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The map label for this gene is hemE [H]

Identifier: 39998542

GI number: 39998542

Start: 3800181

End: 3801203

Strand: Reverse

Name: hemE [H]

Synonym: GSU3453

Alternate gene names: 39998542

Gene position: 3801203-3800181 (Counterclockwise)

Preceding gene: 39998543

Following gene: 39998541

Centisome position: 99.66

GC content: 61.58

Gene sequence:

>1023_bases
ATGAATAATCGTTTTCTCGACGCCTGCTGGGGCAAGCCCGTTGACCGTACTCCCGTGTGGCTCATGCGCCAGGCGGGCCG
CTATCTCCCCGAATATATGGCAGTACGCTCCAAGTGCACCTTCCTGGAACTCTGCAAGACCCCGGAACTGGCGGCAGAGG
TGACCATTCAGCCCATCGACATTCTGAATGTCGACGCGGCGATCCTCTTCTCCGACATCCTCACTCCGGTTGAGCCCATG
GGGCTCAAGCTCGACTTCGTGCCCGGCCCGGTCTTCGAGCACCCCGTACGTACCATGGCCGATGTGGAGAAGCTGCGCAT
TCCCAACCCCGAGGAAGATGTCCCCTACGTACTGGACACCATCAAGATCCTCCGTCGGGAACTGGCCGGCAGGGTTCCCC
TGATCGGCTTCGGCGGAGCGCCGTTCACCCTGGCCTGCTACATGGTTGAAGGCAAGGGTTCCAAGGACTGGGCAAACATC
AAGCGGATGATGTATGCCGCTCCCGACGTCTATGCCGCCCTCATGGACAAGGTTACCATGATGGACATGGAGTACCTGAA
CGCCCAGATCAAGGCCGGTGCCCAGGCGATCCAGATCTTCGACACCTGGGGCGGGGTCCTCTCCCCCACCGATTACGAGA
AGTACGTTCTGCCCTACACCACCAAGCTCATCAACGGCCTGAACCGTCAGAACACGCCGGTGATCCACTTTGTCAAGGGC
GCCGGCACCATGCTGGAGACGGTGCAGAAGGCCGGCGGCGACGTCATGGGGCTCGACTGGCACGTGAATCTTGGGAAGGC
CAGGGACGTGCTCGGTCAGAACATGGCCGTGCAGGGGAACCTGGACCCCACGGTCCTCTACGCCCCCAAAGAGGTCATCG
AGGCCGAGGTGAAGCGGGTGCTCGACGAGAATGCCGGCCGTCCCGGACACATCTTCAACCTGGGACACGGCATCCTGCCG
ACAGTGCCGCCGGAAAACGCCATCCACATGGTGGAGTGCGTGCACCGGCTGTCCCAGAAGTAG

Upstream 100 bases:

>100_bases
CGCCGGGGTTACTGCGGGTGCAGCAATTTGATGCAAATCTCACGCTTCTGGGTTTTTATAATCGAAATTCCAAAGACAAT
TTCTCTGAGGAGGGTTTTCA

Downstream 100 bases:

>100_bases
CCCGATTACCTGCCTGGACAAGGAAAAGGCAGCCCGGCGCTGCCTTTTCCTCATTCCGGCCCAAGCATCGAACCAGCCAT
GGAAAACCGCATCACCGACA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MNNRFLDACWGKPVDRTPVWLMRQAGRYLPEYMAVRSKCTFLELCKTPELAAEVTIQPIDILNVDAAILFSDILTPVEPM
GLKLDFVPGPVFEHPVRTMADVEKLRIPNPEEDVPYVLDTIKILRRELAGRVPLIGFGGAPFTLACYMVEGKGSKDWANI
KRMMYAAPDVYAALMDKVTMMDMEYLNAQIKAGAQAIQIFDTWGGVLSPTDYEKYVLPYTTKLINGLNRQNTPVIHFVKG
AGTMLETVQKAGGDVMGLDWHVNLGKARDVLGQNMAVQGNLDPTVLYAPKEVIEAEVKRVLDENAGRPGHIFNLGHGILP
TVPPENAIHMVECVHRLSQK

Sequences:

>Translated_340_residues
MNNRFLDACWGKPVDRTPVWLMRQAGRYLPEYMAVRSKCTFLELCKTPELAAEVTIQPIDILNVDAAILFSDILTPVEPM
GLKLDFVPGPVFEHPVRTMADVEKLRIPNPEEDVPYVLDTIKILRRELAGRVPLIGFGGAPFTLACYMVEGKGSKDWANI
KRMMYAAPDVYAALMDKVTMMDMEYLNAQIKAGAQAIQIFDTWGGVLSPTDYEKYVLPYTTKLINGLNRQNTPVIHFVKG
AGTMLETVQKAGGDVMGLDWHVNLGKARDVLGQNMAVQGNLDPTVLYAPKEVIEAEVKRVLDENAGRPGHIFNLGHGILP
TVPPENAIHMVECVHRLSQK
>Mature_340_residues
MNNRFLDACWGKPVDRTPVWLMRQAGRYLPEYMAVRSKCTFLELCKTPELAAEVTIQPIDILNVDAAILFSDILTPVEPM
GLKLDFVPGPVFEHPVRTMADVEKLRIPNPEEDVPYVLDTIKILRRELAGRVPLIGFGGAPFTLACYMVEGKGSKDWANI
KRMMYAAPDVYAALMDKVTMMDMEYLNAQIKAGAQAIQIFDTWGGVLSPTDYEKYVLPYTTKLINGLNRQNTPVIHFVKG
AGTMLETVQKAGGDVMGLDWHVNLGKARDVLGQNMAVQGNLDPTVLYAPKEVIEAEVKRVLDENAGRPGHIFNLGHGILP
TVPPENAIHMVECVHRLSQK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=43.3908045977011, Blast_Score=275, Evalue=4e-74,
Organism=Escherichia coli, GI2367337, Length=346, Percent_Identity=53.4682080924855, Blast_Score=357, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320252, Length=354, Percent_Identity=35.8757062146893, Blast_Score=234, Evalue=1e-62,
Organism=Drosophila melanogaster, GI221330099, Length=345, Percent_Identity=40, Blast_Score=247, Evalue=9e-66,
Organism=Drosophila melanogaster, GI19921920, Length=345, Percent_Identity=40, Blast_Score=247, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37816; Mature: 37816

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNRFLDACWGKPVDRTPVWLMRQAGRYLPEYMAVRSKCTFLELCKTPELAAEVTIQPID
CCCCEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHEEEECCEE
ILNVDAAILFSDILTPVEPMGLKLDFVPGPVFEHPVRTMADVEKLRIPNPEEDVPYVLDT
EECCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IKILRRELAGRVPLIGFGGAPFTLACYMVEGKGSKDWANIKRMMYAAPDVYAALMDKVTM
HHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
MDMEYLNAQIKAGAQAIQIFDTWGGVLSPTDYEKYVLPYTTKLINGLNRQNTPVIHFVKG
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEECHHHHHHHHCCCCCCCCEEEEECC
AGTMLETVQKAGGDVMGLDWHVNLGKARDVLGQNMAVQGNLDPTVLYAPKEVIEAEVKRV
CCHHHHHHHHCCCCEEEEEEEEECCHHHHHHCCCEEEECCCCCEEEECCHHHHHHHHHHH
LDENAGRPGHIFNLGHGILPTVPPENAIHMVECVHRLSQK
HHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNRFLDACWGKPVDRTPVWLMRQAGRYLPEYMAVRSKCTFLELCKTPELAAEVTIQPID
CCCCEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHEEEECCEE
ILNVDAAILFSDILTPVEPMGLKLDFVPGPVFEHPVRTMADVEKLRIPNPEEDVPYVLDT
EECCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IKILRRELAGRVPLIGFGGAPFTLACYMVEGKGSKDWANIKRMMYAAPDVYAALMDKVTM
HHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
MDMEYLNAQIKAGAQAIQIFDTWGGVLSPTDYEKYVLPYTTKLINGLNRQNTPVIHFVKG
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEECHHHHHHHHCCCCCCCCEEEEECC
AGTMLETVQKAGGDVMGLDWHVNLGKARDVLGQNMAVQGNLDPTVLYAPKEVIEAEVKRV
CCHHHHHHHHCCCCEEEEEEEEECCHHHHHHCCCEEEECCCCCEEEECCHHHHHHHHHHH
LDENAGRPGHIFNLGHGILPTVPPENAIHMVECVHRLSQK
HHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA