVLPGQVRTRIAIEAASS
AYWHQFVGFDGAVIGLDCFGVSAPATDAFNYLGITVEKIINTLDTLTKQTMV
>Mature_692_residues
MNGLLADLCLLSDNSASVKCKRVGMNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPKNPHWFN
RDRFVLSNGHGSMLLYSLLHLTGYNLDISELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGLANSVGMALAERVLAST
FNHDHFNLVDHYTYTFAGDGCLMEGISHEACSLAGTLGLGKLIVFYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPI
DGHDADQIEQAISAARENTTQPSLIICKTVIGLGSSVAGSEKAHGSPLSAQDINNVREFFNWKHAPFEIPDSIYKQWDHR
EQGEKEEQQWLQLLHEYRQQHPSEHDEFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKASQQCIEFFAPILPEMFG
GSADLTGSNNTDWSGSKAITAHNFSGNYLYYGVREFAMAAIMNGLAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVI
YVLTHDSIGLGEDGPTHQPIEHIAMLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGTDAADLI
KKGGYIIADCEGKPDAILIATGSEVQLAITAAEKAKARGLQVRVVSMPCAERFLAQSDDYKNQVLPGQVRTRIAIEAASS
AYWHQFVGFDGAVIGLDCFGVSAPATDAFNYLGITVEKIINTLDTLTKQTMV

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=590, Percent_Identity=26.7796610169492, Blast_Score=163, Evalue=6e-40,
Organism=Homo sapiens, GI4507521, Length=590, Percent_Identity=26.7796610169492, Blast_Score=163, Evalue=6e-40,
Organism=Homo sapiens, GI133778974, Length=582, Percent_Identity=23.8831615120275, Blast_Score=122, Evalue=1e-27,
Organism=Escherichia coli, GI48994911, Length=657, Percent_Identity=58.751902587519, Blast_Score=828, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=655, Percent_Identity=57.8625954198473, Blast_Score=813, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=593, Percent_Identity=23.9460370994941, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6325331, Length=669, Percent_Identity=46.0388639760837, Blast_Score=570, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319593, Length=672, Percent_Identity=45.0892857142857, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24666278, Length=273, Percent_Identity=31.1355311355311, Blast_Score=120, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45551847, Length=292, Percent_Identity=29.4520547945205, Blast_Score=119, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45550715, Length=292, Percent_Identity=29.4520547945205, Blast_Score=119, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24645119, Length=267, Percent_Identity=29.2134831460674, Blast_Score=97, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 75934; Mature: 75934

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLLADLCLLSDNSASVKCKRVGMNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADI
CCCHHHHHHEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
ATVLWKKFLKFNPKNPHWFNRDRFVLSNGHGSMLLYSLLHLTGYNLDISELKNFRQLHSK
HHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
TPGHPEHGHTPGVETTTGPLGQGLANSVGMALAERVLASTFNHDHFNLVDHYTYTFAGDG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEEEEECCC
CLMEGISHEACSLAGTLGLGKLIVFYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPI
HHHHCCCHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCEECCCCHHHHEEECCEEECCC
DGHDADQIEQAISAARENTTQPSLIICKTVIGLGSSVAGSEKAHGSPLSAQDINNVREFF
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
NWKHAPFEIPDSIYKQWDHREQGEKEEQQWLQLLHEYRQQHPSEHDEFLRRANGDLPDDW
CCCCCCCCCCHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
QEISAGFLKQCLNNEKAIATRKASQQCIEFFAPILPEMFGGSADLTGSNNTDWSGSKAIT
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEE
AHNFSGNYLYYGVREFAMAAIMNGLAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVI
EECCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCEE
YVLTHDSIGLGEDGPTHQPIEHIAMLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSAL
EEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCEE
LLSRQNLPALAHGTDAADLIKKGGYIIADCEGKPDAILIATGSEVQLAITAAEKAKARGL
EEECCCCCCCCCCCCHHHHHHCCCEEEEECCCCCCEEEEEECCCEEEEEEEHHHHHHCCC
QVRVVSMPCAERFLAQSDDYKNQVLPGQVRTRIAIEAASSAYWHQFVGFDGAVIGLDCFG
EEEEEECCHHHHHHHCCCCCCCCCCCCHHHHEEEEEECCHHHHHHHHCCCCEEEEEEECC
VSAPATDAFNYLGITVEKIINTLDTLTKQTMV
CCCCCHHHHHHHHEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGLLADLCLLSDNSASVKCKRVGMNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADI
CCCHHHHHHEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
ATVLWKKFLKFNPKNPHWFNRDRFVLSNGHGSMLLYSLLHLTGYNLDISELKNFRQLHSK
HHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
TPGHPEHGHTPGVETTTGPLGQGLANSVGMALAERVLASTFNHDHFNLVDHYTYTFAGDG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEEEEECCC
CLMEGISHEACSLAGTLGLGKLIVFYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPI
HHHHCCCHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCEECCCCHHHHEEECCEEECCC
DGHDADQIEQAISAARENTTQPSLIICKTVIGLGSSVAGSEKAHGSPLSAQDINNVREFF
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
NWKHAPFEIPDSIYKQWDHREQGEKEEQQWLQLLHEYRQQHPSEHDEFLRRANGDLPDDW
CCCCCCCCCCHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
QEISAGFLKQCLNNEKAIATRKASQQCIEFFAPILPEMFGGSADLTGSNNTDWSGSKAIT
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEE
AHNFSGNYLYYGVREFAMAAIMNGLAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVI
EECCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCEE
YVLTHDSIGLGEDGPTHQPIEHIAMLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSAL
EEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCEE
LLSRQNLPALAHGTDAADLIKKGGYIIADCEGKPDAILIATGSEVQLAITAAEKAKARGL
EEECCCCCCCCCCCCHHHHHHCCCEEEEECCCCCCEEEEEECCCEEEEEEEHHHHHHCCC
QVRVVSMPCAERFLAQSDDYKNQVLPGQVRTRIAIEAASSAYWHQFVGFDGAVIGLDCFG
EEEEEECCHHHHHHHCCCCCCCCCCCCHHHHEEEEEECCHHHHHHHHCCCCEEEEEEECC
VSAPATDAFNYLGITVEKIINTLDTLTKQTMV
CCCCCHHHHHHHHEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]