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The map label for this gene is lpxD

Identifier: 39997364

GI number: 39997364

Start: 2481404

End: 2482447

Strand: Reverse

Name: lpxD

Synonym: GSU2266

Alternate gene names: 39997364

Gene position: 2482447-2481404 (Counterclockwise)

Preceding gene: 39997365

Following gene: 39997363

Centisome position: 65.09

GC content: 63.98

Gene sequence:

>1044_bases
ATGGCCGTGAGCAAGACGCTACAGGAACTGGCTGACTACCTCGGTGGAACGCTGGTCGGCGACGGCTCCCGCCAGATCGT
CGGCGTGGCGAGCCTCGATGACGCCACCGACAGCCAGATCACGTTTCTCGCCAATCCCCGCTATGCGCCGAAGGTTGCCT
CCACCAGGGCCGGCGCGGTCATTTTGCCGCCCGGCGCCGAACGGCACAACCACAACGCCATCATGGTCCCCAATCCCTAT
CTGGCGTTCGCCCGGCTGCTGACCCTCTTCTACGTGGCTCCCCGCGCGGCCCGCGGAGTGATGGACGGAGCCCATGTCGG
CCGGAACGTGAAACTCGGCTCGGAGATAACGATTCACCCGGGTGCGGTGGTCGGCGATAATGTGACCATAGGCGACCGGG
TGACGCTTCATCCGGGAGTGGTGCTCTATGAGGGGGTCACTGTCGGCGACGACGTCACGCTCCATGCCAACGTCACGGTC
TATCAGGGGTGCCGCATCGGCAACCGGGTAACGATCCACGGGGGGACCATCATCGGTTCCGACGGCTTCGGCTACGCGCC
CGACGGCGACGGCTGGTACAAGATCCCCCAGCTGGGCAACGTGGTGATCGAGGATGACGTGGAAATCGGCGCCAACGCCG
CCATCGACCGTGCCGCCCTTGCTTCCACCGTTATCGGTAAAGGGACCAAGGTCGACAACCTCGTCATGATCGCTCACAAC
TGCGTCATCGGCGAGAACTGCATGATCGTCTCCCAGGTGGGCATTTCGGGGAGTACCAAGCTCGGCAGGCGGGTAACGCT
CGGCGGGCAGGTGGGCGTGGCCGGGCACCTTGAGATCGGCGATAATGCCATGATTGGCGCAAAGTCGGGCGTTCCGGGCA
ATGTGCCCTCGGGCACCATTATGAGCGGCATCCCTGCCTTCGATCACCGGGAGTGGCTCCGTGCCTCGGCGGTTGTGCCG
AAACTCCCTGAAATGAAGCGGACTGTGGCCGCCCTGGAAAAACGGCTCCGCGAGCTTGAGGAGAAGCTGGAATCCGCAGT
CTAG

Upstream 100 bases:

>100_bases
ATCATCTTCGTGAAGAACGAGAGCATGATCTTTGCCGACGATAAAGCCGACCTGACCGAGGACGTTCTGAAGATTTTCAA
CGCCTCCCGGAAGAAATAAG

Downstream 100 bases:

>100_bases
CCGGCTCCGCACCGGTTTGTTTCGCTATTTTCGGTCGTGTAATCGAGAAAACGCGACTGTCCTCCGGGCGGTCCGTTTTT
CTCTTTTGAGGAGCGTGAAC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MAVSKTLQELADYLGGTLVGDGSRQIVGVASLDDATDSQITFLANPRYAPKVASTRAGAVILPPGAERHNHNAIMVPNPY
LAFARLLTLFYVAPRAARGVMDGAHVGRNVKLGSEITIHPGAVVGDNVTIGDRVTLHPGVVLYEGVTVGDDVTLHANVTV
YQGCRIGNRVTIHGGTIIGSDGFGYAPDGDGWYKIPQLGNVVIEDDVEIGANAAIDRAALASTVIGKGTKVDNLVMIAHN
CVIGENCMIVSQVGISGSTKLGRRVTLGGQVGVAGHLEIGDNAMIGAKSGVPGNVPSGTIMSGIPAFDHREWLRASAVVP
KLPEMKRTVAALEKRLRELEEKLESAV

Sequences:

>Translated_347_residues
MAVSKTLQELADYLGGTLVGDGSRQIVGVASLDDATDSQITFLANPRYAPKVASTRAGAVILPPGAERHNHNAIMVPNPY
LAFARLLTLFYVAPRAARGVMDGAHVGRNVKLGSEITIHPGAVVGDNVTIGDRVTLHPGVVLYEGVTVGDDVTLHANVTV
YQGCRIGNRVTIHGGTIIGSDGFGYAPDGDGWYKIPQLGNVVIEDDVEIGANAAIDRAALASTVIGKGTKVDNLVMIAHN
CVIGENCMIVSQVGISGSTKLGRRVTLGGQVGVAGHLEIGDNAMIGAKSGVPGNVPSGTIMSGIPAFDHREWLRASAVVP
KLPEMKRTVAALEKRLRELEEKLESAV
>Mature_346_residues
AVSKTLQELADYLGGTLVGDGSRQIVGVASLDDATDSQITFLANPRYAPKVASTRAGAVILPPGAERHNHNAIMVPNPYL
AFARLLTLFYVAPRAARGVMDGAHVGRNVKLGSEITIHPGAVVGDNVTIGDRVTLHPGVVLYEGVTVGDDVTLHANVTVY
QGCRIGNRVTIHGGTIIGSDGFGYAPDGDGWYKIPQLGNVVIEDDVEIGANAAIDRAALASTVIGKGTKVDNLVMIAHNC
VIGENCMIVSQVGISGSTKLGRRVTLGGQVGVAGHLEIGDNAMIGAKSGVPGNVPSGTIMSGIPAFDHREWLRASAVVPK
LPEMKRTVAALEKRLRELEEKLESAV

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=343, Percent_Identity=37.3177842565598, Blast_Score=218, Evalue=6e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_GEOSL (Q74AT5)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_953315.1
- ProteinModelPortal:   Q74AT5
- SMR:   Q74AT5
- GeneID:   2687471
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU2266
- NMPDR:   fig|243231.1.peg.2253
- TIGR:   GSU2266
- HOGENOM:   HBG469615
- OMA:   FIANEKY
- ProtClustDB:   PRK00892
- BioCyc:   GSUL243231:GSU_2266-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 36274; Mature: 36143

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSKTLQELADYLGGTLVGDGSRQIVGVASLDDATDSQITFLANPRYAPKVASTRAGAV
CCHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCEE
ILPPGAERHNHNAIMVPNPYLAFARLLTLFYVAPRAARGVMDGAHVGRNVKLGSEITIHP
EECCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCHHHHCCCCHHHCCCCEECCCEEEECC
GAVVGDNVTIGDRVTLHPGVVLYEGVTVGDDVTLHANVTVYQGCRIGNRVTIHGGTIIGS
CCEECCCEEECCEEEECCCEEEEECEEECCCEEEEEEEEEEECCCCCCEEEEECCEEECC
DGFGYAPDGDGWYKIPQLGNVVIEDDVEIGANAAIDRAALASTVIGKGTKVDNLVMIAHN
CCCCCCCCCCCEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEC
CVIGENCMIVSQVGISGSTKLGRRVTLGGQVGVAGHLEIGDNAMIGAKSGVPGNVPSGTI
EEECCCEEEEEECCCCCCCCCCCEEEECCCCCEEEEEEECCCEEEECCCCCCCCCCCCCH
MSGIPAFDHREWLRASAVVPKLPEMKRTVAALEKRLRELEEKLESAV
HCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVSKTLQELADYLGGTLVGDGSRQIVGVASLDDATDSQITFLANPRYAPKVASTRAGAV
CHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCEE
ILPPGAERHNHNAIMVPNPYLAFARLLTLFYVAPRAARGVMDGAHVGRNVKLGSEITIHP
EECCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCHHHHCCCCHHHCCCCEECCCEEEECC
GAVVGDNVTIGDRVTLHPGVVLYEGVTVGDDVTLHANVTVYQGCRIGNRVTIHGGTIIGS
CCEECCCEEECCEEEECCCEEEEECEEECCCEEEEEEEEEEECCCCCCEEEEECCEEECC
DGFGYAPDGDGWYKIPQLGNVVIEDDVEIGANAAIDRAALASTVIGKGTKVDNLVMIAHN
CCCCCCCCCCCEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEC
CVIGENCMIVSQVGISGSTKLGRRVTLGGQVGVAGHLEIGDNAMIGAKSGVPGNVPSGTI
EEECCCEEEEEECCCCCCCCCCCEEEECCCCCEEEEEEECCCEEEECCCCCCCCCCCCCH
MSGIPAFDHREWLRASAVVPKLPEMKRTVAALEKRLRELEEKLESAV
HCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA