Click here to switch to the map view.

The map label for this gene is groeL [H]

Identifier: 39998429

GI number: 39998429

Start: 3665270

End: 3666904

Strand: Direct

Name: groeL [H]

Synonym: GSU3340

Alternate gene names: 39998429

Gene position: 3665270-3666904 (Clockwise)

Preceding gene: 39998428

Following gene: 308513344

Centisome position: 96.1

GC content: 62.94

Gene sequence:

>1635_bases
ATGGCAGCCAGAATCATCAAGTTCGACCAGGAAGGGCGCAACGCCATCCTGAAAGGTGTCAATACCCTCGCCGACGCGGT
GAAGGTTACCCTCGGCCCCAAAGGCCGCAACGTGGTCATCGAGAAGGCCTTCGGCTCCCCCCTTATCACCAAGGACGGCG
TCACCGTGGCCAAGGAAATCGAGCTCGAGGACAAGTTCGAGAACATGGGCGCCCAGCTCGTGAAGGAAGTCGCCTCCAAG
ACCTCCGACGTTGCCGGTGACGGCACCACCACCGCCACGGTCCTCGCCCAGGCCATCTATCGCCAGGGCTCCAAGCTGGT
GGCCGCCGGCCACAACCCCATGGAGATCAAGCGCGGCATCGACAAGGCCGTCGAGACCATCGTGGCCGAGCTCAAGAGCA
TCTCCAAGCCGATCAAGGATCACAAGGAAATCGCCCAGGTGGGCACCATCTCCGCCAACAACGACAAGACCATCGGCGAC
ATCATCGCCCAGGCCATGGAAAAAGTCGGCAAGGAAGGGGTAATCACTGTCGAGGAAGCCAAGGCCATGGAAACCAGCCT
GGAGACCGTCGAGGGGATGCAGTTCGACCGCGGCTACCTCTCCCCCTACTTCGTGACCGATCCGGAGCGGATGGAGGCGT
CGCTTGAGAACGCCATGATCCTGATCCACGACAAGAAGATCTCCAACATGAAGGACCTTCTCCCGGTGCTGGAGCAGACC
GCCAAGAGCGGCCGTCCGCTGCTGATCATCGCCGAAGACATCGAGGGCGAGGCTCTTGCCACCCTGGTCGTGAACAAGCT
GCGCGGCGTGCTCAACATCTGCGCCGTCAAGGCCCCGGGCTTCGGTGACCGCCGCAAGGCCATGCTGGAAGATATCGCCA
TCCTCACCGGCGGCCAGGTCATCTCCGAGGAGATCGGCAACAAGCTCGAAAACACCACCATGGACATGCTCGGCCGCGCC
AAGCGGATCACCGTGGACAAGGACAACACCACCATCATCGACGGCGACGGCAAGGAAGCCGACATCCAGGGCCGCGTCAA
GCAGATCCGCGCCCAGATCGAGGAGACCACCAGCGACTACGACCGCGAGAAGCTCCAGGAGCGCCTGGCCAAGCTCGTGG
GCGGGGTTGCCGTAATCAAGGTCGGTGCCGCCACCGAGACCGAGATGAAAGAGAAGAAAGCCCGCGTCGAAGATGCCCTG
CACGCCACCCGCGCCGCAGTGGACGAGGGGATCGTCCCCGGAGGCGGCGTTGCCTACCTGCGCGCCCTTGCTTCCCTTGA
TGCCCTCAGCCTTCCTACCGAGCAGCAGTTCGGCGTCAACGTCATCAAGCGCTCCCTGGAGGAGCCCATCCGCCAGATCG
CCCAGAACGCGGGTGTCGACGGCTCCATCGTGGTCGACAAGGTGAAGAACAGCAAGGATGCTTTCGGCTATAACGCCGCC
GAGGACGAGTACGTGGACATGCTCGCCGCCGGGATCATCGACCCGACCAAGGTGTCCCGTTCCGCCCTGCAGAACGCGGC
TTCTGTCGCCGGACTCATGCTCACCACCGAAGCCATGATCGCCGACAAGCCGAAGGAAGAAGCTCCTATGCCTGCCATGC
CCGGCGGCATGGGCGGCATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
CATGCGCGAGGACGACATCCTGGGCGTGATCGAGTAACCGACACCACGCCGGACAGCACAGCACTACCCGAGTGAACCAA
TCCAAGGAGGATAGACAGAT

Downstream 100 bases:

>100_bases
TCAGCCTGCCGTCCAGGTCTGTATCACAATAAAAAAGGAGAAGGGCTTCGGTCCTTCTCCTTTTTTCGTGCCCGGCATCT
CCACCCCGCCAAACGTGCCC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAARIIKFDQEGRNAILKGVNTLADAVKVTLGPKGRNVVIEKAFGSPLITKDGVTVAKEIELEDKFENMGAQLVKEVASK
TSDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGIDKAVETIVAELKSISKPIKDHKEIAQVGTISANNDKTIGD
IIAQAMEKVGKEGVITVEEAKAMETSLETVEGMQFDRGYLSPYFVTDPERMEASLENAMILIHDKKISNMKDLLPVLEQT
AKSGRPLLIIAEDIEGEALATLVVNKLRGVLNICAVKAPGFGDRRKAMLEDIAILTGGQVISEEIGNKLENTTMDMLGRA
KRITVDKDNTTIIDGDGKEADIQGRVKQIRAQIEETTSDYDREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDAL
HATRAAVDEGIVPGGGVAYLRALASLDALSLPTEQQFGVNVIKRSLEEPIRQIAQNAGVDGSIVVDKVKNSKDAFGYNAA
EDEYVDMLAAGIIDPTKVSRSALQNAASVAGLMLTTEAMIADKPKEEAPMPAMPGGMGGMGGMM

Sequences:

>Translated_544_residues
MAARIIKFDQEGRNAILKGVNTLADAVKVTLGPKGRNVVIEKAFGSPLITKDGVTVAKEIELEDKFENMGAQLVKEVASK
TSDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGIDKAVETIVAELKSISKPIKDHKEIAQVGTISANNDKTIGD
IIAQAMEKVGKEGVITVEEAKAMETSLETVEGMQFDRGYLSPYFVTDPERMEASLENAMILIHDKKISNMKDLLPVLEQT
AKSGRPLLIIAEDIEGEALATLVVNKLRGVLNICAVKAPGFGDRRKAMLEDIAILTGGQVISEEIGNKLENTTMDMLGRA
KRITVDKDNTTIIDGDGKEADIQGRVKQIRAQIEETTSDYDREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDAL
HATRAAVDEGIVPGGGVAYLRALASLDALSLPTEQQFGVNVIKRSLEEPIRQIAQNAGVDGSIVVDKVKNSKDAFGYNAA
EDEYVDMLAAGIIDPTKVSRSALQNAASVAGLMLTTEAMIADKPKEEAPMPAMPGGMGGMGGMM
>Mature_543_residues
AARIIKFDQEGRNAILKGVNTLADAVKVTLGPKGRNVVIEKAFGSPLITKDGVTVAKEIELEDKFENMGAQLVKEVASKT
SDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGIDKAVETIVAELKSISKPIKDHKEIAQVGTISANNDKTIGDI
IAQAMEKVGKEGVITVEEAKAMETSLETVEGMQFDRGYLSPYFVTDPERMEASLENAMILIHDKKISNMKDLLPVLEQTA
KSGRPLLIIAEDIEGEALATLVVNKLRGVLNICAVKAPGFGDRRKAMLEDIAILTGGQVISEEIGNKLENTTMDMLGRAK
RITVDKDNTTIIDGDGKEADIQGRVKQIRAQIEETTSDYDREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDALH
ATRAAVDEGIVPGGGVAYLRALASLDALSLPTEQQFGVNVIKRSLEEPIRQIAQNAGVDGSIVVDKVKNSKDAFGYNAAE
DEYVDMLAAGIIDPTKVSRSALQNAASVAGLMLTTEAMIADKPKEEAPMPAMPGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=51.6129032258064, Blast_Score=533, Evalue=1e-151,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=51.6129032258064, Blast_Score=533, Evalue=1e-151,
Organism=Homo sapiens, GI38455427, Length=535, Percent_Identity=22.0560747663551, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=67.4858223062382, Blast_Score=706, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=53.1190926275992, Blast_Score=554, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI193210679, Length=224, Percent_Identity=50.4464285714286, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17564182, Length=564, Percent_Identity=21.9858156028369, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323288, Length=522, Percent_Identity=55.3639846743295, Blast_Score=564, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6322350, Length=573, Percent_Identity=24.78184991274, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322524, Length=368, Percent_Identity=23.0978260869565, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=51.9924098671727, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=51.9924098671727, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.4743833017078, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.4743833017078, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.4743833017078, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI17864606, Length=543, Percent_Identity=44.3830570902394, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24584129, Length=534, Percent_Identity=37.4531835205993, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI19921262, Length=534, Percent_Identity=37.4531835205993, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI28571140, Length=551, Percent_Identity=25.0453720508167, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI18858175, Length=551, Percent_Identity=25.0453720508167, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58150; Mature: 58018

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARIIKFDQEGRNAILKGVNTLADAVKVTLGPKGRNVVIEKAFGSPLITKDGVTVAKEI
CCCEEEEECCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCCCHHHC
ELEDKFENMGAQLVKEVASKTSDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
DKAVETIVAELKSISKPIKDHKEIAQVGTISANNDKTIGDIIAQAMEKVGKEGVITVEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHH
KAMETSLETVEGMQFDRGYLSPYFVTDPERMEASLENAMILIHDKKISNMKDLLPVLEQT
HHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEECCHHCCHHHHHHHHHHH
AKSGRPLLIIAEDIEGEALATLVVNKLRGVLNICAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHH
ISEEIGNKLENTTMDMLGRAKRITVDKDNTTIIDGDGKEADIQGRVKQIRAQIEETTSDY
HHHHHCCHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDALHATRAAVDEGIVPGGGVAYL
HHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RALASLDALSLPTEQQFGVNVIKRSLEEPIRQIAQNAGVDGSIVVDKVKNSKDAFGYNAA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCC
EDEYVDMLAAGIIDPTKVSRSALQNAASVAGLMLTTEAMIADKPKEEAPMPAMPGGMGGM
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGMM
CCCC
>Mature Secondary Structure 
AARIIKFDQEGRNAILKGVNTLADAVKVTLGPKGRNVVIEKAFGSPLITKDGVTVAKEI
CCEEEEECCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCCCHHHC
ELEDKFENMGAQLVKEVASKTSDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
DKAVETIVAELKSISKPIKDHKEIAQVGTISANNDKTIGDIIAQAMEKVGKEGVITVEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHH
KAMETSLETVEGMQFDRGYLSPYFVTDPERMEASLENAMILIHDKKISNMKDLLPVLEQT
HHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEECCHHCCHHHHHHHHHHH
AKSGRPLLIIAEDIEGEALATLVVNKLRGVLNICAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHH
ISEEIGNKLENTTMDMLGRAKRITVDKDNTTIIDGDGKEADIQGRVKQIRAQIEETTSDY
HHHHHCCHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLVGGVAVIKVGAATETEMKEKKARVEDALHATRAAVDEGIVPGGGVAYL
HHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RALASLDALSLPTEQQFGVNVIKRSLEEPIRQIAQNAGVDGSIVVDKVKNSKDAFGYNAA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCC
EDEYVDMLAAGIIDPTKVSRSALQNAASVAGLMLTTEAMIADKPKEEAPMPAMPGGMGGM
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGMM
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA