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The map label for this gene is panC

Identifier: 39996806

GI number: 39996806

Start: 1869693

End: 1870544

Strand: Direct

Name: panC

Synonym: GSU1706

Alternate gene names: 39996806

Gene position: 1869693-1870544 (Clockwise)

Preceding gene: 39996805

Following gene: 39996807

Centisome position: 49.02

GC content: 60.68

Gene sequence:

>852_bases
ATGCGCATCATAGATTCTGTTGCCGACATGCAGGCATTTTCCCGCGATGCCAGGCGTTCGGGGAAAACCATTGCCTTGGT
CCCCACCATGGGCTATCTCCACGACGGACACGCCTCGCTCATGCGCGAGGGGCGCACCCGGGCGGACATCCTGGTGGTGA
GCATTTTTGTCAACCCGACCCAGTTCGGCCCCAACGAGGATTTCACCACGTACCCACGCGACCTGGAGCGAGACCTGCAG
GTTGCCGAAGCAGCCGGGGCGGACGTGATCTTCGCCCCCCGGGCCGATGACATGTATCCTGCCGGATTCCAGACCTATGT
CGATGTGGAAAAGGTGACGCTTCCTCTCTGCGGAGCGAGCCGGCCTGGACATTTCCGCGGAGTAACCACCGTTGTGGCCA
AGCTCTTCAATATCGTCATGCCCCACACGGCGTTTTTCGGCAAGAAGGACTTCCAGCAACTGGCCGTAATCCGTCGGATG
GTTGCGGATCTGAACATGGATCTGAGCATCGTGGGCATGCCCATTATCCGCGAGCCGGACGGATTGGCAATGAGCTCCCG
CAACGCCTACCTGGGGCCGCAGGAGCGCACTAACGCCCTCTGCCTCAATCGGTCCCTTGCCGCCGCACGAACCCTGTTCA
CCGATGGTGAGCGAAGCGTCGCACGCCTGCGCGACACGGTGTTGCGGATACTTACCGAAGTGCCCGGCGCCGCCATCGAC
TATGCTGATTTCCGTGACAGCGAAACACTTGAGCCGGTGGAAGCGGCCAATGAAAAGACTCTCCTCGCCCTGGCCGTCAA
GATAGGAACAACGAGGCTGATCGACAACTGCGTCCTGGGTGAGGAGCAGTAG

Upstream 100 bases:

>100_bases
TACGGCGATGCTCGTACGCTCATTTCCGACGCGGTAGCGTCCTACATCTCAGAAGTCAAGAAAGGAGAATTCCCCACCGA
GGGGCATTCGTTCAGCTGAC

Downstream 100 bases:

>100_bases
TTGTCTGTGCCCGCGGGCAGCCTGACGACTGCCTGCCCAGAGGATGAAGCGAACCATGCCGAAAAATCGTGACGCAGCTC
GTGCCAGCCTTGAGAACCTC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MRIIDSVADMQAFSRDARRSGKTIALVPTMGYLHDGHASLMREGRTRADILVVSIFVNPTQFGPNEDFTTYPRDLERDLQ
VAEAAGADVIFAPRADDMYPAGFQTYVDVEKVTLPLCGASRPGHFRGVTTVVAKLFNIVMPHTAFFGKKDFQQLAVIRRM
VADLNMDLSIVGMPIIREPDGLAMSSRNAYLGPQERTNALCLNRSLAAARTLFTDGERSVARLRDTVLRILTEVPGAAID
YADFRDSETLEPVEAANEKTLLALAVKIGTTRLIDNCVLGEEQ

Sequences:

>Translated_283_residues
MRIIDSVADMQAFSRDARRSGKTIALVPTMGYLHDGHASLMREGRTRADILVVSIFVNPTQFGPNEDFTTYPRDLERDLQ
VAEAAGADVIFAPRADDMYPAGFQTYVDVEKVTLPLCGASRPGHFRGVTTVVAKLFNIVMPHTAFFGKKDFQQLAVIRRM
VADLNMDLSIVGMPIIREPDGLAMSSRNAYLGPQERTNALCLNRSLAAARTLFTDGERSVARLRDTVLRILTEVPGAAID
YADFRDSETLEPVEAANEKTLLALAVKIGTTRLIDNCVLGEEQ
>Mature_283_residues
MRIIDSVADMQAFSRDARRSGKTIALVPTMGYLHDGHASLMREGRTRADILVVSIFVNPTQFGPNEDFTTYPRDLERDLQ
VAEAAGADVIFAPRADDMYPAGFQTYVDVEKVTLPLCGASRPGHFRGVTTVVAKLFNIVMPHTAFFGKKDFQQLAVIRRM
VADLNMDLSIVGMPIIREPDGLAMSSRNAYLGPQERTNALCLNRSLAAARTLFTDGERSVARLRDTVLRILTEVPGAAID
YADFRDSETLEPVEAANEKTLLALAVKIGTTRLIDNCVLGEEQ

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=278, Percent_Identity=46.4028776978417, Blast_Score=242, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6322046, Length=309, Percent_Identity=40.1294498381877, Blast_Score=194, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_GEOSL (Q74CG7)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952757.1
- ProteinModelPortal:   Q74CG7
- SMR:   Q74CG7
- GeneID:   2685348
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1706
- NMPDR:   fig|243231.1.peg.1695
- TIGR:   GSU1706
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   GSUL243231:GSU_1706-MONOMER
- BRENDA:   6.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31164; Mature: 31164

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS01319 RBFA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIDSVADMQAFSRDARRSGKTIALVPTMGYLHDGHASLMREGRTRADILVVSIFVNPT
CCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEEEEEEEECCC
QFGPNEDFTTYPRDLERDLQVAEAAGADVIFAPRADDMYPAGFQTYVDVEKVTLPLCGAS
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHEEEHHHEEEEECCCC
RPGHFRGVTTVVAKLFNIVMPHTAFFGKKDFQQLAVIRRMVADLNMDLSIVGMPIIREPD
CCCCCHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCC
GLAMSSRNAYLGPQERTNALCLNRSLAAARTLFTDGERSVARLRDTVLRILTEVPGAAID
CCEECCCCCCCCCHHHCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEE
YADFRDSETLEPVEAANEKTLLALAVKIGTTRLIDNCVLGEEQ
HHHCCCCCCCCHHHHCCCCEEEEEEEHHCCHHHHHHHHCCCCC
>Mature Secondary Structure
MRIIDSVADMQAFSRDARRSGKTIALVPTMGYLHDGHASLMREGRTRADILVVSIFVNPT
CCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEEEEEEEECCC
QFGPNEDFTTYPRDLERDLQVAEAAGADVIFAPRADDMYPAGFQTYVDVEKVTLPLCGAS
CCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHEEEHHHEEEEECCCC
RPGHFRGVTTVVAKLFNIVMPHTAFFGKKDFQQLAVIRRMVADLNMDLSIVGMPIIREPD
CCCCCHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCC
GLAMSSRNAYLGPQERTNALCLNRSLAAARTLFTDGERSVARLRDTVLRILTEVPGAAID
CCEECCCCCCCCCHHHCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEE
YADFRDSETLEPVEAANEKTLLALAVKIGTTRLIDNCVLGEEQ
HHHCCCCCCCCHHHHCCCCEEEEEEEHHCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA