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The map label for this gene is zraS [H]

Identifier: 39998306

GI number: 39998306

Start: 3521447

End: 3522475

Strand: Direct

Name: zraS [H]

Synonym: GSU3216

Alternate gene names: 39998306

Gene position: 3521447-3522475 (Clockwise)

Preceding gene: 39998305

Following gene: 39998307

Centisome position: 92.33

GC content: 62.78

Gene sequence:

>1029_bases
ATGGTGATCGTGGGAGTACCCTTTGCGGAGGGAGATGCGGAGGGGGTCGAATGCGAAGGGGTTGTGGTCCGCACGGAACC
GGCACCAACCACTCTAGGCGCCGCCATCCAGTACGCAGCCATCAATTTCCGCAACGTCCCCCGCGAATCAGCCTACCTGA
TCCGCGACTATCTGACCGGCTCCCAGCTGCGGTGCGACGAGCAGCGGAAACCGGAACTCCGCCGGCACCCCGAGATGCCC
CCGGTCTGCTGCGACGTGCCCTGCGTAGATCGTGACACCGTTGTCCAGCAGCACCGCCAGCGCACCGAACGGATGGCATT
TCTGCGGGACGTGGCCTCGCGCTTGGCTCCCGCGATCAAGGACCGACTCGCCGGTGTGTCCGGCGCGCTTCAGATCCTCT
CGGAAGAGACGCTCCCCCCCTCCGTTCCCGACGGCATCTACCGCGACATTTTCGAAGAGATAGCAGCCCTTGACAAACTG
GCCGACACCCTGGCCCGCTACCACCGGCCGAGTCTCCCCCTGTTCAGCTCGACCAAACTTGAGCCGGTTGTGGAACGGGC
ACTGGAGACGGTGAAGGAAGTGCTGCAGAGCAAGGACATCGAGATACGGCTGCATCCGGGTGCCGATCTCCCCATTATTC
AAGCCGATGAGGTACTGTTGACCCAGGCATTCGCCGCCCTGTTCGAAAGCGCGGCTGACACCATGAGCCGTGGCATGCTC
ACGGTGCAGTTCTGCTCGGGAACTCCCCGGTGCGACTGCCCGGAATGCGCGTGCGAGAAGGGCGCCAACTGCATTAACGA
ACACGTGAGCGTTCTGATCAGCGATGGGGGGACGGGCACGGCGCCGTTTTCTTTCGATCGGGCGCTGACCCTGTTTCCTG
CCGTGAGCGGAGCCTGTTGCGGCAACGGACTCCCCTTTGCCCACCAGGTTATTGACCAGCACGAGGGATTTCTTTACGTG
GCCAGCAGTCAAGCGAGCGGCTCAATCTTCGTGGTCGAGCTGCCCCGTTATCAGAGCGAGGTATGCTGA

Upstream 100 bases:

>100_bases
CGGTGACACCATGGAGAGTTTCCGCTCCATGTCACTCAACATTTCTTCTCACGGTGTATTCTGCCCGGTTCCCCGGGGGG
TCGACATCAATGACCGGGTC

Downstream 100 bases:

>100_bases
CAATGAACAGTCACCGGATTCTGGTAGTCGACGATGAAAAGCTCATCTCGTGGTCCATTTCCACCATGCTCGAAAAGGCG
GGGCACAGCGTTGCCACGGC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MVIVGVPFAEGDAEGVECEGVVVRTEPAPTTLGAAIQYAAINFRNVPRESAYLIRDYLTGSQLRCDEQRKPELRRHPEMP
PVCCDVPCVDRDTVVQQHRQRTERMAFLRDVASRLAPAIKDRLAGVSGALQILSEETLPPSVPDGIYRDIFEEIAALDKL
ADTLARYHRPSLPLFSSTKLEPVVERALETVKEVLQSKDIEIRLHPGADLPIIQADEVLLTQAFAALFESAADTMSRGML
TVQFCSGTPRCDCPECACEKGANCINEHVSVLISDGGTGTAPFSFDRALTLFPAVSGACCGNGLPFAHQVIDQHEGFLYV
ASSQASGSIFVVELPRYQSEVC

Sequences:

>Translated_342_residues
MVIVGVPFAEGDAEGVECEGVVVRTEPAPTTLGAAIQYAAINFRNVPRESAYLIRDYLTGSQLRCDEQRKPELRRHPEMP
PVCCDVPCVDRDTVVQQHRQRTERMAFLRDVASRLAPAIKDRLAGVSGALQILSEETLPPSVPDGIYRDIFEEIAALDKL
ADTLARYHRPSLPLFSSTKLEPVVERALETVKEVLQSKDIEIRLHPGADLPIIQADEVLLTQAFAALFESAADTMSRGML
TVQFCSGTPRCDCPECACEKGANCINEHVSVLISDGGTGTAPFSFDRALTLFPAVSGACCGNGLPFAHQVIDQHEGFLYV
ASSQASGSIFVVELPRYQSEVC
>Mature_342_residues
MVIVGVPFAEGDAEGVECEGVVVRTEPAPTTLGAAIQYAAINFRNVPRESAYLIRDYLTGSQLRCDEQRKPELRRHPEMP
PVCCDVPCVDRDTVVQQHRQRTERMAFLRDVASRLAPAIKDRLAGVSGALQILSEETLPPSVPDGIYRDIFEEIAALDKL
ADTLARYHRPSLPLFSSTKLEPVVERALETVKEVLQSKDIEIRLHPGADLPIIQADEVLLTQAFAALFESAADTMSRGML
TVQFCSGTPRCDCPECACEKGANCINEHVSVLISDGGTGTAPFSFDRALTLFPAVSGACCGNGLPFAHQVIDQHEGFLYV
ASSQASGSIFVVELPRYQSEVC

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=243, Percent_Identity=24.2798353909465, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37264; Mature: 37264

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIVGVPFAEGDAEGVECEGVVVRTEPAPTTLGAAIQYAAINFRNVPRESAYLIRDYLTG
CEEEEECCCCCCCCCCEECEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
SQLRCDEQRKPELRRHPEMPPVCCDVPCVDRDTVVQQHRQRTERMAFLRDVASRLAPAIK
CCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRLAGVSGALQILSEETLPPSVPDGIYRDIFEEIAALDKLADTLARYHRPSLPLFSSTKL
HHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
EPVVERALETVKEVLQSKDIEIRLHPGADLPIIQADEVLLTQAFAALFESAADTMSRGML
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCE
TVQFCSGTPRCDCPECACEKGANCINEHVSVLISDGGTGTAPFSFDRALTLFPAVSGACC
EEEECCCCCCCCCHHHHHHHCHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHCCCCCCC
GNGLPFAHQVIDQHEGFLYVASSQASGSIFVVELPRYQSEVC
CCCCCHHHHHHHCCCCEEEEEECCCCCCEEEEECCCHHCCCC
>Mature Secondary Structure
MVIVGVPFAEGDAEGVECEGVVVRTEPAPTTLGAAIQYAAINFRNVPRESAYLIRDYLTG
CEEEEECCCCCCCCCCEECEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
SQLRCDEQRKPELRRHPEMPPVCCDVPCVDRDTVVQQHRQRTERMAFLRDVASRLAPAIK
CCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRLAGVSGALQILSEETLPPSVPDGIYRDIFEEIAALDKLADTLARYHRPSLPLFSSTKL
HHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
EPVVERALETVKEVLQSKDIEIRLHPGADLPIIQADEVLLTQAFAALFESAADTMSRGML
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCE
TVQFCSGTPRCDCPECACEKGANCINEHVSVLISDGGTGTAPFSFDRALTLFPAVSGACC
EEEECCCCCCCCCHHHHHHHCHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHCCCCCCC
GNGLPFAHQVIDQHEGFLYVASSQASGSIFVVELPRYQSEVC
CCCCCHHHHHHHCCCCEEEEEECCCCCCEEEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]