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The map label for this gene is lon [H]

Identifier: 39997203

GI number: 39997203

Start: 2316573

End: 2318603

Strand: Reverse

Name: lon [H]

Synonym: GSU2105

Alternate gene names: 39997203

Gene position: 2318603-2316573 (Counterclockwise)

Preceding gene: 39997204

Following gene: 39997202

Centisome position: 60.79

GC content: 56.38

Gene sequence:

>2031_bases
ATGAACGATGTTCTAGACCAGAAGCTGGTCGATGTATTCTCCGGCAAGGTGGTGCGCAAGGACCTGGTGCGCAAGGTCAA
GGTCGGGGCCAACGTGCCGGTATTTGTCCTCGAATACCTTCTGGGAAAATACTGCGCCACGGACGACGAGGCGGCAATGG
AAGCGGGACTTCGGGTGGTGAACAACACCCTCGCCGAAAATTTTGTCCGCCCCGAGGAGGCGAACAAGGCTCAAGCACTG
GTCCGAGAGAAGGGGCGCCATACCTTTATCGACAAGGTGAAGGTCCGCTACCTTGCAGAGGATGACAAATACTGGGCGGA
ATGCGTCAACTTCGGCCACAAGTACCTGCATATTCCGGAACGCTACATACGGGAGTACGATCGGCTGCTCATGGGCGGTG
TCTGGGCGCAGATGGAGATCCGGCACCAGTACGACGAGGAGGCCAAGGGGCGCCGGAGTCCCTTCTGGATTGAAAGCATC
ACCCCTATTCAGTTGGCCACCTTCGACTTAAACGCTTACCAAGAAGGACGTCGGCAGTTCACGTCCGAAGAGTGGGTGGA
TATGCTGATCCGCAGCGTCGGCATGGAGCCGGAGCATTTCACGCGGCGGCTGAAGCTGCTGTTTCTGATACGGCTCATTC
CGCTGTGCGAGGCCAACTACAACCTTGTCGAGCTTGGACCGCGCGGCACCGGCAAGTCCTACGCTTATCAGGAGTTGAGC
CCCTACGCCATTCTGATGACCGGCCCGACGACCGTGGCAAACCTGTTCTTCAACATATCCACCAATAAGATGGGGCTTGT
GGGATTGTGGGATGCGGTGGCTTTTGATGAGGTGGCCGATCTGGAGAAGATGCCCAAGGAAGTCGTAACCACGATGAAGA
CGTACTGCGAGTCCGGGTCGTTCGCCCGTGGCAAGGAGTCGCTCTCCGGCATGGCATCCATTGCGCTGTTCGGGAACACC
AACCAGCCTGTGGAGACGATGGTGAAGTCCTCACACCTCTTCATCCCTTTGCCGGAGATTGTCAGGGAAGACATGGCGTT
CCTGGACCGGATTCACTATTACATCCCCGGCTGGGAAATCCCCAAGATGCGGATCGAGTATTTCACCCAGCATTACGGCT
TCGTCGTGGACTACCTTGCCGAGGCCCTGCGGGAACTGCGCCGGCATAACTTTACTGAAGTCAGCGACCGATATTTCTCG
TTCGGCGCCCACCTGAACGCCCGGGATGTGAAGGCCGTACGCAAGACGGTGTCTGGCCTCGTCAAGCTGCTCTATCCTCA
TGGTGAGTTCACTAAAGACGAACTGGCCGAGACCGTCGACATCGCCATGGAGGGCCGGCGGCGGGTGAAGGAACAACTCA
AGAAGATGGGCTCCTTCGAGTACCACCAGACATCCTTCTCATACCGTGACAACGAGAGCACGGAGGAACGCTACATCGGC
GTCCCCGAGGAAGGTGGCCGTGCCCTGATATCCACTGACCCGCTGGCACCCGGCTCCGTTTATGCGGCATCCGTCAATGC
TGATGGCAAGGTAGGTCTCTATCGGATCGAAGTGGGTGTCTCAGCCGGCACCGGCAAATTGAAGCTTGCCGGTGGCGTGG
AGTCAACGATGAAGGAATCCATTACTCGCGCTTTCGGATTCCTTCAGGGACACAAGGTTCCGATGGGGATAGCGAGTATT
TTCGATACAACGGACTTCCATGTCGAAGCCATCGATCTTCTTACCAACCGGGTAGGTTGCGAAGCCGGTATTGCCTTCAT
CATAGCCATCATATCGGCCATAAAGAAAACCCAGGTTGCCCCGGGAATGGTGATCCTTGGTGACCTGAGTATCCAAGGGA
ACATAAAGGGGGTCTCTTCTCTGTCGGAACCGCTTCAGATCGCAATGGAAAACGGCGCAAAGCGGGCACTCATTCCTCTT
GAGAACAAGCGCAACTTCCTAGAAGTATCCGGGGAGATCGTGGAAAAGGTTGACCCTGTGTTTTTCTCTGACCCCCAGAC
TGCTGCTGCGAAGGCGTTGAACTTATCTTGA

Upstream 100 bases:

>100_bases
AGCTTGAGCATATCGAAATCCGTGCCGTTGATTGTGAGTCCCAGCTGCTGCTTGCCTCATTGACTGGAGTGCCGGTCGAA
CTGGCAATATAGGAGTTACC

Downstream 100 bases:

>100_bases
GAGGCGGCTTTGCTTGTCAGGATAATTGCGCGATACGAAGCCACATGCGCTATGGCCAGTTAGAGCGGAGAATAGGTTGT
GTTAAAACCTTTGACCAAAC

Product: hypothetical protein

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 676; Mature: 676

Protein sequence:

>676_residues
MNDVLDQKLVDVFSGKVVRKDLVRKVKVGANVPVFVLEYLLGKYCATDDEAAMEAGLRVVNNTLAENFVRPEEANKAQAL
VREKGRHTFIDKVKVRYLAEDDKYWAECVNFGHKYLHIPERYIREYDRLLMGGVWAQMEIRHQYDEEAKGRRSPFWIESI
TPIQLATFDLNAYQEGRRQFTSEEWVDMLIRSVGMEPEHFTRRLKLLFLIRLIPLCEANYNLVELGPRGTGKSYAYQELS
PYAILMTGPTTVANLFFNISTNKMGLVGLWDAVAFDEVADLEKMPKEVVTTMKTYCESGSFARGKESLSGMASIALFGNT
NQPVETMVKSSHLFIPLPEIVREDMAFLDRIHYYIPGWEIPKMRIEYFTQHYGFVVDYLAEALRELRRHNFTEVSDRYFS
FGAHLNARDVKAVRKTVSGLVKLLYPHGEFTKDELAETVDIAMEGRRRVKEQLKKMGSFEYHQTSFSYRDNESTEERYIG
VPEEGGRALISTDPLAPGSVYAASVNADGKVGLYRIEVGVSAGTGKLKLAGGVESTMKESITRAFGFLQGHKVPMGIASI
FDTTDFHVEAIDLLTNRVGCEAGIAFIIAIISAIKKTQVAPGMVILGDLSIQGNIKGVSSLSEPLQIAMENGAKRALIPL
ENKRNFLEVSGEIVEKVDPVFFSDPQTAAAKALNLS

Sequences:

>Translated_676_residues
MNDVLDQKLVDVFSGKVVRKDLVRKVKVGANVPVFVLEYLLGKYCATDDEAAMEAGLRVVNNTLAENFVRPEEANKAQAL
VREKGRHTFIDKVKVRYLAEDDKYWAECVNFGHKYLHIPERYIREYDRLLMGGVWAQMEIRHQYDEEAKGRRSPFWIESI
TPIQLATFDLNAYQEGRRQFTSEEWVDMLIRSVGMEPEHFTRRLKLLFLIRLIPLCEANYNLVELGPRGTGKSYAYQELS
PYAILMTGPTTVANLFFNISTNKMGLVGLWDAVAFDEVADLEKMPKEVVTTMKTYCESGSFARGKESLSGMASIALFGNT
NQPVETMVKSSHLFIPLPEIVREDMAFLDRIHYYIPGWEIPKMRIEYFTQHYGFVVDYLAEALRELRRHNFTEVSDRYFS
FGAHLNARDVKAVRKTVSGLVKLLYPHGEFTKDELAETVDIAMEGRRRVKEQLKKMGSFEYHQTSFSYRDNESTEERYIG
VPEEGGRALISTDPLAPGSVYAASVNADGKVGLYRIEVGVSAGTGKLKLAGGVESTMKESITRAFGFLQGHKVPMGIASI
FDTTDFHVEAIDLLTNRVGCEAGIAFIIAIISAIKKTQVAPGMVILGDLSIQGNIKGVSSLSEPLQIAMENGAKRALIPL
ENKRNFLEVSGEIVEKVDPVFFSDPQTAAAKALNLS
>Mature_676_residues
MNDVLDQKLVDVFSGKVVRKDLVRKVKVGANVPVFVLEYLLGKYCATDDEAAMEAGLRVVNNTLAENFVRPEEANKAQAL
VREKGRHTFIDKVKVRYLAEDDKYWAECVNFGHKYLHIPERYIREYDRLLMGGVWAQMEIRHQYDEEAKGRRSPFWIESI
TPIQLATFDLNAYQEGRRQFTSEEWVDMLIRSVGMEPEHFTRRLKLLFLIRLIPLCEANYNLVELGPRGTGKSYAYQELS
PYAILMTGPTTVANLFFNISTNKMGLVGLWDAVAFDEVADLEKMPKEVVTTMKTYCESGSFARGKESLSGMASIALFGNT
NQPVETMVKSSHLFIPLPEIVREDMAFLDRIHYYIPGWEIPKMRIEYFTQHYGFVVDYLAEALRELRRHNFTEVSDRYFS
FGAHLNARDVKAVRKTVSGLVKLLYPHGEFTKDELAETVDIAMEGRRRVKEQLKKMGSFEYHQTSFSYRDNESTEERYIG
VPEEGGRALISTDPLAPGSVYAASVNADGKVGLYRIEVGVSAGTGKLKLAGGVESTMKESITRAFGFLQGHKVPMGIASI
FDTTDFHVEAIDLLTNRVGCEAGIAFIIAIISAIKKTQVAPGMVILGDLSIQGNIKGVSSLSEPLQIAMENGAKRALIPL
ENKRNFLEVSGEIVEKVDPVFFSDPQTAAAKALNLS

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG4930

COG function: function code O; Predicted ATP-dependent Lon-type protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Escherichia coli, GI1786643, Length=147, Percent_Identity=29.9319727891156, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17556486, Length=168, Percent_Identity=26.7857142857143, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 75968; Mature: 75968

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDVLDQKLVDVFSGKVVRKDLVRKVKVGANVPVFVLEYLLGKYCATDDEAAMEAGLRVV
CCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NNTLAENFVRPEEANKAQALVREKGRHTFIDKVKVRYLAEDDKYWAECVNFGHKYLHIPE
HHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHEEEEECCCHHHHHHHHCCCCEEECCH
RYIREYDRLLMGGVWAQMEIRHQYDEEAKGRRSPFWIESITPIQLATFDLNAYQEGRRQF
HHHHHHHHHHHCCHHHHHHHHHHCCHHHCCCCCCCEECCCCCEEEEEEECHHHHHHHHHC
TSEEWVDMLIRSVGMEPEHFTRRLKLLFLIRLIPLCEANYNLVELGPRGTGKSYAYQELS
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHCCC
PYAILMTGPTTVANLFFNISTNKMGLVGLWDAVAFDEVADLEKMPKEVVTTMKTYCESGS
CEEEEEECCHHEEHEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FARGKESLSGMASIALFGNTNQPVETMVKSSHLFIPLPEIVREDMAFLDRIHYYIPGWEI
CCCCHHHHHCCEEEEEECCCCCHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHCCCCCCC
PKMRIEYFTQHYGFVVDYLAEALRELRRHNFTEVSDRYFSFGAHLNARDVKAVRKTVSGL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VKLLYPHGEFTKDELAETVDIAMEGRRRVKEQLKKMGSFEYHQTSFSYRDNESTEERYIG
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHHHEEC
VPEEGGRALISTDPLAPGSVYAASVNADGKVGLYRIEVGVSAGTGKLKLAGGVESTMKES
CCCCCCEEEEECCCCCCCCEEEEEECCCCCEEEEEEEEEEECCCCCEEECCCHHHHHHHH
ITRAFGFLQGHKVPMGIASIFDTTDFHVEAIDLLTNRVGCEAGIAFIIAIISAIKKTQVA
HHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
PGMVILGDLSIQGNIKGVSSLSEPLQIAMENGAKRALIPLENKRNFLEVSGEIVEKVDPV
CCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
FFSDPQTAAAKALNLS
EECCCCHHHHHHCCCC
>Mature Secondary Structure
MNDVLDQKLVDVFSGKVVRKDLVRKVKVGANVPVFVLEYLLGKYCATDDEAAMEAGLRVV
CCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NNTLAENFVRPEEANKAQALVREKGRHTFIDKVKVRYLAEDDKYWAECVNFGHKYLHIPE
HHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHEEEEECCCHHHHHHHHCCCCEEECCH
RYIREYDRLLMGGVWAQMEIRHQYDEEAKGRRSPFWIESITPIQLATFDLNAYQEGRRQF
HHHHHHHHHHHCCHHHHHHHHHHCCHHHCCCCCCCEECCCCCEEEEEEECHHHHHHHHHC
TSEEWVDMLIRSVGMEPEHFTRRLKLLFLIRLIPLCEANYNLVELGPRGTGKSYAYQELS
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHCCC
PYAILMTGPTTVANLFFNISTNKMGLVGLWDAVAFDEVADLEKMPKEVVTTMKTYCESGS
CEEEEEECCHHEEHEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FARGKESLSGMASIALFGNTNQPVETMVKSSHLFIPLPEIVREDMAFLDRIHYYIPGWEI
CCCCHHHHHCCEEEEEECCCCCHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHCCCCCCC
PKMRIEYFTQHYGFVVDYLAEALRELRRHNFTEVSDRYFSFGAHLNARDVKAVRKTVSGL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VKLLYPHGEFTKDELAETVDIAMEGRRRVKEQLKKMGSFEYHQTSFSYRDNESTEERYIG
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHHHEEC
VPEEGGRALISTDPLAPGSVYAASVNADGKVGLYRIEVGVSAGTGKLKLAGGVESTMKES
CCCCCCEEEEECCCCCCCCEEEEEECCCCCEEEEEEEEEEECCCCCEEECCCHHHHHHHH
ITRAFGFLQGHKVPMGIASIFDTTDFHVEAIDLLTNRVGCEAGIAFIIAIISAIKKTQVA
HHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
PGMVILGDLSIQGNIKGVSSLSEPLQIAMENGAKRALIPLENKRNFLEVSGEIVEKVDPV
CCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
FFSDPQTAAAKALNLS
EECCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]