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The map label for this gene is neuA [H]

Identifier: 39997070

GI number: 39997070

Start: 2163165

End: 2163872

Strand: Reverse

Name: neuA [H]

Synonym: GSU1972

Alternate gene names: 39997070

Gene position: 2163872-2163165 (Counterclockwise)

Preceding gene: 39997071

Following gene: 39997069

Centisome position: 56.73

GC content: 63.56

Gene sequence:

>708_bases
ATGCCTGACGCATGTATCGCGGTGATTCCGGCGCGGGGAGGCTCCAAGCGGGTTCCCGGGAAAAACATCAAGCCGCTCAT
GGGCAAGCCCCTGATTGCATACACCGTTGAGGCTGCAGCCGACAGCGGATTGTTCGAACGGATCGTGGTCAGCACCGACT
GTCAGGAAATCGCGGAGGTGGCTCAACGGCACGGGGCGGAAGTTCCGTTCCTGCGGGAGGCATCCCTGGCGGACGACATT
ACTCCTGTCTCGGCAGCGACGGTGGACATGCTGGTGAAGCTCGATCCCGACGGCTCCACCTACGGCTTCGTGTGCCAGAT
GATGCCCAACTGTCCCCTCAAGACCTCAGCCGACGTGCGTGACAGTCATCGTCAGTTCCTGGAGTCCGGCGCTGATTCAC
AGTTGTCCGTGGTGCGCTACGGCTGGCAGAACCCCTGGTGGGCCATGCGCCGGGACGACTCGTTCCGGCTCGATCCGCTC
TTCCGGGAGGCCATGACCCAGCGCAGCCAGGATCTGCCCGAACTCTTCTGCCCGACCGGCGCCATCTGGTGGGCGAAAGC
CGACGTGCTGCGCCGGGAGGGCACCTACCACATCCCGGCGAAGACGGGGTGGGAAATACCCTGGCAACGGGGACTGGATA
TCGACACCTATGACGACTGGGACATGGCAGAAATCCTGTTTCGTCTCGACAGCGCGGGCGGGCGCTGA

Upstream 100 bases:

>100_bases
CGGCGCCGGCTCCACGGTGGTGAGGGATATAACGGTTCCGGGAACCTATGTGGGGAGCCCGGCCAGGAGGATCAAGTGAG
AACGGGGAGGAGGCACACCG

Downstream 100 bases:

>100_bases
ACCTGCCCGTTGCCGCGGGGCCCGATGAGCGAGGGAAGACCCATTAAGACTCTGGCGCTGTACACAACCATTTATCCAGG
CGTAGAGCCCTTTCTGCCCG

Product: acylneuraminate cytidylyltransferase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MPDACIAVIPARGGSKRVPGKNIKPLMGKPLIAYTVEAAADSGLFERIVVSTDCQEIAEVAQRHGAEVPFLREASLADDI
TPVSAATVDMLVKLDPDGSTYGFVCQMMPNCPLKTSADVRDSHRQFLESGADSQLSVVRYGWQNPWWAMRRDDSFRLDPL
FREAMTQRSQDLPELFCPTGAIWWAKADVLRREGTYHIPAKTGWEIPWQRGLDIDTYDDWDMAEILFRLDSAGGR

Sequences:

>Translated_235_residues
MPDACIAVIPARGGSKRVPGKNIKPLMGKPLIAYTVEAAADSGLFERIVVSTDCQEIAEVAQRHGAEVPFLREASLADDI
TPVSAATVDMLVKLDPDGSTYGFVCQMMPNCPLKTSADVRDSHRQFLESGADSQLSVVRYGWQNPWWAMRRDDSFRLDPL
FREAMTQRSQDLPELFCPTGAIWWAKADVLRREGTYHIPAKTGWEIPWQRGLDIDTYDDWDMAEILFRLDSAGGR
>Mature_234_residues
PDACIAVIPARGGSKRVPGKNIKPLMGKPLIAYTVEAAADSGLFERIVVSTDCQEIAEVAQRHGAEVPFLREASLADDIT
PVSAATVDMLVKLDPDGSTYGFVCQMMPNCPLKTSADVRDSHRQFLESGADSQLSVVRYGWQNPWWAMRRDDSFRLDPLF
REAMTQRSQDLPELFCPTGAIWWAKADVLRREGTYHIPAKTGWEIPWQRGLDIDTYDDWDMAEILFRLDSAGGR

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=225, Percent_Identity=32.4444444444444, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 26277; Mature: 26146

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDACIAVIPARGGSKRVPGKNIKPLMGKPLIAYTVEAAADSGLFERIVVSTDCQEIAEV
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEHHHHCCCHHHHHHHCCCHHHHHHH
AQRHGAEVPFLREASLADDITPVSAATVDMLVKLDPDGSTYGFVCQMMPNCPLKTSADVR
HHHCCCCCCCEECCCCCCCCCCCHHHEEEEEEEECCCCCCEEEHEEECCCCCCCCCCCHH
DSHRQFLESGADSQLSVVRYGWQNPWWAMRRDDSFRLDPLFREAMTQRSQDLPELFCPTG
HHHHHHHHCCCCCCEEEEEECCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCHHHHCCCC
AIWWAKADVLRREGTYHIPAKTGWEIPWQRGLDIDTYDDWDMAEILFRLDSAGGR
CEEHHHHHHHHCCCCEECCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
PDACIAVIPARGGSKRVPGKNIKPLMGKPLIAYTVEAAADSGLFERIVVSTDCQEIAEV
CCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEHHHHCCCHHHHHHHCCCHHHHHHH
AQRHGAEVPFLREASLADDITPVSAATVDMLVKLDPDGSTYGFVCQMMPNCPLKTSADVR
HHHCCCCCCCEECCCCCCCCCCCHHHEEEEEEEECCCCCCEEEHEEECCCCCCCCCCCHH
DSHRQFLESGADSQLSVVRYGWQNPWWAMRRDDSFRLDPLFREAMTQRSQDLPELFCPTG
HHHHHHHHCCCCCCEEEEEECCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCHHHHCCCC
AIWWAKADVLRREGTYHIPAKTGWEIPWQRGLDIDTYDDWDMAEILFRLDSAGGR
CEEHHHHHHHHCCCCEECCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1398032; 7830552; 8113198; 8045888; 10710307 [H]