Click here to switch to the map view.

The map label for this gene is ddc [H]

Identifier: 39996807

GI number: 39996807

Start: 1870600

End: 1872258

Strand: Direct

Name: ddc [H]

Synonym: GSU1707

Alternate gene names: 39996807

Gene position: 1870600-1872258 (Clockwise)

Preceding gene: 39996806

Following gene: 39996808

Centisome position: 49.04

GC content: 59.49

Gene sequence:

>1659_bases
ATGCCGAAAAATCGTGACGCAGCTCGTGCCAGCCTTGAGAACCTCTACCGGATCTTCACCGTGCCTGAAGCACCCGACTC
GACCCTCGGCGCTATCGATCAGGCGATTTCCGGCGATGTTACCGGTTTCCTGCAGACCCATATCGTCGCCATCGAGCGTG
ATCTGGAAGATATCGAAGCAAATTTCTCTTCCTTCTCCATTCCGGAAGAACCGACCTACGTTTCCGAATACACCGAATTC
GTCAAAGAGAACCTCGTCGCCCACTCGGTCCATACCGCTTCGCCGGCGTTCGTCGGTCACATGACCTCGGCGCTCCCGTA
CTTCATGCTGCCGCTGGCGCGTCTCATGACCGCCCTCAACCAGAACGTGGTCAAGGTGGAGACATCCAAGGCCTTTACAC
CGATGGAACGGCAGGTCCTTGCCATGCTTCACCACTTGGTCTATCGCCGCGACGAGGACTTCTACCCATCATGGATTCAT
AACAGCCGGCATGCTCTGGGGGCCTTTTGTTCCGGCGGTACCATCGCCAATATTACGGCCCTGTGGGTGGCACGCAACCG
CCTGTTTGCCCCGAACGGAGCATTTCGCGGCATTGCCCAGGAGGGGCTGGCCCGTGCGCTTAAGCATCGCGGCGCGGACG
GCATTGCCGTGCTCGTCTCCGAACGGGGGCACTACTCCCTGGGAAAGGCGACCGACCTGCTCGGCATTGGCCGGGACGAT
CTGGTCAAGGTGAAAACCGACGCGAACAACCGCATTGACCTCAAGGCACTGAGAGAAGAGTGCCGGCGCTTCCAGGACCG
GAACACGCTCCCGCTGGCACTGGTCGGCATCGCCGGAACCACCGAAACCGGCAACGTGGACCCTCTGGAGGCGATGGCCG
ATCTTGCTCAGGAACTTGGCTGCCATTTCCATGTGGATGCCGCGTGGGGTGGACCGACCCTCTTTTCGGATCGCCACCGC
TCTCTGCTTAAGGGTATCGAGCGAGCCGACTCGGTCACCATTGACGGGCATAAGCAGCTCTATGTGCCGATGGGGGCGGG
AATGGTCGTCTTCAAGGATCCCACCGCCCTGTCGGCCATCGAGCATCACGCCAACTATATCCTGCGCCACGGTTCCAAGG
ACCTGGGCAGCCATACCCTGGAGGGATCACGGCCGGGGAAGGCGATGTTGGTACATGCCGGTTTCTCGATCATTGGACGC
AAAGGGTACGAACTGCTGATCGACATGGGGATCGAACGTGCTCGCACCTTTGCCGACATGATCAAGCAGCATCCCGATTT
CGAACTGATCAGCGAACCGGAACTGAATATCCTTACTTATCGCTACTGCCCGGCCGCCGTTCAGCAGACCTTGCACGACG
TGACGGACCGGGAACGCGCCGATATCAATGCACTCCTCGATCTGGTCTGCCAGTTGCTGCAGAAATTCCAGCGCGAAGCC
GGGAAAACATTTGTCTCCCGGACACGGCTGCATGTGGCGCGCCATGATCGGGAACTCACCGTGCTGCGCGTCGTCCTGGC
CAACCCGCTGACAACTGACGAGATTCTGGAGTCCGTACTGGCGGAGCAGTGTGAACTCGTGCAACTGCCGGAGATTCAGG
CAGTGCTGCAGCAGGTGGAAGAGCTCTGTACCGGCTTGGCAAAAGCAGCTTCATGGTAG

Upstream 100 bases:

>100_bases
ACAACGAGGCTGATCGACAACTGCGTCCTGGGTGAGGAGCAGTAGTTGTCTGTGCCCGCGGGCAGCCTGACGACTGCCTG
CCCAGAGGATGAAGCGAACC

Downstream 100 bases:

>100_bases
AAGCATGACGTTCTGTTTGTGCTAACGAGCGGGATGATTGACTAAGCGAGGATCAGTACGATGGAGCTCTACGCCGCCTC
ATACCTTGTTCCCATTTCAT

Product: group II decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MPKNRDAARASLENLYRIFTVPEAPDSTLGAIDQAISGDVTGFLQTHIVAIERDLEDIEANFSSFSIPEEPTYVSEYTEF
VKENLVAHSVHTASPAFVGHMTSALPYFMLPLARLMTALNQNVVKVETSKAFTPMERQVLAMLHHLVYRRDEDFYPSWIH
NSRHALGAFCSGGTIANITALWVARNRLFAPNGAFRGIAQEGLARALKHRGADGIAVLVSERGHYSLGKATDLLGIGRDD
LVKVKTDANNRIDLKALREECRRFQDRNTLPLALVGIAGTTETGNVDPLEAMADLAQELGCHFHVDAAWGGPTLFSDRHR
SLLKGIERADSVTIDGHKQLYVPMGAGMVVFKDPTALSAIEHHANYILRHGSKDLGSHTLEGSRPGKAMLVHAGFSIIGR
KGYELLIDMGIERARTFADMIKQHPDFELISEPELNILTYRYCPAAVQQTLHDVTDRERADINALLDLVCQLLQKFQREA
GKTFVSRTRLHVARHDRELTVLRVVLANPLTTDEILESVLAEQCELVQLPEIQAVLQQVEELCTGLAKAASW

Sequences:

>Translated_552_residues
MPKNRDAARASLENLYRIFTVPEAPDSTLGAIDQAISGDVTGFLQTHIVAIERDLEDIEANFSSFSIPEEPTYVSEYTEF
VKENLVAHSVHTASPAFVGHMTSALPYFMLPLARLMTALNQNVVKVETSKAFTPMERQVLAMLHHLVYRRDEDFYPSWIH
NSRHALGAFCSGGTIANITALWVARNRLFAPNGAFRGIAQEGLARALKHRGADGIAVLVSERGHYSLGKATDLLGIGRDD
LVKVKTDANNRIDLKALREECRRFQDRNTLPLALVGIAGTTETGNVDPLEAMADLAQELGCHFHVDAAWGGPTLFSDRHR
SLLKGIERADSVTIDGHKQLYVPMGAGMVVFKDPTALSAIEHHANYILRHGSKDLGSHTLEGSRPGKAMLVHAGFSIIGR
KGYELLIDMGIERARTFADMIKQHPDFELISEPELNILTYRYCPAAVQQTLHDVTDRERADINALLDLVCQLLQKFQREA
GKTFVSRTRLHVARHDRELTVLRVVLANPLTTDEILESVLAEQCELVQLPEIQAVLQQVEELCTGLAKAASW
>Mature_551_residues
PKNRDAARASLENLYRIFTVPEAPDSTLGAIDQAISGDVTGFLQTHIVAIERDLEDIEANFSSFSIPEEPTYVSEYTEFV
KENLVAHSVHTASPAFVGHMTSALPYFMLPLARLMTALNQNVVKVETSKAFTPMERQVLAMLHHLVYRRDEDFYPSWIHN
SRHALGAFCSGGTIANITALWVARNRLFAPNGAFRGIAQEGLARALKHRGADGIAVLVSERGHYSLGKATDLLGIGRDDL
VKVKTDANNRIDLKALREECRRFQDRNTLPLALVGIAGTTETGNVDPLEAMADLAQELGCHFHVDAAWGGPTLFSDRHRS
LLKGIERADSVTIDGHKQLYVPMGAGMVVFKDPTALSAIEHHANYILRHGSKDLGSHTLEGSRPGKAMLVHAGFSIIGRK
GYELLIDMGIERARTFADMIKQHPDFELISEPELNILTYRYCPAAVQQTLHDVTDRERADINALLDLVCQLLQKFQREAG
KTFVSRTRLHVARHDRELTVLRVVLANPLTTDEILESVLAEQCELVQLPEIQAVLQQVEELCTGLAKAASW

Specific function: Catalyzes The Production Of Gaba. [C]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=447, Percent_Identity=27.2930648769575, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI194294551, Length=445, Percent_Identity=27.8651685393258, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI197276620, Length=500, Percent_Identity=24.8, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI4503875, Length=500, Percent_Identity=24.8, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI58331246, Length=445, Percent_Identity=25.6179775280899, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI4503281, Length=386, Percent_Identity=23.0569948186528, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI132814448, Length=386, Percent_Identity=23.0569948186528, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI92110055, Length=383, Percent_Identity=23.2375979112272, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17555682, Length=469, Percent_Identity=27.2921108742004, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71993062, Length=451, Percent_Identity=27.2727272727273, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71993058, Length=377, Percent_Identity=29.1777188328912, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320500, Length=264, Percent_Identity=25, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17136594, Length=392, Percent_Identity=28.3163265306122, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24657193, Length=376, Percent_Identity=25.7978723404255, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24657185, Length=376, Percent_Identity=25.7978723404255, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24657188, Length=376, Percent_Identity=25.7978723404255, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21356415, Length=382, Percent_Identity=25.3926701570681, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24652373, Length=231, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: 3820 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 61161; Mature: 61029

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKNRDAARASLENLYRIFTVPEAPDSTLGAIDQAISGDVTGFLQTHIVAIERDLEDIEA
CCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
NFSSFSIPEEPTYVSEYTEFVKENLVAHSVHTASPAFVGHMTSALPYFMLPLARLMTALN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
QNVVKVETSKAFTPMERQVLAMLHHLVYRRDEDFYPSWIHNSRHALGAFCSGGTIANITA
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHCCCCCHHHHHH
LWVARNRLFAPNGAFRGIAQEGLARALKHRGADGIAVLVSERGHYSLGKATDLLGIGRDD
HHHHHCCEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
LVKVKTDANNRIDLKALREECRRFQDRNTLPLALVGIAGTTETGNVDPLEAMADLAQELG
EEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCC
CHFHVDAAWGGPTLFSDRHRSLLKGIERADSVTIDGHKQLYVPMGAGMVVFKDPTALSAI
CEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEECCCEEEEECCHHHHHH
EHHANYILRHGSKDLGSHTLEGSRPGKAMLVHAGFSIIGRKGYELLIDMGIERARTFADM
HHHHHHHHHCCCCHHCCCCCCCCCCCCEEEEECCHHHHCCCCHHHHHHHCHHHHHHHHHH
IKQHPDFELISEPELNILTYRYCPAAVQQTLHDVTDRERADINALLDLVCQLLQKFQREA
HHCCCCCCEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKTFVSRTRLHVARHDRELTVLRVVLANPLTTDEILESVLAEQCELVQLPEIQAVLQQVE
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
ELCTGLAKAASW
HHHHHHHHHCCC
>Mature Secondary Structure 
PKNRDAARASLENLYRIFTVPEAPDSTLGAIDQAISGDVTGFLQTHIVAIERDLEDIEA
CCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
NFSSFSIPEEPTYVSEYTEFVKENLVAHSVHTASPAFVGHMTSALPYFMLPLARLMTALN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
QNVVKVETSKAFTPMERQVLAMLHHLVYRRDEDFYPSWIHNSRHALGAFCSGGTIANITA
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHCCCCCHHHHHH
LWVARNRLFAPNGAFRGIAQEGLARALKHRGADGIAVLVSERGHYSLGKATDLLGIGRDD
HHHHHCCEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
LVKVKTDANNRIDLKALREECRRFQDRNTLPLALVGIAGTTETGNVDPLEAMADLAQELG
EEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCC
CHFHVDAAWGGPTLFSDRHRSLLKGIERADSVTIDGHKQLYVPMGAGMVVFKDPTALSAI
CEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEECCCEEEEECCHHHHHH
EHHANYILRHGSKDLGSHTLEGSRPGKAMLVHAGFSIIGRKGYELLIDMGIERARTFADM
HHHHHHHHHCCCCHHCCCCCCCCCCCCEEEEECCHHHHCCCCHHHHHHHCHHHHHHHHHH
IKQHPDFELISEPELNILTYRYCPAAVQQTLHDVTDRERADINALLDLVCQLLQKFQREA
HHCCCCCCEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKTFVSRTRLHVARHDRELTVLRVVLANPLTTDEILESVLAEQCELVQLPEIQAVLQQVE
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
ELCTGLAKAASW
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]