Click here to switch to the map view.

The map label for this gene is merA-2 [H]

Identifier: 39998513

GI number: 39998513

Start: 3769624

End: 3771030

Strand: Direct

Name: merA-2 [H]

Synonym: GSU3424

Alternate gene names: 39998513

Gene position: 3769624-3771030 (Clockwise)

Preceding gene: 39998509

Following gene: 39998514

Centisome position: 98.83

GC content: 67.52

Gene sequence:

>1407_bases
ATGTCCGACAAACACGACCTCATCATCCTCGGCTCAGGCTCCACCGCCTTCGCTGCCGCGCTCCGCGCCCACTCCAGGGG
CGCCCGGGTCCTCATGGTCGAGAAGAGCGTCCTCGGCGGCACCTGCATCAACTGGGGGTGCGTGCCGAGCAAGACCCTGA
TCCACGGGGCGCTATTCTATCAGGAGGGACGGCTCGGGGCAAGGCTCGGCCTCGGAGAGTGCGGAAACGCCGTGGACCTG
GCCCCCCTCATGACCCGCAAGGAAGAGGTGGTAAAGCACCTGCGCACCACCAGGTACCTGGATATACTCCGGAACACGCC
GGGGCTGGAACTGGCCAAGGGGACCGGCCGATTCCTGGGATCCGGCCGGCTGGAGGTGGTGGACCAGGTCTACCGCTGCG
ACCGCTACCTCGTGGCCGTCGGCGGCACCCCCCGCATCCCGAAGATACCGGGCCTGGAGTCCACCCCGTTCCTCACCAGC
CGGGGCGCGCTCCTGCTGAAACGCTTTCCGGCATCCCTCATCATCATCGGCGGCGGGGTCATAGCCGTGGAACTGGGGCA
GATGTTCCAGCGCTTGGGCACCCGGGTGACCATCCTCGAACACGGCCCGCGCATCCTCGCCCCCATAGAGCCGGAACCCG
CCCTGGCGATACGGAACGTCCTCAGGGACGAGGGGATGGAGATCATCTGCCACTCTCCGGTCTGCGCGGTGTCGGGAGAC
GGCTCCGCGGTGAGCGTGGAGGTCGAGCGCGAGGACGGACGCCGGACCTATACGGCGGAAAAGCTCCTTCTGGCCGTGGG
CACCACGCCGGCCACCCGCGGCATCGGCCTGGAGCTGGCCGGCGTGGAGACCGACGGCAGGGGATTCGTCACGGTGGACG
AACGGATGAGGACCACGGCTCCGGGCATCTGGGCCGCCGGCGACTGCACCGGCGGTATGATGATCGCCACGGTGGGGGCG
CGGGAGGGAATCATCGCCGTGGACGACATGTTCGCCACCGGCTGCGGCTGCGCCATGGATCACCTGAGTGTCCCCATGGC
CATCTTTACCGACCCCGAGGTGGGGGCCGTCGGTTACACCGAACAGGGCGCCCGGGACGCCGGACTCGACCCGATCGTGA
GCATTCTCCCCGTGTCAGCCATTCCCAAGGCCCATGTGACCGGGCATACGGCAGGCGTCATCAAACTGGTGGCGGAGCGG
GCCACGGGACGGCTGCTGGGGGCTCACCTGGCCTGCCACCGGGGAGCCGAGCTCATCAACGAGGCAGCCCTGGCCATTCG
GCTGAAGGCTACGTTCGAGGATCTGGCAAACGCCTTGCACGTCTACCCTTCAATAGGAGAGGGGCTGCGGCTCTGCGCCC
AGGGATTCACGAGGGATGTCAGCAAGTTGTCGTGCTGTGCGGAGTGA

Upstream 100 bases:

>100_bases
TGGTAAGGCTTACCGCGGCCATGAATCCTCCTTGTTGCCATAACGTACTTCTCAAACGCACGCATTCGGGTACACTGTCA
GAACCAGGGAGAACCATGCC

Downstream 100 bases:

>100_bases
TGGACCATGGAACCGGCCGGCGTCTACGCAAAAAATGTTCAGATTGACCGGGAATTGTCACAGCGGCTGCACGGGGCGCT
CACCTGTGGCAAGGAGGAGC

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSDKHDLIILGSGSTAFAAALRAHSRGARVLMVEKSVLGGTCINWGCVPSKTLIHGALFYQEGRLGARLGLGECGNAVDL
APLMTRKEEVVKHLRTTRYLDILRNTPGLELAKGTGRFLGSGRLEVVDQVYRCDRYLVAVGGTPRIPKIPGLESTPFLTS
RGALLLKRFPASLIIIGGGVIAVELGQMFQRLGTRVTILEHGPRILAPIEPEPALAIRNVLRDEGMEIICHSPVCAVSGD
GSAVSVEVEREDGRRTYTAEKLLLAVGTTPATRGIGLELAGVETDGRGFVTVDERMRTTAPGIWAAGDCTGGMMIATVGA
REGIIAVDDMFATGCGCAMDHLSVPMAIFTDPEVGAVGYTEQGARDAGLDPIVSILPVSAIPKAHVTGHTAGVIKLVAER
ATGRLLGAHLACHRGAELINEAALAIRLKATFEDLANALHVYPSIGEGLRLCAQGFTRDVSKLSCCAE

Sequences:

>Translated_468_residues
MSDKHDLIILGSGSTAFAAALRAHSRGARVLMVEKSVLGGTCINWGCVPSKTLIHGALFYQEGRLGARLGLGECGNAVDL
APLMTRKEEVVKHLRTTRYLDILRNTPGLELAKGTGRFLGSGRLEVVDQVYRCDRYLVAVGGTPRIPKIPGLESTPFLTS
RGALLLKRFPASLIIIGGGVIAVELGQMFQRLGTRVTILEHGPRILAPIEPEPALAIRNVLRDEGMEIICHSPVCAVSGD
GSAVSVEVEREDGRRTYTAEKLLLAVGTTPATRGIGLELAGVETDGRGFVTVDERMRTTAPGIWAAGDCTGGMMIATVGA
REGIIAVDDMFATGCGCAMDHLSVPMAIFTDPEVGAVGYTEQGARDAGLDPIVSILPVSAIPKAHVTGHTAGVIKLVAER
ATGRLLGAHLACHRGAELINEAALAIRLKATFEDLANALHVYPSIGEGLRLCAQGFTRDVSKLSCCAE
>Mature_467_residues
SDKHDLIILGSGSTAFAAALRAHSRGARVLMVEKSVLGGTCINWGCVPSKTLIHGALFYQEGRLGARLGLGECGNAVDLA
PLMTRKEEVVKHLRTTRYLDILRNTPGLELAKGTGRFLGSGRLEVVDQVYRCDRYLVAVGGTPRIPKIPGLESTPFLTSR
GALLLKRFPASLIIIGGGVIAVELGQMFQRLGTRVTILEHGPRILAPIEPEPALAIRNVLRDEGMEIICHSPVCAVSGDG
SAVSVEVEREDGRRTYTAEKLLLAVGTTPATRGIGLELAGVETDGRGFVTVDERMRTTAPGIWAAGDCTGGMMIATVGAR
EGIIAVDDMFATGCGCAMDHLSVPMAIFTDPEVGAVGYTEQGARDAGLDPIVSILPVSAIPKAHVTGHTAGVIKLVAERA
TGRLLGAHLACHRGAELINEAALAIRLKATFEDLANALHVYPSIGEGLRLCAQGFTRDVSKLSCCAE

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=32.4618736383442, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=27.4509803921569, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI148277071, Length=453, Percent_Identity=23.3995584988962, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI148277065, Length=453, Percent_Identity=23.3995584988962, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI33519430, Length=453, Percent_Identity=23.3995584988962, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI33519428, Length=453, Percent_Identity=23.3995584988962, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI33519426, Length=453, Percent_Identity=23.3995584988962, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI22035672, Length=433, Percent_Identity=26.0969976905312, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI291045266, Length=428, Percent_Identity=22.4299065420561, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=33.1868131868132, Blast_Score=228, Evalue=9e-61,
Organism=Escherichia coli, GI1786307, Length=469, Percent_Identity=30.2771855010661, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1789915, Length=452, Percent_Identity=30.0884955752212, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI87082354, Length=473, Percent_Identity=26.215644820296, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789065, Length=187, Percent_Identity=28.3422459893048, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=31.6593886462882, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71983419, Length=433, Percent_Identity=27.2517321016166, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71983429, Length=433, Percent_Identity=27.2517321016166, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=23.1578947368421, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=32.5531914893617, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=25.5913978494624, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=24.8945147679325, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=33.6244541484716, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24640549, Length=508, Percent_Identity=24.8031496062992, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24640553, Length=508, Percent_Identity=24.8031496062992, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24640551, Length=508, Percent_Identity=24.8031496062992, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17737741, Length=510, Percent_Identity=25.8823529411765, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 49411; Mature: 49280

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKHDLIILGSGSTAFAAALRAHSRGARVLMVEKSVLGGTCINWGCVPSKTLIHGALFY
CCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCCCHHHHHEEEEE
QEGRLGARLGLGECGNAVDLAPLMTRKEEVVKHLRTTRYLDILRNTPGLELAKGTGRFLG
ECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
SGRLEVVDQVYRCDRYLVAVGGTPRIPKIPGLESTPFLTSRGALLLKRFPASLIIIGGGV
CCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHEECCCCEEEEEECCE
IAVELGQMFQRLGTRVTILEHGPRILAPIEPEPALAIRNVLRDEGMEIICHSPVCAVSGD
EEHHHHHHHHHHCCEEEEEECCCEEEECCCCCHHHHHHHHHHHCCCEEEECCCEEEECCC
GSAVSVEVEREDGRRTYTAEKLLLAVGTTPATRGIGLELAGVETDGRGFVTVDERMRTTA
CCEEEEEEECCCCCEEEEHHEEEEEECCCCCCCCCCEEEEEEEECCCEEEEECCHHHHCC
PGIWAAGDCTGGMMIATVGAREGIIAVDDMFATGCGCAMDHLSVPMAIFTDPEVGAVGYT
CCEEECCCCCCCEEEEEECCCCCEEEEHHHHHCCCCHHHHHCCCCEEEEECCCCCCCCCC
EQGARDAGLDPIVSILPVSAIPKAHVTGHTAGVIKLVAERATGRLLGAHLACHRGAELIN
CCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
EAALAIRLKATFEDLANALHVYPSIGEGLRLCAQGFTRDVSKLSCCAE
CCEEEEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDKHDLIILGSGSTAFAAALRAHSRGARVLMVEKSVLGGTCINWGCVPSKTLIHGALFY
CCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCCCHHHHHEEEEE
QEGRLGARLGLGECGNAVDLAPLMTRKEEVVKHLRTTRYLDILRNTPGLELAKGTGRFLG
ECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
SGRLEVVDQVYRCDRYLVAVGGTPRIPKIPGLESTPFLTSRGALLLKRFPASLIIIGGGV
CCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHEECCCCEEEEEECCE
IAVELGQMFQRLGTRVTILEHGPRILAPIEPEPALAIRNVLRDEGMEIICHSPVCAVSGD
EEHHHHHHHHHHCCEEEEEECCCEEEECCCCCHHHHHHHHHHHCCCEEEECCCEEEECCC
GSAVSVEVEREDGRRTYTAEKLLLAVGTTPATRGIGLELAGVETDGRGFVTVDERMRTTA
CCEEEEEEECCCCCEEEEHHEEEEEECCCCCCCCCCEEEEEEEECCCEEEEECCHHHHCC
PGIWAAGDCTGGMMIATVGAREGIIAVDDMFATGCGCAMDHLSVPMAIFTDPEVGAVGYT
CCEEECCCCCCCEEEEEECCCCCEEEEHHHHHCCCCHHHHHCCCCEEEEECCCCCCCCCC
EQGARDAGLDPIVSILPVSAIPKAHVTGHTAGVIKLVAERATGRLLGAHLACHRGAELIN
CCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
EAALAIRLKATFEDLANALHVYPSIGEGLRLCAQGFTRDVSKLSCCAE
CCEEEEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]