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The map label for this gene is yycG [H]

Identifier: 39998228

GI number: 39998228

Start: 3444551

End: 3446005

Strand: Direct

Name: yycG [H]

Synonym: GSU3138

Alternate gene names: 39998228

Gene position: 3444551-3446005 (Clockwise)

Preceding gene: 39998227

Following gene: 39998233

Centisome position: 90.31

GC content: 61.99

Gene sequence:

>1455_bases
ATGACCACACCGACACCAATTCGCATGCTGATTCTTGAAGATTCCGAGGACGATCTCCTTCTGCTGCTGCGCGAAGTGCG
CCGCGGGGGAATCGATCCCGCCTACGAGCGCGCCGACAGTGCCGCAGGGCTTCGCCGAGCCCTTGATGCCGGGGAATGGG
ACGTCATTGTTTCGGATTACAACATGCCCCAGTTCGGGGCGCTCCCCGCCCTGGACATCGTAAAAGAGCGGGGCCTCGAC
GTTCCGTTCATCATCGTGTCGGGCAAGATCGGCGAGGATCTGGCCGTTGCCGCCATGAAAGCGGGCGCCCACGACTACCT
CATGAAGGGCAACCTTTCCCGCCTCGTCCCCGCCATCGAGCGGGAACTGCGCGAGGCTGACGAACGCCGGCGCCGGCGCC
AGGCCGAAGAGGCCATGCACGCCCAGTTCAACCAGATCAGTACCATCTTCGACTCTCTCAACGCCCTGGTCTACGTTGTC
GACATGAACTCCTACGAGCTGCTCTACCTGAACAAGTTCGGCGCCCAGCTCTTCGGAGAAGCATGGGAAGGCCGGACCTG
CCACGACGTGCTCCATGGTGGCCGGTCCACCCCCTGCGACTTCTGCACCAACGACAAACTGATCATGGACGGCAAAGCGC
TCCCCCCCTACATCTGGGAGTACCAGAACAGCATCAGCAGCCGCTGGTACCAATGCATCGACAAGGCCATCCGCTGGACC
GACGGACGCATGGTCCGGATGGAGATTGCCATCGACATCACCGAGCGCAAAGAGATGGAGCGGATGAAGGACGAAATGAT
CTCGGCAGTCAGCCACGAGATGCATACCCCCCTCACCGCCATGATGGGCTTTACGGAGTTTCTGCTGGAGAACGAGGTGG
ACCGGGACCTGCAGAAAAATTACCTGAAGACCATCTACCGGGAGACCGAGCGGCTCAACGAGCTCATCACCAACTTCCTG
CAGCTCCAGCGGCTCAAGGCGAGCATGGTCAAGTTCCGGATAACGCCTGTTGCCGTCGGACTGCTGGTGGCGGATGTCGT
CTCGCTCTACGCCGCCGCCTCCAAGAAGCACCGGATTGTAGTCGAATGCCCTCCCGACCTGCCGCCGGTACGGGGGAACG
AGGAGCAGCTCTACCAAGCCATTTCCAACCTGGTGTCCAACGCCATCAAGTACTCCCCCGACGGGGGCGACGTGACCATC
GGCGCCAGCGCCGCCGCCGACATCGTAACGCTCTGGGTCAGGGACCAAGGGATAGGAATCTCTCCCGAATTCCAGGAAAA
GATCTTCGAGCGCTTCTTCCGGGTCGACAACAGCGACCGGCGCAAGGTGGGCGGGGCAGGCCTGGGCCTGACCCTCGTAC
GGGAAATCGTGGCCACCCACGGCGGCCGGAGCTGGGTGGAGAGCTCGCCGGGCAAAGGAAGCACCTTCTTCATCTCCCTG
CCGGCCATGACGTGA

Upstream 100 bases:

>100_bases
GATCGTACCCGGTACGAGCGGTTCAAGGACAACCGCGACGTCGCCCGTAACGCCGGTATAATTCACCGCTGACCGCCACG
AGAGGGTCAACGAGGACTCC

Downstream 100 bases:

>100_bases
ACCGGCGTCAGTGTGACAGCCAGAGGTAGTCGGCGTCCTCCACGGAGATCGCCCCGTTCTGAACCACCGGATCGGGAAGA
ACCACCCTGCTGGCGAGACC

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MTTPTPIRMLILEDSEDDLLLLLREVRRGGIDPAYERADSAAGLRRALDAGEWDVIVSDYNMPQFGALPALDIVKERGLD
VPFIIVSGKIGEDLAVAAMKAGAHDYLMKGNLSRLVPAIERELREADERRRRRQAEEAMHAQFNQISTIFDSLNALVYVV
DMNSYELLYLNKFGAQLFGEAWEGRTCHDVLHGGRSTPCDFCTNDKLIMDGKALPPYIWEYQNSISSRWYQCIDKAIRWT
DGRMVRMEIAIDITERKEMERMKDEMISAVSHEMHTPLTAMMGFTEFLLENEVDRDLQKNYLKTIYRETERLNELITNFL
QLQRLKASMVKFRITPVAVGLLVADVVSLYAAASKKHRIVVECPPDLPPVRGNEEQLYQAISNLVSNAIKYSPDGGDVTI
GASAAADIVTLWVRDQGIGISPEFQEKIFERFFRVDNSDRRKVGGAGLGLTLVREIVATHGGRSWVESSPGKGSTFFISL
PAMT

Sequences:

>Translated_484_residues
MTTPTPIRMLILEDSEDDLLLLLREVRRGGIDPAYERADSAAGLRRALDAGEWDVIVSDYNMPQFGALPALDIVKERGLD
VPFIIVSGKIGEDLAVAAMKAGAHDYLMKGNLSRLVPAIERELREADERRRRRQAEEAMHAQFNQISTIFDSLNALVYVV
DMNSYELLYLNKFGAQLFGEAWEGRTCHDVLHGGRSTPCDFCTNDKLIMDGKALPPYIWEYQNSISSRWYQCIDKAIRWT
DGRMVRMEIAIDITERKEMERMKDEMISAVSHEMHTPLTAMMGFTEFLLENEVDRDLQKNYLKTIYRETERLNELITNFL
QLQRLKASMVKFRITPVAVGLLVADVVSLYAAASKKHRIVVECPPDLPPVRGNEEQLYQAISNLVSNAIKYSPDGGDVTI
GASAAADIVTLWVRDQGIGISPEFQEKIFERFFRVDNSDRRKVGGAGLGLTLVREIVATHGGRSWVESSPGKGSTFFISL
PAMT
>Mature_483_residues
TTPTPIRMLILEDSEDDLLLLLREVRRGGIDPAYERADSAAGLRRALDAGEWDVIVSDYNMPQFGALPALDIVKERGLDV
PFIIVSGKIGEDLAVAAMKAGAHDYLMKGNLSRLVPAIERELREADERRRRRQAEEAMHAQFNQISTIFDSLNALVYVVD
MNSYELLYLNKFGAQLFGEAWEGRTCHDVLHGGRSTPCDFCTNDKLIMDGKALPPYIWEYQNSISSRWYQCIDKAIRWTD
GRMVRMEIAIDITERKEMERMKDEMISAVSHEMHTPLTAMMGFTEFLLENEVDRDLQKNYLKTIYRETERLNELITNFLQ
LQRLKASMVKFRITPVAVGLLVADVVSLYAAASKKHRIVVECPPDLPPVRGNEEQLYQAISNLVSNAIKYSPDGGDVTIG
ASAAADIVTLWVRDQGIGISPEFQEKIFERFFRVDNSDRRKVGGAGLGLTLVREIVATHGGRSWVESSPGKGSTFFISLP
AMT

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF [H]

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789149, Length=260, Percent_Identity=31.9230769230769, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI48994928, Length=242, Percent_Identity=31.404958677686, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788549, Length=258, Percent_Identity=29.8449612403101, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790346, Length=228, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=26.3779527559055, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=26.4822134387352, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786783, Length=213, Percent_Identity=29.1079812206573, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1788393, Length=224, Percent_Identity=29.4642857142857, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=28.0172413793103, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=25.4385964912281, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=27.1551724137931, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790861, Length=199, Percent_Identity=28.643216080402, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=223, Percent_Identity=27.3542600896861, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=25.6637168141593, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790300, Length=277, Percent_Identity=27.0758122743682, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788279, Length=231, Percent_Identity=29.8701298701299, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1789808, Length=210, Percent_Identity=30, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789403, Length=200, Percent_Identity=30.5, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790567, Length=242, Percent_Identity=28.099173553719, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54502; Mature: 54371

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTPIRMLILEDSEDDLLLLLREVRRGGIDPAYERADSAAGLRRALDAGEWDVIVSDY
CCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECC
NMPQFGALPALDIVKERGLDVPFIIVSGKIGEDLAVAAMKAGAHDYLMKGNLSRLVPAIE
CCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHHCCCHHHHHHHHH
RELREADERRRRRQAEEAMHAQFNQISTIFDSLNALVYVVDMNSYELLYLNKFGAQLFGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEEEHHHHHHHHH
AWEGRTCHDVLHGGRSTPCDFCTNDKLIMDGKALPPYIWEYQNSISSRWYQCIDKAIRWT
CCCCCCHHHHHCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
DGRMVRMEIAIDITERKEMERMKDEMISAVSHEMHTPLTAMMGFTEFLLENEVDRDLQKN
CCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
YLKTIYRETERLNELITNFLQLQRLKASMVKFRITPVAVGLLVADVVSLYAAASKKHRIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VECPPDLPPVRGNEEQLYQAISNLVSNAIKYSPDGGDVTIGASAAADIVTLWVRDQGIGI
EECCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCEEECCCHHHHEEEEEEECCCCCC
SPEFQEKIFERFFRVDNSDRRKVGGAGLGLTLVREIVATHGGRSWVESSPGKGSTFFISL
CHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEC
PAMT
CCCC
>Mature Secondary Structure 
TTPTPIRMLILEDSEDDLLLLLREVRRGGIDPAYERADSAAGLRRALDAGEWDVIVSDY
CCCCCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECC
NMPQFGALPALDIVKERGLDVPFIIVSGKIGEDLAVAAMKAGAHDYLMKGNLSRLVPAIE
CCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHHCCCHHHHHHHHH
RELREADERRRRRQAEEAMHAQFNQISTIFDSLNALVYVVDMNSYELLYLNKFGAQLFGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEEEHHHHHHHHH
AWEGRTCHDVLHGGRSTPCDFCTNDKLIMDGKALPPYIWEYQNSISSRWYQCIDKAIRWT
CCCCCCHHHHHCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
DGRMVRMEIAIDITERKEMERMKDEMISAVSHEMHTPLTAMMGFTEFLLENEVDRDLQKN
CCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
YLKTIYRETERLNELITNFLQLQRLKASMVKFRITPVAVGLLVADVVSLYAAASKKHRIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VECPPDLPPVRGNEEQLYQAISNLVSNAIKYSPDGGDVTIGASAAADIVTLWVRDQGIGI
EECCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCEEECCCHHHHEEEEEEECCCCCC
SPEFQEKIFERFFRVDNSDRRKVGGAGLGLTLVREIVATHGGRSWVESSPGKGSTFFISL
CHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEC
PAMT
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9829949; 10878122; 11758928 [H]