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The map label for this gene is uvrB

Identifier: 39998352

GI number: 39998352

Start: 3577166

End: 3579160

Strand: Direct

Name: uvrB

Synonym: GSU3262

Alternate gene names: 39998352

Gene position: 3577166-3579160 (Clockwise)

Preceding gene: 39998351

Following gene: 39998353

Centisome position: 93.79

GC content: 62.76

Gene sequence:

>1995_bases
ATGGAACGCTTCAGACTGGCTAGCGATTACGAGCCCCGCGGCGACCAGCCCCGGGCCATTGCCGAACTCTCGGAAGGGAT
TGTCAGGGGCGACCGGGATCAGGTGCTCCTGGGGGTCACCGGCAGCGGCAAAACGTTTACCATGGCCAACGTCATCGCCG
CCGTGAACCGCCCCGCCTTGGTCCTGGCCCCCAACAAGACCCTGGCGGCCCAGCTCTATGGCGAATTCCGGGAACTATTT
CCGGACAATGCCGTGGAATATTTCGTCTCATACTACGACTACTACCAGCCGGAAGCCTACATCCCCACCACCGACACCTT
CATCGAGAAGGATTCCTCCATCAACGACGAGATCGACAAGTTGCGCCATGCGGCCACGCGGAGCCTGCTGACCCGGCGCG
ACGTGATCATCGTTGCCTCGGTGTCATGCATATACGGCATCGGCTCCCCGGCCGAGTACCAGGCCATGCACATCTTCTTT
CACCAGGGGGACGAGTACGGCCGGGACGAACTGCTGCGGAAGCTGGTCGACATCCAGTATGAACGGAATGATCTGGACTT
CCACCGGGGGACCTTCCGGGTGCGGGGGGACATCGTGGAGATATTCCCGGCCCACGAGGGGGAGCGGGCCTACCGGATCG
AGTTCTTCGGCGACACGGTGGACGCGATCAGCGAAATCGATCCCTTGCGAGGCGTGGTGGTCCAGCGCCTGACCAAGTGC
GCCGTCTATCCGGCTTCCCATTACGTGGCGACGCGCGAGACCCTGGACCGGGCCATGGAGGAGATCCGCACCGACCTGCG
GGAGCGACTCCAGTGGTTCCGGGAGCGGAACATGCTCGTGGAGGCCCAGCGGCTGGAACAGCGAACAATGTTCGACCTGG
AGATGATGGAGGAGATGGGATTCTGCCAGGGGATCGAGAACTATTCCCGCTACTTCGACGGCCGGACGCCGGGGGAGCCC
CCCTACACCCTGCTCGACTACTTCCCCCGTGACTTCATCCTCTTCGTGGACGAATCCCACATTACCGTCTCCCAGGTAGG
GGGGATGTACCGGGGGGACCGGAGCAGGAAAGAAACTTTGGTGAACTACGGCTTCCGCCTACCGGCGGCCCTGGACAACC
GGCCCCTCACCTTCGGGGAGTTCACCGAACGGCTCAACCAGAGCGTCTACGTCTCGGCCACCCCGGCCGACTACGAGCTG
CAGCAGAGCGGCGGCGTGGTGGTGGAACAGGTGATCAGGCCCACGGGCCTCCTGGACCCGGTCATCGAGGTCCGTCCTGC
CACGGAGCAGGTGGACGATCTCCTGCACGAGGTCCGGGAGACCACGGCCCGGGGCGAACGGGTGCTCGTAACCACCCTCA
CCAAGCGGATGGCCGAGGACCTGACCGATTACTACCGGGACCTGGGGGTGCGGGTCAGATACCTCCATTCCGACATAGAC
ACTATCCAGCGGATGCAGATCATCCGTGATCTGCGCATGGGGGAGTTCGATGTCCTGGTCGGCATCAACCTCCTGCGGGA
AGGGCTCGACATTCCCGAAGTGTCGCTGGTGGCGATTCTCGACGCCGACAAGGAGGGGTTCCTCCGCTCCGCCCGTTCCC
TCATCCAGACCTGTGGCCGGGCCGCTCGCAACGTGAACGGCAGGGTCATCATGTACGCCGATACCGTAACCGGCTCCATG
CAGAGCTGCCTCGACGAAACCGCCCGGCGTCGTGCTCTTCAGGAGGCCTTCAACACCGAACACGGCATCACGCCCCAGAC
CGTGAAAAAGGGGCTGCGGACCATCCTGGAGTCCATCGAGGAGCGTGATTACTACACCGTCGCCGCCGTTGCCGAGACTC
GGGAAGAGTACATCTCTGCCGACGAGATACCGAAAAGGGTGAAGAAGCTCCGCAAGGAGATGCTCGACGCGGCAAAGAAG
CTGGAGTTCGAACGGGCGGCCGATCTCAGGGATCAGATCAAAAAACTGGAAGAAATGGAGCTGCGGCTGCGCTGA

Upstream 100 bases:

>100_bases
CAACCTCACTCCCAAGTCCGCCGGCGCGGCACGATAGACGTCCCCGCGGCACGGGCTCACCCGTGCCGTTCCATTTTCTT
CCCAAGGTGTCCCCATTTCC

Downstream 100 bases:

>100_bases
CCGCTCCACGGGGGACATCCGATGAAGGAACCACGCGTACTGCTCGTTGATGACGAGCGATTCTTCCTGAATCTCCAGCA
GGAGTTTCTGGCGGATTCCC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 664; Mature: 664

Protein sequence:

>664_residues
MERFRLASDYEPRGDQPRAIAELSEGIVRGDRDQVLLGVTGSGKTFTMANVIAAVNRPALVLAPNKTLAAQLYGEFRELF
PDNAVEYFVSYYDYYQPEAYIPTTDTFIEKDSSINDEIDKLRHAATRSLLTRRDVIIVASVSCIYGIGSPAEYQAMHIFF
HQGDEYGRDELLRKLVDIQYERNDLDFHRGTFRVRGDIVEIFPAHEGERAYRIEFFGDTVDAISEIDPLRGVVVQRLTKC
AVYPASHYVATRETLDRAMEEIRTDLRERLQWFRERNMLVEAQRLEQRTMFDLEMMEEMGFCQGIENYSRYFDGRTPGEP
PYTLLDYFPRDFILFVDESHITVSQVGGMYRGDRSRKETLVNYGFRLPAALDNRPLTFGEFTERLNQSVYVSATPADYEL
QQSGGVVVEQVIRPTGLLDPVIEVRPATEQVDDLLHEVRETTARGERVLVTTLTKRMAEDLTDYYRDLGVRVRYLHSDID
TIQRMQIIRDLRMGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSARSLIQTCGRAARNVNGRVIMYADTVTGSM
QSCLDETARRRALQEAFNTEHGITPQTVKKGLRTILESIEERDYYTVAAVAETREEYISADEIPKRVKKLRKEMLDAAKK
LEFERAADLRDQIKKLEEMELRLR

Sequences:

>Translated_664_residues
MERFRLASDYEPRGDQPRAIAELSEGIVRGDRDQVLLGVTGSGKTFTMANVIAAVNRPALVLAPNKTLAAQLYGEFRELF
PDNAVEYFVSYYDYYQPEAYIPTTDTFIEKDSSINDEIDKLRHAATRSLLTRRDVIIVASVSCIYGIGSPAEYQAMHIFF
HQGDEYGRDELLRKLVDIQYERNDLDFHRGTFRVRGDIVEIFPAHEGERAYRIEFFGDTVDAISEIDPLRGVVVQRLTKC
AVYPASHYVATRETLDRAMEEIRTDLRERLQWFRERNMLVEAQRLEQRTMFDLEMMEEMGFCQGIENYSRYFDGRTPGEP
PYTLLDYFPRDFILFVDESHITVSQVGGMYRGDRSRKETLVNYGFRLPAALDNRPLTFGEFTERLNQSVYVSATPADYEL
QQSGGVVVEQVIRPTGLLDPVIEVRPATEQVDDLLHEVRETTARGERVLVTTLTKRMAEDLTDYYRDLGVRVRYLHSDID
TIQRMQIIRDLRMGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSARSLIQTCGRAARNVNGRVIMYADTVTGSM
QSCLDETARRRALQEAFNTEHGITPQTVKKGLRTILESIEERDYYTVAAVAETREEYISADEIPKRVKKLRKEMLDAAKK
LEFERAADLRDQIKKLEEMELRLR
>Mature_664_residues
MERFRLASDYEPRGDQPRAIAELSEGIVRGDRDQVLLGVTGSGKTFTMANVIAAVNRPALVLAPNKTLAAQLYGEFRELF
PDNAVEYFVSYYDYYQPEAYIPTTDTFIEKDSSINDEIDKLRHAATRSLLTRRDVIIVASVSCIYGIGSPAEYQAMHIFF
HQGDEYGRDELLRKLVDIQYERNDLDFHRGTFRVRGDIVEIFPAHEGERAYRIEFFGDTVDAISEIDPLRGVVVQRLTKC
AVYPASHYVATRETLDRAMEEIRTDLRERLQWFRERNMLVEAQRLEQRTMFDLEMMEEMGFCQGIENYSRYFDGRTPGEP
PYTLLDYFPRDFILFVDESHITVSQVGGMYRGDRSRKETLVNYGFRLPAALDNRPLTFGEFTERLNQSVYVSATPADYEL
QQSGGVVVEQVIRPTGLLDPVIEVRPATEQVDDLLHEVRETTARGERVLVTTLTKRMAEDLTDYYRDLGVRVRYLHSDID
TIQRMQIIRDLRMGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSARSLIQTCGRAARNVNGRVIMYADTVTGSM
QSCLDETARRRALQEAFNTEHGITPQTVKKGLRTILESIEERDYYTVAAVAETREEYISADEIPKRVKKLRKEMLDAAKK
LEFERAADLRDQIKKLEEMELRLR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=665, Percent_Identity=59.2481203007519, Blast_Score=788, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_GEOSL (Q747K3)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954303.1
- ProteinModelPortal:   Q747K3
- SMR:   Q747K3
- GeneID:   2686379
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3262
- NMPDR:   fig|243231.1.peg.3241
- TIGR:   GSU3262
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   GSUL243231:GSU_3262-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76386; Mature: 76386

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERFRLASDYEPRGDQPRAIAELSEGIVRGDRDQVLLGVTGSGKTFTMANVIAAVNRPAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEHHHHHHHHCCCCEE
VLAPNKTLAAQLYGEFRELFPDNAVEYFVSYYDYYQPEAYIPTTDTFIEKDSSINDEIDK
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHH
LRHAATRSLLTRRDVIIVASVSCIYGIGSPAEYQAMHIFFHQGDEYGRDELLRKLVDIQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCC
ERNDLDFHRGTFRVRGDIVEIFPAHEGERAYRIEFFGDTVDAISEIDPLRGVVVQRLTKC
CCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEEECCHHHHHHHCCHHHHHHHHHHHHH
AVYPASHYVATRETLDRAMEEIRTDLRERLQWFRERNMLVEAQRLEQRTMFDLEMMEEMG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
FCQGIENYSRYFDGRTPGEPPYTLLDYFPRDFILFVDESHITVSQVGGMYRGDRSRKETL
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCEEHHHHCCCCCCCCHHHHHH
VNYGFRLPAALDNRPLTFGEFTERLNQSVYVSATPADYELQQSGGVVVEQVIRPTGLLDP
HHCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCEEHHCCCHHHHHHHCCCCCCCC
VIEVRPATEQVDDLLHEVRETTARGERVLVTTLTKRMAEDLTDYYRDLGVRVRYLHSDID
HHHCCCCHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHH
TIQRMQIIRDLRMGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSARSLIQTCGR
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHH
AARNVNGRVIMYADTVTGSMQSCLDETARRRALQEAFNTEHGITPQTVKKGLRTILESIE
HHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ERDYYTVAAVAETREEYISADEIPKRVKKLRKEMLDAAKKLEFERAADLRDQIKKLEEME
HCCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRLR
HHCC
>Mature Secondary Structure
MERFRLASDYEPRGDQPRAIAELSEGIVRGDRDQVLLGVTGSGKTFTMANVIAAVNRPAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEHHHHHHHHCCCCEE
VLAPNKTLAAQLYGEFRELFPDNAVEYFVSYYDYYQPEAYIPTTDTFIEKDSSINDEIDK
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHH
LRHAATRSLLTRRDVIIVASVSCIYGIGSPAEYQAMHIFFHQGDEYGRDELLRKLVDIQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCC
ERNDLDFHRGTFRVRGDIVEIFPAHEGERAYRIEFFGDTVDAISEIDPLRGVVVQRLTKC
CCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEEECCHHHHHHHCCHHHHHHHHHHHHH
AVYPASHYVATRETLDRAMEEIRTDLRERLQWFRERNMLVEAQRLEQRTMFDLEMMEEMG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
FCQGIENYSRYFDGRTPGEPPYTLLDYFPRDFILFVDESHITVSQVGGMYRGDRSRKETL
HHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCEEHHHHCCCCCCCCHHHHHH
VNYGFRLPAALDNRPLTFGEFTERLNQSVYVSATPADYELQQSGGVVVEQVIRPTGLLDP
HHCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCEEHHCCCHHHHHHHCCCCCCCC
VIEVRPATEQVDDLLHEVRETTARGERVLVTTLTKRMAEDLTDYYRDLGVRVRYLHSDID
HHHCCCCHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHH
TIQRMQIIRDLRMGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSARSLIQTCGR
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHH
AARNVNGRVIMYADTVTGSMQSCLDETARRRALQEAFNTEHGITPQTVKKGLRTILESIE
HHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ERDYYTVAAVAETREEYISADEIPKRVKKLRKEMLDAAKKLEFERAADLRDQIKKLEEME
HCCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRLR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA