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The map label for this gene is dxs-2

Identifier: 39996863

GI number: 39996863

Start: 1926084

End: 1927964

Strand: Reverse

Name: dxs-2

Synonym: GSU1764

Alternate gene names: 39996863

Gene position: 1927964-1926084 (Counterclockwise)

Preceding gene: 39996864

Following gene: 39996862

Centisome position: 50.55

GC content: 62.36

Gene sequence:

>1881_bases
ATGTCTCGTATTCTCGACAGGGTAGATTCTCCCTCTGACCTGAAGGGGCTCACTACGGCCGAGTTGGGCATCCTTGCAGA
GGAGATACGGCAGGAAATCATAACCGTCTGCTCCCGCAACGGCGGTCACCTGGCGCCGAGTCTCGGCGTGGTGGAGCTTA
CTCTGGCCCTGCATAGGGTATTCACCTCGCCTGAGGATAAAATCGTCTGGGACGTGGGACACCAAGCCTATGCCCACAAA
CTCGTGACCGGCCGCCGGGACCGGTTCGCAACCCTGCGGACCCTTGGAGGGATCAGCGGCTTCCTCAAGCGGGCCGAGTC
GCCCCACGACGTGTTTGACGCCGGCCATGCCTCCACTTCCATATCCGCCGCCCTGGGGCTTGCGGCGGCCCGTGACCTCG
CCGGCAGGAACAACAAGGTAGTGGCGGTCATCGGCGACGGCTCCATGACCGGCGGTATCGCCTATGAAGGGCTCAACCAC
GCGGGGCACCTGAACCGTGATCTGGTCGTGGTTCTGAACGACAACGAGATGTCCATCGCCGAGAACGTGGGCGCTCTGTC
CAATTTTCTGAGCCGTACCGTTACCAGCGAGTTCGTTCATACCCTGAAGAAGGATGTGGAAACCTTTCTCGGGGGGCTCG
ACCGGATCGGCCGGAACGTCCTCAAGGTGGCCAAACGGGCGGAAGAGTCTCTCAAGGGACTCTTTACGCCGGGAATGCTC
TTCGAAGCCTTCGGGTTCGAGTATATCGGCCCCATCGACGGACACGACATCGGCCGCCTCACGGAAACCTTCGAAAAGGT
CAAGCGGTTCGATGATGCGGTCCTGATCCACGTTCTGACCAAAAAGGGAAAGGGGTTTGCCCCGGCCGAAGCCAAACCGT
CGCTTTTCCACGGGGTCGGCCCCTTTGACCCTGTCAGCGGCGAAATCGTAAAAGGAAAGGGCGGGGCCACCTCCTACACG
GGAGTCTTCGGCCAGGCCCTGACGCGGATTGCCGATGAAGACGAGCGGGTAGTCGCCATCACTGCGGCCATGCCCGACGG
TACGGGCCTCGGCTCCTTCTCGGCTCGCCACCCCGGTCGCTTCTTCGATGTGGGGATCGCGGAGCAGCATGGCGTAACCT
TTGCCGCCGGCCTCGCGGCCGAGGGGTACCGGCCGGTTTTCGCCATTTACTCTTCGTTCCTGCAGCGGGCCTATGACCAG
CTTTTCCACGATGTCTGCCTCATGAACCTGCCGGTGACCTTTGCCATTGACCGGTCCGGGGTCGTGGGAAGCGATGGTCC
GACCCACCACGGGCTCTTTGACCTGTCCTACCTGCGTACCCTGCCCAACATGGTCGTAATGGCCCCCAAGGATGAAAACG
AGCTGCAACACATGCTCAAGACCGCCATCGACCATAATGGCCCCGCAGCGGTCCGCTATCCCCGCGGCAATGGGCTCGGC
GTGCCCCTTGACCAGTCGCTGGCTCCGATCCCCCTGGGCACGTCGGAAGTGCTGCGTGCCGGCAGCGGCACCTGTGTGGT
TCTGGCGGTCGGCGCCATGGTCGGGCCCGCCCTCGAAGCGGCTAACACCCTTGAAGGCGAGGGCATTGACCTGACCGTGG
TCAACGTCCGTTTTGTGAAACCCCTCGACCGGGAGCTTATCCTGTCGTACGTCGGCCGGGCCGGAACGCTGGTGACTATT
GAGGAAAACGTCCTTCAAGGGGGCTTTGGTTCAGCCGTGCTCGAACTGCTTGCCGATGAAGGAGTAGGAGGCGTTGCCGT
GCACCGGTTCGGCTACCCCGACCGGTATGTGGAGCAGGGTGAACAACATGAACTGCGGTCACGCTACGGCCTCGATGCCG
AGGGGATTGCCGGACGGATCAGGACGTTGTCCGCGCGCTAG

Upstream 100 bases:

>100_bases
AGGAACTTCTCGATCTCGCCATTGAGGCCCTTTCGCCCTTTGACCACCGGGCTGACCCCCTTCGGGAAATCGCCCGGTAC
ATCGTGTCACGGAAATCATG

Downstream 100 bases:

>100_bases
ATGCGGATCAATTTCTCCTACCGGGAACAACGGTTGGGCTGACCATGCGTTTAGGGCCACCATCTATGGGGGCAGCCGAT
GAAATACGTAGATCTCGTCA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase 2; DXP synthase 2; DXPS 2

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MSRILDRVDSPSDLKGLTTAELGILAEEIRQEIITVCSRNGGHLAPSLGVVELTLALHRVFTSPEDKIVWDVGHQAYAHK
LVTGRRDRFATLRTLGGISGFLKRAESPHDVFDAGHASTSISAALGLAAARDLAGRNNKVVAVIGDGSMTGGIAYEGLNH
AGHLNRDLVVVLNDNEMSIAENVGALSNFLSRTVTSEFVHTLKKDVETFLGGLDRIGRNVLKVAKRAEESLKGLFTPGML
FEAFGFEYIGPIDGHDIGRLTETFEKVKRFDDAVLIHVLTKKGKGFAPAEAKPSLFHGVGPFDPVSGEIVKGKGGATSYT
GVFGQALTRIADEDERVVAITAAMPDGTGLGSFSARHPGRFFDVGIAEQHGVTFAAGLAAEGYRPVFAIYSSFLQRAYDQ
LFHDVCLMNLPVTFAIDRSGVVGSDGPTHHGLFDLSYLRTLPNMVVMAPKDENELQHMLKTAIDHNGPAAVRYPRGNGLG
VPLDQSLAPIPLGTSEVLRAGSGTCVVLAVGAMVGPALEAANTLEGEGIDLTVVNVRFVKPLDRELILSYVGRAGTLVTI
EENVLQGGFGSAVLELLADEGVGGVAVHRFGYPDRYVEQGEQHELRSRYGLDAEGIAGRIRTLSAR

Sequences:

>Translated_626_residues
MSRILDRVDSPSDLKGLTTAELGILAEEIRQEIITVCSRNGGHLAPSLGVVELTLALHRVFTSPEDKIVWDVGHQAYAHK
LVTGRRDRFATLRTLGGISGFLKRAESPHDVFDAGHASTSISAALGLAAARDLAGRNNKVVAVIGDGSMTGGIAYEGLNH
AGHLNRDLVVVLNDNEMSIAENVGALSNFLSRTVTSEFVHTLKKDVETFLGGLDRIGRNVLKVAKRAEESLKGLFTPGML
FEAFGFEYIGPIDGHDIGRLTETFEKVKRFDDAVLIHVLTKKGKGFAPAEAKPSLFHGVGPFDPVSGEIVKGKGGATSYT
GVFGQALTRIADEDERVVAITAAMPDGTGLGSFSARHPGRFFDVGIAEQHGVTFAAGLAAEGYRPVFAIYSSFLQRAYDQ
LFHDVCLMNLPVTFAIDRSGVVGSDGPTHHGLFDLSYLRTLPNMVVMAPKDENELQHMLKTAIDHNGPAAVRYPRGNGLG
VPLDQSLAPIPLGTSEVLRAGSGTCVVLAVGAMVGPALEAANTLEGEGIDLTVVNVRFVKPLDRELILSYVGRAGTLVTI
EENVLQGGFGSAVLELLADEGVGGVAVHRFGYPDRYVEQGEQHELRSRYGLDAEGIAGRIRTLSAR
>Mature_625_residues
SRILDRVDSPSDLKGLTTAELGILAEEIRQEIITVCSRNGGHLAPSLGVVELTLALHRVFTSPEDKIVWDVGHQAYAHKL
VTGRRDRFATLRTLGGISGFLKRAESPHDVFDAGHASTSISAALGLAAARDLAGRNNKVVAVIGDGSMTGGIAYEGLNHA
GHLNRDLVVVLNDNEMSIAENVGALSNFLSRTVTSEFVHTLKKDVETFLGGLDRIGRNVLKVAKRAEESLKGLFTPGMLF
EAFGFEYIGPIDGHDIGRLTETFEKVKRFDDAVLIHVLTKKGKGFAPAEAKPSLFHGVGPFDPVSGEIVKGKGGATSYTG
VFGQALTRIADEDERVVAITAAMPDGTGLGSFSARHPGRFFDVGIAEQHGVTFAAGLAAEGYRPVFAIYSSFLQRAYDQL
FHDVCLMNLPVTFAIDRSGVVGSDGPTHHGLFDLSYLRTLPNMVVMAPKDENELQHMLKTAIDHNGPAAVRYPRGNGLGV
PLDQSLAPIPLGTSEVLRAGSGTCVVLAVGAMVGPALEAANTLEGEGIDLTVVNVRFVKPLDRELILSYVGRAGTLVTIE
ENVLQGGFGSAVLELLADEGVGGVAVHRFGYPDRYVEQGEQHELRSRYGLDAEGIAGRIRTLSAR

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=423, Percent_Identity=27.1867612293144, Blast_Score=123, Evalue=7e-28,
Organism=Homo sapiens, GI4507521, Length=423, Percent_Identity=27.1867612293144, Blast_Score=123, Evalue=7e-28,
Organism=Homo sapiens, GI225637463, Length=307, Percent_Identity=28.9902280130293, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI225637461, Length=307, Percent_Identity=28.9902280130293, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI225637459, Length=307, Percent_Identity=28.9902280130293, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI133778974, Length=673, Percent_Identity=24.2199108469539, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI156564403, Length=234, Percent_Identity=28.6324786324786, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI291084858, Length=226, Percent_Identity=28.7610619469027, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786622, Length=619, Percent_Identity=47.9806138933764, Blast_Score=585, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI17539652, Length=432, Percent_Identity=27.7777777777778, Blast_Score=108, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325331, Length=282, Percent_Identity=26.9503546099291, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45551847, Length=625, Percent_Identity=25.44, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI45550715, Length=625, Percent_Identity=25.44, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24645119, Length=581, Percent_Identity=25.8175559380379, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24666278, Length=549, Percent_Identity=26.0473588342441, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21358145, Length=235, Percent_Identity=26.3829787234043, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24650940, Length=235, Percent_Identity=26.3829787234043, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS2_GEOSL (Q74CB0)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952814.1
- ProteinModelPortal:   Q74CB0
- GeneID:   2686761
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1764
- NMPDR:   fig|243231.1.peg.1752
- TIGR:   GSU1764
- HOGENOM:   HBG571647
- OMA:   GKEELEN
- ProtClustDB:   PRK05444
- BioCyc:   GSUL243231:GSU_1764-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 66832; Mature: 66701

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRILDRVDSPSDLKGLTTAELGILAEEIRQEIITVCSRNGGHLAPSLGVVELTLALHRV
CCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
FTSPEDKIVWDVGHQAYAHKLVTGRRDRFATLRTLGGISGFLKRAESPHDVFDAGHASTS
HCCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHH
ISAALGLAAARDLAGRNNKVVAVIGDGSMTGGIAYEGLNHAGHLNRDLVVVLNDNEMSIA
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCCEEEEECCCCHHHH
ENVGALSNFLSRTVTSEFVHTLKKDVETFLGGLDRIGRNVLKVAKRAEESLKGLFTPGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FEAFGFEYIGPIDGHDIGRLTETFEKVKRFDDAVLIHVLTKKGKGFAPAEAKPSLFHGVG
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHEEEEEECCCCCCCCCCCCCCCHHCCCC
PFDPVSGEIVKGKGGATSYTGVFGQALTRIADEDERVVAITAAMPDGTGLGSFSARHPGR
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCC
FFDVGIAEQHGVTFAAGLAAEGYRPVFAIYSSFLQRAYDQLFHDVCLMNLPVTFAIDRSG
EEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VVGSDGPTHHGLFDLSYLRTLPNMVVMAPKDENELQHMLKTAIDHNGPAAVRYPRGNGLG
CCCCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
VPLDQSLAPIPLGTSEVLRAGSGTCVVLAVGAMVGPALEAANTLEGEGIDLTVVNVRFVK
CCCCCCCCCCCCCHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEEEEEEEEECC
PLDRELILSYVGRAGTLVTIEENVLQGGFGSAVLELLADEGVGGVAVHRFGYPDRYVEQG
CCCHHHHHHHHCCCCEEEEEEHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHCC
EQHELRSRYGLDAEGIAGRIRTLSAR
HHHHHHHHCCCCHHHHHHHHEEECCC
>Mature Secondary Structure 
SRILDRVDSPSDLKGLTTAELGILAEEIRQEIITVCSRNGGHLAPSLGVVELTLALHRV
CHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
FTSPEDKIVWDVGHQAYAHKLVTGRRDRFATLRTLGGISGFLKRAESPHDVFDAGHASTS
HCCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHH
ISAALGLAAARDLAGRNNKVVAVIGDGSMTGGIAYEGLNHAGHLNRDLVVVLNDNEMSIA
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCCEEEEECCCCHHHH
ENVGALSNFLSRTVTSEFVHTLKKDVETFLGGLDRIGRNVLKVAKRAEESLKGLFTPGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FEAFGFEYIGPIDGHDIGRLTETFEKVKRFDDAVLIHVLTKKGKGFAPAEAKPSLFHGVG
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHEEEEEECCCCCCCCCCCCCCCHHCCCC
PFDPVSGEIVKGKGGATSYTGVFGQALTRIADEDERVVAITAAMPDGTGLGSFSARHPGR
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCC
FFDVGIAEQHGVTFAAGLAAEGYRPVFAIYSSFLQRAYDQLFHDVCLMNLPVTFAIDRSG
EEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VVGSDGPTHHGLFDLSYLRTLPNMVVMAPKDENELQHMLKTAIDHNGPAAVRYPRGNGLG
CCCCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
VPLDQSLAPIPLGTSEVLRAGSGTCVVLAVGAMVGPALEAANTLEGEGIDLTVVNVRFVK
CCCCCCCCCCCCCHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEEEEEEEEECC
PLDRELILSYVGRAGTLVTIEENVLQGGFGSAVLELLADEGVGGVAVHRFGYPDRYVEQG
CCCHHHHHHHHCCCCEEEEEEHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHCC
EQHELRSRYGLDAEGIAGRIRTLSAR
HHHHHHHHCCCCHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA