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The map label for this gene is htrB [H]

Identifier: 39998509

GI number: 39998509

Start: 3765224

End: 3766147

Strand: Direct

Name: htrB [H]

Synonym: GSU3420

Alternate gene names: 39998509

Gene position: 3765224-3766147 (Clockwise)

Preceding gene: 39998506

Following gene: 39998513

Centisome position: 98.72

GC content: 66.34

Gene sequence:

>924_bases
GTGGACACGTCTCTTTCTTTACGCAAACGTCTCAAGTGGCACCTGGGCGTCTTCGCGGCCATCGTCGCGACCCTGCCGGT
GCTGCTGCTTCCCGCGCCGGTCGCCGTAGCCCTCGGGGGGGCAGCCGGCTCTCTCGCCTTCCGGCTCCTGGGCAAGGTGC
GCCGGAACACCGTCACGAACATCAGGAACGCGCTCCCCGCGCTCCAATCCATGGAAGGGTGGGATCCGGCAGCGGGCACG
CCGGAGGAGATCGCCCGGCGCACCTTCGTCAACCTGGGGCGGACCGCCGTGGAGATCATCAAGCTCTGCTACGGACAGGG
ACAGGGGCTGGTGGAGGGGACGGAACTGCGGGGAATGGAGCACTACCTGCGGGCAAAGGAGCGGGGCAAGGGGGTCATTT
TCATCACGGGGCACTGCGATAACTGGGAGATCGTGGCCCACGCCTTCGGCACCCATTCCGACGGCATGGCCGTGGTGGCC
CGCCGCCAGAAGTACGAGCCGCTGACAAGGCTGCTTGAGCGGCTGCGCAACCGGCACGGCAACAGCGTCATCTACGCCGA
CGGCGCGGCACGACAGATCTTTTTCCGCTTGAGGAAGAACGGCGCCATCGGCCTGCTCATGGACCAGGCAGTCCATCCCA
GCGAGGGAGAGCTGGTGGAATTTCTGGGGAAAAAGGCATGGACCACCACCATGCCGGCCCTGTTGGCGGCCAAGACCGGC
GCGGCCCTAGTCCCCGGATTCGGGAGGCGGGAGGGGAATCGTCACGTGCTGGAATTCTTCCCCGAGATAGCACCCGACCC
CGCCGGCGACCCCATCGCCACCACCAGGCTCCTCAACCGCGCCATCGAAGCCTACATCGTCCGCCACCCGGACCAGTGGC
TCTGGGTCTATAACCGCTGGAAGCGAGTACCGGCGGAGCAGTAG

Upstream 100 bases:

>100_bases
GTTTTTTAACGCACACTAATGCTATTTCACAACAAAGGACAGCCCTGGGGCCGCATGATTTTGGTTGGTCCCGGGAGAGG
GGTATGGTATGAGATAGGCC

Downstream 100 bases:

>100_bases
CCGCCCCGTATCCCCTGCGGCGATCCCGCGAGGTTGTCAACGGATCGCACAACAGGGATGCGGCGGCGCAGGTCAGGCCG
GGCGCCTCCCGGCAGCGGCC

Product: lipid A biosynthesis lauroyl acyltransferase

Products: NA

Alternate protein names: Heat shock protein B [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MDTSLSLRKRLKWHLGVFAAIVATLPVLLLPAPVAVALGGAAGSLAFRLLGKVRRNTVTNIRNALPALQSMEGWDPAAGT
PEEIARRTFVNLGRTAVEIIKLCYGQGQGLVEGTELRGMEHYLRAKERGKGVIFITGHCDNWEIVAHAFGTHSDGMAVVA
RRQKYEPLTRLLERLRNRHGNSVIYADGAARQIFFRLRKNGAIGLLMDQAVHPSEGELVEFLGKKAWTTTMPALLAAKTG
AALVPGFGRREGNRHVLEFFPEIAPDPAGDPIATTRLLNRAIEAYIVRHPDQWLWVYNRWKRVPAEQ

Sequences:

>Translated_307_residues
MDTSLSLRKRLKWHLGVFAAIVATLPVLLLPAPVAVALGGAAGSLAFRLLGKVRRNTVTNIRNALPALQSMEGWDPAAGT
PEEIARRTFVNLGRTAVEIIKLCYGQGQGLVEGTELRGMEHYLRAKERGKGVIFITGHCDNWEIVAHAFGTHSDGMAVVA
RRQKYEPLTRLLERLRNRHGNSVIYADGAARQIFFRLRKNGAIGLLMDQAVHPSEGELVEFLGKKAWTTTMPALLAAKTG
AALVPGFGRREGNRHVLEFFPEIAPDPAGDPIATTRLLNRAIEAYIVRHPDQWLWVYNRWKRVPAEQ
>Mature_307_residues
MDTSLSLRKRLKWHLGVFAAIVATLPVLLLPAPVAVALGGAAGSLAFRLLGKVRRNTVTNIRNALPALQSMEGWDPAAGT
PEEIARRTFVNLGRTAVEIIKLCYGQGQGLVEGTELRGMEHYLRAKERGKGVIFITGHCDNWEIVAHAFGTHSDGMAVVA
RRQKYEPLTRLLERLRNRHGNSVIYADGAARQIFFRLRKNGAIGLLMDQAVHPSEGELVEFLGKKAWTTTMPALLAAKTG
AALVPGFGRREGNRHVLEFFPEIAPDPAGDPIATTRLLNRAIEAYIVRHPDQWLWVYNRWKRVPAEQ

Specific function: Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA. Has 10 fold selectivity for lauroyl- ACP over myristoyl-ACP [H]

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family [H]

Homologues:

Organism=Escherichia coli, GI1787292, Length=281, Percent_Identity=24.9110320284698, Blast_Score=84, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004960
- InterPro:   IPR011920 [H]

Pfam domain/function: PF03279 Lip_A_acyltrans [H]

EC number: 2.3.1.-

Molecular weight: Translated: 33990; Mature: 33990

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTSLSLRKRLKWHLGVFAAIVATLPVLLLPAPVAVALGGAAGSLAFRLLGKVRRNTVTN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHH
IRNALPALQSMEGWDPAAGTPEEIARRTFVNLGRTAVEIIKLCYGQGQGLVEGTELRGME
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
HYLRAKERGKGVIFITGHCDNWEIVAHAFGTHSDGMAVVARRQKYEPLTRLLERLRNRHG
HHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCC
NSVIYADGAARQIFFRLRKNGAIGLLMDQAVHPSEGELVEFLGKKAWTTTMPALLAAKTG
CEEEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCC
AALVPGFGRREGNRHVLEFFPEIAPDPAGDPIATTRLLNRAIEAYIVRHPDQWLWVYNRW
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEECCCHHHHHHHHH
KRVPAEQ
HCCCCCC
>Mature Secondary Structure
MDTSLSLRKRLKWHLGVFAAIVATLPVLLLPAPVAVALGGAAGSLAFRLLGKVRRNTVTN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHH
IRNALPALQSMEGWDPAAGTPEEIARRTFVNLGRTAVEIIKLCYGQGQGLVEGTELRGME
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
HYLRAKERGKGVIFITGHCDNWEIVAHAFGTHSDGMAVVARRQKYEPLTRLLERLRNRHG
HHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCC
NSVIYADGAARQIFFRLRKNGAIGLLMDQAVHPSEGELVEFLGKKAWTTTMPALLAAKTG
CEEEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCC
AALVPGFGRREGNRHVLEFFPEIAPDPAGDPIATTRLLNRAIEAYIVRHPDQWLWVYNRW
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEECCCHHHHHHHHH
KRVPAEQ
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]