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The map label for this gene is trpC [H]

Identifier: 39997475

GI number: 39997475

Start: 2608851

End: 2609651

Strand: Reverse

Name: trpC [H]

Synonym: GSU2380

Alternate gene names: 39997475

Gene position: 2609651-2608851 (Counterclockwise)

Preceding gene: 39997476

Following gene: 39997474

Centisome position: 68.42

GC content: 66.67

Gene sequence:

>801_bases
ATGACCGATACCCCCGATATCCTGAAGAAGATCGTCGAGCACAAGCGGGGCGAAGTGGCTGCGGCCCGGTCCGCTGCCCC
CCTTGCCGAGGTGAAGGCCCGCATCGCGGATCTGGAGGACCAGCCCCGGGGCTTCGAGCGGGCCCTGCGGGACTGCCACG
CCTCCGGCTGGACCGCCGTCATCGCCGAGGTGAAGAAAGGGTCCCCCTCCAAGGGGGTCATCCGCCCCGATTTCGATCCC
CTGGAGATTGCCGAGACCTACGAGCAGAACGGCGCCGCCTGCCTCTCTGTCCTGACCGACGAGCAGTTCTTCCTGGGCAA
CCTCCGCTACCTGGCCCTGATCCGGGAACAGGTGCGGCTGCCGCTGCTGCGCAAGGATTTCCTCTTCGACCCCTATCAGG
TCTACGAGGCTCGCGCCGCCGGGGCCGACGCCATCCTCCTCATCGCGGCCATGCTGGAACCGGCGCAGATCGAGGATCTG
GCCGGGTTTGCCCGGGAGCAGTACCTCGACGTGCTGCTGGAGGTCCACGACGAGCAGGAGCTGGAGACGGCCCTTGCGTC
GAGCTGCACCCTGATCGGGATCAACAACCGCAACCTCCGCACCTTCGTCACCGACCTGGGCACCACCGAGCGGCTCATCC
CCATGATCCCCGCCGACCGGTTCGTGGTGACCGAGAGCGGCATCAATACCCGTGACGACATCCTCCGCCTCCAGGCTGCC
GGCGCCCACGGCTTCCTCATCGGCGAGTCCCTCATGCGGGAAGAGGATATCGGGGCAAAACTGCGGGAGTTGCTGGGATA
G

Upstream 100 bases:

>100_bases
GACCCGGCTGAAGGGGTTCGCATCGCCGCCGAGGCCATCGATTCGGGCCGTGCCCTGGCAAAGCTGGAAGAACTCATCAC
CCTGACCAACGAGTAAACCC

Downstream 100 bases:

>100_bases
TTCAGTGGCCCCCACGATCAGACAGACGCCATCGCAAAGGAGATCCGATGCAAACTAAAATAGTGCTGGACGAAAGCCGC
ATCCCGACCCACTGGTACAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MTDTPDILKKIVEHKRGEVAAARSAAPLAEVKARIADLEDQPRGFERALRDCHASGWTAVIAEVKKGSPSKGVIRPDFDP
LEIAETYEQNGAACLSVLTDEQFFLGNLRYLALIREQVRLPLLRKDFLFDPYQVYEARAAGADAILLIAAMLEPAQIEDL
AGFAREQYLDVLLEVHDEQELETALASSCTLIGINNRNLRTFVTDLGTTERLIPMIPADRFVVTESGINTRDDILRLQAA
GAHGFLIGESLMREEDIGAKLRELLG

Sequences:

>Translated_266_residues
MTDTPDILKKIVEHKRGEVAAARSAAPLAEVKARIADLEDQPRGFERALRDCHASGWTAVIAEVKKGSPSKGVIRPDFDP
LEIAETYEQNGAACLSVLTDEQFFLGNLRYLALIREQVRLPLLRKDFLFDPYQVYEARAAGADAILLIAAMLEPAQIEDL
AGFAREQYLDVLLEVHDEQELETALASSCTLIGINNRNLRTFVTDLGTTERLIPMIPADRFVVTESGINTRDDILRLQAA
GAHGFLIGESLMREEDIGAKLRELLG
>Mature_265_residues
TDTPDILKKIVEHKRGEVAAARSAAPLAEVKARIADLEDQPRGFERALRDCHASGWTAVIAEVKKGSPSKGVIRPDFDPL
EIAETYEQNGAACLSVLTDEQFFLGNLRYLALIREQVRLPLLRKDFLFDPYQVYEARAAGADAILLIAAMLEPAQIEDLA
GFAREQYLDVLLEVHDEQELETALASSCTLIGINNRNLRTFVTDLGTTERLIPMIPADRFVVTESGINTRDDILRLQAAG
AHGFLIGESLMREEDIGAKLRELLG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=259, Percent_Identity=41.6988416988417, Blast_Score=177, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6322638, Length=228, Percent_Identity=39.0350877192982, Blast_Score=161, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29428; Mature: 29297

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTPDILKKIVEHKRGEVAAARSAAPLAEVKARIADLEDQPRGFERALRDCHASGWTAV
CCCCHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHH
IAEVKKGSPSKGVIRPDFDPLEIAETYEQNGAACLSVLTDEQFFLGNLRYLALIREQVRL
HHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
PLLRKDFLFDPYQVYEARAAGADAILLIAAMLEPAQIEDLAGFAREQYLDVLLEVHDEQE
CHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHH
LETALASSCTLIGINNRNLRTFVTDLGTTERLIPMIPADRFVVTESGINTRDDILRLQAA
HHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCC
GAHGFLIGESLMREEDIGAKLRELLG
CCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDTPDILKKIVEHKRGEVAAARSAAPLAEVKARIADLEDQPRGFERALRDCHASGWTAV
CCCHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHH
IAEVKKGSPSKGVIRPDFDPLEIAETYEQNGAACLSVLTDEQFFLGNLRYLALIREQVRL
HHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
PLLRKDFLFDPYQVYEARAAGADAILLIAAMLEPAQIEDLAGFAREQYLDVLLEVHDEQE
CHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHH
LETALASSCTLIGINNRNLRTFVTDLGTTERLIPMIPADRFVVTESGINTRDDILRLQAA
HHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCC
GAHGFLIGESLMREEDIGAKLRELLG
CCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]