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The map label for this gene is uppS

Identifier: 39997015

GI number: 39997015

Start: 2096378

End: 2097118

Strand: Reverse

Name: uppS

Synonym: GSU1917

Alternate gene names: 39997015

Gene position: 2097118-2096378 (Counterclockwise)

Preceding gene: 39997016

Following gene: 39997014

Centisome position: 54.98

GC content: 56.68

Gene sequence:

>741_bases
ATGCACGGCCTCATACCCGATAAACTCCCCAGGCACTTGGCCATTATCATGGACGGTAACGGCCGCTGGGCTCAGGAACG
GATGCTCACGCGGATCATCGGCCACCAGAAAGGGGTGGAAACGGTCAGGATCATCGTCGAGGAGTGTTCCCGGCTCGGTA
TCGGATATCTGACGCTATTCGCTTTTTCAGCTGAGAACTGGCTTCGGCCAAAAACCGAGGTCAAGGCGCTGATGGCCCTG
CTGAAGAAGTACATTGCATCTGAGGCTGCGCGGATGGATGCGAACAATATCCGGTTTAATGTCATCGGCAACCGTGATGA
ACTGCCGCCGGATGTGAATAAAGCCGTTCAGGGAGCAATCGACCGGACCAGCGGCAATACCGGTATGATCCTTACTCTGG
CACTTTCCTACGGCGCGCGCCAGGAGATCATGACGGCGGCTACGCGGATAGCCTCCGATATTGCTTCCGGCGTGCTCAAG
GCCGATGATCTCAGTGAGACTGCCTTTGCCTCGTATCTGTTCACCAGCGGGCTCCCTGATCCCGATTTTCTCATCCGCAC
GAGCGGAGAGATGAGGATCAGCAATTTTCTTCTTTGGCAGCTGGCCTATACGGAGTTCTACTTCTCCTCGGTCAACTGGC
CAGAATTCACGCCGGAGGAACTGTACCGGGCATTGAGCGATTACCAGGCCCGCGAGCGGCGTTTCGGTCGCACAAGCGCC
CAGATCAACACGAGGAGCTAG

Upstream 100 bases:

>100_bases
AACCTGTTAATTTCGTTTTTTTCCTTGCGCCCATACTGCTTTTATGGTTTAATCCCCTTTAACCCCTCGTTTAAAGGGGA
TTTTTTGTTTCTGGTGACAT

Downstream 100 bases:

>100_bases
CCATTAAGCGCGTCATTACTGGAGCAATTGCCCTCCCTCTGCTGATTCTGTTCGTCCTCAAGGCGAGCTATGTTCTTTTT
GCATCGTTCGTCGTTGTTCT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MHGLIPDKLPRHLAIIMDGNGRWAQERMLTRIIGHQKGVETVRIIVEECSRLGIGYLTLFAFSAENWLRPKTEVKALMAL
LKKYIASEAARMDANNIRFNVIGNRDELPPDVNKAVQGAIDRTSGNTGMILTLALSYGARQEIMTAATRIASDIASGVLK
ADDLSETAFASYLFTSGLPDPDFLIRTSGEMRISNFLLWQLAYTEFYFSSVNWPEFTPEELYRALSDYQARERRFGRTSA
QINTRS

Sequences:

>Translated_246_residues
MHGLIPDKLPRHLAIIMDGNGRWAQERMLTRIIGHQKGVETVRIIVEECSRLGIGYLTLFAFSAENWLRPKTEVKALMAL
LKKYIASEAARMDANNIRFNVIGNRDELPPDVNKAVQGAIDRTSGNTGMILTLALSYGARQEIMTAATRIASDIASGVLK
ADDLSETAFASYLFTSGLPDPDFLIRTSGEMRISNFLLWQLAYTEFYFSSVNWPEFTPEELYRALSDYQARERRFGRTSA
QINTRS
>Mature_246_residues
MHGLIPDKLPRHLAIIMDGNGRWAQERMLTRIIGHQKGVETVRIIVEECSRLGIGYLTLFAFSAENWLRPKTEVKALMAL
LKKYIASEAARMDANNIRFNVIGNRDELPPDVNKAVQGAIDRTSGNTGMILTLALSYGARQEIMTAATRIASDIASGVLK
ADDLSETAFASYLFTSGLPDPDFLIRTSGEMRISNFLLWQLAYTEFYFSSVNWPEFTPEELYRALSDYQARERRFGRTSA
QINTRS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=35.2678571428571, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=35.2678571428571, Blast_Score=156, Evalue=1e-38,
Organism=Escherichia coli, GI1786371, Length=238, Percent_Identity=41.1764705882353, Blast_Score=194, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=35.8407079646018, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=33.0232558139535, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=223, Percent_Identity=28.6995515695067, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=37.9464285714286, Blast_Score=157, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_GEOSL (P60482)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952966.1
- ProteinModelPortal:   P60482
- SMR:   P60482
- GeneID:   2686735
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1917
- NMPDR:   fig|243231.1.peg.1904
- TIGR:   GSU1917
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14830
- BioCyc:   GSUL243231:GSU_1917-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 27689; Mature: 27689

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 18-18

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGLIPDKLPRHLAIIMDGNGRWAQERMLTRIIGHQKGVETVRIIVEECSRLGIGYLTLF
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHH
AFSAENWLRPKTEVKALMALLKKYIASEAARMDANNIRFNVIGNRDELPPDVNKAVQGAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHH
DRTSGNTGMILTLALSYGARQEIMTAATRIASDIASGVLKADDLSETAFASYLFTSGLPD
HCCCCCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
PDFLIRTSGEMRISNFLLWQLAYTEFYFSSVNWPEFTPEELYRALSDYQARERRFGRTSA
CCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
QINTRS
CEECCC
>Mature Secondary Structure
MHGLIPDKLPRHLAIIMDGNGRWAQERMLTRIIGHQKGVETVRIIVEECSRLGIGYLTLF
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHH
AFSAENWLRPKTEVKALMALLKKYIASEAARMDANNIRFNVIGNRDELPPDVNKAVQGAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHH
DRTSGNTGMILTLALSYGARQEIMTAATRIASDIASGVLKADDLSETAFASYLFTSGLPD
HCCCCCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
PDFLIRTSGEMRISNFLLWQLAYTEFYFSSVNWPEFTPEELYRALSDYQARERRFGRTSA
CCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
QINTRS
CEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA