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The map label for this gene is atoC [H]

Identifier: 39998507

GI number: 39998507

Start: 3761065

End: 3762537

Strand: Reverse

Name: atoC [H]

Synonym: GSU3418

Alternate gene names: 39998507

Gene position: 3762537-3761065 (Counterclockwise)

Preceding gene: 39998508

Following gene: 39998503

Centisome position: 98.65

GC content: 63.2

Gene sequence:

>1473_bases
ATGAGCCCGGAAAAGTACCCCCCCAAGCCCATCCTGCTGGTTGACGATGAGGCTGCGTGGTTGCGCAGCCTGTCGCTCAC
GCTACGGGAAGCCACCGGCATTGATAATATCATCAAATGCTCCGATAGCAGGCAGGTGATGGATATTCTGCGCGAGACCG
AGGTGAGCCTGATTCTGCTCGACCTGACCATGCCCTACTTCTCCGGCACAGACCTGCTGCAGATGATCGGCCAAGAATAT
CCGGACATTCCGGTGATCGTCCTGAGCGGACTGAACCAGGTGGAAACGGCTGTGCGCTGCATGCAGTTGGGAGCCTTCGA
TTACTACGTGAAGACCGTGGAGAAGGAGCGCCTCATCACCGGCATCCAGCGGGCGTTCTCCATGCAGGAGATGCGCAACG
AAAATCGCAGCCTCAAGGCGCGGTTCCTGGAAGACCACCTGGCTCATCCGGAGGCTTTTGCGGAAATCATGACCGCCAGC
AAGAAGATGCGGGCGGTCTTCCAGTACTGCGAGGCCGTGGCCCAGAGCAGCGAACCGATCCTGATCACCGGTGAAAGCGG
AGTCGGCAAGGAGCTCATCGCCCGCGCCGTCCACCGCATCCGCTGCCCCGGCGGTCCCTGGGTGGCGGTAAACGCGGCGG
GGCTCGACGATACCATCTTTGCAGACACTCTGTTCGGGCACGCCCGCGGCGCGTTTACCGGCGCCGAGCGCGAGCGGCGC
GGCATGATCGAAGAGGCCGCCGGCGGTACCCTCTTTCTGGACGAAATAGGGGACCTGAGCCATGCCTCCCAGGTGAAGCT
GCTCCGGCTCCTCCAGGAGGGGGAATTTTTCCCCATCGGTTCGGACACTCCCCGCAAGCTCCGGGCCAGGCTCGTGTTCG
CCACCAACCACGACCTGAGCGGCAAGAACGGTTCCAACGGGTTCCGCAAGGACCTCTACTTCCGTCTCAACGCTCACCAG
GTCCAGATTCCTCCCCTGCGGGAGCGGTTCGAGGACCTGCCGCTGCTCATCGACCATTTCCTCTCGGAAGCCGCTGATAC
CCTGGGTAAACGTCGCCCCACCCCACCCCGGGAGCTGGCAACGCTCCTGTCCATCTACTCTTTTCCGGGGAACATCCGCG
AATTGCGGGCCATGATCTACGATGCGGTGAGCCGCCATCGCTCCCATGTCCTGTCCTTGGACAGCTTCAAGGAGAAGATC
GGTTACAGCACGGACCTGCCGTCCCCGGCGCCCGATGCGGAGATCATTTTCCCCGAGCGGCTGCCGACCCTTGAAGAGGG
AGGGCACAGGCTGGTCATGGAGGCGGTCCGGCGCGCCCGGGGCAATCAGACCCTGGCGGCGGCCATGCTCGGCATAACCC
GGCAGGCGCTTGCCAAGCGGCTGAAGCAGTTCCCCGATGCCACTCCCGCTCCCCCCGCACGTGCCGTAGGGAGTGGGCTG
GAGCGGGTGCTGCAGTTCTTTCCTGCCCATTGA

Upstream 100 bases:

