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The map label for this gene is adhc1 [H]

Identifier: 39998215

GI number: 39998215

Start: 3425543

End: 3426601

Strand: Reverse

Name: adhc1 [H]

Synonym: GSU3125

Alternate gene names: 39998215

Gene position: 3426601-3425543 (Counterclockwise)

Preceding gene: 39998216

Following gene: 39998214

Centisome position: 89.84

GC content: 64.12

Gene sequence:

>1059_bases
ATGTACAAAGCCAGAGCCTATTCTGCCGCCAGCGCCGCTTCGCCGCTGGCCCTCGACACCATTCCCCGCCGCGAGACGAC
CGAGCGCGACGTGCAGATCGAGATCCTCTTCTGCGGCGTCTGCCACTCGGATCTCCACACGGTGCGGGACGAGTGGAACA
GCGTCATGCCCACGGTCTACCCCTGCGTGCCGGGGCACGAGATCGTCGGCCGGATTACCAGGGTCGGTTCCGCTGTCACG
AAATTCAAACCGGGCGATCTTGCCGGCGTCGGCTGCCTGGTCGACTCGGATCACACCTGCCCGAGTTGCCAGTCGAACCT
GGAGCAGTTCTGCCCAGACGCCACCTTCACCTACAACTCGCCGGACAAGCACCAGGCAGCGCCGGTCACCTACGGCGGCT
ACTCCGAGAGCATCGTGGTCGATGAGCGCTTCGTGCTGCATGTCCCCGCCACCCTCGACCTGGCCGGAGTCGCGCCGCTG
CTCTGCGCCGGCATCACCACCTACTCGCCGATTCGCCGCTGGGGCGACATCAGGGGGAAGAAGGCCGGTGTCGTCGGCCT
CGGCGGACTGGGGCACATGGGGGTCAAGTTCGCCCGTGCGTTCGGTGCCCAGGTGGTGGTTTTCACCACCTCTCCGGGCA
AGAAGGAGGATGCCCTTCGTCTCGGTGCCCACGAGGTCATCGTTTCCACCAATGCGGAAGAGATGCAGCAGCACGCCGGC
ACGTTCGACTTCATCCTCGACACCATCGCCGCCGACCATGACATCAACGCCTACCTCAACATGCTCGGCCGCGACGGCAC
CATCACCCTGGTTGGCGCGCCGGAGAAGCCGCTGGAGGTATCCGCCTTCGCTCTCCTGTTCGGCCGCCGCAGCCTTTCCG
GGTCGATCATCGGCGGCATCGCCGAGACCCAGGAGATGCTCGACTTCTGCGGCCAGCACAACATCACCGCCGATGTGGAG
GTCATCCCGATTCAGAAGATCAATGAGGCCTACGAGCGGCTGCTCAAGTCGGATGTGAAGTATCGCTTTTCCATCGATAT
GGCGTCGCTGAAAGGGTAA

Upstream 100 bases:

>100_bases
CCCTCATCGTCCCTCTCCCCAACGGGCGAGGCGAGAAGACCCAGAGGGCCGGGGTGAGGGGCAAGGCAGTGTAAAAACAA
ACCGCCAAGGAGAATCAGCC

Downstream 100 bases:

>100_bases
TGGCGACGCAACCGAAGGGCGGACCGGGATGCCGGTCCGGCCCTGACGGAGGTTGGTATGGAGATGGAGCAGATCGAGGC
TCAGGAGGGCGATGAACGAA

Product: alcohol dehydrogenase, zinc-containing

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MYKARAYSAASAASPLALDTIPRRETTERDVQIEILFCGVCHSDLHTVRDEWNSVMPTVYPCVPGHEIVGRITRVGSAVT
KFKPGDLAGVGCLVDSDHTCPSCQSNLEQFCPDATFTYNSPDKHQAAPVTYGGYSESIVVDERFVLHVPATLDLAGVAPL
LCAGITTYSPIRRWGDIRGKKAGVVGLGGLGHMGVKFARAFGAQVVVFTTSPGKKEDALRLGAHEVIVSTNAEEMQQHAG
TFDFILDTIAADHDINAYLNMLGRDGTITLVGAPEKPLEVSAFALLFGRRSLSGSIIGGIAETQEMLDFCGQHNITADVE
VIPIQKINEAYERLLKSDVKYRFSIDMASLKG

Sequences:

>Translated_352_residues
MYKARAYSAASAASPLALDTIPRRETTERDVQIEILFCGVCHSDLHTVRDEWNSVMPTVYPCVPGHEIVGRITRVGSAVT
KFKPGDLAGVGCLVDSDHTCPSCQSNLEQFCPDATFTYNSPDKHQAAPVTYGGYSESIVVDERFVLHVPATLDLAGVAPL
LCAGITTYSPIRRWGDIRGKKAGVVGLGGLGHMGVKFARAFGAQVVVFTTSPGKKEDALRLGAHEVIVSTNAEEMQQHAG
TFDFILDTIAADHDINAYLNMLGRDGTITLVGAPEKPLEVSAFALLFGRRSLSGSIIGGIAETQEMLDFCGQHNITADVE
VIPIQKINEAYERLLKSDVKYRFSIDMASLKG
>Mature_352_residues
MYKARAYSAASAASPLALDTIPRRETTERDVQIEILFCGVCHSDLHTVRDEWNSVMPTVYPCVPGHEIVGRITRVGSAVT
KFKPGDLAGVGCLVDSDHTCPSCQSNLEQFCPDATFTYNSPDKHQAAPVTYGGYSESIVVDERFVLHVPATLDLAGVAPL
LCAGITTYSPIRRWGDIRGKKAGVVGLGGLGHMGVKFARAFGAQVVVFTTSPGKKEDALRLGAHEVIVSTNAEEMQQHAG
TFDFILDTIAADHDINAYLNMLGRDGTITLVGAPEKPLEVSAFALLFGRRSLSGSIIGGIAETQEMLDFCGQHNITADVE
VIPIQKINEAYERLLKSDVKYRFSIDMASLKG

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=26.8096514745308, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI34577061, Length=366, Percent_Identity=26.5027322404372, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4501929, Length=365, Percent_Identity=25.7534246575342, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=24.9322493224932, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=24.9322493224932, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI71565152, Length=368, Percent_Identity=23.9130434782609, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4501939, Length=349, Percent_Identity=22.9226361031519, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI156523966, Length=349, Percent_Identity=22.9226361031519, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786518, Length=350, Percent_Identity=57.4285714285714, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI87082401, Length=346, Percent_Identity=31.5028901734104, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87081918, Length=314, Percent_Identity=26.4331210191083, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI226510992, Length=319, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788073, Length=256, Percent_Identity=25.78125, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790045, Length=293, Percent_Identity=23.8907849829352, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788407, Length=265, Percent_Identity=26.0377358490566, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=346, Percent_Identity=25.1445086705202, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17562584, Length=345, Percent_Identity=25.5072463768116, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17562582, Length=355, Percent_Identity=23.0985915492958, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=329, Percent_Identity=27.0516717325228, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=331, Percent_Identity=27.190332326284, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=201, Percent_Identity=30.3482587064677, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=324, Percent_Identity=34.5679012345679, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319949, Length=325, Percent_Identity=32.9230769230769, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323961, Length=336, Percent_Identity=30.3571428571429, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6324486, Length=341, Percent_Identity=28.7390029325513, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323729, Length=335, Percent_Identity=28.0597014925373, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319621, Length=340, Percent_Identity=27.3529411764706, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319258, Length=311, Percent_Identity=26.6881028938907, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=369, Percent_Identity=24.6612466124661, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=22.7882037533512, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37990; Mature: 37990

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKARAYSAASAASPLALDTIPRRETTERDVQIEILFCGVCHSDLHTVRDEWNSVMPTVY
CCCCCCCCCCCCCCCCEECCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCEEE
PCVPGHEIVGRITRVGSAVTKFKPGDLAGVGCLVDSDHTCPSCQSNLEQFCPDATFTYNS
CCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEECCC
PDKHQAAPVTYGGYSESIVVDERFVLHVPATLDLAGVAPLLCAGITTYSPIRRWGDIRGK
CCCCCCCCEEECCCCCEEEECCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCC
KAGVVGLGGLGHMGVKFARAFGAQVVVFTTSPGKKEDALRLGAHEVIVSTNAEEMQQHAG
CCCEEEECCCHHHHHHHHHHHCCEEEEEECCCCCCCHHHHCCCEEEEEECCHHHHHHHCC
TFDFILDTIAADHDINAYLNMLGRDGTITLVGAPEKPLEVSAFALLFGRRSLSGSIIGGI
HHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHCCH
AETQEMLDFCGQHNITADVEVIPIQKINEAYERLLKSDVKYRFSIDMASLKG
HHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHCCCEEEEEEHHHCCC
>Mature Secondary Structure
MYKARAYSAASAASPLALDTIPRRETTERDVQIEILFCGVCHSDLHTVRDEWNSVMPTVY
CCCCCCCCCCCCCCCCEECCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCEEE
PCVPGHEIVGRITRVGSAVTKFKPGDLAGVGCLVDSDHTCPSCQSNLEQFCPDATFTYNS
CCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEECCC
PDKHQAAPVTYGGYSESIVVDERFVLHVPATLDLAGVAPLLCAGITTYSPIRRWGDIRGK
CCCCCCCCEEECCCCCEEEECCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCC
KAGVVGLGGLGHMGVKFARAFGAQVVVFTTSPGKKEDALRLGAHEVIVSTNAEEMQQHAG
CCCEEEECCCHHHHHHHHHHHCCEEEEEECCCCCCCHHHHCCCEEEEEECCHHHHHHHCC
TFDFILDTIAADHDINAYLNMLGRDGTITLVGAPEKPLEVSAFALLFGRRSLSGSIIGGI
HHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHCCH
AETQEMLDFCGQHNITADVEVIPIQKINEAYERLLKSDVKYRFSIDMASLKG
HHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHCCCEEEEEEHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]