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The map label for this gene is bioD [C]

Identifier: 39996781

GI number: 39996781

Start: 1841919

End: 1843010

Strand: Reverse

Name: bioD [C]

Synonym: GSU1681

Alternate gene names: 39996781

Gene position: 1843010-1841919 (Counterclockwise)

Preceding gene: 39996784

Following gene: 39996780

Centisome position: 48.32

GC content: 56.68

Gene sequence:

>1092_bases
ATGGCCAAAAAAGTCTTTATCGGCGCTACAGGACAAAACTGCGGAAAAACAACCATGAGCGTCTCGCTCATGCACTTGGC
GCGACAGAAATACCAGAGGGTCGGCTTCATCAAGCCCATCGGCCCCAAGATCGAGATGTACAACGGCCTCACCGTCGACA
TGGACGCCATCCTCATGGCGCGGACCTTCGGCCTGGAAGAAGACCTGGCCCTCATGAATCCCGTGCCCCTCCCCAAGAAC
TTCACCCGCGACTACCTGAGCGGCAAGTTTGACTGCCATACTCTCAAAAAAAAGATTGTCGAAGCATTCGAAATACTTGA
CCAGAGCTATGACTTCCTGATTATCGAGGGTGCCGGCCACTGCGGAGTCGGCTCCGTCATCGGTCTCAGCAATGCCTGTG
TAGCCCATATGCTCGGGGCACCGGTAATCGTGGTGACTGACAGCGGTATCGGCAGCGCCATCGATGCCGTGCACCTCAAC
CTGGCCCTCTACGAAAAGGAGGAGGCCGACGTCCGGATGGTCATCGTCAACAAGCTCCGCTCAGACAAGCGGGACTCGAT
CCTCGGCTTCCTCAGGCGGGGGTTCCCGGGGCGTTCACTCCAGGTTACCGGTGGCTTCAACTATTCTCCCGTCCTGGCAA
ACCCGACCCTTTCCCATATCGGAAAACTTCTCAATCTCCCCGTTCATGGCGACGCGGACGGGCACAGCCGGATCATCCAC
CACATTCACCTGGGAGCGGCATCGTCCCAACGGGTGGTGGACGCCCTGGAGGATGCCACACTGCTGGTCCTCACCAGTTC
ACGGGATGAGCTGATCGTCACCCTGTCGTCTCTGTATCATATCCCATCCTATAGGGACAAGATCGCAGGCCTCGTCATTG
CTGGTCACATGCCGGTATCGGAAATAACCCAGCAGATTCTGGACGACAGCATGATCCCCTACATCCGGGTTCATGACTCC
ACGGCGCGAGTGTTCACAACGCTTATGGAGGACGTTTCCAAGATCACTGCCGAGGACCAGGAAAAGCTCAACTGGATCAG
GGCAAATGCCGAGAACGAAATCGATTTCGAGGCAATAGACGCTCTGCTCTGA

Upstream 100 bases:

>100_bases
TGCATGCAAAATAATGCGAAACAAAGCTGTCGGCACCGTATTCCGCGCAGCCGGCAGCCTTCATGCTTCCGAGTGAATTA
CCTACGCAATCGGGGGGACC

Downstream 100 bases:

>100_bases
TTGCCTGCGCCATGCCCTATCGCTATCTGCCAGATATCGCCACGGCCGACGTCGCCTTTGAAGCGTGGGGTGAAACTCGT
GAAGAGATGTTCTGCGCTGC

Product: cobyrinic acid a,c-diamide synthase

Products: ADP; Dethiobiotin; H+; Phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MAKKVFIGATGQNCGKTTMSVSLMHLARQKYQRVGFIKPIGPKIEMYNGLTVDMDAILMARTFGLEEDLALMNPVPLPKN
FTRDYLSGKFDCHTLKKKIVEAFEILDQSYDFLIIEGAGHCGVGSVIGLSNACVAHMLGAPVIVVTDSGIGSAIDAVHLN
LALYEKEEADVRMVIVNKLRSDKRDSILGFLRRGFPGRSLQVTGGFNYSPVLANPTLSHIGKLLNLPVHGDADGHSRIIH
HIHLGAASSQRVVDALEDATLLVLTSSRDELIVTLSSLYHIPSYRDKIAGLVIAGHMPVSEITQQILDDSMIPYIRVHDS
TARVFTTLMEDVSKITAEDQEKLNWIRANAENEIDFEAIDALL

Sequences:

>Translated_363_residues
MAKKVFIGATGQNCGKTTMSVSLMHLARQKYQRVGFIKPIGPKIEMYNGLTVDMDAILMARTFGLEEDLALMNPVPLPKN
FTRDYLSGKFDCHTLKKKIVEAFEILDQSYDFLIIEGAGHCGVGSVIGLSNACVAHMLGAPVIVVTDSGIGSAIDAVHLN
LALYEKEEADVRMVIVNKLRSDKRDSILGFLRRGFPGRSLQVTGGFNYSPVLANPTLSHIGKLLNLPVHGDADGHSRIIH
HIHLGAASSQRVVDALEDATLLVLTSSRDELIVTLSSLYHIPSYRDKIAGLVIAGHMPVSEITQQILDDSMIPYIRVHDS
TARVFTTLMEDVSKITAEDQEKLNWIRANAENEIDFEAIDALL
>Mature_362_residues
AKKVFIGATGQNCGKTTMSVSLMHLARQKYQRVGFIKPIGPKIEMYNGLTVDMDAILMARTFGLEEDLALMNPVPLPKNF
TRDYLSGKFDCHTLKKKIVEAFEILDQSYDFLIIEGAGHCGVGSVIGLSNACVAHMLGAPVIVVTDSGIGSAIDAVHLNL
ALYEKEEADVRMVIVNKLRSDKRDSILGFLRRGFPGRSLQVTGGFNYSPVLANPTLSHIGKLLNLPVHGDADGHSRIIHH
IHLGAASSQRVVDALEDATLLVLTSSRDELIVTLSSLYHIPSYRDKIAGLVIAGHMPVSEITQQILDDSMIPYIRVHDST
ARVFTTLMEDVSKITAEDQEKLNWIRANAENEIDFEAIDALL

Specific function: Bioconversion of pimelate into dethiobiotin. [C]

COG id: COG0857

COG function: function code R; BioD-like N-terminal domain of phosphotransacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To Synechocystis PCC 6803 slr0039 [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010766 [H]

Pfam domain/function: PF07085 DRTGG [H]

EC number: 6.3.3.3 [C]

Molecular weight: Translated: 39818; Mature: 39686

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKVFIGATGQNCGKTTMSVSLMHLARQKYQRVGFIKPIGPKIEMYNGLTVDMDAILMA
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEECHHHHHHH
RTFGLEEDLALMNPVPLPKNFTRDYLSGKFDCHTLKKKIVEAFEILDQSYDFLIIEGAGH
HHCCCCCCHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
CGVGSVIGLSNACVAHMLGAPVIVVTDSGIGSAIDAVHLNLALYEKEEADVRMVIVNKLR
CCCCHHHCCHHHHHHHHHCCCEEEEECCCCCCHHHHEEEEEEEEECCCCCEEEEEEHHHC
SDKRDSILGFLRRGFPGRSLQVTGGFNYSPVLANPTLSHIGKLLNLPVHGDADGHSRIIH
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCEECCCCHHHHHHHHCCCCCCCCCCHHHEEE
HIHLGAASSQRVVDALEDATLLVLTSSRDELIVTLSSLYHIPSYRDKIAGLVIAGHMPVS
EEEECCCCCHHHHHHHCCCEEEEEECCCCCEEEEEHHHHCCCCHHHHHCEEEEECCCCHH
EITQQILDDSMIPYIRVHDSTARVFTTLMEDVSKITAEDQEKLNWIRANAENEIDFEAID
HHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHH
ALL
HCC
>Mature Secondary Structure 
AKKVFIGATGQNCGKTTMSVSLMHLARQKYQRVGFIKPIGPKIEMYNGLTVDMDAILMA
CCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEECHHHHHHH
RTFGLEEDLALMNPVPLPKNFTRDYLSGKFDCHTLKKKIVEAFEILDQSYDFLIIEGAGH
HHCCCCCCHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
CGVGSVIGLSNACVAHMLGAPVIVVTDSGIGSAIDAVHLNLALYEKEEADVRMVIVNKLR
CCCCHHHCCHHHHHHHHHCCCEEEEECCCCCCHHHHEEEEEEEEECCCCCEEEEEEHHHC
SDKRDSILGFLRRGFPGRSLQVTGGFNYSPVLANPTLSHIGKLLNLPVHGDADGHSRIIH
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCEECCCCHHHHHHHHCCCCCCCCCCHHHEEE
HIHLGAASSQRVVDALEDATLLVLTSSRDELIVTLSSLYHIPSYRDKIAGLVIAGHMPVS
EEEECCCCCHHHHHHHCCCEEEEEECCCCCEEEEEHHHHCCCCHHHHHCEEEEECCCCHH
EITQQILDDSMIPYIRVHDSTARVFTTLMEDVSKITAEDQEKLNWIRANAENEIDFEAID
HHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHH
ALL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Mg2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.045 {7,8-diaminononanoate}} 40 {MgCl2}} 0.42 {ATP}} 10 {HCO3-}} [C]

Substrates: ATP; CO2; 7,8-Diaminononanoate [C]

Specific reaction: ATP + CO2 + 7,8-Diaminononanoate <==> ADP + Dethiobiotin + (3) H+ + Phosphate [C]

General reaction: Carboxylation; Heteroatomic ring closure [C]

Inhibitor: Ag+; Cd2+; Co2+; Cu2+; Hg2+; Ni2+ [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]