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The map label for this gene is nadC [H]

Identifier: 39997034

GI number: 39997034

Start: 2117756

End: 2118586

Strand: Reverse

Name: nadC [H]

Synonym: GSU1936

Alternate gene names: 39997034

Gene position: 2118586-2117756 (Counterclockwise)

Preceding gene: 39997038

Following gene: 39997033

Centisome position: 55.55

GC content: 62.33

Gene sequence:

>831_bases
ATGACCGGTCTTGATCCCATTATCGACAACGCCCTCCAGGAAGATATCCATACCGGCGACATCACGACCCTTTCCGTAGT
CCCTGAGCCCCGTCCGGCCCGCGCCCGCCTGATTGCCAAGGAGCCGCTCGTTCTGGCTGGCATCGGTGTGGCTGCCCGCG
TTTTCCATCGCCTCGATCCGGCAATCAGGTTCGATGCCCGTTTCCCCGATGGCGCACGGGTAGAGACGGGTACACTGCTC
GCCGAGATGGCCGGTGATTCGGCTATGCTGTTGCAGGGTGAGCGGGTGGCACTCAATCTTCTTCAGCGCATGTGCGGCAT
TGCAACGCTTACCGCCCGTTATGTGGAGGCGGTGGCCGGAACCGGCGCCCGTATTGTAGACACCCGCAAGACCATGCCGG
GACTTCGAGTTCTGGACAAGCACGCGGTGCGCCTTGGCGGGGGCATCAACCACCGGACCGGCCTGTACGACGGTGTTCTC
ATCAAGGAAAACCATATTGCCGCTGCCGGCGGGATTACCGAAGCGGTCCGCCGGGCCCGGGCCTACATCCCCCACACCAT
GAAGATCGAGGTGGAAACCGAATGCCTTGAAGAGGTTGCCGAGGCACTGGAGGCCGGGGCCGACATCATTATGCTGGACA
ACATGGACCTGGATGCCATGCGCAGGGCGGTCGGCCTCATCGCAGGCCGGGCTCTGGTGGAAGCGTCGGGAGGGGTAAAC
CTGGAGACGGTGCGGGGAATAGCCGAAACCGGTGTCGATATTATTTCGGTGGGAGCATTGACCCACTCGGCGCGTGCCAT
GGACATCTCCATGCTGTTGGAGGCCGAGTGA

Upstream 100 bases:

>100_bases
GCGCCCTCTTTGCGGTTGCGGGGTTCCGCGTCCTGTGCTATATAAGGCTCAATTTACCTGCGTGTCTGAAGCGCGCGGAG
CCCAAGCGAGGTACTCCGGC

Downstream 100 bases:

>100_bases
GCGGAGAGCGCCCACGCCCTGCCGAGGCGACCGAGCGGGACATGGATCGGAAGATCCTGGAGCTGTTCCGGAGCCGTTCG
GGGGGGGTCGTCTCCGGTGA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTGLDPIIDNALQEDIHTGDITTLSVVPEPRPARARLIAKEPLVLAGIGVAARVFHRLDPAIRFDARFPDGARVETGTLL
AEMAGDSAMLLQGERVALNLLQRMCGIATLTARYVEAVAGTGARIVDTRKTMPGLRVLDKHAVRLGGGINHRTGLYDGVL
IKENHIAAAGGITEAVRRARAYIPHTMKIEVETECLEEVAEALEAGADIIMLDNMDLDAMRRAVGLIAGRALVEASGGVN
LETVRGIAETGVDIISVGALTHSARAMDISMLLEAE

Sequences:

>Translated_276_residues
MTGLDPIIDNALQEDIHTGDITTLSVVPEPRPARARLIAKEPLVLAGIGVAARVFHRLDPAIRFDARFPDGARVETGTLL
AEMAGDSAMLLQGERVALNLLQRMCGIATLTARYVEAVAGTGARIVDTRKTMPGLRVLDKHAVRLGGGINHRTGLYDGVL
IKENHIAAAGGITEAVRRARAYIPHTMKIEVETECLEEVAEALEAGADIIMLDNMDLDAMRRAVGLIAGRALVEASGGVN
LETVRGIAETGVDIISVGALTHSARAMDISMLLEAE
>Mature_275_residues
TGLDPIIDNALQEDIHTGDITTLSVVPEPRPARARLIAKEPLVLAGIGVAARVFHRLDPAIRFDARFPDGARVETGTLLA
EMAGDSAMLLQGERVALNLLQRMCGIATLTARYVEAVAGTGARIVDTRKTMPGLRVLDKHAVRLGGGINHRTGLYDGVLI
KENHIAAAGGITEAVRRARAYIPHTMKIEVETECLEEVAEALEAGADIIMLDNMDLDAMRRAVGLIAGRALVEASGGVNL
ETVRGIAETGVDIISVGALTHSARAMDISMLLEAE

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=275, Percent_Identity=37.0909090909091, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1786299, Length=269, Percent_Identity=46.0966542750929, Blast_Score=187, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6321162, Length=278, Percent_Identity=33.8129496402878, Blast_Score=151, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29350; Mature: 29219

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGLDPIIDNALQEDIHTGDITTLSVVPEPRPARARLIAKEPLVLAGIGVAARVFHRLDP
CCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHEEEECCCEEEECHHHHHHHHHHCCC
AIRFDARFPDGARVETGTLLAEMAGDSAMLLQGERVALNLLQRMCGIATLTARYVEAVAG
CEEEECCCCCCCEEEHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGARIVDTRKTMPGLRVLDKHAVRLGGGINHRTGLYDGVLIKENHIAAAGGITEAVRRAR
CCCEEEECHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEECCCHHHHHHHHH
AYIPHTMKIEVETECLEEVAEALEAGADIIMLDNMDLDAMRRAVGLIAGRALVEASGGVN
HHCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHEECCCCCC
LETVRGIAETGVDIISVGALTHSARAMDISMLLEAE
HHHHHHHHHCCCCEEEECHHHHCCHHEEEEEEEECC
>Mature Secondary Structure 
TGLDPIIDNALQEDIHTGDITTLSVVPEPRPARARLIAKEPLVLAGIGVAARVFHRLDP
CCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHEEEECCCEEEECHHHHHHHHHHCCC
AIRFDARFPDGARVETGTLLAEMAGDSAMLLQGERVALNLLQRMCGIATLTARYVEAVAG
CEEEECCCCCCCEEEHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGARIVDTRKTMPGLRVLDKHAVRLGGGINHRTGLYDGVLIKENHIAAAGGITEAVRRAR
CCCEEEECHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEECCCHHHHHHHHH
AYIPHTMKIEVETECLEEVAEALEAGADIIMLDNMDLDAMRRAVGLIAGRALVEASGGVN
HHCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHEECCCCCC
LETVRGIAETGVDIISVGALTHSARAMDISMLLEAE
HHHHHHHHHCCCCEEEECHHHHCCHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]