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The map label for this gene is atoC [H]

Identifier: 39997038

GI number: 39997038

Start: 2123258

End: 2124625

Strand: Reverse

Name: atoC [H]

Synonym: GSU1940

Alternate gene names: 39997038

Gene position: 2124625-2123258 (Counterclockwise)

Preceding gene: 39997039

Following gene: 39997034

Centisome position: 55.7

GC content: 58.04

Gene sequence:

>1368_bases
ATGGAAAAACTGCTGATCGTCGACGACAACGAAGATATTCGCAAACAGCTGAAATGGGGCATCGGCAAGGAGTACACGCT
GTTCCTGGCGGCCGATGCCCGGGAGGCCATTGATGTTTTTCGCAAACAGCGGCCGACGGTGGTTACCCTTGACCTGGGGC
TGCCACCCCATGAGGATAGCTCCGAGGAGGGGTTCCGCTGTCTGGAGGAGATGCTGCGCATCGCTCCCGATGTGAAGGTA
ATCGTCATTACCGGCAACGATGGCAGGGAAAACGCGGTCAAGGCGGTTCAACTGGGGGCCTACGATTTTTATCAGAAACC
GATCAATCTCGACGAGTTGAAGGTGATCGTGAAGCGGGCGTTCCACCTTCAGACGTTGGAGGAGGAGAATCGGCGCCTCC
AGAGTGCGCTGGACGGCGGCTCCACTGAATTCAGGGGGTTTGTCGGCCAATGTCCCGAGATGCAGCAGGTATTTTCCACA
ATCCGCAAGGTAGCGGCTTCCGATATCTCGGTACTGATCCACGGCGAGAGCGGCACGGGCAAGGAACTGGTGGCCCGGGC
GATCCACGCCATGAGTCTGCGCAAGGACGGGCCGTTTATTCCCATCAACTGTGGCGCCATCCCTGAAAACCTTCTGGAGG
CGGAGCTCTTCGGACACGAGAAGGGGGCGTTCACCGGCGCCCTCAATCGAGTGCTGGGGAAGGTCGAGTACGCCCACAAA
GGGACCCTGTTCCTCGACGAAATCGGAGAGTTACCGCTTAATCTTCAGGTAAAGCTTTTACGTTTTCTGCAGGAGAAGGT
TATCCAGCGGGTCGGCGGCAGGGAGGACATCGCCGTTGATGCCCGGATCGTGGCTGCCACTAATGTTGACATCGCCCGCT
CCATGGCCGAGGGGACCTTCAGGGAAGACCTGTTCTACCGGATCGGTGTGGTTTCCATCACCCTGCCTCCCCTCAGAAGC
CGGGGAGAAGATGTAATGCTCCTGGCGAATCTGTTCCTGAAACGATTTTCGATTGAGTTGCGCAAGAAGACCAAGGGGTT
CAGCTCAACATCGCGTGAATATCTCGAAGCCTACGCCTGGCCCGGCAACGTGCGGGAGTTGGAGAACAAGGTCCAGCGGG
CCGTGCTCATGGCAGCGTCGCCGATTATCGAGCCGGATGACCTGGGATTCACCGAACGGCCGATACCGAGGGCATCCACA
TCGCTGGAGGGCGTATCGCTCCGTGAGGCACGGGATCGAGTTGAGCGTGAGATGGTACGCGAGGCCATATCAAGGTGCAA
GGGGAACATTGCCCGAGCAGCCGAGGAGTTGGGGATCAGCCGGCCAACTATCTACGACCTGATGAAAAAACACGGGATAA
GTGGGTAA

Upstream 100 bases:

>100_bases
CGCCGGATCGTGGAGGCACACGGCGGGAGAATAGACGTGGAGAGTACGCCCGGACAGGGTGCGATGTTTACGGTGTGGTT
GTAAGGGGGTAGGAGATTCC

Downstream 100 bases:

>100_bases
GAGGGATGTCAGGTCAGGGGTGCATTGACAGGGGCTCTTTCTTTTTGTCGCCTGCGGCCCGAGACCCGTTACCGGTTTTA
CCTTTAGGTTCATGGCCGGT

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MEKLLIVDDNEDIRKQLKWGIGKEYTLFLAADAREAIDVFRKQRPTVVTLDLGLPPHEDSSEEGFRCLEEMLRIAPDVKV
IVITGNDGRENAVKAVQLGAYDFYQKPINLDELKVIVKRAFHLQTLEEENRRLQSALDGGSTEFRGFVGQCPEMQQVFST
IRKVAASDISVLIHGESGTGKELVARAIHAMSLRKDGPFIPINCGAIPENLLEAELFGHEKGAFTGALNRVLGKVEYAHK
GTLFLDEIGELPLNLQVKLLRFLQEKVIQRVGGREDIAVDARIVAATNVDIARSMAEGTFREDLFYRIGVVSITLPPLRS
RGEDVMLLANLFLKRFSIELRKKTKGFSSTSREYLEAYAWPGNVRELENKVQRAVLMAASPIIEPDDLGFTERPIPRAST
SLEGVSLREARDRVEREMVREAISRCKGNIARAAEELGISRPTIYDLMKKHGISG

Sequences:

>Translated_455_residues
MEKLLIVDDNEDIRKQLKWGIGKEYTLFLAADAREAIDVFRKQRPTVVTLDLGLPPHEDSSEEGFRCLEEMLRIAPDVKV
IVITGNDGRENAVKAVQLGAYDFYQKPINLDELKVIVKRAFHLQTLEEENRRLQSALDGGSTEFRGFVGQCPEMQQVFST
IRKVAASDISVLIHGESGTGKELVARAIHAMSLRKDGPFIPINCGAIPENLLEAELFGHEKGAFTGALNRVLGKVEYAHK
GTLFLDEIGELPLNLQVKLLRFLQEKVIQRVGGREDIAVDARIVAATNVDIARSMAEGTFREDLFYRIGVVSITLPPLRS
RGEDVMLLANLFLKRFSIELRKKTKGFSSTSREYLEAYAWPGNVRELENKVQRAVLMAASPIIEPDDLGFTERPIPRAST
SLEGVSLREARDRVEREMVREAISRCKGNIARAAEELGISRPTIYDLMKKHGISG
>Mature_455_residues
MEKLLIVDDNEDIRKQLKWGIGKEYTLFLAADAREAIDVFRKQRPTVVTLDLGLPPHEDSSEEGFRCLEEMLRIAPDVKV
IVITGNDGRENAVKAVQLGAYDFYQKPINLDELKVIVKRAFHLQTLEEENRRLQSALDGGSTEFRGFVGQCPEMQQVFST
IRKVAASDISVLIHGESGTGKELVARAIHAMSLRKDGPFIPINCGAIPENLLEAELFGHEKGAFTGALNRVLGKVEYAHK
GTLFLDEIGELPLNLQVKLLRFLQEKVIQRVGGREDIAVDARIVAATNVDIARSMAEGTFREDLFYRIGVVSITLPPLRS
RGEDVMLLANLFLKRFSIELRKKTKGFSSTSREYLEAYAWPGNVRELENKVQRAVLMAASPIIEPDDLGFTERPIPRAST
SLEGVSLREARDRVEREMVREAISRCKGNIARAAEELGISRPTIYDLMKKHGISG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=459, Percent_Identity=44.0087145969499, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1790437, Length=450, Percent_Identity=41.5555555555556, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1788905, Length=449, Percent_Identity=37.8619153674833, Blast_Score=294, Evalue=9e-81,
Organism=Escherichia coli, GI1790299, Length=473, Percent_Identity=37.2093023255814, Blast_Score=288, Evalue=7e-79,
Organism=Escherichia coli, GI87082152, Length=334, Percent_Identity=43.7125748502994, Blast_Score=255, Evalue=4e-69,
Organism=Escherichia coli, GI87082117, Length=374, Percent_Identity=39.8395721925134, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789233, Length=358, Percent_Identity=42.7374301675978, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1789087, Length=335, Percent_Identity=41.4925373134328, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1786524, Length=324, Percent_Identity=42.2839506172839, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI87081872, Length=319, Percent_Identity=42.0062695924765, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI1787583, Length=331, Percent_Identity=34.7432024169184, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI87081858, Length=338, Percent_Identity=32.8402366863905, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1789828, Length=323, Percent_Identity=31.8885448916409, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50882; Mature: 50882

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLLIVDDNEDIRKQLKWGIGKEYTLFLAADAREAIDVFRKQRPTVVTLDLGLPPHEDS
CCCEEEEECCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCC
SEEGFRCLEEMLRIAPDVKVIVITGNDGRENAVKAVQLGAYDFYQKPINLDELKVIVKRA
CHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHH
FHLQTLEEENRRLQSALDGGSTEFRGFVGQCPEMQQVFSTIRKVAASDISVLIHGESGTG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCC
KELVARAIHAMSLRKDGPFIPINCGAIPENLLEAELFGHEKGAFTGALNRVLGKVEYAHK
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
GTLFLDEIGELPLNLQVKLLRFLQEKVIQRVGGREDIAVDARIVAATNVDIARSMAEGTF
CCEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECEEEEEECCHHHHHHHHHCHH
REDLFYRIGVVSITLPPLRSRGEDVMLLANLFLKRFSIELRKKTKGFSSTSREYLEAYAW
HHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
PGNVRELENKVQRAVLMAASPIIEPDDLGFTERPIPRASTSLEGVSLREARDRVEREMVR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EAISRCKGNIARAAEELGISRPTIYDLMKKHGISG
HHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MEKLLIVDDNEDIRKQLKWGIGKEYTLFLAADAREAIDVFRKQRPTVVTLDLGLPPHEDS
CCCEEEEECCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCC
SEEGFRCLEEMLRIAPDVKVIVITGNDGRENAVKAVQLGAYDFYQKPINLDELKVIVKRA
CHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHH
FHLQTLEEENRRLQSALDGGSTEFRGFVGQCPEMQQVFSTIRKVAASDISVLIHGESGTG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCC
KELVARAIHAMSLRKDGPFIPINCGAIPENLLEAELFGHEKGAFTGALNRVLGKVEYAHK
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
GTLFLDEIGELPLNLQVKLLRFLQEKVIQRVGGREDIAVDARIVAATNVDIARSMAEGTF
CCEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECEEEEEECCHHHHHHHHHCHH
REDLFYRIGVVSITLPPLRSRGEDVMLLANLFLKRFSIELRKKTKGFSSTSREYLEAYAW
HHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
PGNVRELENKVQRAVLMAASPIIEPDDLGFTERPIPRASTSLEGVSLREARDRVEREMVR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EAISRCKGNIARAAEELGISRPTIYDLMKKHGISG
HHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]