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The map label for this gene is ygcA [C]

Identifier: 39996847

GI number: 39996847

Start: 1912930

End: 1914246

Strand: Reverse

Name: ygcA [C]

Synonym: GSU1748

Alternate gene names: 39996847

Gene position: 1914246-1912930 (Counterclockwise)

Preceding gene: 39996848

Following gene: 39996845

Centisome position: 50.19

GC content: 61.2

Gene sequence:

>1317_bases
ATGACTGAGGCGCGTATCCGCATTGAATCCCTCGCCTTCGGCGGGGCAGGTTTCGGGCGACTTGAGGGCAAAGCCTGCTT
CGTGCCGTTTACCGCTCCGGGCGACCTCGTCCGCATCCGGGTTGCTGTTGACAAACCGTCTTATCTTGAGGGCGAGACAC
TTGAGATTCTTGAGCCCTCACCCGACCGCATCGCACCGCCGTGCCCGGTCTTCGGGATCTGTGGCGGGTGTTCATGGCAG
CACCTGCGCTACGATGCCCAGGCGGAAGCCAAAGAGCGCATCTTCGTCGATACTCTGTGGCGTTTCGGACGGGTCGAACG
GGACGCCGTCGCCCCCTTTGCCGTTGCGGATAATCCCTTTGGCTATCGGTGCCGGGCTCAGTTCAAGATACGGTGGAGCG
GCGGGCGCCTGCACATGGGCTTTTATCGCAGGGGATCTCACTATGTGATCGATGCGCCCGCGGAATGCGTCATCTGTGAC
CCCGCCATCAATCTGACCCTGCGGGACCTGAGATTGGTTCTGCCGGATTTCTCCGAACCGGACAAGATTCCCCAGATTGA
CGCTGCAACCGGCGAAGACGGACACGTTCTTCTGGTCGTACACTATATCGGAGACAATCCCGGTCGAGCCGCCGACTTTT
TTCGCTCGATCCAGCCTCATCTGGCTTCGGTGACCGGCATTCATCTCCAGTGCGGGCGCAAGGATTCCATCATGCACGTC
TGGGGAGTCGATTCACTGTCGTATACCGTTCCTGGGCTGGGCGATCAGGGGCGCCCCCTGTCCCTGTCGTTCAGGAGGGG
AGGGTTCTCCCAGGTAAATTATCGCCAGAACCGGGTGCTGGTGAGCAAAGCTTTGCACCTGGCCGGAGTGGGGCCCGGCC
GACGGGTGCTCGATCTGTTTTGCGGCAACGGTAATTTTTCGCTTCCCCTGGCGTCCGGCGGAGCTCAGCTCGTTGGAGTC
GAGGACTACGGGCCGTCAATTGACGACGCGCGGAAAAACGCGGACTTCAATGGGATCGGTGATGTGGAGTTTATCGCCAT
CGACGCCGCCGACGGCACCCGCCGCCTGAGAGCTGCGGGTGAGCATTTCGATACGGTCATCCTGGATCCCCCCCGGACCG
GTGCCCGGGATGCGGTCGGCGAGGTGGCGATACTGGCTCCGGAACGTATCGTGTACGTCTCCTGTGATCCGCCGACGCTC
GGACGCGATCTCGGAGTGCTGCGCAAGGCTGGATACCGCGTAGTCGGCAGCCATGGCGTCGATATGTTTCCTCAGACCTA
CCACATAGAGAGCGTAACGCTCCTGATACGCTCCTGA

Upstream 100 bases:

>100_bases
TATGTTTCATCTTCTGCTTTTCCGATACGGTTCGTTCAATCGGAGCTGGAACGCGCCCGCAGCAAACGGCTGAAGGCGCC
AGGGTTCCTTGTTTCCGGCC

Downstream 100 bases:

>100_bases
CGTTACACGTTACACAGTAACGGCTCGACTCCGGTCGGTCAGCTATTTTCTTTTAGGTACGACATCAAAGAAGATTTTTC
GGGAGGTAGTCATGTTTTTC

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MTEARIRIESLAFGGAGFGRLEGKACFVPFTAPGDLVRIRVAVDKPSYLEGETLEILEPSPDRIAPPCPVFGICGGCSWQ
HLRYDAQAEAKERIFVDTLWRFGRVERDAVAPFAVADNPFGYRCRAQFKIRWSGGRLHMGFYRRGSHYVIDAPAECVICD
PAINLTLRDLRLVLPDFSEPDKIPQIDAATGEDGHVLLVVHYIGDNPGRAADFFRSIQPHLASVTGIHLQCGRKDSIMHV
WGVDSLSYTVPGLGDQGRPLSLSFRRGGFSQVNYRQNRVLVSKALHLAGVGPGRRVLDLFCGNGNFSLPLASGGAQLVGV
EDYGPSIDDARKNADFNGIGDVEFIAIDAADGTRRLRAAGEHFDTVILDPPRTGARDAVGEVAILAPERIVYVSCDPPTL
GRDLGVLRKAGYRVVGSHGVDMFPQTYHIESVTLLIRS

Sequences:

>Translated_438_residues
MTEARIRIESLAFGGAGFGRLEGKACFVPFTAPGDLVRIRVAVDKPSYLEGETLEILEPSPDRIAPPCPVFGICGGCSWQ
HLRYDAQAEAKERIFVDTLWRFGRVERDAVAPFAVADNPFGYRCRAQFKIRWSGGRLHMGFYRRGSHYVIDAPAECVICD
PAINLTLRDLRLVLPDFSEPDKIPQIDAATGEDGHVLLVVHYIGDNPGRAADFFRSIQPHLASVTGIHLQCGRKDSIMHV
WGVDSLSYTVPGLGDQGRPLSLSFRRGGFSQVNYRQNRVLVSKALHLAGVGPGRRVLDLFCGNGNFSLPLASGGAQLVGV
EDYGPSIDDARKNADFNGIGDVEFIAIDAADGTRRLRAAGEHFDTVILDPPRTGARDAVGEVAILAPERIVYVSCDPPTL
GRDLGVLRKAGYRVVGSHGVDMFPQTYHIESVTLLIRS
>Mature_437_residues
TEARIRIESLAFGGAGFGRLEGKACFVPFTAPGDLVRIRVAVDKPSYLEGETLEILEPSPDRIAPPCPVFGICGGCSWQH
LRYDAQAEAKERIFVDTLWRFGRVERDAVAPFAVADNPFGYRCRAQFKIRWSGGRLHMGFYRRGSHYVIDAPAECVICDP
AINLTLRDLRLVLPDFSEPDKIPQIDAATGEDGHVLLVVHYIGDNPGRAADFFRSIQPHLASVTGIHLQCGRKDSIMHVW
GVDSLSYTVPGLGDQGRPLSLSFRRGGFSQVNYRQNRVLVSKALHLAGVGPGRRVLDLFCGNGNFSLPLASGGAQLVGVE
DYGPSIDDARKNADFNGIGDVEFIAIDAADGTRRLRAAGEHFDTVILDPPRTGARDAVGEVAILAPERIVYVSCDPPTLG
RDLGVLRKAGYRVVGSHGVDMFPQTYHIESVTLLIRS

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain

Homologues:

Organism=Homo sapiens, GI34222389, Length=196, Percent_Identity=36.2244897959184, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI51173878, Length=196, Percent_Identity=36.2244897959184, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1789148, Length=434, Percent_Identity=33.1797235023041, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1790403, Length=337, Percent_Identity=27.299703264095, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787083, Length=188, Percent_Identity=30.8510638297872, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24666579, Length=229, Percent_Identity=29.2576419213974, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1748_GEOSL (Q74CC6)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952798.1
- ProteinModelPortal:   Q74CC6
- SMR:   Q74CC6
- GeneID:   2687018
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1748
- NMPDR:   fig|243231.1.peg.1736
- TIGR:   GSU1748
- HOGENOM:   HBG690163
- OMA:   VVFVEGA
- ProtClustDB:   CLSK828524
- BioCyc:   GSUL243231:GSU_1748-MONOMER
- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- TIGRFAMs:   TIGR00479

