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The map label for this gene is ribA [H]

Identifier: 39996790

GI number: 39996790

Start: 1849051

End: 1850253

Strand: Direct

Name: ribA [H]

Synonym: GSU1690

Alternate gene names: 39996790

Gene position: 1849051-1850253 (Clockwise)

Preceding gene: 39996789

Following gene: 39996791

Centisome position: 48.48

GC content: 59.93

Gene sequence:

>1203_bases
ATGCCGGTTGCACGTATTGAGGAAGCAATTGAAGATATCCGCCAAGGCAAGATGGTGATTCTGGTGGACGATGAGGACCG
TGAGAACGAAGGCGACCTGACCATGGCCGCGGAAATGGTGACCCCCGAGGCGATCAACTTCATGGCCCGGTTCGGGCGGG
GGCTCATCTGTCTCACCATGACGACCGAACGGTGCGATCATCTCCAACTGCCACTCATGGTTTCGGCAAACACTTCCTCG
TTCGGCACGGCCTTCACCGTATCCATCGAGGCAAAACGGGGGGTGACAACCGGCATCTCAGCGGCGGACCGGGCCCACAC
CATTCTGACCGCTGTTGCCGATGACGCAAAGGCAGATGACCTCGCCCGTCCGGGCCATGTGTTCCCGCTGCGGGCCAAGC
CGGGCGGAGTGCTCGTTCGTGCCGGCCAAACCGAAGGCTCGGTCGATCTGGCTCGTCTTGCCGGACTCAAGCCCGCCGGC
GTCATTTGTGAGATCATGAACGATGACGGCACCATGGCGCGAATGCCGCAACTCAAGGTTTTCGCCAAGGAGCACGGAAT
CAGGATCTGCACCATCGCGGATCTGGTGGCCTATCGGCTCAAGCACGAGTCCCTGGTGAGGCGTGCGGCAGACGTGCTTC
TGCCCACGGATTTCGGGGAATTCAGGGCCATTGCATTTGAGAACGACGTTGACCGACTGGAGCACTTGGCGCTGGTTAAG
GGAGAGATCAGGGGGGATGAGCCGGTGCTCGTCCGGGTGCATTCCGAGTGCATGACCGGCGACGTTTTCGGCAGCCTGCG
CTGCGACTGCGGCAGCCAGCTCCATCGGGCTATGGAAATGATCGAGGCCGAAGGGCGCGGGGTCATCCTCTACATGCGCC
AGGAAGGGCGCGGTATCGGTCTGTTCAACAAGTTAAAAGCCTATGCCCTGCAGGACGAAGGGAAAGACACGGTGGAGGCG
AACCTGGCCCTGGGCTTCAAGCCGGACCTGCGTGATTATGGCATCGGCGCCCAGATTCTCGTGAACCTGGGGGTGCGGAA
CATCAGGCTTCTGACCAACAACCCCCGCAAACTGATCGGCCTCCAGGGTTACGGCATCAATATCGTGGAGCGAGTTCCCA
TCGAAATTCCGCCCACCACTACGAATCTCGACTATCTCAAGGCCAAGCGCGAAAAGCTCGGCCATTTGCTGGAAAATATC
TGA

Upstream 100 bases:

>100_bases
ACCCTCAAAGGGGGACGGCGGGGTAACCCTTGAGCTTCTTGCAAAGAACGGATTTTTGTGAGATATGAAATGATTACCTA
TGTAAGGGACGGAGAGACCA

Downstream 100 bases:

>100_bases
GGAGGATACCATGCCCCGATTCATCGAAGGCAAGCTCGACGCTACCGGACTTCGATTCGGCATTATTGTGAGCCGCTTCA
ACAGCTTTATCGGAGAGCGG

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MPVARIEEAIEDIRQGKMVILVDDEDRENEGDLTMAAEMVTPEAINFMARFGRGLICLTMTTERCDHLQLPLMVSANTSS
FGTAFTVSIEAKRGVTTGISAADRAHTILTAVADDAKADDLARPGHVFPLRAKPGGVLVRAGQTEGSVDLARLAGLKPAG
VICEIMNDDGTMARMPQLKVFAKEHGIRICTIADLVAYRLKHESLVRRAADVLLPTDFGEFRAIAFENDVDRLEHLALVK
GEIRGDEPVLVRVHSECMTGDVFGSLRCDCGSQLHRAMEMIEAEGRGVILYMRQEGRGIGLFNKLKAYALQDEGKDTVEA
NLALGFKPDLRDYGIGAQILVNLGVRNIRLLTNNPRKLIGLQGYGINIVERVPIEIPPTTTNLDYLKAKREKLGHLLENI

Sequences:

>Translated_400_residues
MPVARIEEAIEDIRQGKMVILVDDEDRENEGDLTMAAEMVTPEAINFMARFGRGLICLTMTTERCDHLQLPLMVSANTSS
FGTAFTVSIEAKRGVTTGISAADRAHTILTAVADDAKADDLARPGHVFPLRAKPGGVLVRAGQTEGSVDLARLAGLKPAG
VICEIMNDDGTMARMPQLKVFAKEHGIRICTIADLVAYRLKHESLVRRAADVLLPTDFGEFRAIAFENDVDRLEHLALVK
GEIRGDEPVLVRVHSECMTGDVFGSLRCDCGSQLHRAMEMIEAEGRGVILYMRQEGRGIGLFNKLKAYALQDEGKDTVEA
NLALGFKPDLRDYGIGAQILVNLGVRNIRLLTNNPRKLIGLQGYGINIVERVPIEIPPTTTNLDYLKAKREKLGHLLENI
>Mature_399_residues
PVARIEEAIEDIRQGKMVILVDDEDRENEGDLTMAAEMVTPEAINFMARFGRGLICLTMTTERCDHLQLPLMVSANTSSF
GTAFTVSIEAKRGVTTGISAADRAHTILTAVADDAKADDLARPGHVFPLRAKPGGVLVRAGQTEGSVDLARLAGLKPAGV
ICEIMNDDGTMARMPQLKVFAKEHGIRICTIADLVAYRLKHESLVRRAADVLLPTDFGEFRAIAFENDVDRLEHLALVKG
EIRGDEPVLVRVHSECMTGDVFGSLRCDCGSQLHRAMEMIEAEGRGVILYMRQEGRGIGLFNKLKAYALQDEGKDTVEAN
LALGFKPDLRDYGIGAQILVNLGVRNIRLLTNNPRKLIGLQGYGINIVERVPIEIPPTTTNLDYLKAKREKLGHLLENI

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=56.4356435643564, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=55.2083333333333, Blast_Score=210, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=43.6274509803922, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6319438, Length=197, Percent_Identity=44.6700507614213, Blast_Score=144, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 43865; Mature: 43734

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVARIEEAIEDIRQGKMVILVDDEDRENEGDLTMAAEMVTPEAINFMARFGRGLICLTM
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEE
TTERCDHLQLPLMVSANTSSFGTAFTVSIEAKRGVTTGISAADRAHTILTAVADDAKADD
ECCCCCCEECCEEEECCCCCCCEEEEEEEEECCCCCCCCCCCHHHHEEEEECCCCCCCCC
LARPGHVFPLRAKPGGVLVRAGQTEGSVDLARLAGLKPAGVICEIMNDDGTMARMPQLKV
CCCCCCEEEEECCCCCEEEECCCCCCCCHHHHHCCCCCCCEEEEEECCCCCEECCCCCEE
FAKEHGIRICTIADLVAYRLKHESLVRRAADVLLPTDFGEFRAIAFENDVDRLEHLALVK
EHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEECCCHHHHHHHHHHH
GEIRGDEPVLVRVHSECMTGDVFGSLRCDCGSQLHRAMEMIEAEGRGVILYMRQEGRGIG
CCCCCCCCEEEEEECCHHCCCCCCCEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
LFNKLKAYALQDEGKDTVEANLALGFKPDLRDYGIGAQILVNLGVRNIRLLTNNPRKLIG
HHHHHHHEEECCCCCCEEEEEEEECCCCCHHHCCCCCEEEEECCCCEEEEEECCCCEEEE
LQGYGINIVERVPIEIPPTTTNLDYLKAKREKLGHLLENI
ECCCCCEEEEECCEECCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVARIEEAIEDIRQGKMVILVDDEDRENEGDLTMAAEMVTPEAINFMARFGRGLICLTM
CHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEE
TTERCDHLQLPLMVSANTSSFGTAFTVSIEAKRGVTTGISAADRAHTILTAVADDAKADD
ECCCCCCEECCEEEECCCCCCCEEEEEEEEECCCCCCCCCCCHHHHEEEEECCCCCCCCC
LARPGHVFPLRAKPGGVLVRAGQTEGSVDLARLAGLKPAGVICEIMNDDGTMARMPQLKV
CCCCCCEEEEECCCCCEEEECCCCCCCCHHHHHCCCCCCCEEEEEECCCCCEECCCCCEE
FAKEHGIRICTIADLVAYRLKHESLVRRAADVLLPTDFGEFRAIAFENDVDRLEHLALVK
EHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEECCCHHHHHHHHHHH
GEIRGDEPVLVRVHSECMTGDVFGSLRCDCGSQLHRAMEMIEAEGRGVILYMRQEGRGIG
CCCCCCCCEEEEEECCHHCCCCCCCEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
LFNKLKAYALQDEGKDTVEANLALGFKPDLRDYGIGAQILVNLGVRNIRLLTNNPRKLIG
HHHHHHHEEECCCCCCEEEEEEEECCCCCHHHCCCCCEEEEECCCCEEEEEECCCCEEEE
LQGYGINIVERVPIEIPPTTTNLDYLKAKREKLGHLLENI
ECCCCCEEEEECCEECCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]