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The map label for this gene is pdhR [H]

Identifier: 39996726

GI number: 39996726

Start: 1780852

End: 1781577

Strand: Direct

Name: pdhR [H]

Synonym: GSU1626

Alternate gene names: 39996726

Gene position: 1780852-1781577 (Clockwise)

Preceding gene: 39996724

Following gene: 39996730

Centisome position: 46.69

GC content: 55.37

Gene sequence:

>726_bases
ATGAACTTCAAGCCGATCAAGCCCAAAAAAATATCAACCCAAATCGCCGAGCAGATCCGCAGCTCCATTCTTGCCGGCGA
ATTCACCCCAGGGGAAAAGCTTCCACCTGAGCGTGAGCTGGCAGAGATGTTCGGCGTTTCGCGTCCGTCGGTCCGCGAAG
CCCTCAATATTCTGGCTGCAGCAGGTCTTGTGGAGTCGTACCAGGGGGGCGGGACTATCGTCAAATCCCTCATGGATGCC
GCGTCTGGGCCGCCTCTGTCCGAGATTATCAAGGTCGAGCAGGAGAGGGCGCTGGATGTCATCGAAGTCCGCAAATGCAT
GGAGGCATGGACTGCCTATTATGCCGCCCAGCGTGCGCTACCCGATGATGTCCGTAAACTTGAAGGAATCGTCTGGAATA
TGGAGGCAAACCTTAACGGTCTCAAGCCTTCCGAGGATTTGGATGCCAATTTCCACATTGTGATTGCCCGTTCAACCCAC
AATGTGGTCTGGCTCCACCTGATGCAGACTATTTTCGAGGCCATGAAGGAGTTCCAGCGCAGTGTCTGGCGGGCCGTTTA
CCTTACCGAAGAGGACCACAGGACGCTCTTTGCTCATCATAAAGCCATCTTCGAGGCGATACGCGACAAAGATTGCGAGC
GTGCCCGCAACGCCATGCTCGGCCATCTGACATTCGCCGAGAAGCGGAGCAGTATCTATGTAAACCAGTCCCGCCAGGAC
CGTTGA

Upstream 100 bases:

>100_bases
TCCTCTGACCGCTTGCTCAGGATAATACTGATTGCCTTCGGTTGAGCTATGGTGTATTCATATCCGGTCATATGATTAAT
GTCTCATCCGGAAGCCCGCC

Downstream 100 bases:

>100_bases
TAACTTTTCCGGCTTTAACAAACAAATAAGGGGCGCGCCGTTTCATGTGGCGCGCCCCCTTATTTGTTTGTGTGGGTAAG
TATCGGCGTATAAGTGGTGA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MNFKPIKPKKISTQIAEQIRSSILAGEFTPGEKLPPERELAEMFGVSRPSVREALNILAAAGLVESYQGGGTIVKSLMDA
ASGPPLSEIIKVEQERALDVIEVRKCMEAWTAYYAAQRALPDDVRKLEGIVWNMEANLNGLKPSEDLDANFHIVIARSTH
NVVWLHLMQTIFEAMKEFQRSVWRAVYLTEEDHRTLFAHHKAIFEAIRDKDCERARNAMLGHLTFAEKRSSIYVNQSRQD
R

Sequences:

>Translated_241_residues
MNFKPIKPKKISTQIAEQIRSSILAGEFTPGEKLPPERELAEMFGVSRPSVREALNILAAAGLVESYQGGGTIVKSLMDA
ASGPPLSEIIKVEQERALDVIEVRKCMEAWTAYYAAQRALPDDVRKLEGIVWNMEANLNGLKPSEDLDANFHIVIARSTH
NVVWLHLMQTIFEAMKEFQRSVWRAVYLTEEDHRTLFAHHKAIFEAIRDKDCERARNAMLGHLTFAEKRSSIYVNQSRQD
R
>Mature_241_residues
MNFKPIKPKKISTQIAEQIRSSILAGEFTPGEKLPPERELAEMFGVSRPSVREALNILAAAGLVESYQGGGTIVKSLMDA
ASGPPLSEIIKVEQERALDVIEVRKCMEAWTAYYAAQRALPDDVRKLEGIVWNMEANLNGLKPSEDLDANFHIVIARSTH
NVVWLHLMQTIFEAMKEFQRSVWRAVYLTEEDHRTLFAHHKAIFEAIRDKDCERARNAMLGHLTFAEKRSSIYVNQSRQD
R

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=234, Percent_Identity=37.1794871794872, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790032, Length=230, Percent_Identity=34.3478260869565, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790780, Length=222, Percent_Identity=31.5315315315315, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI48994955, Length=212, Percent_Identity=28.7735849056604, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1789353, Length=225, Percent_Identity=26.2222222222222, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789621, Length=231, Percent_Identity=28.1385281385281, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI87082208, Length=227, Percent_Identity=29.5154185022026, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786950, Length=67, Percent_Identity=49.2537313432836, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 27363; Mature: 27363

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFKPIKPKKISTQIAEQIRSSILAGEFTPGEKLPPERELAEMFGVSRPSVREALNILAA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
AGLVESYQGGGTIVKSLMDAASGPPLSEIIKVEQERALDVIEVRKCMEAWTAYYAAQRAL
HHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDDVRKLEGIVWNMEANLNGLKPSEDLDANFHIVIARSTHNVVWLHLMQTIFEAMKEFQR
HHHHHHHHHEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
SVWRAVYLTEEDHRTLFAHHKAIFEAIRDKDCERARNAMLGHLTFAEKRSSIYVNQSRQD
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
R
C
>Mature Secondary Structure
MNFKPIKPKKISTQIAEQIRSSILAGEFTPGEKLPPERELAEMFGVSRPSVREALNILAA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
AGLVESYQGGGTIVKSLMDAASGPPLSEIIKVEQERALDVIEVRKCMEAWTAYYAAQRAL
HHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDDVRKLEGIVWNMEANLNGLKPSEDLDANFHIVIARSTHNVVWLHLMQTIFEAMKEFQR
HHHHHHHHHEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
SVWRAVYLTEEDHRTLFAHHKAIFEAIRDKDCERARNAMLGHLTFAEKRSSIYVNQSRQD
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]