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The map label for this gene is kinA [H]

Identifier: 39997483

GI number: 39997483

Start: 2617037

End: 2619238

Strand: Reverse

Name: kinA [H]

Synonym: GSU2388

Alternate gene names: 39997483

Gene position: 2619238-2617037 (Counterclockwise)

Preceding gene: 39997484

Following gene: 39997482

Centisome position: 68.67

GC content: 65.53

Gene sequence:

>2202_bases
GTGCTCACTGTGGGACTGATCGCGCGATCAGCCCAGCGCAGCGATCTTCTGCATCACGTGGGGGCAAGCAACCTCACCCT
GGCGCGGGCGGTCGCGCGGGAGGTGGAGAGCAGCCTGCGGGAACCGTCCAACTTCATCGAGCACATCGGCAAGGTTCTGG
AGGATGATAAGGACCAGGCCAGCCAGTCTGTCGAACTTGCGGAAGAGATCAGTTCCACCGGTCTCTTCGAATCGCTTTTC
CTGCTCGACCGCACCGGCAGGGTCGTGAACGTTGCACTTGCGCGCAATGCAAAGGGTTCGTCCGGCGATTACCTCGGCAT
GGATTTCTCCAGGCTGCCGATTTTCCTGGAAACGCGCACCAAGGGGGAGTTGAGCCGGTCCAAGGTATTCCTGTCGTCTA
TTTCCGGAGATCCGGCGGTCATGTTCGCCGCGCCGGCCGGGGATGGGGTCGTGGTCGGCACCCTCGGGCTCAGGGTGTTG
AGCGACATTTCCGCCCATGCGAAGCCCGACGACCAGGGAACGGTCATCATCGTCAGCAGTCGCGGCAAGGTCATCGGTCA
TCCGGACTACTCCCTGGTCCGCCGGCAGACCGACCTGGGCGGGCTCGACATCGTCCGCGAGGGGCTGGCGGGCAAGGCCG
GCACCCATACCTACGTGATGAACGGCAAGAGCCACCTCGGCAGCGTGGTGCAGATTCCGGGGACGGGGTGGCTCGTCATC
GTCGAGGTCCCCCTGGCTACGGCCCTGGCCCCGGTGAACGAGATCGAGATGATTTTCCGGATTGCCATCCTGGCGACCAT
CGTGCTGGCTTCGCTGCTGGCCCTGGCGGGGAGGTCGGTGATCTTCCGTCCGGTCACGGCGCTTATGGCCAGCGCCCGTC
AGATCGCCCGCGGCAGCTATGACGTTGTGCCTCTGCCCCGCAGCTTCCGCGAAATAGACGAGCTGGGGGACGGGTTCCGC
TCCATGGCCGATGCGGTCAAGACGCGGGAAAGCGAGCTGAAGGAGCGCAACGAAGAGCTGGCCATGACCGAAGAGGAGTT
GCGCCAGCAGCTCGACGAGTACCAGGTGAGCCAGGACCGGCTGGTGGAAAGCGAGGAGCGCTACCGCCAGCTGGTGGAAT
CCGCTCCCGATGCCGTCCTCATCCACTGTGATGGCCGTTACGTATTCGCCAACCCCGCGGCCCTGCGCCTGTACGGTGCC
GATACCGCCGATCAGCTCCTGGGGCGGGAGATTACAGATTTCGTCCATCCCAACAGCCGCCAGGTGGTTGCCGAGCGGAT
CAAGCTGCTCTACCAGGAGCGGAGTCCGGCGCCGCTGTGCGAGCAGCAGATCGTTCGCCTGGACGGAACCGTGGTTGATG
TGGAGGTGGTGGGCATCCCTTACTCCCATCAGGGCCGACCGGCCGTGCAGGCGGTGCTGCGGGAGATCACCGAGCGCAAG
CAGGCGGAACAGCGGATTCGCCAGCTCAACGCAGAGCTTGAGGAGCGGGTGCGCGAGCGGACGGCCCTGCTGGAGGCCGC
CAATCGTGAGCTGGAATCGTTCAGCTACTCGGTATCCCACGATCTTCGGGCGCCCCTGCGCCACATAAACGGATTCGGCC
TGGCGCTGATGGAGGAGTGCGGCGACGTCCTCCCGGAAACGGGCAAGGGCTATCTGGAGCGGATCAGGAGCGCGGCCCGG
CGCATGGGCCAGCTCATCGACGACCTGCTGGAGCTGTCGCGCGTTTCCCGCGAGGTCATGCGGCGGGAGCGGGTCAACCT
GAGCCGGATAGCGCGGGAACTGGTGCGGGAGCACCAGGAGAGCTGGCCGGAGCGGCGGGTTTCCTTCGAGATCGACGACG
GTATCACGGCGGAGGGGGACCCGACGCTTCTGCGCGTGGCCCTTGCCAACCTTGTGGACAATGCCTGGAAGTATACGGCG
AAAAACGAGGAGGCCCATATCCGGGTCGGCACGGCCGACGTCGACGGCATCCGGGCCGTCTTCGTCAGCGACGACGGCGC
CGGTTTCGACATGCGCTACGTGGACAAGCTGTTCCGGCCGTTCCAGCGGCTCCATCGGACCGAGGAGTTCGAGGGGACCG
GCATCGGGCTCGCCACGGTCATGCGGATCGTCCAGCGCCACGGAGGCCGCGTCTGGGCCGAGGGCGAGGTGGGCAAGGGG
GCAACCGTCTATTTTACCCTGGACCAGCCCGAAGGGGGGTAG

Upstream 100 bases:

>100_bases
TGCGCCAGGGAGCGTTCCGGCGGGTGGAGGTGCCGTGAACCGGCGGATAAGCTTCAAGACGGCTCTGCTGGCGGCCCTGC
TCATAGTAGGGGTGGTGCCG

Downstream 100 bases:

>100_bases
CATGGAACAGTCCCTGACCAGTGAGCACGAAGAGCTGCTGCGTCTCATTGTCGACGCCGACCGTGACGGCGCCAATGCAC
TGATCGACCGGTGGGCGGAC

Product: sensory box histidine kinase

Products: NA

Alternate protein names: Stage II sporulation protein F; Stage II sporulation protein J [H]

Number of amino acids: Translated: 733; Mature: 733

Protein sequence:

>733_residues
MLTVGLIARSAQRSDLLHHVGASNLTLARAVAREVESSLREPSNFIEHIGKVLEDDKDQASQSVELAEEISSTGLFESLF
LLDRTGRVVNVALARNAKGSSGDYLGMDFSRLPIFLETRTKGELSRSKVFLSSISGDPAVMFAAPAGDGVVVGTLGLRVL
SDISAHAKPDDQGTVIIVSSRGKVIGHPDYSLVRRQTDLGGLDIVREGLAGKAGTHTYVMNGKSHLGSVVQIPGTGWLVI
VEVPLATALAPVNEIEMIFRIAILATIVLASLLALAGRSVIFRPVTALMASARQIARGSYDVVPLPRSFREIDELGDGFR
SMADAVKTRESELKERNEELAMTEEELRQQLDEYQVSQDRLVESEERYRQLVESAPDAVLIHCDGRYVFANPAALRLYGA
DTADQLLGREITDFVHPNSRQVVAERIKLLYQERSPAPLCEQQIVRLDGTVVDVEVVGIPYSHQGRPAVQAVLREITERK
QAEQRIRQLNAELEERVRERTALLEAANRELESFSYSVSHDLRAPLRHINGFGLALMEECGDVLPETGKGYLERIRSAAR
RMGQLIDDLLELSRVSREVMRRERVNLSRIARELVREHQESWPERRVSFEIDDGITAEGDPTLLRVALANLVDNAWKYTA
KNEEAHIRVGTADVDGIRAVFVSDDGAGFDMRYVDKLFRPFQRLHRTEEFEGTGIGLATVMRIVQRHGGRVWAEGEVGKG
ATVYFTLDQPEGG

Sequences:

>Translated_733_residues
MLTVGLIARSAQRSDLLHHVGASNLTLARAVAREVESSLREPSNFIEHIGKVLEDDKDQASQSVELAEEISSTGLFESLF
LLDRTGRVVNVALARNAKGSSGDYLGMDFSRLPIFLETRTKGELSRSKVFLSSISGDPAVMFAAPAGDGVVVGTLGLRVL
SDISAHAKPDDQGTVIIVSSRGKVIGHPDYSLVRRQTDLGGLDIVREGLAGKAGTHTYVMNGKSHLGSVVQIPGTGWLVI
VEVPLATALAPVNEIEMIFRIAILATIVLASLLALAGRSVIFRPVTALMASARQIARGSYDVVPLPRSFREIDELGDGFR
SMADAVKTRESELKERNEELAMTEEELRQQLDEYQVSQDRLVESEERYRQLVESAPDAVLIHCDGRYVFANPAALRLYGA
DTADQLLGREITDFVHPNSRQVVAERIKLLYQERSPAPLCEQQIVRLDGTVVDVEVVGIPYSHQGRPAVQAVLREITERK
QAEQRIRQLNAELEERVRERTALLEAANRELESFSYSVSHDLRAPLRHINGFGLALMEECGDVLPETGKGYLERIRSAAR
RMGQLIDDLLELSRVSREVMRRERVNLSRIARELVREHQESWPERRVSFEIDDGITAEGDPTLLRVALANLVDNAWKYTA
KNEEAHIRVGTADVDGIRAVFVSDDGAGFDMRYVDKLFRPFQRLHRTEEFEGTGIGLATVMRIVQRHGGRVWAEGEVGKG
ATVYFTLDQPEGG
>Mature_733_residues
MLTVGLIARSAQRSDLLHHVGASNLTLARAVAREVESSLREPSNFIEHIGKVLEDDKDQASQSVELAEEISSTGLFESLF
LLDRTGRVVNVALARNAKGSSGDYLGMDFSRLPIFLETRTKGELSRSKVFLSSISGDPAVMFAAPAGDGVVVGTLGLRVL
SDISAHAKPDDQGTVIIVSSRGKVIGHPDYSLVRRQTDLGGLDIVREGLAGKAGTHTYVMNGKSHLGSVVQIPGTGWLVI
VEVPLATALAPVNEIEMIFRIAILATIVLASLLALAGRSVIFRPVTALMASARQIARGSYDVVPLPRSFREIDELGDGFR
SMADAVKTRESELKERNEELAMTEEELRQQLDEYQVSQDRLVESEERYRQLVESAPDAVLIHCDGRYVFANPAALRLYGA
DTADQLLGREITDFVHPNSRQVVAERIKLLYQERSPAPLCEQQIVRLDGTVVDVEVVGIPYSHQGRPAVQAVLREITERK
QAEQRIRQLNAELEERVRERTALLEAANRELESFSYSVSHDLRAPLRHINGFGLALMEECGDVLPETGKGYLERIRSAAR
RMGQLIDDLLELSRVSREVMRRERVNLSRIARELVREHQESWPERRVSFEIDDGITAEGDPTLLRVALANLVDNAWKYTA
KNEEAHIRVGTADVDGIRAVFVSDDGAGFDMRYVDKLFRPFQRLHRTEEFEGTGIGLATVMRIVQRHGGRVWAEGEVGKG
ATVYFTLDQPEGG

Specific function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=415, Percent_Identity=24.0963855421687, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=374, Percent_Identity=28.3422459893048, Blast_Score=93, Evalue=8e-20,
Organism=Escherichia coli, GI1788549, Length=425, Percent_Identity=25.4117647058824, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790346, Length=253, Percent_Identity=31.2252964426877, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI145693157, Length=390, Percent_Identity=25.3846153846154, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1786783, Length=286, Percent_Identity=29.020979020979, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1790436, Length=250, Percent_Identity=28.4, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=26.271186440678, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=195, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1788393, Length=244, Percent_Identity=26.2295081967213, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1790861, Length=230, Percent_Identity=26.9565217391304, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR013655
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF08447 PAS_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 81135; Mature: 81135

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVGLIARSAQRSDLLHHVGASNLTLARAVAREVESSLREPSNFIEHIGKVLEDDKDQA
CEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHH
SQSVELAEEISSTGLFESLFLLDRTGRVVNVALARNAKGSSGDYLGMDFSRLPIFLETRT
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEECCCHHHCCEEEEECC
KGELSRSKVFLSSISGDPAVMFAAPAGDGVVVGTLGLRVLSDISAHAKPDDQGTVIIVSS
CCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHCCCCCCCCEEEEEEC
RGKVIGHPDYSLVRRQTDLGGLDIVREGLAGKAGTHTYVMNGKSHLGSVVQIPGTGWLVI
CCCEECCCCHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEECCHHHCCCEEEECCCCEEEE
VEVPLATALAPVNEIEMIFRIAILATIVLASLLALAGRSVIFRPVTALMASARQIARGSY
EECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
DVVPLPRSFREIDELGDGFRSMADAVKTRESELKERNEELAMTEEELRQQLDEYQVSQDR
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHH
LVESEERYRQLVESAPDAVLIHCDGRYVFANPAALRLYGADTADQLLGREITDFVHPNSR
HHHHHHHHHHHHHCCCCEEEEEECCEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCH
QVVAERIKLLYQERSPAPLCEQQIVRLDGTVVDVEVVGIPYSHQGRPAVQAVLREITERK
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHH
QAEQRIRQLNAELEERVRERTALLEAANRELESFSYSVSHDLRAPLRHINGFGLALMEEC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GDVLPETGKGYLERIRSAARRMGQLIDDLLELSRVSREVMRRERVNLSRIARELVREHQE
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
SWPERRVSFEIDDGITAEGDPTLLRVALANLVDNAWKYTAKNEEAHIRVGTADVDGIRAV
CCCHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEE
FVSDDGAGFDMRYVDKLFRPFQRLHRTEEFEGTGIGLATVMRIVQRHGGRVWAEGEVGKG
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCC
ATVYFTLDQPEGG
EEEEEEECCCCCC
>Mature Secondary Structure
MLTVGLIARSAQRSDLLHHVGASNLTLARAVAREVESSLREPSNFIEHIGKVLEDDKDQA
CEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHH
SQSVELAEEISSTGLFESLFLLDRTGRVVNVALARNAKGSSGDYLGMDFSRLPIFLETRT
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEECCCHHHCCEEEEECC
KGELSRSKVFLSSISGDPAVMFAAPAGDGVVVGTLGLRVLSDISAHAKPDDQGTVIIVSS
CCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHCCCCCCCCEEEEEEC
RGKVIGHPDYSLVRRQTDLGGLDIVREGLAGKAGTHTYVMNGKSHLGSVVQIPGTGWLVI
CCCEECCCCHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEECCHHHCCCEEEECCCCEEEE
VEVPLATALAPVNEIEMIFRIAILATIVLASLLALAGRSVIFRPVTALMASARQIARGSY
EECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
DVVPLPRSFREIDELGDGFRSMADAVKTRESELKERNEELAMTEEELRQQLDEYQVSQDR
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHH
LVESEERYRQLVESAPDAVLIHCDGRYVFANPAALRLYGADTADQLLGREITDFVHPNSR
HHHHHHHHHHHHHCCCCEEEEEECCEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCH
QVVAERIKLLYQERSPAPLCEQQIVRLDGTVVDVEVVGIPYSHQGRPAVQAVLREITERK
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHH
QAEQRIRQLNAELEERVRERTALLEAANRELESFSYSVSHDLRAPLRHINGFGLALMEEC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GDVLPETGKGYLERIRSAARRMGQLIDDLLELSRVSREVMRRERVNLSRIARELVREHQE
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
SWPERRVSFEIDDGITAEGDPTLLRVALANLVDNAWKYTAKNEEAHIRVGTADVDGIRAV
CCCHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEE
FVSDDGAGFDMRYVDKLFRPFQRLHRTEEFEGTGIGLATVMRIVQRHGGRVWAEGEVGKG
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCC
ATVYFTLDQPEGG
EEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2104615; 2509430; 9384377 [H]