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The map label for this gene is ispA [C]

Identifier: 39996864

GI number: 39996864

Start: 1927964

End: 1928857

Strand: Reverse

Name: ispA [C]

Synonym: GSU1765

Alternate gene names: 39996864

Gene position: 1928857-1927964 (Counterclockwise)

Preceding gene: 39996865

Following gene: 39996863

Centisome position: 50.57

GC content: 61.74

Gene sequence:

>894_bases
ATGGATCTGAAAGGTTATCTTAAAGAACGCTGTGCCTTGGTGGACGAGGCTCTGGAGCGCCATCTGCCGGCTGAAGACGA
GCTCCCGTCTTCGGTGCACCGCGCCATGCGTTATTCGGTATTTGCCGGTGGGAAACGGGTCCGCCCGATCCTGATGCTGG
CAGCCTGCGATGCCGTGGGCGGCGATACGGCGCTGGCCCTGCCGGCGGCCTGCGCCATGGAGATGATCCATACCTACTCT
CTCATCCACGATGACCTGCCGGCAATGGATGACGATGATTTCCGCCGCGGGCGGCCGACGAACCACAAGGTATTCGGCGA
AGCCATTGCCATCCTTGCCGGCGATGCCCTGCTTACCGAGGCGTTCATCCTCATCAGCTCTCCCTCCTATGCTGCCGCGG
TTGGAAGCGATCGACTCCTGCCGGTTATTCACGAGATCGCCCTCTGTGCCGGTTCGCGGGGAATGGTCGGCGGGCAGGTG
GTCGACATGGAGAGCGAGGGGAACAAAGAGATCGATCTGGCAACAGTCCAATATATCCACACCCGCAAGACCGGTGCGCT
GATCAAGGCCTCCATCAAGGCGGGAGCAGTACTGGGGGGAGCCAACGCGGACGCGGTCAAGGCCGTGACACGCTACGGCG
AAGCCATTGGCCTGGCGTTCCAGATCGCCGACGATATCCTCGATATCGAGGGAACAACCGAGCAGATCGGCAAGGACGCG
GGCAGTGATGAAGCTCGGGGGAAAGCCACCTATCCGGCCGTGCTGGGCCTGGCTGAATCCAAGCGGCGCGCCCAGGAACT
TCTCGATCTCGCCATTGAGGCCCTTTCGCCCTTTGACCACCGGGCTGACCCCCTTCGGGAAATCGCCCGGTACATCGTGT
CACGGAAATCATGA

Upstream 100 bases:

>100_bases
CTCAAAAAGAAGGACGGCACGTTCGTGCGCGAAGACTTCCGGCTGGATGACGAATAGTCCGGTTCCGCGTGCGTGCATTT
TTACGTGAAAGGATGGTCCG

Downstream 100 bases:

>100_bases
TGTCTCGTATTCTCGACAGGGTAGATTCTCCCTCTGACCTGAAGGGGCTCACTACGGCCGAGTTGGGCATCCTTGCAGAG
GAGATACGGCAGGAAATCAT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MDLKGYLKERCALVDEALERHLPAEDELPSSVHRAMRYSVFAGGKRVRPILMLAACDAVGGDTALALPAACAMEMIHTYS
LIHDDLPAMDDDDFRRGRPTNHKVFGEAIAILAGDALLTEAFILISSPSYAAAVGSDRLLPVIHEIALCAGSRGMVGGQV
VDMESEGNKEIDLATVQYIHTRKTGALIKASIKAGAVLGGANADAVKAVTRYGEAIGLAFQIADDILDIEGTTEQIGKDA
GSDEARGKATYPAVLGLAESKRRAQELLDLAIEALSPFDHRADPLREIARYIVSRKS

Sequences:

>Translated_297_residues
MDLKGYLKERCALVDEALERHLPAEDELPSSVHRAMRYSVFAGGKRVRPILMLAACDAVGGDTALALPAACAMEMIHTYS
LIHDDLPAMDDDDFRRGRPTNHKVFGEAIAILAGDALLTEAFILISSPSYAAAVGSDRLLPVIHEIALCAGSRGMVGGQV
VDMESEGNKEIDLATVQYIHTRKTGALIKASIKAGAVLGGANADAVKAVTRYGEAIGLAFQIADDILDIEGTTEQIGKDA
GSDEARGKATYPAVLGLAESKRRAQELLDLAIEALSPFDHRADPLREIARYIVSRKS
>Mature_297_residues
MDLKGYLKERCALVDEALERHLPAEDELPSSVHRAMRYSVFAGGKRVRPILMLAACDAVGGDTALALPAACAMEMIHTYS
LIHDDLPAMDDDDFRRGRPTNHKVFGEAIAILAGDALLTEAFILISSPSYAAAVGSDRLLPVIHEIALCAGSRGMVGGQV
VDMESEGNKEIDLATVQYIHTRKTGALIKASIKAGAVLGGANADAVKAVTRYGEAIGLAFQIADDILDIEGTTEQIGKDA
GSDEARGKATYPAVLGLAESKRRAQELLDLAIEALSPFDHRADPLREIARYIVSRKS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=233, Percent_Identity=32.618025751073, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786623, Length=300, Percent_Identity=42.6666666666667, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789578, Length=236, Percent_Identity=31.7796610169492, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17505681, Length=301, Percent_Identity=27.5747508305648, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24651612, Length=223, Percent_Identity=32.7354260089686, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31723; Mature: 31723

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKGYLKERCALVDEALERHLPAEDELPSSVHRAMRYSVFAGGKRVRPILMLAACDAVG
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
GDTALALPAACAMEMIHTYSLIHDDLPAMDDDDFRRGRPTNHKVFGEAIAILAGDALLTE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCHHHHHH
AFILISSPSYAAAVGSDRLLPVIHEIALCAGSRGMVGGQVVDMESEGNKEIDLATVQYIH
HHHEEECCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEHHHHHHHH
TRKTGALIKASIKAGAVLGGANADAVKAVTRYGEAIGLAFQIADDILDIEGTTEQIGKDA
HCCCCHHEEEHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCC
GSDEARGKATYPAVLGLAESKRRAQELLDLAIEALSPFDHRADPLREIARYIVSRKS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDLKGYLKERCALVDEALERHLPAEDELPSSVHRAMRYSVFAGGKRVRPILMLAACDAVG
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
GDTALALPAACAMEMIHTYSLIHDDLPAMDDDDFRRGRPTNHKVFGEAIAILAGDALLTE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCHHHHHH
AFILISSPSYAAAVGSDRLLPVIHEIALCAGSRGMVGGQVVDMESEGNKEIDLATVQYIH
HHHEEECCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEHHHHHHHH
TRKTGALIKASIKAGAVLGGANADAVKAVTRYGEAIGLAFQIADDILDIEGTTEQIGKDA
HCCCCHHEEEHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCC
GSDEARGKATYPAVLGLAESKRRAQELLDLAIEALSPFDHRADPLREIARYIVSRKS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]