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The map label for this gene is atoC [H]

Identifier: 39998307

GI number: 39998307

Start: 3522478

End: 3523983

Strand: Direct

Name: atoC [H]

Synonym: GSU3217

Alternate gene names: 39998307

Gene position: 3522478-3523983 (Clockwise)

Preceding gene: 39998306

Following gene: 39998308

Centisome position: 92.35

GC content: 60.82

Gene sequence:

>1506_bases
ATGAACAGTCACCGGATTCTGGTAGTCGACGATGAAAAGCTCATCTCGTGGTCCATTTCCACCATGCTCGAAAAGGCGGG
GCACAGCGTTGCCACGGCCGCATCGGGGACCGAGGCGCTCCAGAAGTTCCAGAATTTCCGCCCCGAGGTCGTATTGCTCG
ACATCAGTCTTCCCGACATGAGCGGACTTGAGATCCTCGCCCGGGTCAAGGAAGAGAACGAGGACGTTACGGTCATCATG
ATTACCGCCAACTCCAACGCGGACGAGGCGGTGACAGCCTTCCAGCGCGGCGCCGACGACTTTTTCGGCAAGCCGTTCTG
CCTGGAAACCCTGCGTCACGTGGTTGACAAGGCCCTGGAGCGGATGAAGCTCAAAAAAGAGGTGGATATCTTCAGGCGCG
AACGACGCAAGAAGGGAGATTTCGACCAGCTGGTGGGGCGTTCCTCCAAAATGGTGGAGGTATTCAAGCTGATCAACGTT
TGTTCCCGCACCGATGCAAAGACAGTCCTGATAACCGGTGAGAGCGGTACCGGCAAAGAGCTGGTGGCCCGCGCCGTCCA
TCTGCACAGTGCCCGCTCGGACCGGCCCTTCATCGAAGTCAACTGTGCCGCAATCCCGGAAAACCTTCTGGAAAACGAGC
TGTTCGGTCATGAAAAGGGCGCCTTCACCGATGCGTCCCGCAAGCAGAAGGGTATTTTCGAGCTGGCCGAGGGGGGAACG
GTCTTCCTGGATGAAATCGGCGACATGCCGCTGCAGATGCAGGCCAAGCTTTTGAAAGTAATGGAGACCAAGCGGTTCCG
GCGCCTGGGGGGGGAAGACGACGTGGAGGCCGACGTACGGATCATCGCCGCCACCAACCAGAACCTGCCCAAGATGGTGG
CAGACGGCGGGTTCAGGGGCGACCTCTTCTTCCGCCTGAACGTCATGAACATCCGCCTGCCTCCGCTCAGAGAGCGGAGC
GAGGATATCCCGACCCTGGTAAGCTATTTCATCCGGCGGCTCAACGACGAGTACGGCCGCTCGGTGGAGGGGATCAGCGA
TGACGCGCTGGCCACGCTGACCGGGCACAACTGGCCGGGCAACGTGCGCGAATTGCGCAACTCCGTTGAACGGGCAATGA
TGCTGGAGCCGTCCAGAACCCTCAGCCTTGGCTGTTTTACCGACGATTTCCAGTACGGTGGAGGGGCCGCCGAATCTTCA
CCGGTCCCGGCTGGCTCGATCGCCAGCGATGCGCCGGGGACCCTTTCCATCCGGCTCCCCTCCGACGGGCTCTCCATCGA
AGAGGTAGAAAAACAGCTCATCATCCTGGCCCTGGAGCGGACCGGCGGCAACCAGACCAAGGCCGCCCAGTACCTCAAAA
TGACCCGCGACACGCTGCGTTACCGGATGAAAAAGTTCGGCCTCTCGGAAAGCGGCTGGCAAGACGACGCCGGTGACGAC
AAGGAGGGGGAACTGGGCGTGCCCAGACGGACTGAACGGCCGACCACCACGTGGCGCACGCTCTGA

Upstream 100 bases:

>100_bases
TTGACCAGCACGAGGGATTTCTTTACGTGGCCAGCAGTCAAGCGAGCGGCTCAATCTTCGTGGTCGAGCTGCCCCGTTAT
CAGAGCGAGGTATGCTGACA

Downstream 100 bases:

>100_bases
GAGGGGACCATGTTCCGCCTGCTTTTTGCCATAACCATCCTGCTGGCCCTGTCTCTGCCAGGAACAGCCCTGGCGCTCAC
CTGCACCATCAAGGGGTGCC

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MNSHRILVVDDEKLISWSISTMLEKAGHSVATAASGTEALQKFQNFRPEVVLLDISLPDMSGLEILARVKEENEDVTVIM
ITANSNADEAVTAFQRGADDFFGKPFCLETLRHVVDKALERMKLKKEVDIFRRERRKKGDFDQLVGRSSKMVEVFKLINV
CSRTDAKTVLITGESGTGKELVARAVHLHSARSDRPFIEVNCAAIPENLLENELFGHEKGAFTDASRKQKGIFELAEGGT
VFLDEIGDMPLQMQAKLLKVMETKRFRRLGGEDDVEADVRIIAATNQNLPKMVADGGFRGDLFFRLNVMNIRLPPLRERS
EDIPTLVSYFIRRLNDEYGRSVEGISDDALATLTGHNWPGNVRELRNSVERAMMLEPSRTLSLGCFTDDFQYGGGAAESS
PVPAGSIASDAPGTLSIRLPSDGLSIEEVEKQLIILALERTGGNQTKAAQYLKMTRDTLRYRMKKFGLSESGWQDDAGDD
KEGELGVPRRTERPTTTWRTL

Sequences:

>Translated_501_residues
MNSHRILVVDDEKLISWSISTMLEKAGHSVATAASGTEALQKFQNFRPEVVLLDISLPDMSGLEILARVKEENEDVTVIM
ITANSNADEAVTAFQRGADDFFGKPFCLETLRHVVDKALERMKLKKEVDIFRRERRKKGDFDQLVGRSSKMVEVFKLINV
CSRTDAKTVLITGESGTGKELVARAVHLHSARSDRPFIEVNCAAIPENLLENELFGHEKGAFTDASRKQKGIFELAEGGT
VFLDEIGDMPLQMQAKLLKVMETKRFRRLGGEDDVEADVRIIAATNQNLPKMVADGGFRGDLFFRLNVMNIRLPPLRERS
EDIPTLVSYFIRRLNDEYGRSVEGISDDALATLTGHNWPGNVRELRNSVERAMMLEPSRTLSLGCFTDDFQYGGGAAESS
PVPAGSIASDAPGTLSIRLPSDGLSIEEVEKQLIILALERTGGNQTKAAQYLKMTRDTLRYRMKKFGLSESGWQDDAGDD
KEGELGVPRRTERPTTTWRTL
>Mature_501_residues
MNSHRILVVDDEKLISWSISTMLEKAGHSVATAASGTEALQKFQNFRPEVVLLDISLPDMSGLEILARVKEENEDVTVIM
ITANSNADEAVTAFQRGADDFFGKPFCLETLRHVVDKALERMKLKKEVDIFRRERRKKGDFDQLVGRSSKMVEVFKLINV
CSRTDAKTVLITGESGTGKELVARAVHLHSARSDRPFIEVNCAAIPENLLENELFGHEKGAFTDASRKQKGIFELAEGGT
VFLDEIGDMPLQMQAKLLKVMETKRFRRLGGEDDVEADVRIIAATNQNLPKMVADGGFRGDLFFRLNVMNIRLPPLRERS
EDIPTLVSYFIRRLNDEYGRSVEGISDDALATLTGHNWPGNVRELRNSVERAMMLEPSRTLSLGCFTDDFQYGGGAAESS
PVPAGSIASDAPGTLSIRLPSDGLSIEEVEKQLIILALERTGGNQTKAAQYLKMTRDTLRYRMKKFGLSESGWQDDAGDD
KEGELGVPRRTERPTTTWRTL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=472, Percent_Identity=39.4067796610169, Blast_Score=352, Evalue=4e-98,
Organism=Escherichia coli, GI1790299, Length=473, Percent_Identity=40.169133192389, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1790437, Length=460, Percent_Identity=39.3478260869565, Blast_Score=318, Evalue=7e-88,
Organism=Escherichia coli, GI1788905, Length=483, Percent_Identity=35.6107660455487, Blast_Score=289, Evalue=4e-79,
Organism=Escherichia coli, GI1789087, Length=337, Percent_Identity=44.8071216617211, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI87082117, Length=329, Percent_Identity=42.8571428571429, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1789233, Length=333, Percent_Identity=44.4444444444444, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI87081872, Length=327, Percent_Identity=40.6727828746177, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1786524, Length=376, Percent_Identity=38.2978723404255, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI87082152, Length=233, Percent_Identity=45.9227467811159, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1787583, Length=233, Percent_Identity=45.0643776824034, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI87081858, Length=300, Percent_Identity=33.3333333333333, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789828, Length=370, Percent_Identity=31.3513513513514, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1787229, Length=124, Percent_Identity=32.258064516129, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787375, Length=105, Percent_Identity=30.4761904761905, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1787487, Length=205, Percent_Identity=24.390243902439, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790552, Length=127, Percent_Identity=27.5590551181102, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786599, Length=122, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789402, Length=104, Percent_Identity=35.5769230769231, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790860, Length=123, Percent_Identity=30.0813008130081, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790863, Length=106, Percent_Identity=32.0754716981132, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786911, Length=116, Percent_Identity=31.8965517241379, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI145693157, Length=118, Percent_Identity=28.8135593220339, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 55815; Mature: 55815

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSHRILVVDDEKLISWSISTMLEKAGHSVATAASGTEALQKFQNFRPEVVLLDISLPDM
CCCCEEEEEECCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCCCEEEEEECCCCC
SGLEILARVKEENEDVTVIMITANSNADEAVTAFQRGADDFFGKPFCLETLRHVVDKALE
CHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHH
RMKLKKEVDIFRRERRKKGDFDQLVGRSSKMVEVFKLINVCSRTDAKTVLITGESGTGKE
HHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
LVARAVHLHSARSDRPFIEVNCAAIPENLLENELFGHEKGAFTDASRKQKGIFELAEGGT
HHHHHHHHHCCCCCCCEEEEEHHHCCHHHHHHHHCCCCCCCCCCCHHHHCCCCEECCCCE
VFLDEIGDMPLQMQAKLLKVMETKRFRRLGGEDDVEADVRIIAATNQNLPKMVADGGFRG
EEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCC
DLFFRLNVMNIRLPPLRERSEDIPTLVSYFIRRLNDEYGRSVEGISDDALATLTGHNWPG
EEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCC
NVRELRNSVERAMMLEPSRTLSLGCFTDDFQYGGGAAESSPVPAGSIASDAPGTLSIRLP
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
SDGLSIEEVEKQLIILALERTGGNQTKAAQYLKMTRDTLRYRMKKFGLSESGWQDDAGDD
CCCCCHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
KEGELGVPRRTERPTTTWRTL
CCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNSHRILVVDDEKLISWSISTMLEKAGHSVATAASGTEALQKFQNFRPEVVLLDISLPDM
CCCCEEEEEECCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCCCEEEEEECCCCC
SGLEILARVKEENEDVTVIMITANSNADEAVTAFQRGADDFFGKPFCLETLRHVVDKALE
CHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHH
RMKLKKEVDIFRRERRKKGDFDQLVGRSSKMVEVFKLINVCSRTDAKTVLITGESGTGKE
HHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
LVARAVHLHSARSDRPFIEVNCAAIPENLLENELFGHEKGAFTDASRKQKGIFELAEGGT
HHHHHHHHHCCCCCCCEEEEEHHHCCHHHHHHHHCCCCCCCCCCCHHHHCCCCEECCCCE
VFLDEIGDMPLQMQAKLLKVMETKRFRRLGGEDDVEADVRIIAATNQNLPKMVADGGFRG
EEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCC
DLFFRLNVMNIRLPPLRERSEDIPTLVSYFIRRLNDEYGRSVEGISDDALATLTGHNWPG
EEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCC
NVRELRNSVERAMMLEPSRTLSLGCFTDDFQYGGGAAESSPVPAGSIASDAPGTLSIRLP
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
SDGLSIEEVEKQLIILALERTGGNQTKAAQYLKMTRDTLRYRMKKFGLSESGWQDDAGDD
CCCCCHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
KEGELGVPRRTERPTTTWRTL
CCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]