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 47808; Mature: 47677

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS50926 TRAM; PS01230 TRMA_1; PS01231 TRMA_2

Important sites: ACT_SITE 395-395 BINDING 271-271 BINDING 300-300 BINDING 321-321 BINDING 369-369

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEARIRIESLAFGGAGFGRLEGKACFVPFTAPGDLVRIRVAVDKPSYLEGETLEILEPS
CCCCEEEEEEEEECCCCCCEECCCEEEEEECCCCCEEEEEEEECCCCCCCCCEEEEECCC
PDRIAPPCPVFGICGGCSWQHLRYDAQAEAKERIFVDTLWRFGRVERDAVAPFAVADNPF
CCCCCCCCCEEEECCCCCCHHEEECCCCCHHHEEEHHHHHHHCCCCHHHCCCEEEECCCC
GYRCRAQFKIRWSGGRLHMGFYRRGSHYVIDAPAECVICDPAINLTLRDLRLVLPDFSEP
CEEEEEEEEEEECCCEEEEEEEECCCEEEEECCCCEEEECCCCCEEEEEEEEECCCCCCC
DKIPQIDAATGEDGHVLLVVHYIGDNPGRAADFFRSIQPHLASVTGIHLQCGRKDSIMHV
CCCCCEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHCHHHHHEEEEEEEECCCCCEEEE
WGVDSLSYTVPGLGDQGRPLSLSFRRGGFSQVNYRQNRVLVSKALHLAGVGPGRRVLDLF
EECCCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHCCCCCCCEEEEEE
CGNGNFSLPLASGGAQLVGVEDYGPSIDDARKNADFNGIGDVEFIAIDAADGTRRLRAAG
ECCCCEEEEEECCCEEEEEECCCCCCCCHHHCCCCCCCCCCEEEEEEECCCCHHHHHHCC
EHFDTVILDPPRTGARDAVGEVAILAPERIVYVSCDPPTLGRDLGVLRKAGYRVVGSHGV
CCCCEEEECCCCCCCCHHHCCEEEECCCEEEEEECCCCCCCCHHHHHHHCCEEEEECCCC
DMFPQTYHIESVTLLIRS
CCCCCEEEEEEEEEEEEC
>Mature Secondary Structure 
TEARIRIESLAFGGAGFGRLEGKACFVPFTAPGDLVRIRVAVDKPSYLEGETLEILEPS
CCCEEEEEEEEECCCCCCEECCCEEEEEECCCCCEEEEEEEECCCCCCCCCEEEEECCC
PDRIAPPCPVFGICGGCSWQHLRYDAQAEAKERIFVDTLWRFGRVERDAVAPFAVADNPF
CCCCCCCCCEEEECCCCCCHHEEECCCCCHHHEEEHHHHHHHCCCCHHHCCCEEEECCCC
GYRCRAQFKIRWSGGRLHMGFYRRGSHYVIDAPAECVICDPAINLTLRDLRLVLPDFSEP
CEEEEEEEEEEECCCEEEEEEEECCCEEEEECCCCEEEECCCCCEEEEEEEEECCCCCCC
DKIPQIDAATGEDGHVLLVVHYIGDNPGRAADFFRSIQPHLASVTGIHLQCGRKDSIMHV
CCCCCEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHCHHHHHEEEEEEEECCCCCEEEE
WGVDSLSYTVPGLGDQGRPLSLSFRRGGFSQVNYRQNRVLVSKALHLAGVGPGRRVLDLF
EECCCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHCCCCCCCEEEEEE
CGNGNFSLPLASGGAQLVGVEDYGPSIDDARKNADFNGIGDVEFIAIDAADGTRRLRAAG
ECCCCEEEEEECCCEEEEEECCCCCCCCHHHCCCCCCCCCCEEEEEEECCCCHHHHHHCC
EHFDTVILDPPRTGARDAVGEVAILAPERIVYVSCDPPTLGRDLGVLRKAGYRVVGSHGV
CCCCEEEECCCCCCCCHHHCCEEEECCCEEEEEECCCCCCCCHHHHHHHCCEEEEECCCC
DMFPQTYHIESVTLLIRS
CCCCCEEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA