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The map label for this gene is pyrD [H]

Identifier: 39996854

GI number: 39996854

Start: 1918043

End: 1918960

Strand: Reverse

Name: pyrD [H]

Synonym: GSU1755

Alternate gene names: 39996854

Gene position: 1918960-1918043 (Counterclockwise)

Preceding gene: 39996855

Following gene: 39996853

Centisome position: 50.31

GC content: 59.48

Gene sequence:

>918_bases
ATGCAGAAACCTGACCTTTCCGTTGAGATTGCTGGCATCACGCTGAGAAACCCGGTCATGACCGCCTCGGGCACCTTCGG
CTACGGCGAGGAGTTCTCGGAGTACGTGAACCTGGAGGCGATCGGCGCCATCATCACCAAAGGGCTGTCCTTGAAGCCCA
AGGCCGGCAATCCGACCCCGCGTATCGTCGAAACCACCGGTGGAATGCTGAACGCCATCGGTCTGCAAAATGTGGGCATT
GATGCCTTTGTCGAGAAAAAGGTACCGTTTCTCCGCACGGTTGCCACGCCGGTGATCGTTAATTTTTTCGGAAACACCCT
CGAAGAATATGCCGAACTCGCCGAGCGCCTGGACCTGATACCCGAAGTGGCTGCCGTGGAGATCAATATTTCCTGCCCGA
ACGTCAAACATGGCGGGATCGTTTTCGGTACAGACCCCAAGGCCGCCTATTCGGTGGTAAAGGCAGTGCGGGAGGCCACC
ATCAAGCCGGTGATCGTCAAGCTGTCGCCCAATGTGACCGATATTGTGGAGATGGCCTGGGCCTGTGCCGATGCGGAAGC
CGACGCCCTTTCCCTCATTAATACCCTCACCGGCATGGCCATTGATCTGGACAAGCGCCGTCCAATCCTGGCCAACGTGA
CCGGCGGCCTCTCCGGACCGGCGGTGAAGCCGATCGCGCTACGCATGGTCTGGCAGGTTGCCAGGGCGGTGAAGATTCCG
GTTATCGGCATAGGGGGCATCATGACCGGCATCGATGCTCTGGAGTTCATGCTTGCCGGCGCAACGGCCGTGCAGGTTGG
CACCGCCAACTTCCTGGATCCGGGCGCCGCGGGCCGGATTGCTGCGGAAATGGAGCGATATCTGGCGGATAACGGTATCG
CCGATGTTAAGGAGATGATCGGCGCCCTGGAGGTCTAG

Upstream 100 bases:

>100_bases
TCAGACGAGTCGCCGGACTACCGTTGCGTGTGCAAGGATGGGCCGGTTTTCGCCTTTGATCAGTTGAAATGGGTGTAGCG
CCCCGGAGCGAGGAGCACTA

Downstream 100 bases:

>100_bases
CGCCGGCAGCCAGCATGCATGCCGATGCCAGAGGCGGGGACCGGTGTCTCCGCCTCTGTCCGTTTGCGGGAGGAGCAGAA
CGTATGGAAACCTGGCGGCG

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MQKPDLSVEIAGITLRNPVMTASGTFGYGEEFSEYVNLEAIGAIITKGLSLKPKAGNPTPRIVETTGGMLNAIGLQNVGI
DAFVEKKVPFLRTVATPVIVNFFGNTLEEYAELAERLDLIPEVAAVEINISCPNVKHGGIVFGTDPKAAYSVVKAVREAT
IKPVIVKLSPNVTDIVEMAWACADAEADALSLINTLTGMAIDLDKRRPILANVTGGLSGPAVKPIALRMVWQVARAVKIP
VIGIGGIMTGIDALEFMLAGATAVQVGTANFLDPGAAGRIAAEMERYLADNGIADVKEMIGALEV

Sequences:

>Translated_305_residues
MQKPDLSVEIAGITLRNPVMTASGTFGYGEEFSEYVNLEAIGAIITKGLSLKPKAGNPTPRIVETTGGMLNAIGLQNVGI
DAFVEKKVPFLRTVATPVIVNFFGNTLEEYAELAERLDLIPEVAAVEINISCPNVKHGGIVFGTDPKAAYSVVKAVREAT
IKPVIVKLSPNVTDIVEMAWACADAEADALSLINTLTGMAIDLDKRRPILANVTGGLSGPAVKPIALRMVWQVARAVKIP
VIGIGGIMTGIDALEFMLAGATAVQVGTANFLDPGAAGRIAAEMERYLADNGIADVKEMIGALEV
>Mature_305_residues
MQKPDLSVEIAGITLRNPVMTASGTFGYGEEFSEYVNLEAIGAIITKGLSLKPKAGNPTPRIVETTGGMLNAIGLQNVGI
DAFVEKKVPFLRTVATPVIVNFFGNTLEEYAELAERLDLIPEVAAVEINISCPNVKHGGIVFGTDPKAAYSVVKAVREAT
IKPVIVKLSPNVTDIVEMAWACADAEADALSLINTLTGMAIDLDKRRPILANVTGGLSGPAVKPIALRMVWQVARAVKIP
VIGIGGIMTGIDALEFMLAGATAVQVGTANFLDPGAAGRIAAEMERYLADNGIADVKEMIGALEV

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=296, Percent_Identity=31.4189189189189, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI45006951, Length=321, Percent_Identity=27.4143302180685, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI87082059, Length=324, Percent_Identity=30.5555555555556, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71984108, Length=295, Percent_Identity=27.4576271186441, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17509475, Length=326, Percent_Identity=26.3803680981595, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322633, Length=322, Percent_Identity=29.8136645962733, Blast_Score=102, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24640763, Length=301, Percent_Identity=31.5614617940199, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18858217, Length=301, Percent_Identity=31.5614617940199, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281361352, Length=319, Percent_Identity=27.5862068965517, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17137316, Length=319, Percent_Identity=27.5862068965517, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32069; Mature: 32069

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKPDLSVEIAGITLRNPVMTASGTFGYGEEFSEYVNLEAIGAIITKGLSLKPKAGNPTP
CCCCCCEEEEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
RIVETTGGMLNAIGLQNVGIDAFVEKKVPFLRTVATPVIVNFFGNTLEEYAELAERLDLI
CEEECCCCEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PEVAAVEINISCPNVKHGGIVFGTDPKAAYSVVKAVREATIKPVIVKLSPNVTDIVEMAW
CCEEEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
ACADAEADALSLINTLTGMAIDLDKRRPILANVTGGLSGPAVKPIALRMVWQVARAVKIP
HHCCCCHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCC
VIGIGGIMTGIDALEFMLAGATAVQVGTANFLDPGAAGRIAAEMERYLADNGIADVKEMI
EEECCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
GALEV
HHCCC
>Mature Secondary Structure
MQKPDLSVEIAGITLRNPVMTASGTFGYGEEFSEYVNLEAIGAIITKGLSLKPKAGNPTP
CCCCCCEEEEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
RIVETTGGMLNAIGLQNVGIDAFVEKKVPFLRTVATPVIVNFFGNTLEEYAELAERLDLI
CEEECCCCEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PEVAAVEINISCPNVKHGGIVFGTDPKAAYSVVKAVREATIKPVIVKLSPNVTDIVEMAW
CCEEEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
ACADAEADALSLINTLTGMAIDLDKRRPILANVTGGLSGPAVKPIALRMVWQVARAVKIP
HHCCCCHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCC
VIGIGGIMTGIDALEFMLAGATAVQVGTANFLDPGAAGRIAAEMERYLADNGIADVKEMI
EEECCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
GALEV
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA