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The map label for this gene is thrC

Identifier: 161723252

GI number: 161723252

Start: 1816951

End: 1818219

Strand: Reverse

Name: thrC

Synonym: lpg1643

Alternate gene names: 161723252

Gene position: 1818219-1816951 (Counterclockwise)

Preceding gene: 52841872

Following gene: 52841870

Centisome position: 53.51

GC content: 36.49

Gene sequence:

>1269_bases
ATGAAAATTAGAATAAAGAGTACGAGAGGACAATGTGTCTCCACAATAGACGAAGCGATACTGTCAGGCCTGGCAGGGGA
TGGTGGGTTATTTGTACCTGACAGGTTTCCCAATTTAACAATAAAAAAATTTTATGAATACGGTAATTTAATCGACTTTT
CTGTTAATTTACTCTCGCCATTTTTTTCAGATAGTAAAATTGATGTAAATAATGCTTTTTTTCAAAAATTCCTCACCTTC
TCCTTTCCGTTACATCATCTTTTTAAGAAAAGTTATGTACTGGAGTTGTTTCATGGCCCAACCCTGTCTTTTAAAGATTT
AGGAACTCAATTTTTCAGTGAATGTTTATTGCATCTGATAGAAAACAAGAGCGCCAAAGTTCTGGTCGCAACATCTGGTG
ATACTGGCGCTGCGATTGCTCATGCTTTGGATGGGAAAAGAGATCTGGAAGGAATCATTTTATTTCCTAAAGATAAACTT
ACTTTCAGACAACAATCTCAAATTACTTGTTGGGGAGAGAATATTCGTGCATTGGCTGTTAATGGCAGTTTTGATCAATG
TCAACAGCTGGTGAAGCTGGTATTTGCCAAAAGAGAACATAAAGGAATATTGACTACAGCCAATAGCATGAATATAGCCA
GATTATTACCACAGATTATTTTCTATGCTTTTACCAGCATTCAATTGGCATTAAGACATAATCATTCTGTTAATTTTATA
GTTCCAGGCGGAAACCTGGGGAATGTTACGGCTTGTTATTGGGCAAAAATGCTGGGTTTTCCGGTTGAGCAAATTTTAAT
AGCTAATAATATTAATAGTGCACTGGGCGAATTTTTGTTAACTGGAGCTTATCAAGCCAAATCGGTTACTAAAACATTGG
CAACAGCGATGGATGTAGGTGAGCCAAGCAATTTGGACCGCTTATTCGTTTTATTTAATAATTATTCTGAATGTAAAAAA
CAGATGAATGCAGAATCTGTTAGTGATGAGCAAATTAAGCAAGCTATCCTACATTGTTACAATAAATATCATTATATAAT
TTGCCCTCATACCGCCACAGCTTATCATCGTCTAAGTACAATCAATCAGGACAAACCCTGGGTTATTGTGGCACCAGGGC
ACCCGGCCAAATTTGAAGAGGTATTAGAACCACTATTGAAAAAAGAAATTCCTGTCCCGGAACAGCTGAAGGTCCTTTTA
GGCAGAAAACAACATTATTCAATCATAGAGCCAAACTATCATGCTTTGTATCATTTCTTAGTTGAATGA

Upstream 100 bases:

>100_bases
ACTAAAGTATAGCTGTTAGCAATATACCGCGAAGCAAAAGTTGTCTTTGAAAGTGACTTACTGGTTAATAATATTTCATC
AGAAGGTGCAAAGGCTGCAG

Downstream 100 bases:

>100_bases
AGGCCATTACAGAGGCAAATTGTTGTGATGGCATATAACATAATAGCATTGGTTAATTATCACCAGCGTCTTTGATTGGC
TCAAACTCATAAGCTAAGTC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKIRIKSTRGQCVSTIDEAILSGLAGDGGLFVPDRFPNLTIKKFYEYGNLIDFSVNLLSPFFSDSKIDVNNAFFQKFLTF
SFPLHHLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLIENKSAKVLVATSGDTGAAIAHALDGKRDLEGIILFPKDKL
TFRQQSQITCWGENIRALAVNGSFDQCQQLVKLVFAKREHKGILTTANSMNIARLLPQIIFYAFTSIQLALRHNHSVNFI
VPGGNLGNVTACYWAKMLGFPVEQILIANNINSALGEFLLTGAYQAKSVTKTLATAMDVGEPSNLDRLFVLFNNYSECKK
QMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLSTINQDKPWVIVAPGHPAKFEEVLEPLLKKEIPVPEQLKVLL
GRKQHYSIIEPNYHALYHFLVE

Sequences:

>Translated_422_residues
MKIRIKSTRGQCVSTIDEAILSGLAGDGGLFVPDRFPNLTIKKFYEYGNLIDFSVNLLSPFFSDSKIDVNNAFFQKFLTF
SFPLHHLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLIENKSAKVLVATSGDTGAAIAHALDGKRDLEGIILFPKDKL
TFRQQSQITCWGENIRALAVNGSFDQCQQLVKLVFAKREHKGILTTANSMNIARLLPQIIFYAFTSIQLALRHNHSVNFI
VPGGNLGNVTACYWAKMLGFPVEQILIANNINSALGEFLLTGAYQAKSVTKTLATAMDVGEPSNLDRLFVLFNNYSECKK
QMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLSTINQDKPWVIVAPGHPAKFEEVLEPLLKKEIPVPEQLKVLL
GRKQHYSIIEPNYHALYHFLVE
>Mature_422_residues
MKIRIKSTRGQCVSTIDEAILSGLAGDGGLFVPDRFPNLTIKKFYEYGNLIDFSVNLLSPFFSDSKIDVNNAFFQKFLTF
SFPLHHLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLIENKSAKVLVATSGDTGAAIAHALDGKRDLEGIILFPKDKL
TFRQQSQITCWGENIRALAVNGSFDQCQQLVKLVFAKREHKGILTTANSMNIARLLPQIIFYAFTSIQLALRHNHSVNFI
VPGGNLGNVTACYWAKMLGFPVEQILIANNINSALGEFLLTGAYQAKSVTKTLATAMDVGEPSNLDRLFVLFNNYSECKK
QMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLSTINQDKPWVIVAPGHPAKFEEVLEPLLKKEIPVPEQLKVLL
GRKQHYSIIEPNYHALYHFLVE

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=460, Percent_Identity=30.8695652173913, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI149193323, Length=437, Percent_Identity=29.9771167048055, Blast_Score=166, Evalue=4e-41,
Organism=Escherichia coli, GI1786185, Length=386, Percent_Identity=35.7512953367876, Blast_Score=223, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6319901, Length=455, Percent_Identity=32.0879120879121, Blast_Score=204, Evalue=1e-53,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 47504; Mature: 47504

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRIKSTRGQCVSTIDEAILSGLAGDGGLFVPDRFPNLTIKKFYEYGNLIDFSVNLLSP
CEEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHCCCEEEEEHHHHHH
FFSDSKIDVNNAFFQKFLTFSFPLHHLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLI
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ENKSAKVLVATSGDTGAAIAHALDGKRDLEGIILFPKDKLTFRQQSQITCWGENIRALAV
CCCCCEEEEEECCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEECCCEEEEEE
NGSFDQCQQLVKLVFAKREHKGILTTANSMNIARLLPQIIFYAFTSIQLALRHNHSVNFI
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEE
VPGGNLGNVTACYWAKMLGFPVEQILIANNINSALGEFLLTGAYQAKSVTKTLATAMDVG
ECCCCCCCHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
EPSNLDRLFVLFNNYSECKKQMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLST
CCCCCCEEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
INQDKPWVIVAPGHPAKFEEVLEPLLKKEIPVPEQLKVLLGRKQHYSIIEPNYHALYHFL
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEECCCHHHHHHHH
VE
CC
>Mature Secondary Structure
MKIRIKSTRGQCVSTIDEAILSGLAGDGGLFVPDRFPNLTIKKFYEYGNLIDFSVNLLSP
CEEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHCCCEEEEEHHHHHH
FFSDSKIDVNNAFFQKFLTFSFPLHHLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLI
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
ENKSAKVLVATSGDTGAAIAHALDGKRDLEGIILFPKDKLTFRQQSQITCWGENIRALAV
CCCCCEEEEEECCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEECCCEEEEEE
NGSFDQCQQLVKLVFAKREHKGILTTANSMNIARLLPQIIFYAFTSIQLALRHNHSVNFI
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEE
VPGGNLGNVTACYWAKMLGFPVEQILIANNINSALGEFLLTGAYQAKSVTKTLATAMDVG
ECCCCCCCHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
EPSNLDRLFVLFNNYSECKKQMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLST
CCCCCCEEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
INQDKPWVIVAPGHPAKFEEVLEPLLKKEIPVPEQLKVLLGRKQHYSIIEPNYHALYHFL
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEECCCHHHHHHHH
VE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]