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The map label for this gene is lpxD1 [H]

Identifier: 52840355

GI number: 52840355

Start: 114931

End: 116001

Strand: Reverse

Name: lpxD1 [H]

Synonym: lpg0100

Alternate gene names: 52840355

Gene position: 116001-114931 (Counterclockwise)

Preceding gene: 52840357

Following gene: 52840354

Centisome position: 3.41

GC content: 40.34

Gene sequence:

>1071_bases
TTGAAAGGTAAACCAATGAATTCTTCTCTTCGTGATATAGCAAACCTTGTTCAAGGTATGGTTATTGGCAATGATGCCAT
CACTGTTTCCACACTATCACCCATAGATAATATACTTCCCGGATCTTTAGTTTTCGCCGAAGGTGAAGACAATATCAAAC
TTGCTGAAAACTCTGAAGCAGCAGCTATTCTTATTGGTCAAGGTACTATCGATTCCCCAAAGCCATTAATTCAGGTAAAA
AACCCTTTTAAAGCATTTATTGCCTTACTCAACCATTTTTATCCCCCAAGGAGAATATCTCCGGGGGTACACCCCACTGC
TGTAATAGGTGCAGAAGTACAATTAGGTGATGAAGTTTATGTTGGGCCATTCGTAGTCATTGAATCAGGAAGTATTATAG
GCAACCACTCGGTGCTCAAAAGCCATATTCATATCGGCCATAATGTGGTCATTGGAGATCACACAACCATTCACCCCCAA
GTCACTATTTATGATAATTGCCGTATCGGTTCGAATGTCACTATCCATGCCTCTACAGTAATAGGTTCTGATGGCTTTGG
GTATACTTTTGTTGATGGCCAACATCTCAAAGTACCTCATTCGGGATATGTGGTAATTGAAAATAATGTCGAAATTGGAG
CCAACACAGCGATAGATAAGGCCACATTAGGTGCTACAGTGATAGGTGAAGGTACAAAAATTGATAATTTGGTACAAATC
GCTCACTCAGTCAAATTAGGCAAGCATAATATTATTTGCGCTTTTACTGGCATTGCCGGCAGTACCACTACCGGAAACAA
TGTCATCTTTGCAGCCAACGTGGGAGTGAGTGACCATGTTCACATCGAGGATGAGGTCATATTAGGCGCACGTACAGGAG
TTCCTCCACACAAACACTTAAAAAAAGGGACGGTATATCTTGGTAATCCGGCAAAACCTAAAGATGTTGCGATTAAGCAC
GAACTGTCAGTGAATCGTATCCCATTAATACGAAAAAACATTAAATCACTTACCGAGCAAGTGGCTGTAATTAACAAAAA
ACTTGATATTAAAGCAAAAGAGGTAGAGTAA

Upstream 100 bases:

>100_bases
TCATGATAAGAAAAATTATTAATCTGAAAGCCATCTGAATCGAGGATAATTCACTCGAAAATGGACCATAAGAGGTATAT
AATCGCTCTATTTTGCGGAA

Downstream 100 bases:

>100_bases
CTATGAAACCGCCTCTGATTCTAATAGACGGATCTTCCTATTTCTTTAGAGCGTTTCATGCCCTTCCACCATTGACAAAC
TCCAAAGGCCAGCCTACAGG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MKGKPMNSSLRDIANLVQGMVIGNDAITVSTLSPIDNILPGSLVFAEGEDNIKLAENSEAAAILIGQGTIDSPKPLIQVK
NPFKAFIALLNHFYPPRRISPGVHPTAVIGAEVQLGDEVYVGPFVVIESGSIIGNHSVLKSHIHIGHNVVIGDHTTIHPQ
VTIYDNCRIGSNVTIHASTVIGSDGFGYTFVDGQHLKVPHSGYVVIENNVEIGANTAIDKATLGATVIGEGTKIDNLVQI
AHSVKLGKHNIICAFTGIAGSTTTGNNVIFAANVGVSDHVHIEDEVILGARTGVPPHKHLKKGTVYLGNPAKPKDVAIKH
ELSVNRIPLIRKNIKSLTEQVAVINKKLDIKAKEVE

Sequences:

>Translated_356_residues
MKGKPMNSSLRDIANLVQGMVIGNDAITVSTLSPIDNILPGSLVFAEGEDNIKLAENSEAAAILIGQGTIDSPKPLIQVK
NPFKAFIALLNHFYPPRRISPGVHPTAVIGAEVQLGDEVYVGPFVVIESGSIIGNHSVLKSHIHIGHNVVIGDHTTIHPQ
VTIYDNCRIGSNVTIHASTVIGSDGFGYTFVDGQHLKVPHSGYVVIENNVEIGANTAIDKATLGATVIGEGTKIDNLVQI
AHSVKLGKHNIICAFTGIAGSTTTGNNVIFAANVGVSDHVHIEDEVILGARTGVPPHKHLKKGTVYLGNPAKPKDVAIKH
ELSVNRIPLIRKNIKSLTEQVAVINKKLDIKAKEVE
>Mature_356_residues
MKGKPMNSSLRDIANLVQGMVIGNDAITVSTLSPIDNILPGSLVFAEGEDNIKLAENSEAAAILIGQGTIDSPKPLIQVK
NPFKAFIALLNHFYPPRRISPGVHPTAVIGAEVQLGDEVYVGPFVVIESGSIIGNHSVLKSHIHIGHNVVIGDHTTIHPQ
VTIYDNCRIGSNVTIHASTVIGSDGFGYTFVDGQHLKVPHSGYVVIENNVEIGANTAIDKATLGATVIGEGTKIDNLVQI
AHSVKLGKHNIICAFTGIAGSTTTGNNVIFAANVGVSDHVHIEDEVILGARTGVPPHKHLKKGTVYLGNPAKPKDVAIKH
ELSVNRIPLIRKNIKSLTEQVAVINKKLDIKAKEVE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=336, Percent_Identity=30.6547619047619, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 37841; Mature: 37841

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKPMNSSLRDIANLVQGMVIGNDAITVSTLSPIDNILPGSLVFAEGEDNIKLAENSEA
CCCCCCCHHHHHHHHHHHCEEECCCEEEEEECCCHHHCCCCCEEEECCCCCEEEECCCCE
AAILIGQGTIDSPKPLIQVKNPFKAFIALLNHFYPPRRISPGVHPTAVIGAEVQLGDEVY
EEEEEECCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCEEE
VGPFVVIESGSIIGNHSVLKSHIHIGHNVVIGDHTTIHPQVTIYDNCRIGSNVTIHASTV
ECCEEEEECCCEEECHHHHHHHEEECCEEEECCCEEECCEEEEEECCCCCCEEEEEEEEE
IGSDGFGYTFVDGQHLKVPHSGYVVIENNVEIGANTAIDKATLGATVIGEGTKIDNLVQI
ECCCCCCEEEECCCEEECCCCCEEEEECCEEECCCCCCCHHHCCEEEEECCCCHHHHHHH
AHSVKLGKHNIICAFTGIAGSTTTGNNVIFAANVGVSDHVHIEDEVILGARTGVPPHKHL
HHHHCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCEEEECCEEEEEECCCCCCHHHH
KKGTVYLGNPAKPKDVAIKHELSVNRIPLIRKNIKSLTEQVAVINKKLDIKAKEVE
CCCEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCC
>Mature Secondary Structure
MKGKPMNSSLRDIANLVQGMVIGNDAITVSTLSPIDNILPGSLVFAEGEDNIKLAENSEA
CCCCCCCHHHHHHHHHHHCEEECCCEEEEEECCCHHHCCCCCEEEECCCCCEEEECCCCE
AAILIGQGTIDSPKPLIQVKNPFKAFIALLNHFYPPRRISPGVHPTAVIGAEVQLGDEVY
EEEEEECCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCEEE
VGPFVVIESGSIIGNHSVLKSHIHIGHNVVIGDHTTIHPQVTIYDNCRIGSNVTIHASTV
ECCEEEEECCCEEECHHHHHHHEEECCEEEECCCEEECCEEEEEECCCCCCEEEEEEEEE
IGSDGFGYTFVDGQHLKVPHSGYVVIENNVEIGANTAIDKATLGATVIGEGTKIDNLVQI
ECCCCCCEEEECCCEEECCCCCEEEEECCEEECCCCCCCHHHCCEEEEECCCCHHHHHHH
AHSVKLGKHNIICAFTGIAGSTTTGNNVIFAANVGVSDHVHIEDEVILGARTGVPPHKHL
HHHHCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCEEEECCEEEEEECCCCCCHHHH
KKGTVYLGNPAKPKDVAIKHELSVNRIPLIRKNIKSLTEQVAVINKKLDIKAKEVE
CCCEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA