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The map label for this gene is bioC [H]

Identifier: 39997721

GI number: 39997721

Start: 2898797

End: 2899600

Strand: Reverse

Name: bioC [H]

Synonym: GSU2627

Alternate gene names: 39997721

Gene position: 2899600-2898797 (Counterclockwise)

Preceding gene: 39997722

Following gene: 308513326

Centisome position: 76.02

GC content: 67.79

Gene sequence:

>804_bases
ATGATTGATCGCCGCAAGGTCCGCAACGCCTTCCACCGGGGGGCCGCCGACTATGATGCCTATGCCGCGGTGCAGAAGCG
GGTCATGGAGCGGATACTTTCCCTCCTCTTCGCCGAGGGGGTCGAGCCGGCCCGGATTCTCGACGTGGGGGCCGGCACCG
GCGCCCTTGCCCTGCGCCTTGCCGACCGCTACCCGTCGGCCGCCATAACCTGCGTTGATCTGGCCCACGGCATGGCCCGG
CAGGCCCGCGACAACCTGGGCCGGACCATGGAGCGCCTGGTTGCCGTGGCCGATGCGGAGCATCTTCCCCTTCGCGACGG
TGTCTTCGACCTGGTAGTCTCCACCTCCACCTTCCAGTGGCTCACCACGCTCGACCGGGCCTTCGCGGAGGCCCGCAGGG
TTCTGGCCGATGACGGGCTGTTCGCTTTTGCCCTGTTTGGCGACGGGACCTTCAAGGAACTCAAGGCATCCTACCGGGCC
GCTCTCCATTCGGTGCCGCGCGGCGGCCGGGATCGGACCCACCGGTTCTTTACGCGGGACGAGGTGCGGGCGGCGCTGGC
GCGGGCGGGATTCAGGTCGGTTGAGGTTTTCGATGAAGACGAGGTGGAATACCACCCGGACGTGCCGGCCTTTCTCCGCT
CCGTGAAGCGGATCGGCGCCGGCAACGCCTCGCCGGTCGCCGGGCGGGGCCTTTCGGGGAGGCGGGTCATGGAAACGATG
ATGCGGACGTATGCCGAGCGCTTCGGCGGTGCCGATGGAATTCCAGCCACCTACACGGTGGTCTATGGGGTGGGGAAGCG
TTAG

Upstream 100 bases:

>100_bases
CGATTCCTGTTGTTCGCCGGAACCGGCCATGCCCCCTTTCTTTCCCGTCCCCGGGAATTCAACAGCGAGGTGACACGCTT
TCTGCGCGAGGTGGCCGGAG

Downstream 100 bases:

>100_bases
CTGAAAACGTGAAGCGCCGGGAAGCAGGGGGCAGCGCGCGGCGCTGCCCTTCGACCGGAGATCAGACCGCCTGGAGAATG
AAGCACTTGAGGTATTCGGT

Product: biotin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MIDRRKVRNAFHRGAADYDAYAAVQKRVMERILSLLFAEGVEPARILDVGAGTGALALRLADRYPSAAITCVDLAHGMAR
QARDNLGRTMERLVAVADAEHLPLRDGVFDLVVSTSTFQWLTTLDRAFAEARRVLADDGLFAFALFGDGTFKELKASYRA
ALHSVPRGGRDRTHRFFTRDEVRAALARAGFRSVEVFDEDEVEYHPDVPAFLRSVKRIGAGNASPVAGRGLSGRRVMETM
MRTYAERFGGADGIPATYTVVYGVGKR

Sequences:

>Translated_267_residues
MIDRRKVRNAFHRGAADYDAYAAVQKRVMERILSLLFAEGVEPARILDVGAGTGALALRLADRYPSAAITCVDLAHGMAR
QARDNLGRTMERLVAVADAEHLPLRDGVFDLVVSTSTFQWLTTLDRAFAEARRVLADDGLFAFALFGDGTFKELKASYRA
ALHSVPRGGRDRTHRFFTRDEVRAALARAGFRSVEVFDEDEVEYHPDVPAFLRSVKRIGAGNASPVAGRGLSGRRVMETM
MRTYAERFGGADGIPATYTVVYGVGKR
>Mature_267_residues
MIDRRKVRNAFHRGAADYDAYAAVQKRVMERILSLLFAEGVEPARILDVGAGTGALALRLADRYPSAAITCVDLAHGMAR
QARDNLGRTMERLVAVADAEHLPLRDGVFDLVVSTSTFQWLTTLDRAFAEARRVLADDGLFAFALFGDGTFKELKASYRA
ALHSVPRGGRDRTHRFFTRDEVRAALARAGFRSVEVFDEDEVEYHPDVPAFLRSVKRIGAGNASPVAGRGLSGRRVMETM
MRTYAERFGGADGIPATYTVVYGVGKR

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=224, Percent_Identity=29.9107142857143, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1786994, Length=254, Percent_Identity=25.1968503937008, Blast_Score=71, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19922210, Length=223, Percent_Identity=28.2511210762332, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 29414; Mature: 29414

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRRKVRNAFHRGAADYDAYAAVQKRVMERILSLLFAEGVEPARILDVGAGTGALALRL
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCHHHHHHH
ADRYPSAAITCVDLAHGMARQARDNLGRTMERLVAVADAEHLPLRDGVFDLVVSTSTFQW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LTTLDRAFAEARRVLADDGLFAFALFGDGTFKELKASYRAALHSVPRGGRDRTHRFFTRD
HHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EVRAALARAGFRSVEVFDEDEVEYHPDVPAFLRSVKRIGAGNASPVAGRGLSGRRVMETM
HHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
MRTYAERFGGADGIPATYTVVYGVGKR
HHHHHHHHCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MIDRRKVRNAFHRGAADYDAYAAVQKRVMERILSLLFAEGVEPARILDVGAGTGALALRL
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCHHHHHHH
ADRYPSAAITCVDLAHGMARQARDNLGRTMERLVAVADAEHLPLRDGVFDLVVSTSTFQW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LTTLDRAFAEARRVLADDGLFAFALFGDGTFKELKASYRAALHSVPRGGRDRTHRFFTRD
HHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EVRAALARAGFRSVEVFDEDEVEYHPDVPAFLRSVKRIGAGNASPVAGRGLSGRRVMETM
HHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
MRTYAERFGGADGIPATYTVVYGVGKR
HHHHHHHHCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]