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The map label for this gene is ribE [H]

Identifier: 39996789

GI number: 39996789

Start: 1848358

End: 1849011

Strand: Direct

Name: ribE [H]

Synonym: GSU1689

Alternate gene names: 39996789

Gene position: 1848358-1849011 (Clockwise)

Preceding gene: 39996788

Following gene: 39996790

Centisome position: 48.46

GC content: 61.01

Gene sequence:

>654_bases
ATGTTCACTGGATTGATTGAAGACGTGGGTACCGCGCGGCGGTTGGAGCGCCGGGGAGAGGCGGCACGCCTTGCCGTGGC
CACAGCGCTGCCGCTTGAGTCCGTGAATCTGGGCGACTCGGTCGCGGTCAATGGTGCCTGTCTCACGGTGGTAGCAAAAG
GGGGGGGCGAACTCACCTTCGATGTTTCCCCCGAGTCATTGGAACGTACCACGATCGGCAGTCTGGCAACGGGAGCTCCG
GTAAACCTGGAGCGGGCTCTCCGTCTTGGAGACCGTCTCGGCGGCCACCTGGTGACGGGTCATGTGGATTTGGTGGCAAC
GGTCGAGGGGCGTCGCGAGGTGTCCGGCAACATCCTGTTCACCTTCCGGATGGCTTCCGGATTCAGCCGTTACCTGGTGG
CCAAGGGCTCGGTGGCCGTGGACGGTATCAGCCTGACGGTAAACAGGGTTGACGCCGACTCGTTTTCGGTCAATGTCATT
CCCCATACCGCGGTGAAAACGACCCTGGAGCACCTTCGGCCGGGCGACCGGGTCAATATTGAGACGGACATTCTCGGCAA
ATACATCGAACGACTCCTGGGAGGCGGTACGGAACCCTCAAAGGGGGACGGCGGGGTAACCCTTGAGCTTCTTGCAAAGA
ACGGATTTTTGTGA

Upstream 100 bases:

>100_bases
GAAAATCGGTGGAGCGCATGGGGCGGGCATTTCGCCTGGAAACGGCGCGGGTGCGGCGTTTCGGCGGCGACGTCATGATC
GAGGCCTATCCGGAGGAAGC

Downstream 100 bases:

>100_bases
GATATGAAATGATTACCTATGTAAGGGACGGAGAGACCAATGCCGGTTGCACGTATTGAGGAAGCAATTGAAGATATCCG
CCAAGGCAAGATGGTGATTC

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MFTGLIEDVGTARRLERRGEAARLAVATALPLESVNLGDSVAVNGACLTVVAKGGGELTFDVSPESLERTTIGSLATGAP
VNLERALRLGDRLGGHLVTGHVDLVATVEGRREVSGNILFTFRMASGFSRYLVAKGSVAVDGISLTVNRVDADSFSVNVI
PHTAVKTTLEHLRPGDRVNIETDILGKYIERLLGGGTEPSKGDGGVTLELLAKNGFL

Sequences:

>Translated_217_residues
MFTGLIEDVGTARRLERRGEAARLAVATALPLESVNLGDSVAVNGACLTVVAKGGGELTFDVSPESLERTTIGSLATGAP
VNLERALRLGDRLGGHLVTGHVDLVATVEGRREVSGNILFTFRMASGFSRYLVAKGSVAVDGISLTVNRVDADSFSVNVI
PHTAVKTTLEHLRPGDRVNIETDILGKYIERLLGGGTEPSKGDGGVTLELLAKNGFL
>Mature_217_residues
MFTGLIEDVGTARRLERRGEAARLAVATALPLESVNLGDSVAVNGACLTVVAKGGGELTFDVSPESLERTTIGSLATGAP
VNLERALRLGDRLGGHLVTGHVDLVATVEGRREVSGNILFTFRMASGFSRYLVAKGSVAVDGISLTVNRVDADSFSVNVI
PHTAVKTTLEHLRPGDRVNIETDILGKYIERLLGGGTEPSKGDGGVTLELLAKNGFL

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats [H]

Homologues:

Organism=Escherichia coli, GI1787952, Length=187, Percent_Identity=38.5026737967914, Blast_Score=117, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6319733, Length=228, Percent_Identity=37.280701754386, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001783
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00677 Lum_binding [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 22764; Mature: 22764

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00693 LUM_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGLIEDVGTARRLERRGEAARLAVATALPLESVNLGDSVAVNGACLTVVAKGGGELTF
CCCCHHHHHHHHHHHHHCCCHHEEEEEEECCCCCCCCCCCEEECCEEEEEEECCCCEEEE
DVSPESLERTTIGSLATGAPVNLERALRLGDRLGGHLVTGHVDLVATVEGRREVSGNILF
ECCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEEEECCCCCCCCCEEE
TFRMASGFSRYLVAKGSVAVDGISLTVNRVDADSFSVNVIPHTAVKTTLEHLRPGDRVNI
EEEECCCCCEEEEECCCEEEEEEEEEEEEECCCCEEEEEECCHHHHHHHHHCCCCCCEEE
ETDILGKYIERLLGGGTEPSKGDGGVTLELLAKNGFL
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MFTGLIEDVGTARRLERRGEAARLAVATALPLESVNLGDSVAVNGACLTVVAKGGGELTF
CCCCHHHHHHHHHHHHHCCCHHEEEEEEECCCCCCCCCCCEEECCEEEEEEECCCCEEEE
DVSPESLERTTIGSLATGAPVNLERALRLGDRLGGHLVTGHVDLVATVEGRREVSGNILF
ECCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEEEECCCCCCCCCEEE
TFRMASGFSRYLVAKGSVAVDGISLTVNRVDADSFSVNVIPHTAVKTTLEHLRPGDRVNI
EEEECCCCCEEEEECCCEEEEEEEEEEEEECCCCEEEEEECCHHHHHHHHHCCCCCCEEE
ETDILGKYIERLLGGGTEPSKGDGGVTLELLAKNGFL
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]