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The map label for this gene is hisG-2

Identifier: 39998191

GI number: 39998191

Start: 3404878

End: 3405516

Strand: Reverse

Name: hisG-2

Synonym: GSU3101

Alternate gene names: 39998191

Gene position: 3405516-3404878 (Counterclockwise)

Preceding gene: 39998192

Following gene: 39998190

Centisome position: 89.29

GC content: 59.31

Gene sequence:

>639_bases
ATGACCGACTACATTACCATCGCCATCCCCAAGGGGCGGATTCTCGAAGAATCAGTAACCCTCTTCGGCAAGATTGGAAT
CAACTGCGACGAGCTCCTCTCCAACACCCGAAAGCTCATCTTTGAAAACCACGAGCAGCGGATGCGGTACATGATCGTCC
GGGCCACTGACGTTCCCACGTATGTGGAGTACGGCTGCGCCGACCTCGGTATCGTCGGCAAGGACACTCTCATGGAGCAG
GAAAAGGACCTCTATGAGCCCCTGGACCTCAAGTTCGGCTACTGCCGGATGATGGTGGCCGAGCCGGCAGGACTTGCCCT
GGACGACGACCCCTCCAGCTGGACCAACATCCGGATCGCCACCAAGTATCCCAACGTGACCGAGAAGTATTTCGCCCGCA
AGGGGGTTCAGGTGGAGATCATCAAGCTCTACGGGTCCATCGAGTTGGCCCCGCTGGTCGGGCTTTCCGAGCGGATCGTG
GACCTGGTGTCCACCGGGGAGACCCTGCGCCAGAACGGCCTGGTCGAGGTTGAGACCATCGCCGAGATCACCACGCGTCT
CATCGTCAACCGGGCGAGCCTCAAGACCAAGCATCCCCGGATTACCGAGATCATCGAAGGGCTGGAGAAGCACGTATGA

Upstream 100 bases:

>100_bases
GGCCTCGGTGCCGATATCCAACGTGTAAAGGAGTGACCCGACGGCAGGCGCGGGTGCCGATGCAGGCCCCCGGCTCCTGG
TCGCCGGTCCCTGACATGTC

Downstream 100 bases:

>100_bases
GATTCCTCGACATCAGGGATACGAACTTTGACGCGGAATTCGCTGCCATCCTCGCCCGGGGCGAGGAGACCGGCCGCGAG
GTGGAGCAGGTGGTTCTCGA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT 2; ATP-PRTase 2

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MTDYITIAIPKGRILEESVTLFGKIGINCDELLSNTRKLIFENHEQRMRYMIVRATDVPTYVEYGCADLGIVGKDTLMEQ
EKDLYEPLDLKFGYCRMMVAEPAGLALDDDPSSWTNIRIATKYPNVTEKYFARKGVQVEIIKLYGSIELAPLVGLSERIV
DLVSTGETLRQNGLVEVETIAEITTRLIVNRASLKTKHPRITEIIEGLEKHV

Sequences:

>Translated_212_residues
MTDYITIAIPKGRILEESVTLFGKIGINCDELLSNTRKLIFENHEQRMRYMIVRATDVPTYVEYGCADLGIVGKDTLMEQ
EKDLYEPLDLKFGYCRMMVAEPAGLALDDDPSSWTNIRIATKYPNVTEKYFARKGVQVEIIKLYGSIELAPLVGLSERIV
DLVSTGETLRQNGLVEVETIAEITTRLIVNRASLKTKHPRITEIIEGLEKHV
>Mature_211_residues
TDYITIAIPKGRILEESVTLFGKIGINCDELLSNTRKLIFENHEQRMRYMIVRATDVPTYVEYGCADLGIVGKDTLMEQE
KDLYEPLDLKFGYCRMMVAEPAGLALDDDPSSWTNIRIATKYPNVTEKYFARKGVQVEIIKLYGSIELAPLVGLSERIVD
LVSTGETLRQNGLVEVETIAEITTRLIVNRASLKTKHPRITEIIEGLEKHV

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=192, Percent_Identity=39.0625, Blast_Score=106, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320896, Length=218, Percent_Identity=33.0275229357798, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS12_GEOSL (P60836)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954142.1
- ProteinModelPortal:   P60836
- SMR:   P60836
- GeneID:   2688462
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3101
- NMPDR:   fig|243231.1.peg.3080
- TIGR:   GSU3101
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   GSUL243231:GSU_3101-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23980; Mature: 23849

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYITIAIPKGRILEESVTLFGKIGINCDELLSNTRKLIFENHEQRMRYMIVRATDVPT
CCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHEEEEEEEECCCCH
YVEYGCADLGIVGKDTLMEQEKDLYEPLDLKFGYCRMMVAEPAGLALDDDPSSWTNIRIA
HHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEECCCCCCCCEEEEE
TKYPNVTEKYFARKGVQVEIIKLYGSIELAPLVGLSERIVDLVSTGETLRQNGLVEVETI
ECCCCHHHHHHHHCCCEEEEEEEECCEEEEHHCCHHHHHHHHHHCCHHHHHCCCEEHHHH
AEITTRLIVNRASLKTKHPRITEIIEGLEKHV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TDYITIAIPKGRILEESVTLFGKIGINCDELLSNTRKLIFENHEQRMRYMIVRATDVPT
CCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHEEEEEEEECCCCH
YVEYGCADLGIVGKDTLMEQEKDLYEPLDLKFGYCRMMVAEPAGLALDDDPSSWTNIRIA
HHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEECCCCCCCCEEEEE
TKYPNVTEKYFARKGVQVEIIKLYGSIELAPLVGLSERIVDLVSTGETLRQNGLVEVETI
ECCCCHHHHHHHHCCCEEEEEEEECCEEEEHHCCHHHHHHHHHHCCHHHHHCCCEEHHHH
AEITTRLIVNRASLKTKHPRITEIIEGLEKHV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA