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The map label for this gene is trpS [H]

Identifier: 39996932

GI number: 39996932

Start: 1998944

End: 1999927

Strand: Reverse

Name: trpS [H]

Synonym: GSU1833

Alternate gene names: 39996932

Gene position: 1999927-1998944 (Counterclockwise)

Preceding gene: 39996933

Following gene: 304569790

Centisome position: 52.43

GC content: 59.76

Gene sequence:

>984_bases
ATGAGCAACAAGCGGATAGTAAGCGGCATGAGACCCACCGGCAAGCTTCACCTCGGCCATTTCCACGGGGTGCTGGCAAA
CTGGCGTGAGCTTCAGGAGGAGTATGAATGTTTCTTCTTCGCCGCTGACTGGCATTCTCTCACCACCGAGTATGACAATA
CCGGCGCAATTCTCGAGAACATCCGCGAAATGGTTCTCGACTGGCTTGCCTTCGGGGTCGATCCGGCCAAAAGTGTCATA
TTCCGCCAGAGTCTCGTGCCCCAGCATGCGGAACTCAACCTGATTCTTTCCATGATTACGCCCGTGTCGTGGCTTGAGCG
CAACCCGACCTTCAAGGAAATGCAGGACAACCTTGACGCCAAGGATCTTTCCACCTTCGGCTTCCTCGGCTATCCGGTCC
TCATGGCGGCGGACATCATCCTCTACCGGGCGGCAAAGGTGCCGGTGGGACATGACCAGCTGCCCCACCTGGAGATAACC
CGCGAGATCGCCCGCCGCTTCAACTACCTCTACCGTGAAGTTTTCCCCGAACCGGCGGCGCTCCTTACGGAGACCCCCAA
GGTGCTCGGCCTCGACGGCCGAAAGATGAGCAAGTCGTACGGTAATTCCATCTATCTCTCCGAGACTGCCGAAGAGACGA
GCAAAAAAATCATGTCCATGGTGACCGACACCCAGCGGGTCCGCCGCAGCGATCCGGGCGAGCCGGACCGGTGCGTGGCA
TTCAACCTACATCGTCTCTATGTTCCCGACGACGAACGGGCCGAGATCGTCGAGTCCTGCCGTGGCGCAACGATCGGTTG
TGTGGACTGCAAGAAGATCCTTGCCCGCCATCTTGTGGAGACACTTGCGCCGTTCCGCGCCAAGCGCGTGGAACTTGCGG
CCCGTCCGGAACTGGTGGACGAGATTCTGGCCGAGGGCAGCGATCGGGCGGCCCGCGAGGCAACCGTGACCATGACCGAC
GTGCGGGACGCCATCAGACTATGA

Upstream 100 bases:

>100_bases
GGTGTACAATGTCACGCATTTTCTGATGAGATAACAGGTGCGCGGACCCGGTGGATGAAGCGATGGTCCACCGTTGTCCC
GTGCCGGTAAGGAGCCTGTA

Downstream 100 bases:

>100_bases
GTGAAGGGGAAACCCTCACACTCGGCCTTGAAGGAGCCGCCTCGCCCTATACGGTCAGGCTCGAGGTGTTCGAAGGCCCC
CTGGATCTACTCCTGCACCT

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSNKRIVSGMRPTGKLHLGHFHGVLANWRELQEEYECFFFAADWHSLTTEYDNTGAILENIREMVLDWLAFGVDPAKSVI
FRQSLVPQHAELNLILSMITPVSWLERNPTFKEMQDNLDAKDLSTFGFLGYPVLMAADIILYRAAKVPVGHDQLPHLEIT
REIARRFNYLYREVFPEPAALLTETPKVLGLDGRKMSKSYGNSIYLSETAEETSKKIMSMVTDTQRVRRSDPGEPDRCVA
FNLHRLYVPDDERAEIVESCRGATIGCVDCKKILARHLVETLAPFRAKRVELAARPELVDEILAEGSDRAAREATVTMTD
VRDAIRL

Sequences:

>Translated_327_residues
MSNKRIVSGMRPTGKLHLGHFHGVLANWRELQEEYECFFFAADWHSLTTEYDNTGAILENIREMVLDWLAFGVDPAKSVI
FRQSLVPQHAELNLILSMITPVSWLERNPTFKEMQDNLDAKDLSTFGFLGYPVLMAADIILYRAAKVPVGHDQLPHLEIT
REIARRFNYLYREVFPEPAALLTETPKVLGLDGRKMSKSYGNSIYLSETAEETSKKIMSMVTDTQRVRRSDPGEPDRCVA
FNLHRLYVPDDERAEIVESCRGATIGCVDCKKILARHLVETLAPFRAKRVELAARPELVDEILAEGSDRAAREATVTMTD
VRDAIRL
>Mature_326_residues
SNKRIVSGMRPTGKLHLGHFHGVLANWRELQEEYECFFFAADWHSLTTEYDNTGAILENIREMVLDWLAFGVDPAKSVIF
RQSLVPQHAELNLILSMITPVSWLERNPTFKEMQDNLDAKDLSTFGFLGYPVLMAADIILYRAAKVPVGHDQLPHLEITR
EIARRFNYLYREVFPEPAALLTETPKVLGLDGRKMSKSYGNSIYLSETAEETSKKIMSMVTDTQRVRRSDPGEPDRCVAF
NLHRLYVPDDERAEIVESCRGATIGCVDCKKILARHLVETLAPFRAKRVELAARPELVDEILAEGSDRAAREATVTMTDV
RDAIRL

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=332, Percent_Identity=32.8313253012048, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI41352700, Length=183, Percent_Identity=39.8907103825137, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1789786, Length=238, Percent_Identity=39.0756302521008, Blast_Score=154, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI71982800, Length=333, Percent_Identity=31.8318318318318, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71982793, Length=333, Percent_Identity=31.8318318318318, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320474, Length=345, Percent_Identity=32.1739130434783, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24666151, Length=333, Percent_Identity=34.2342342342342, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 37139; Mature: 37008

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKRIVSGMRPTGKLHLGHFHGVLANWRELQEEYECFFFAADWHSLTTEYDNTGAILEN
CCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHEEEEEECHHHHHCCCCCCHHHHHH
IREMVLDWLAFGVDPAKSVIFRQSLVPQHAELNLILSMITPVSWLERNPTFKEMQDNLDA
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCH
KDLSTFGFLGYPVLMAADIILYRAAKVPVGHDQLPHLEITREIARRFNYLYREVFPEPAA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHH
LLTETPKVLGLDGRKMSKSYGNSIYLSETAEETSKKIMSMVTDTQRVRRSDPGEPDRCVA
HHHCCCHHCCCCCHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
FNLHRLYVPDDERAEIVESCRGATIGCVDCKKILARHLVETLAPFRAKRVELAARPELVD
EEEEEEECCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
EILAEGSDRAAREATVTMTDVRDAIRL
HHHHCCCCCHHHHHEEHHHHHHHHHCC
>Mature Secondary Structure 
SNKRIVSGMRPTGKLHLGHFHGVLANWRELQEEYECFFFAADWHSLTTEYDNTGAILEN
CCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHEEEEEECHHHHHCCCCCCHHHHHH
IREMVLDWLAFGVDPAKSVIFRQSLVPQHAELNLILSMITPVSWLERNPTFKEMQDNLDA
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCH
KDLSTFGFLGYPVLMAADIILYRAAKVPVGHDQLPHLEITREIARRFNYLYREVFPEPAA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHH
LLTETPKVLGLDGRKMSKSYGNSIYLSETAEETSKKIMSMVTDTQRVRRSDPGEPDRCVA
HHHCCCHHCCCCCHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
FNLHRLYVPDDERAEIVESCRGATIGCVDCKKILARHLVETLAPFRAKRVELAARPELVD
EEEEEEECCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
EILAEGSDRAAREATVTMTDVRDAIRL
HHHHCCCCCHHHHHEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]