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The map label for this gene is hom [H]

Identifier: 39996793

GI number: 39996793

Start: 1851187

End: 1852497

Strand: Direct

Name: hom [H]

Synonym: GSU1693

Alternate gene names: 39996793

Gene position: 1851187-1852497 (Clockwise)

Preceding gene: 39996792

Following gene: 39996796

Centisome position: 48.53

GC content: 58.5

Gene sequence:

>1311_bases
ATGAAAGAGATCAAGATCGGACTCATCGGTTTCGGCACCATCGGCACGGGTGTCGCCAAGCTCCTCCAGGCCAACGCCGG
CCTCATTGCCGACAAGGTCGGCGCTATGGTTACTCTTAAAAAAATTGCCGATCTGGACGTAACCACCGACAGGGGCATCG
AGCTCCCTCCGGGAACGCTCACCAGCAATGTGGCCGACGTGCTCGATGATCCGGAGATCAGCGTGGTGATTGAGCTGATC
GGCGGGTATGAGCCGGCCAAGAGTTTCGTGCTGCGTGCCATCAACAACGGCAAGCACGTTGTTACCGCCAACAAGGCCCT
GCTCGCCCTGCACGGGGAGGAGATCTACCCGGCGGCCGCTGCCAAGGGGGTTCAGGTACTTTTCGAGGCGGCGGTAGGCG
GCGGCATCCCGGTCATCTCGGCCATACTGGGTAACATGGCGGCAAACAACTTCACCACGGTGCTCGGCATCCTCAACGGA
ACCTGCAACTATATCCTCACCCGCATGACTCAGGAAGGGGCCGATTTTGGCGATGTCCTCAAGACCGCCCAGGAACTGGG
CTATGCCGAGGCGGATCCGACCTTCGACATCGAGGGGGTCGATACTGCCCACAAACTGGCGCTGCTGGTTTCCCTCTGTT
TCGGGACAAAGGTTGATTTCAACGCCATCCACACCGAAGGGATCAGTTCCATCTCGTCAGCGGATATTGGTTTTGCCCGG
GATTTCGGGTACAAGATCAAGCTGCTCGCCATTGGCAAGCGCACCGGCGATACCGTGGAAGCCCGTGTCCACCCGACCAT
GATCCCTGTCAACTACCCACTTGCCGATGTGGACGGGGTTTTCAATGCCATCCGCTTCACCGGCGATTTTATCGGTCCAG
TGATGTTCTATGGCCGCGGCGCCGGCATGGATCCCACCGCCAGTGCGGTAGTGGGCGATGTCATTGAAATCGCCCGGAAT
ATCATTGCCGGCGTAAGCCGCCGGTGCGCGCCCCTCGGCTATCGGGACGAGGCAGTCACGACGCTTGCCCTCAAGCCCAT
GGGTGAGATCGAGGGCAAGTACTATCTTCGCTTCAGTGCCGTCGACAAGCCCGGAGTGCTGGCAAAAATCTCGGGGGCCC
TCGGCAAGTACGATATCAGCATTGAATCGATGATTCAGAAGGGGAGGAGCGCCGGTGAATCGGTGCCCATCGTGATCATG
ACCCATGAGGCCCGTGAAAAGGACATTCGCGCTGCTCTTGAGGAAATCGACACCTTCGAGCTCATCAGCGAGAAGAGCAG
GTTCATCAGGATTGAGGACAACTTGGAATAA

Upstream 100 bases:

>100_bases
GCCGGCTTTTATCAACGGCATTCTGGACGAAATCGCTTCAACGCTCCCTGATAAGGGGTAGCGGCCTCACTAATCCCGAC
AGGCACCAGAACGAGGAATC

Downstream 100 bases:

>100_bases
AAACGTAATGCCGGAAATTTGTGACAGAGAAAGGCAGCCGTTGCAGGCTGCCTTTTTTCATGTCTCGTCGGTATGGGCGG
CTGGGATGAGTTGCGTAAAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKEIKIGLIGFGTIGTGVAKLLQANAGLIADKVGAMVTLKKIADLDVTTDRGIELPPGTLTSNVADVLDDPEISVVIELI
GGYEPAKSFVLRAINNGKHVVTANKALLALHGEEIYPAAAAKGVQVLFEAAVGGGIPVISAILGNMAANNFTTVLGILNG
TCNYILTRMTQEGADFGDVLKTAQELGYAEADPTFDIEGVDTAHKLALLVSLCFGTKVDFNAIHTEGISSISSADIGFAR
DFGYKIKLLAIGKRTGDTVEARVHPTMIPVNYPLADVDGVFNAIRFTGDFIGPVMFYGRGAGMDPTASAVVGDVIEIARN
IIAGVSRRCAPLGYRDEAVTTLALKPMGEIEGKYYLRFSAVDKPGVLAKISGALGKYDISIESMIQKGRSAGESVPIVIM
THEAREKDIRAALEEIDTFELISEKSRFIRIEDNLE

Sequences:

>Translated_436_residues
MKEIKIGLIGFGTIGTGVAKLLQANAGLIADKVGAMVTLKKIADLDVTTDRGIELPPGTLTSNVADVLDDPEISVVIELI
GGYEPAKSFVLRAINNGKHVVTANKALLALHGEEIYPAAAAKGVQVLFEAAVGGGIPVISAILGNMAANNFTTVLGILNG
TCNYILTRMTQEGADFGDVLKTAQELGYAEADPTFDIEGVDTAHKLALLVSLCFGTKVDFNAIHTEGISSISSADIGFAR
DFGYKIKLLAIGKRTGDTVEARVHPTMIPVNYPLADVDGVFNAIRFTGDFIGPVMFYGRGAGMDPTASAVVGDVIEIARN
IIAGVSRRCAPLGYRDEAVTTLALKPMGEIEGKYYLRFSAVDKPGVLAKISGALGKYDISIESMIQKGRSAGESVPIVIM
THEAREKDIRAALEEIDTFELISEKSRFIRIEDNLE
>Mature_436_residues
MKEIKIGLIGFGTIGTGVAKLLQANAGLIADKVGAMVTLKKIADLDVTTDRGIELPPGTLTSNVADVLDDPEISVVIELI
GGYEPAKSFVLRAINNGKHVVTANKALLALHGEEIYPAAAAKGVQVLFEAAVGGGIPVISAILGNMAANNFTTVLGILNG
TCNYILTRMTQEGADFGDVLKTAQELGYAEADPTFDIEGVDTAHKLALLVSLCFGTKVDFNAIHTEGISSISSADIGFAR
DFGYKIKLLAIGKRTGDTVEARVHPTMIPVNYPLADVDGVFNAIRFTGDFIGPVMFYGRGAGMDPTASAVVGDVIEIARN
IIAGVSRRCAPLGYRDEAVTTLALKPMGEIEGKYYLRFSAVDKPGVLAKISGALGKYDISIESMIQKGRSAGESVPIVIM
THEAREKDIRAALEEIDTFELISEKSRFIRIEDNLE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=251, Percent_Identity=28.6852589641434, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790376, Length=362, Percent_Identity=23.7569060773481, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=359, Percent_Identity=25.9052924791086, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46290; Mature: 46290

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIKIGLIGFGTIGTGVAKLLQANAGLIADKVGAMVTLKKIADLDVTTDRGIELPPGTL
CCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHEEHHHHHCCCCCCCCCCCCCCCCH
TSNVADVLDDPEISVVIELIGGYEPAKSFVLRAINNGKHVVTANKALLALHGEEIYPAAA
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECCCCCCHHH
AKGVQVLFEAAVGGGIPVISAILGNMAANNFTTVLGILNGTCNYILTRMTQEGADFGDVL
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
KTAQELGYAEADPTFDIEGVDTAHKLALLVSLCFGTKVDFNAIHTEGISSISSADIGFAR
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCEEE
DFGYKIKLLAIGKRTGDTVEARVHPTMIPVNYPLADVDGVFNAIRFTGDFIGPVMFYGRG
CCCCEEEEEEEECCCCCEEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
AGMDPTASAVVGDVIEIARNIIAGVSRRCAPLGYRDEAVTTLALKPMGEIEGKYYLRFSA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEC
VDKPGVLAKISGALGKYDISIESMIQKGRSAGESVPIVIMTHEAREKDIRAALEEIDTFE
CCCCCCEEEECCCCCEECCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
LISEKSRFIRIEDNLE
HHHCCCCEEEEECCCC
>Mature Secondary Structure
MKEIKIGLIGFGTIGTGVAKLLQANAGLIADKVGAMVTLKKIADLDVTTDRGIELPPGTL
CCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHEEHHHHHCCCCCCCCCCCCCCCCH
TSNVADVLDDPEISVVIELIGGYEPAKSFVLRAINNGKHVVTANKALLALHGEEIYPAAA
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECCCCCCHHH
AKGVQVLFEAAVGGGIPVISAILGNMAANNFTTVLGILNGTCNYILTRMTQEGADFGDVL
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
KTAQELGYAEADPTFDIEGVDTAHKLALLVSLCFGTKVDFNAIHTEGISSISSADIGFAR
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCEEE
DFGYKIKLLAIGKRTGDTVEARVHPTMIPVNYPLADVDGVFNAIRFTGDFIGPVMFYGRG
CCCCEEEEEEEECCCCCEEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
AGMDPTASAVVGDVIEIARNIIAGVSRRCAPLGYRDEAVTTLALKPMGEIEGKYYLRFSA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEC
VDKPGVLAKISGALGKYDISIESMIQKGRSAGESVPIVIMTHEAREKDIRAALEEIDTFE
CCCCCCEEEECCCCCEECCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
LISEKSRFIRIEDNLE
HHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]