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The map label for this gene is hoxF [H]

Identifier: 39997815

GI number: 39997815

Start: 2997688

End: 2999400

Strand: Reverse

Name: hoxF [H]

Synonym: GSU2721

Alternate gene names: 39997815

Gene position: 2999400-2997688 (Counterclockwise)

Preceding gene: 39997816

Following gene: 39997814

Centisome position: 78.64

GC content: 69.06

Gene sequence:

>1713_bases
ATGAACCCCGCCGATCTCCATGCCATGGCCCGGGAAGAACAGGCCCGCCAGGAGGCGCTGCGGTGCCGTATCATGGTCTG
TGCCGGTACCCCCTGTCTTTCCGCCGGCGCACTGGCGGTCCTGGACGCGCTGCGCCAGGCGGTGGAGGAGAGCCGGCTCG
ATGCGGAGATCGAGGCCGTCAGCACCGGCTGCATGGGGCCGTGCAGCCGCGGTCCCCTCGTGAAAGTGGCAGTTCAGGGG
AAACCCGAGATCGTCTACGAGCGCGTCACCCCCGAACTGGCCCGCCAGATTCTCTACTCGGTGGTGAAGGGGCGCCGGCC
GCCGACGGCCTCGCCGCTGCCGCCGGATCACCCCTATTTCACCCGCCAGATGAAGATCGTCTTGGCCAACTGCGGTTCCA
TCGACCCCGAGCGGATCGAGGAGTATGTGGCCACGGGGGGCTACGATGCCCTTGCCCACGCCCTGCACGAGATGACCCCC
GAGGATGTCTGTCGCGAGATCTCCGCTTCGGGACTGCGGGGGCGGGGGGGGGCCGGCTATCCGGCCGGCGTCAAGTGGAA
CCTGGCCCGCAAGGCGCCGGGCGAGCGGAAATACGTGGTGGCCAACGGCGACGAGGGGGACCCGGGCGCCTACATGGACC
GCTCCGTCATGGAGTCGGACCCCCACCGCATCCTGGAAGGAATGGCCATTGCCGGCTACGCCATCGGCGCGGATCAGGGC
TACATCTACGTCCGGGGCGAGTACTACCTGGCCGGAAGGCGGCTCGAGGCCGCCATCCGCGACGCCGAGCGCAAGGGGCT
CCTGGGAAGCCGGGTGCTCGGCAGCAACTTCAGTTTCCGCATCGACATCCGCACCGGCGCCGGCGCCTTTGTCTGCGGCG
AGGAAACCTCGCTCATGGCTTCCATCATGGGGCGGCGCGGACAGCCCTGGCACCGGCCGCCCTATCCGGCCCAGCGGGGG
CTCTGGGGGTGTCCGACCCTCATCAATAACGTGGAGACCCTTGCCACCGTCCCGGCTATCATCGGACGCGGGGCCACCTG
GTACGCCGGCATCGGCTCGACCCGGAGCCCGGGAACCAAGGTCTATGCCCTGGCCGGCCAGGTGGAGACCGCCGGCCTGA
TCGAAGTCCCCATGGGTACCACGCTGCGGGAGGTGGTGTTCGACATCGGCGGCGGAATCCCCGGCGGCAAGCGCTTCAAG
GCTGCCCAGTCGGGCGGCCCTTCGGGCGGCTGCATTCCGGCCGAACACCTGGACACCCCCCTCGATTACGAAAGTATGGA
GCGGATCGGCACCATCATGGGCTCCGGCGGACTTATCATCATGGACGAGACGAGCTGCATGCCCGACGTCGCCTCGTTTT
TCCTCGATTTCTGCCGGGACGAGAGCTGCGGCAAGTGCATCCCGTGCCGCGTCGGCAGCATGGAGATGCACCGGCTGCTG
CGCCGCATAACCTCCGGCACCGCTTGGCCGGACGACCTGCGCCGGCTGGAGGAGCTCTGCGATCTGATGGGCGCCACGAG
CCTCTGTGGTCTCGGCCAGACCGCGCCCAACCCGGTGGTGAGCACCCTGCGCTACTTCCGGCACGAATACGAGGCCCACA
TCCGCGAGCGCCGCTGCCCGGCGGGCCGCTGCACCATGGCTGCCGAGCAGGAGCCCGGACCCGGCGGCAAGGCACTCCTG
CACGCCGTCGGCGTCCCTGGGGAGGTAGGCTGA

Upstream 100 bases:

>100_bases
CCGATTCGGCCGCCGCCGCCGTCCGGGTCATGCTGGCGGAAAAGAGCCCGGCCCGCGCAGAAACGGTCCGCCCGGTTCGC
CGCCGCAAGGGTGAAGGCCA

Downstream 100 bases:

>100_bases
TGCCGGTCATTACTCTGACCATCGACGACGAACTGATCAGCGGTCGCGAGGGGGAAACCCTGCTCCAGGTGATCAAGGAA
CACGGCATATCGCTCCCCAC

Product: NAD-reducing hydrogenase subunit alpha

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MNPADLHAMAREEQARQEALRCRIMVCAGTPCLSAGALAVLDALRQAVEESRLDAEIEAVSTGCMGPCSRGPLVKVAVQG
KPEIVYERVTPELARQILYSVVKGRRPPTASPLPPDHPYFTRQMKIVLANCGSIDPERIEEYVATGGYDALAHALHEMTP
EDVCREISASGLRGRGGAGYPAGVKWNLARKAPGERKYVVANGDEGDPGAYMDRSVMESDPHRILEGMAIAGYAIGADQG
YIYVRGEYYLAGRRLEAAIRDAERKGLLGSRVLGSNFSFRIDIRTGAGAFVCGEETSLMASIMGRRGQPWHRPPYPAQRG
LWGCPTLINNVETLATVPAIIGRGATWYAGIGSTRSPGTKVYALAGQVETAGLIEVPMGTTLREVVFDIGGGIPGGKRFK
AAQSGGPSGGCIPAEHLDTPLDYESMERIGTIMGSGGLIIMDETSCMPDVASFFLDFCRDESCGKCIPCRVGSMEMHRLL
RRITSGTAWPDDLRRLEELCDLMGATSLCGLGQTAPNPVVSTLRYFRHEYEAHIRERRCPAGRCTMAAEQEPGPGGKALL
HAVGVPGEVG

Sequences:

>Translated_570_residues
MNPADLHAMAREEQARQEALRCRIMVCAGTPCLSAGALAVLDALRQAVEESRLDAEIEAVSTGCMGPCSRGPLVKVAVQG
KPEIVYERVTPELARQILYSVVKGRRPPTASPLPPDHPYFTRQMKIVLANCGSIDPERIEEYVATGGYDALAHALHEMTP
EDVCREISASGLRGRGGAGYPAGVKWNLARKAPGERKYVVANGDEGDPGAYMDRSVMESDPHRILEGMAIAGYAIGADQG
YIYVRGEYYLAGRRLEAAIRDAERKGLLGSRVLGSNFSFRIDIRTGAGAFVCGEETSLMASIMGRRGQPWHRPPYPAQRG
LWGCPTLINNVETLATVPAIIGRGATWYAGIGSTRSPGTKVYALAGQVETAGLIEVPMGTTLREVVFDIGGGIPGGKRFK
AAQSGGPSGGCIPAEHLDTPLDYESMERIGTIMGSGGLIIMDETSCMPDVASFFLDFCRDESCGKCIPCRVGSMEMHRLL
RRITSGTAWPDDLRRLEELCDLMGATSLCGLGQTAPNPVVSTLRYFRHEYEAHIRERRCPAGRCTMAAEQEPGPGGKALL
HAVGVPGEVG
>Mature_570_residues
MNPADLHAMAREEQARQEALRCRIMVCAGTPCLSAGALAVLDALRQAVEESRLDAEIEAVSTGCMGPCSRGPLVKVAVQG
KPEIVYERVTPELARQILYSVVKGRRPPTASPLPPDHPYFTRQMKIVLANCGSIDPERIEEYVATGGYDALAHALHEMTP
EDVCREISASGLRGRGGAGYPAGVKWNLARKAPGERKYVVANGDEGDPGAYMDRSVMESDPHRILEGMAIAGYAIGADQG
YIYVRGEYYLAGRRLEAAIRDAERKGLLGSRVLGSNFSFRIDIRTGAGAFVCGEETSLMASIMGRRGQPWHRPPYPAQRG
LWGCPTLINNVETLATVPAIIGRGATWYAGIGSTRSPGTKVYALAGQVETAGLIEVPMGTTLREVVFDIGGGIPGGKRFK
AAQSGGPSGGCIPAEHLDTPLDYESMERIGTIMGSGGLIIMDETSCMPDVASFFLDFCRDESCGKCIPCRVGSMEMHRLL
RRITSGTAWPDDLRRLEELCDLMGATSLCGLGQTAPNPVVSTLRYFRHEYEAHIRERRCPAGRCTMAAEQEPGPGGKALL
HAVGVPGEVG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=379, Percent_Identity=40.1055408970976, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI20149568, Length=379, Percent_Identity=40.1055408970976, Blast_Score=300, Evalue=3e-81,
Organism=Escherichia coli, GI1788620, Length=404, Percent_Identity=40.0990099009901, Blast_Score=331, Evalue=7e-92,
Organism=Caenorhabditis elegans, GI17531727, Length=374, Percent_Identity=39.0374331550802, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI45550452, Length=378, Percent_Identity=39.9470899470899, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI19920794, Length=376, Percent_Identity=38.8297872340425, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24653819, Length=385, Percent_Identity=31.6883116883117, Blast_Score=225, Evalue=8e-59,
Organism=Drosophila melanogaster, GI24653817, Length=355, Percent_Identity=29.2957746478873, Blast_Score=191, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 61240; Mature: 61240

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPADLHAMAREEQARQEALRCRIMVCAGTPCLSAGALAVLDALRQAVEESRLDAEIEAV
CCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
STGCMGPCSRGPLVKVAVQGKPEIVYERVTPELARQILYSVVKGRRPPTASPLPPDHPYF
HCCCCCCCCCCCEEEEEECCCCCEEHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
TRQMKIVLANCGSIDPERIEEYVATGGYDALAHALHEMTPEDVCREISASGLRGRGGAGY
HHHHEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
PAGVKWNLARKAPGERKYVVANGDEGDPGAYMDRSVMESDPHRILEGMAIAGYAIGADQG
CCCCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHEEEEEECCCC
YIYVRGEYYLAGRRLEAAIRDAERKGLLGSRVLGSNFSFRIDIRTGAGAFVCGEETSLMA
EEEEEEEEEECCHHHHHHHHHHHHCCCCCCCEECCCCEEEEEEECCCCEEEECCHHHHHH
SIMGRRGQPWHRPPYPAQRGLWGCPTLINNVETLATVPAIIGRGATWYAGIGSTRSPGTK
HHHCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCE
VYALAGQVETAGLIEVPMGTTLREVVFDIGGGIPGGKRFKAAQSGGPSGGCIPAEHLDTP
EEEEECCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCCEEHHCCCCCCCCCCCHHHCCCC
LDYESMERIGTIMGSGGLIIMDETSCMPDVASFFLDFCRDESCGKCIPCRVGSMEMHRLL
CCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
RRITSGTAWPDDLRRLEELCDLMGATSLCGLGQTAPNPVVSTLRYFRHEYEAHIRERRCP
HHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
AGRCTMAAEQEPGPGGKALLHAVGVPGEVG
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNPADLHAMAREEQARQEALRCRIMVCAGTPCLSAGALAVLDALRQAVEESRLDAEIEAV
CCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
STGCMGPCSRGPLVKVAVQGKPEIVYERVTPELARQILYSVVKGRRPPTASPLPPDHPYF
HCCCCCCCCCCCEEEEEECCCCCEEHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
TRQMKIVLANCGSIDPERIEEYVATGGYDALAHALHEMTPEDVCREISASGLRGRGGAGY
HHHHEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
PAGVKWNLARKAPGERKYVVANGDEGDPGAYMDRSVMESDPHRILEGMAIAGYAIGADQG
CCCCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHEEEEEECCCC
YIYVRGEYYLAGRRLEAAIRDAERKGLLGSRVLGSNFSFRIDIRTGAGAFVCGEETSLMA
EEEEEEEEEECCHHHHHHHHHHHHCCCCCCCEECCCCEEEEEEECCCCEEEECCHHHHHH
SIMGRRGQPWHRPPYPAQRGLWGCPTLINNVETLATVPAIIGRGATWYAGIGSTRSPGTK
HHHCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCE
VYALAGQVETAGLIEVPMGTTLREVVFDIGGGIPGGKRFKAAQSGGPSGGCIPAEHLDTP
EEEEECCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCCEEHHCCCCCCCCCCCHHHCCCC
LDYESMERIGTIMGSGGLIIMDETSCMPDVASFFLDFCRDESCGKCIPCRVGSMEMHRLL
CCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
RRITSGTAWPDDLRRLEELCDLMGATSLCGLGQTAPNPVVSTLRYFRHEYEAHIRERRCP
HHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
AGRCTMAAEQEPGPGGKALLHAVGVPGEVG
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]