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The map label for this gene is ribH

Identifier: 39996791

GI number: 39996791

Start: 1850264

End: 1850731

Strand: Direct

Name: ribH

Synonym: GSU1691

Alternate gene names: 39996791

Gene position: 1850264-1850731 (Clockwise)

Preceding gene: 39996790

Following gene: 39996792

Centisome position: 48.51

GC content: 60.04

Gene sequence:

>468_bases
ATGCCCCGATTCATCGAAGGCAAGCTCGACGCTACCGGACTTCGATTCGGCATTATTGTGAGCCGCTTCAACAGCTTTAT
CGGAGAGCGGCTTCTTGAGGGTGCCCTGGACGCTCTGGTCCGCCACGGTGGCGATGATGGCGACATCGACGTCGTCAGGG
TCCCTGGGGCCTTTGAAATTCCGCTTACGGCCCAGAAACTGGTCCAGAAGGGAAACTACGATGCCGTAATCTGCCTCGGT
GCCGTGATTCGCGGCTCCACGCCTCACTTCGATTACGTGGCTGCCGAGGTTTCCAAGGGGATCGCGCATGTTTCCCTGGC
CACCGGCGTGCCGGTCGTCTTTGGCGTGCTTACCACTGATACCATCGAGCAGGCAATCGAAAGGGCCGGAACCAAAGCTG
GAAACAAGGGCTTCGATGCGGCAGTGACCGCCATCGAAACGGCGCGCCTCTACCGGGAGCTCCGCTAG

Upstream 100 bases:

>100_bases
GTTCCCATCGAAATTCCGCCCACCACTACGAATCTCGACTATCTCAAGGCCAAGCGCGAAAAGCTCGGCCATTTGCTGGA
AAATATCTGAGGAGGATACC

Downstream 100 bases:

>100_bases
TGGGCGCCCGCCGCCTCGGCAGGGAATTGGCCCTGCAGATGCTGTACTCAAGGGACTATGCTGCCGGCGAAGCTGCGCCG
CTCCTTGAGCTCGTGCTGGA

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MPRFIEGKLDATGLRFGIIVSRFNSFIGERLLEGALDALVRHGGDDGDIDVVRVPGAFEIPLTAQKLVQKGNYDAVICLG
AVIRGSTPHFDYVAAEVSKGIAHVSLATGVPVVFGVLTTDTIEQAIERAGTKAGNKGFDAAVTAIETARLYRELR

Sequences:

>Translated_155_residues
MPRFIEGKLDATGLRFGIIVSRFNSFIGERLLEGALDALVRHGGDDGDIDVVRVPGAFEIPLTAQKLVQKGNYDAVICLG
AVIRGSTPHFDYVAAEVSKGIAHVSLATGVPVVFGVLTTDTIEQAIERAGTKAGNKGFDAAVTAIETARLYRELR
>Mature_154_residues
PRFIEGKLDATGLRFGIIVSRFNSFIGERLLEGALDALVRHGGDDGDIDVVRVPGAFEIPLTAQKLVQKGNYDAVICLGA
VIRGSTPHFDYVAAEVSKGIAHVSLATGVPVVFGVLTTDTIEQAIERAGTKAGNKGFDAAVTAIETARLYRELR

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=154, Percent_Identity=54.5454545454545, Blast_Score=164, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324429, Length=148, Percent_Identity=33.1081081081081, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_GEOSL (P61723)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952742.1
- ProteinModelPortal:   P61723
- SMR:   P61723
- GeneID:   2687086
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1691
- NMPDR:   fig|243231.1.peg.1680
- TIGR:   GSU1691
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- ProtClustDB:   PRK00061
- BioCyc:   GSUL243231:GSU_1691-MONOMER
- BRENDA:   2.5.1.9
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16511; Mature: 16380

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFIEGKLDATGLRFGIIVSRFNSFIGERLLEGALDALVRHGGDDGDIDVVRVPGAFEI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEC
PLTAQKLVQKGNYDAVICLGAVIRGSTPHFDYVAAEVSKGIAHVSLATGVPVVFGVLTTD
CCCHHHHHHCCCCCEEEEEHHHHCCCCCCHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHH
TIEQAIERAGTKAGNKGFDAAVTAIETARLYRELR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRFIEGKLDATGLRFGIIVSRFNSFIGERLLEGALDALVRHGGDDGDIDVVRVPGAFEI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEC
PLTAQKLVQKGNYDAVICLGAVIRGSTPHFDYVAAEVSKGIAHVSLATGVPVVFGVLTTD
CCCHHHHHHCCCCCEEEEEHHHHCCCCCCHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHH
TIEQAIERAGTKAGNKGFDAAVTAIETARLYRELR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA