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The map label for this gene is nth [C]

Identifier: 39998466

GI number: 39998466

Start: 3710946

End: 3711632

Strand: Reverse

Name: nth [C]

Synonym: GSU3377

Alternate gene names: 39998466

Gene position: 3711632-3710946 (Counterclockwise)

Preceding gene: 39998467

Following gene: 39998461

Centisome position: 97.31

GC content: 62.3

Gene sequence:

>687_bases
ATGAGCGGATCCTCGGTGACAACGGCGGGTGGGCCTGAGGGGGTGCGTGACCGGCTCATGGCGGTCTACGATCAACTCTT
CGCGGCCTACGGACCCCGCCACTGGTGGCCCGCAGACACCCCCTTCGAGGTCTGCGTCGGTGCAATCCTGACCCAGAATA
CCAACTGGGGCAACGTGGAAAAGGCCATTGTCCGGCTCAAGGCTGCGGGGCTCCTCTCCCCGGAGGGGCTGCGCGATGTA
CCTGTTGCCGAGTTGGCGGAGACGATCAGGCCGGCCGGTTACTACAATGTCAAAAGCGCCCGGCTCAAGGATTTTGTCGG
GTTTCTCTTCGGCCGCTTCGGCGGTAGCCTGGAGCGGATGTTTGCGGGAGAGTGGCGGGAACTGCGACGGGAACTGCTTG
GGGTAAGGGGTATCGGCCGGGAGACAGCCGACTCGATCCTGCTCTATGCGGGAGGCAAACCTTCCTTCGTGGTTGATGCC
TATACGAAACGCCTGTTTTCCGCCCTGGGTCTCGTGGCCCCGACGACCGACTATGAGACCGTCCGCGCACTCTTCATGGA
CAACCTTCCCGAAGACACTACGCTGTTCAACGAATATCACGCCCTCATCGTGGAGCATTGCAAGCGGCACTGCACCACCC
GCCCCCGTTGCGGCGAGTGCGGACTCCATCTGTTATGTCGAGCCTGA

Upstream 100 bases:

>100_bases
GCCCTGGCGCGCCGGCTGGGGTATGACCCGAAGCTTCGGCACCCGGGGAGTGCCCTCATGAAGGAGTACGAAGAGGTAAC
CGAGGCGGTCCGGCGGGTGT

Downstream 100 bases:

>100_bases
CATGAGCTCCACCCTGTTGCGACCGTTCTGCTTGGCCCGGTAGAGGGCCTCGTCGGCCTGCCTGAAGAGGGAGTCGGTCC
CCTCGATGCGGGGTGATGGA

Product: helix-hairpin-helix domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSGSSVTTAGGPEGVRDRLMAVYDQLFAAYGPRHWWPADTPFEVCVGAILTQNTNWGNVEKAIVRLKAAGLLSPEGLRDV
PVAELAETIRPAGYYNVKSARLKDFVGFLFGRFGGSLERMFAGEWRELRRELLGVRGIGRETADSILLYAGGKPSFVVDA
YTKRLFSALGLVAPTTDYETVRALFMDNLPEDTTLFNEYHALIVEHCKRHCTTRPRCGECGLHLLCRA

Sequences:

>Translated_228_residues
MSGSSVTTAGGPEGVRDRLMAVYDQLFAAYGPRHWWPADTPFEVCVGAILTQNTNWGNVEKAIVRLKAAGLLSPEGLRDV
PVAELAETIRPAGYYNVKSARLKDFVGFLFGRFGGSLERMFAGEWRELRRELLGVRGIGRETADSILLYAGGKPSFVVDA
YTKRLFSALGLVAPTTDYETVRALFMDNLPEDTTLFNEYHALIVEHCKRHCTTRPRCGECGLHLLCRA
>Mature_227_residues
SGSSVTTAGGPEGVRDRLMAVYDQLFAAYGPRHWWPADTPFEVCVGAILTQNTNWGNVEKAIVRLKAAGLLSPEGLRDVP
VAELAETIRPAGYYNVKSARLKDFVGFLFGRFGGSLERMFAGEWRELRRELLGVRGIGRETADSILLYAGGKPSFVVDAY
TKRLFSALGLVAPTTDYETVRALFMDNLPEDTTLFNEYHALIVEHCKRHCTTRPRCGECGLHLLCRA

Specific function: Has Both An Apurinic And/Or Apyrimidinic Endonuclease Activity And A DNA N-Glycosylase Activity. Incises Damaged DNA At Cytosines, Thymines And Guanines. Acts On A Damaged Strand, 5' From The Damaged Site. Required For The Repair Of Both Oxidative DNA Da

COG id: COG2231

COG function: function code L; Uncharacterized protein related to Endonuclease III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Drosophila melanogaster, GI45550361, Length=188, Percent_Identity=28.7234042553192, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 4.2.99.18

Molecular weight: Translated: 25246; Mature: 25115

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSSVTTAGGPEGVRDRLMAVYDQLFAAYGPRHWWPADTPFEVCVGAILTQNTNWGNVE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
KAIVRLKAAGLLSPEGLRDVPVAELAETIRPAGYYNVKSARLKDFVGFLFGRFGGSLERM
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
FAGEWRELRRELLGVRGIGRETADSILLYAGGKPSFVVDAYTKRLFSALGLVAPTTDYET
HHHHHHHHHHHHHHHCCCCCHHHCCEEEEECCCCCEEHHHHHHHHHHHHHHCCCCCCHHH
VRALFMDNLPEDTTLFNEYHALIVEHCKRHCTTRPRCGECGLHLLCRA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCC
>Mature Secondary Structure 
SGSSVTTAGGPEGVRDRLMAVYDQLFAAYGPRHWWPADTPFEVCVGAILTQNTNWGNVE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
KAIVRLKAAGLLSPEGLRDVPVAELAETIRPAGYYNVKSARLKDFVGFLFGRFGGSLERM
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
FAGEWRELRRELLGVRGIGRETADSILLYAGGKPSFVVDAYTKRLFSALGLVAPTTDYET
HHHHHHHHHHHHHHHCCCCCHHHCCEEEEECCCCCEEHHHHHHHHHHHHHHCCCCCCHHH
VRALFMDNLPEDTTLFNEYHALIVEHCKRHCTTRPRCGECGLHLLCRA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Carbon-Oxygen Lyase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]