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The map label for this gene is fabF

Identifier: 52840357

GI number: 52840357

Start: 117029

End: 118258

Strand: Reverse

Name: fabF

Synonym: lpg0102

Alternate gene names: 52840357

Gene position: 118258-117029 (Counterclockwise)

Preceding gene: 52840358

Following gene: 52840355

Centisome position: 3.48

GC content: 44.72

Gene sequence:

>1230_bases
ATGAAAAAAAGGGTTGTTATTACTGGTATGGAAATAACGTCATCCATAGGATCGGGAATTGATAAATTTTGGCTTGCTGC
ATCTCAAGGTCAATGCGGAATTAAACGCATCCAATCTTATGATCCATCCCCCTATTCGACCCAAATAGCAGGTGAGATTA
CAGACTTATCTCTCGACCATCTCCCCGAATTCAACAAAAGCAAACGTTATCCTCGCGCTGCTCAGTATGCATTATTTTGC
GCACATCATGCCATCGAGAAAGCAGGGCTTGAGCAAGCTGAGCTCAATGCAGCAGGCACCTTTATAGGCACAAGCATTGG
CGGTCAACCTGAACTGGAAGCAGGTTACAGGTTATTCTTTACAGACAGCTGGAAGAAAATCCCCCCTCTTAGCGTGATTA
GGGGGATGCCCAATTCAATCGCCAATCATATCGCAATTGCTTTTGGCATAGGTGGACCAAACTCAACCATTTCCAATGCC
TGTGTTTCATCCGGGGAAGCGATAGGCATGGCTTACCAACAAATTGCCCATGGCAATTTGACCACAGCTCTTTGCGGAGG
AACAGAATCTTTAGTCTGGGAATCGGTTATGGCTGCCTGGTGTAAGCTTAGAGTAATGTCAACTAACAATGAAAATCCCT
CACAAGCCAGCAGACCGTTTGATCTCAATCGGGATGGAATGGTTATGGCGGATGGGGCTGGGATATTAATTCTTGAAGAG
CTACAACAAGCAAAAGCAAGGGGAGCACAAATTCTCGGAGAAATCATTGGCTATGGCGCAAGTTGTGATGCATTCCATGT
CACAGCGCCAAACTCACAAGGACAAGCAAGAGCTATTGTTGCTGCTTTAAATGATGCCAAATTATCAATTAACGATGTCC
ATTACATCAACGCACATGGGACAGGAACCCAGCTCAATGACAGCACAGAAACAGAAACGATTAAAATGGTTTTCGGTAAA
AGAGCCTATGACATCCCGATTACTGCTCAAAAAGCCATGACAGGACATGCGATTGGGGCAGCAGGAGCAATGGAAATCAT
TGCAACAACACTAAGCTTGCAAAAAAACACGCTGTTACCAACTATTAACCTGCATACCCCAGACCCAGCCTGTGATCTGG
ATTATGTGCCTAATGCTGCGCGAGAAAAAACCATTGATATTGCTTTATCCAACCATTTCGCTTTCGGTGGAGCAAATGCC
GCTTTAGTTCTGCGCAAATACATTAGTTAA

Upstream 100 bases:

>100_bases
TTACATATTATAAATATGGCTTGACATAATTAAAATCTCACCATTAGTATTGCGAATGGCGATAGAGGAAGGCTTGTTTT
ATCAAAAATAAGGATAATTA

Downstream 100 bases:

>100_bases
GAATATAAATAGCTTACGCTAAACAGCAATTGATTATTATATAAATGGGTCAATCGTGGCCCTTTGGTAATATTAACTCC
ATCACCACCCAAATAACTTT

Product: 3-oxoacyl-(acyl carrier protein) synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKKRVVITGMEITSSIGSGIDKFWLAASQGQCGIKRIQSYDPSPYSTQIAGEITDLSLDHLPEFNKSKRYPRAAQYALFC
AHHAIEKAGLEQAELNAAGTFIGTSIGGQPELEAGYRLFFTDSWKKIPPLSVIRGMPNSIANHIAIAFGIGGPNSTISNA
CVSSGEAIGMAYQQIAHGNLTTALCGGTESLVWESVMAAWCKLRVMSTNNENPSQASRPFDLNRDGMVMADGAGILILEE
LQQAKARGAQILGEIIGYGASCDAFHVTAPNSQGQARAIVAALNDAKLSINDVHYINAHGTGTQLNDSTETETIKMVFGK
RAYDIPITAQKAMTGHAIGAAGAMEIIATTLSLQKNTLLPTINLHTPDPACDLDYVPNAAREKTIDIALSNHFAFGGANA
ALVLRKYIS

Sequences:

>Translated_409_residues
MKKRVVITGMEITSSIGSGIDKFWLAASQGQCGIKRIQSYDPSPYSTQIAGEITDLSLDHLPEFNKSKRYPRAAQYALFC
AHHAIEKAGLEQAELNAAGTFIGTSIGGQPELEAGYRLFFTDSWKKIPPLSVIRGMPNSIANHIAIAFGIGGPNSTISNA
CVSSGEAIGMAYQQIAHGNLTTALCGGTESLVWESVMAAWCKLRVMSTNNENPSQASRPFDLNRDGMVMADGAGILILEE
LQQAKARGAQILGEIIGYGASCDAFHVTAPNSQGQARAIVAALNDAKLSINDVHYINAHGTGTQLNDSTETETIKMVFGK
RAYDIPITAQKAMTGHAIGAAGAMEIIATTLSLQKNTLLPTINLHTPDPACDLDYVPNAAREKTIDIALSNHFAFGGANA
ALVLRKYIS
>Mature_409_residues
MKKRVVITGMEITSSIGSGIDKFWLAASQGQCGIKRIQSYDPSPYSTQIAGEITDLSLDHLPEFNKSKRYPRAAQYALFC
AHHAIEKAGLEQAELNAAGTFIGTSIGGQPELEAGYRLFFTDSWKKIPPLSVIRGMPNSIANHIAIAFGIGGPNSTISNA
CVSSGEAIGMAYQQIAHGNLTTALCGGTESLVWESVMAAWCKLRVMSTNNENPSQASRPFDLNRDGMVMADGAGILILEE
LQQAKARGAQILGEIIGYGASCDAFHVTAPNSQGQARAIVAALNDAKLSINDVHYINAHGTGTQLNDSTETETIKMVFGK
RAYDIPITAQKAMTGHAIGAAGAMEIIATTLSLQKNTLLPTINLHTPDPACDLDYVPNAAREKTIDIALSNHFAFGGANA
ALVLRKYIS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=34.7619047619048, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI223972627, Length=162, Percent_Identity=41.9753086419753, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI41872631, Length=280, Percent_Identity=27.1428571428571, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=38.780487804878, Blast_Score=278, Evalue=4e-76,
Organism=Escherichia coli, GI1788663, Length=417, Percent_Identity=35.4916067146283, Blast_Score=219, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71983541, Length=411, Percent_Identity=28.2238442822384, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=33.7121212121212, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI212642053, Length=345, Percent_Identity=24.6376811594203, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=255, Percent_Identity=27.0588235294118, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=30.0668151447661, Blast_Score=179, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=34.2042755344418, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI19920632, Length=342, Percent_Identity=28.3625730994152, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221330659, Length=342, Percent_Identity=28.3625730994152, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24581345, Length=358, Percent_Identity=24.5810055865922, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43554; Mature: 43554

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRVVITGMEITSSIGSGIDKFWLAASQGQCGIKRIQSYDPSPYSTQIAGEITDLSLDH
CCCEEEEECHHHHHHHHCCHHHHHEECCCCCHHHHHHHCCCCCCCCEEECCCEECCCHHH
LPEFNKSKRYPRAAQYALFCAHHAIEKAGLEQAELNAAGTFIGTSIGGQPELEAGYRLFF
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEECCCCCCCCCCCCEEEEE
TDSWKKIPPLSVIRGMPNSIANHIAIAFGIGGPNSTISNACVSSGEAIGMAYQQIAHGNL
ECCCCCCCCHHHHHCCCHHHHCCEEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHCCCC
TTALCGGTESLVWESVMAAWCKLRVMSTNNENPSQASRPFDLNRDGMVMADGAGILILEE
EEEEECCCHHHHHHHHHHHHHEEEEEECCCCCCHHCCCCCCCCCCCEEEECCCCEEEHHH
LQQAKARGAQILGEIIGYGASCDAFHVTAPNSQGQARAIVAALNDAKLSINDVHYINAHG
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEEECCCEEEECEEEEEECCC
TGTQLNDSTETETIKMVFGKRAYDIPITAQKAMTGHAIGAAGAMEIIATTLSLQKNTLLP
CCCCCCCCCCHHEEEEECCCEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
TINLHTPDPACDLDYVPNAAREKTIDIALSNHFAFGGANAALVLRKYIS
EEEECCCCCCCCCCCCCCCCCCCEEEEEEECCEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MKKRVVITGMEITSSIGSGIDKFWLAASQGQCGIKRIQSYDPSPYSTQIAGEITDLSLDH
CCCEEEEECHHHHHHHHCCHHHHHEECCCCCHHHHHHHCCCCCCCCEEECCCEECCCHHH
LPEFNKSKRYPRAAQYALFCAHHAIEKAGLEQAELNAAGTFIGTSIGGQPELEAGYRLFF
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEECCCCCCCCCCCCEEEEE
TDSWKKIPPLSVIRGMPNSIANHIAIAFGIGGPNSTISNACVSSGEAIGMAYQQIAHGNL
ECCCCCCCCHHHHHCCCHHHHCCEEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHCCCC
TTALCGGTESLVWESVMAAWCKLRVMSTNNENPSQASRPFDLNRDGMVMADGAGILILEE
EEEEECCCHHHHHHHHHHHHHEEEEEECCCCCCHHCCCCCCCCCCCEEEECCCCEEEHHH
LQQAKARGAQILGEIIGYGASCDAFHVTAPNSQGQARAIVAALNDAKLSINDVHYINAHG
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEEECCCEEEECEEEEEECCC
TGTQLNDSTETETIKMVFGKRAYDIPITAQKAMTGHAIGAAGAMEIIATTLSLQKNTLLP
CCCCCCCCCCHHEEEEECCCEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
TINLHTPDPACDLDYVPNAAREKTIDIALSNHFAFGGANAALVLRKYIS
EEEECCCCCCCCCCCCCCCCCCCEEEEEEECCEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]