>100_bases
TCGTCAGAAGTTATGGCGGCACACTCGAATTCCAGTCCGTCCCGGGAGCCGGGACAACGGCTACCCTGTCCCTGCCGGCC
GAAAAGGAGGTTATTGCCGC

Downstream 100 bases:

>100_bases
ACCGTCAGCAGGTGCTAAGAAGCAGGCTGCCACCAGCCGTGGTAACTGAAGGGGACGTGGTGGGTGAGTCGAACGAGGGC
CAGGGGGCCATCGGCGATCC

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MSPEKYPPKPILLVDDEAAWLRSLSLTLREATGIDNIIKCSDSRQVMDILRETEVSLILLDLTMPYFSGTDLLQMIGQEY
PDIPVIVLSGLNQVETAVRCMQLGAFDYYVKTVEKERLITGIQRAFSMQEMRNENRSLKARFLEDHLAHPEAFAEIMTAS
KKMRAVFQYCEAVAQSSEPILITGESGVGKELIARAVHRIRCPGGPWVAVNAAGLDDTIFADTLFGHARGAFTGAERERR
GMIEEAAGGTLFLDEIGDLSHASQVKLLRLLQEGEFFPIGSDTPRKLRARLVFATNHDLSGKNGSNGFRKDLYFRLNAHQ
VQIPPLRERFEDLPLLIDHFLSEAADTLGKRRPTPPRELATLLSIYSFPGNIRELRAMIYDAVSRHRSHVLSLDSFKEKI
GYSTDLPSPAPDAEIIFPERLPTLEEGGHRLVMEAVRRARGNQTLAAAMLGITRQALAKRLKQFPDATPAPPARAVGSGL
ERVLQFFPAH

Sequences:

>Translated_490_residues
MSPEKYPPKPILLVDDEAAWLRSLSLTLREATGIDNIIKCSDSRQVMDILRETEVSLILLDLTMPYFSGTDLLQMIGQEY
PDIPVIVLSGLNQVETAVRCMQLGAFDYYVKTVEKERLITGIQRAFSMQEMRNENRSLKARFLEDHLAHPEAFAEIMTAS
KKMRAVFQYCEAVAQSSEPILITGESGVGKELIARAVHRIRCPGGPWVAVNAAGLDDTIFADTLFGHARGAFTGAERERR
GMIEEAAGGTLFLDEIGDLSHASQVKLLRLLQEGEFFPIGSDTPRKLRARLVFATNHDLSGKNGSNGFRKDLYFRLNAHQ
VQIPPLRERFEDLPLLIDHFLSEAADTLGKRRPTPPRELATLLSIYSFPGNIRELRAMIYDAVSRHRSHVLSLDSFKEKI
GYSTDLPSPAPDAEIIFPERLPTLEEGGHRLVMEAVRRARGNQTLAAAMLGITRQALAKRLKQFPDATPAPPARAVGSGL
ERVLQFFPAH
>Mature_489_residues
SPEKYPPKPILLVDDEAAWLRSLSLTLREATGIDNIIKCSDSRQVMDILRETEVSLILLDLTMPYFSGTDLLQMIGQEYP
DIPVIVLSGLNQVETAVRCMQLGAFDYYVKTVEKERLITGIQRAFSMQEMRNENRSLKARFLEDHLAHPEAFAEIMTASK
KMRAVFQYCEAVAQSSEPILITGESGVGKELIARAVHRIRCPGGPWVAVNAAGLDDTIFADTLFGHARGAFTGAERERRG
MIEEAAGGTLFLDEIGDLSHASQVKLLRLLQEGEFFPIGSDTPRKLRARLVFATNHDLSGKNGSNGFRKDLYFRLNAHQV
QIPPLRERFEDLPLLIDHFLSEAADTLGKRRPTPPRELATLLSIYSFPGNIRELRAMIYDAVSRHRSHVLSLDSFKEKIG
YSTDLPSPAPDAEIIFPERLPTLEEGGHRLVMEAVRRARGNQTLAAAMLGITRQALAKRLKQFPDATPAPPARAVGSGLE
RVLQFFPAH

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=470, Percent_Identity=36.1702127659575, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI1790437, Length=454, Percent_Identity=35.4625550660793, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1790299, Length=477, Percent_Identity=33.1236897274633, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1788905, Length=465, Percent_Identity=34.1935483870968, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1789087, Length=362, Percent_Identity=38.121546961326, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI87082117, Length=367, Percent_Identity=35.149863760218, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI1789233, Length=227, Percent_Identity=37.4449339207048, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI87082152, Length=315, Percent_Identity=36.8253968253968, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1787583, Length=320, Percent_Identity=32.5, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87081872, Length=316, Percent_Identity=35.126582278481, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1786524, Length=332, Percent_Identity=34.0361445783133, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789828, Length=256, Percent_Identity=33.984375, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87081858, Length=318, Percent_Identity=29.559748427673, Blast_Score=109, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 54626; Mature: 54494

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPEKYPPKPILLVDDEAAWLRSLSLTLREATGIDNIIKCSDSRQVMDILRETEVSLILL
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHCCCEEEEE
DLTMPYFSGTDLLQMIGQEYPDIPVIVLSGLNQVETAVRCMQLGAFDYYVKTVEKERLIT
EECCCCCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
GIQRAFSMQEMRNENRSLKARFLEDHLAHPEAFAEIMTASKKMRAVFQYCEAVAQSSEPI
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LITGESGVGKELIARAVHRIRCPGGPWVAVNAAGLDDTIFADTLFGHARGAFTGAERERR
EEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHH
GMIEEAAGGTLFLDEIGDLSHASQVKLLRLLQEGEFFPIGSDTPRKLRARLVFATNHDLS
CCHHHHCCCEEEHHHHCCCCHHHHHHHHHHHHCCCEECCCCCCHHHHHEEEEEEECCCCC
GKNGSNGFRKDLYFRLNAHQVQIPPLRERFEDLPLLIDHFLSEAADTLGKRRPTPPRELA
CCCCCCCCCCCEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
TLLSIYSFPGNIRELRAMIYDAVSRHRSHVLSLDSFKEKIGYSTDLPSPAPDAEIIFPER
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCC
LPTLEEGGHRLVMEAVRRARGNQTLAAAMLGITRQALAKRLKQFPDATPAPPARAVGSGL
CCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ERVLQFFPAH
HHHHHHHCCC
>Mature Secondary Structure 
SPEKYPPKPILLVDDEAAWLRSLSLTLREATGIDNIIKCSDSRQVMDILRETEVSLILL
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHCCCEEEEE
DLTMPYFSGTDLLQMIGQEYPDIPVIVLSGLNQVETAVRCMQLGAFDYYVKTVEKERLIT
EECCCCCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
GIQRAFSMQEMRNENRSLKARFLEDHLAHPEAFAEIMTASKKMRAVFQYCEAVAQSSEPI
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LITGESGVGKELIARAVHRIRCPGGPWVAVNAAGLDDTIFADTLFGHARGAFTGAERERR
EEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHH
GMIEEAAGGTLFLDEIGDLSHASQVKLLRLLQEGEFFPIGSDTPRKLRARLVFATNHDLS
CCHHHHCCCEEEHHHHCCCCHHHHHHHHHHHHCCCEECCCCCCHHHHHEEEEEEECCCCC
GKNGSNGFRKDLYFRLNAHQVQIPPLRERFEDLPLLIDHFLSEAADTLGKRRPTPPRELA
CCCCCCCCCCCEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
TLLSIYSFPGNIRELRAMIYDAVSRHRSHVLSLDSFKEKIGYSTDLPSPAPDAEIIFPER
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCC
LPTLEEGGHRLVMEAVRRARGNQTLAAAMLGITRQALAKRLKQFPDATPAPPARAVGSGL
CCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ERVLQFFPAH
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]