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The map label for this gene is mrpD [H]

Identifier: 39997438

GI number: 39997438

Start: 2558900

End: 2560414

Strand: Reverse

Name: mrpD [H]

Synonym: GSU2341

Alternate gene names: 39997438

Gene position: 2560414-2558900 (Counterclockwise)

Preceding gene: 39997439

Following gene: 39997437

Centisome position: 67.13

GC content: 66.67

Gene sequence:

>1515_bases
ATGAAACTTCTTCTCTTCCTCCCCCTCATCATCCCGCTGGCCACGGCTGTGGCGGGGCTTTTCGCCTGGAACCGGCGGGA
GCTCCAACGGCTGTTGGGCGTCTGCGGCACGACGGCGCTCCTGGGGGCGGGGGTGGCGCTCCTCACGGTTGTGCAACGTC
AGGGGGTGGTCAGCGTCCAGGCGGGGAACTGGCCCGCCCCCTTCGGCATCACCCTGGTAGCCGACCTCTTCAGCGCCGTC
ATGGTGGTGGTGGTCGGCGCCATGGGGCTGGCAGTGGCGGTCTATTCCCTGGCGAGCGCCGACATCGATCACGAGTCCCT
GGGATACCATCCCCTCATGCAGGTGCTGCTGCTGGGGGTCTGCGGGTCGCTCCTGACCGGGGACCTGTTCAACCTCTACG
TCTGGTTCGAGGTGATGCTGATCGCCTCGTTCGTGCTCCTGGCCCTTGGCGGCCGTCGGCAGCAGATGGAGGGGGCAATT
AAGTATGTGGCCCTGAACCTGATCGCCTCGGCTTTTTTCCTGGCCGGGATCGGTATCCTCTATGGCGTGGCAGGAACCCT
GAACATGGCGGATCTGGCCCGTCAGTTGCGGGCGGTTCCCCACGGCGGCACCGTGCCGGTCATCGCTGCGCTCCTCTTTG
CCGCCTTCGGGATCAAATCGGCGGTGTTTCCGCTCTTTTTCTGGCTTCCCGCCTCCTACCACACCCCTCCCGTGGCGGTG
ACCACAATTTTTTCGGCACTGCTGACCAAGGTGGGGGTCTATGTGCTGGTGCGGATATTTACCCTCATTTTCGTCCAGGA
GGCCGAGGCGGGCCGAACCCTGATCCTGGCGGCTGCGGGGCTCACCATGGTGACCGGGGTCCTGGGAGCCGTGGCCCAGC
ACGAGATGAGACGCCTGCTCTCGTTTCACATCGTGAGCCAGATCGGCTACCTGGTCATGGGGCTCGGGCTCCTGACGCCC
CTGGCCCTGGCCGGGACGATATTCTTCATGGTCCACGTCATTGCCGCCAAGTCGGCCCTCTTTCTGGTGGCAGGCATCGT
GAAGCGGCTGACCGGCACCACGGAACTGGCCGAGTTGGGCGGGCTCTACGAGGGGCGTCCGCTGGTGGCGGGGCTCTTTC
TCGTGCCGGCCCTGGCACTGGCGGGGATTCCGCCCCTGTCCGGCTTCTGGGCCAAGCTGGCCCTGGTGCGGGCGGGCCTT
GGGGAGGGGCGGTACGTGGTGGTGGCAGCGGCCCTGGCGGTGAGCATCCTGACCCTCTTCTCCATGACCAAAATCTGGGC
AGAGGCCTTCTGGAAGGACCACCCCGTGCGAGAGGGGGAGGCCCACGCTCAGTACCACCCCCACATTCCGGGCGGGGCGC
GGCTGCTGCTGGGAGTGCCGGCCCTGGTCCTGGCCCTGGCCACGGTGGCCATGGGGGTGGGGGCCGAGCCCCTCTTCCGG
CTTTCCCTGACCGCCGCCGACCAGCTGCTCAATCCGGACCTCTACATCGCAGCGGTACTGGGGGTGAAGCCGTGA

Upstream 100 bases:

>100_bases
AGGCCTTTGCCCTGGTCCTGATCAAGCGGGTCTACCAGACCGTGGGCACCGACGATCTGGACGAGATGACCACGACCGAT
ACCGAGTACCGGAGCAATTG

Downstream 100 bases:

>100_bases
CCCCGTTTCTTGCCAATATCCTTCTGGCACTGGCCTGGATGGCCCTCACCGGCACCTATACGGCCGGCGGGTTTTTCACC
GGCGCGCTCGCCGGGTTCTT

Product: monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MKLLLFLPLIIPLATAVAGLFAWNRRELQRLLGVCGTTALLGAGVALLTVVQRQGVVSVQAGNWPAPFGITLVADLFSAV
MVVVVGAMGLAVAVYSLASADIDHESLGYHPLMQVLLLGVCGSLLTGDLFNLYVWFEVMLIASFVLLALGGRRQQMEGAI
KYVALNLIASAFFLAGIGILYGVAGTLNMADLARQLRAVPHGGTVPVIAALLFAAFGIKSAVFPLFFWLPASYHTPPVAV
TTIFSALLTKVGVYVLVRIFTLIFVQEAEAGRTLILAAAGLTMVTGVLGAVAQHEMRRLLSFHIVSQIGYLVMGLGLLTP
LALAGTIFFMVHVIAAKSALFLVAGIVKRLTGTTELAELGGLYEGRPLVAGLFLVPALALAGIPPLSGFWAKLALVRAGL
GEGRYVVVAAALAVSILTLFSMTKIWAEAFWKDHPVREGEAHAQYHPHIPGGARLLLGVPALVLALATVAMGVGAEPLFR
LSLTAADQLLNPDLYIAAVLGVKP

Sequences:

>Translated_504_residues
MKLLLFLPLIIPLATAVAGLFAWNRRELQRLLGVCGTTALLGAGVALLTVVQRQGVVSVQAGNWPAPFGITLVADLFSAV
MVVVVGAMGLAVAVYSLASADIDHESLGYHPLMQVLLLGVCGSLLTGDLFNLYVWFEVMLIASFVLLALGGRRQQMEGAI
KYVALNLIASAFFLAGIGILYGVAGTLNMADLARQLRAVPHGGTVPVIAALLFAAFGIKSAVFPLFFWLPASYHTPPVAV
TTIFSALLTKVGVYVLVRIFTLIFVQEAEAGRTLILAAAGLTMVTGVLGAVAQHEMRRLLSFHIVSQIGYLVMGLGLLTP
LALAGTIFFMVHVIAAKSALFLVAGIVKRLTGTTELAELGGLYEGRPLVAGLFLVPALALAGIPPLSGFWAKLALVRAGL
GEGRYVVVAAALAVSILTLFSMTKIWAEAFWKDHPVREGEAHAQYHPHIPGGARLLLGVPALVLALATVAMGVGAEPLFR
LSLTAADQLLNPDLYIAAVLGVKP
>Mature_504_residues
MKLLLFLPLIIPLATAVAGLFAWNRRELQRLLGVCGTTALLGAGVALLTVVQRQGVVSVQAGNWPAPFGITLVADLFSAV
MVVVVGAMGLAVAVYSLASADIDHESLGYHPLMQVLLLGVCGSLLTGDLFNLYVWFEVMLIASFVLLALGGRRQQMEGAI
KYVALNLIASAFFLAGIGILYGVAGTLNMADLARQLRAVPHGGTVPVIAALLFAAFGIKSAVFPLFFWLPASYHTPPVAV
TTIFSALLTKVGVYVLVRIFTLIFVQEAEAGRTLILAAAGLTMVTGVLGAVAQHEMRRLLSFHIVSQIGYLVMGLGLLTP
LALAGTIFFMVHVIAAKSALFLVAGIVKRLTGTTELAELGGLYEGRPLVAGLFLVPALALAGIPPLSGFWAKLALVRAGL
GEGRYVVVAAALAVSILTLFSMTKIWAEAFWKDHPVREGEAHAQYHPHIPGGARLLLGVPALVLALATVAMGVGAEPLFR
LSLTAADQLLNPDLYIAAVLGVKP

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=331, Percent_Identity=24.1691842900302, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788829, Length=400, Percent_Identity=29.75, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788831, Length=401, Percent_Identity=25.1870324189526, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788827, Length=342, Percent_Identity=25.4385964912281, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI145693160, Length=345, Percent_Identity=25.7971014492754, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788613, Length=370, Percent_Identity=26.7567567567568, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI2367154, Length=443, Percent_Identity=24.6049661399549, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788614, Length=355, Percent_Identity=24.5070422535211, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 53033; Mature: 53033

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCHHHHHHCCCCC
>Mature Secondary Structure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HHHHHHHHHCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]