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The map label for this gene is mscS [H]

Identifier: 39996657

GI number: 39996657

Start: 1711580

End: 1712404

Strand: Direct

Name: mscS [H]

Synonym: GSU1557

Alternate gene names: 39996657

Gene position: 1711580-1712404 (Clockwise)

Preceding gene: 39996654

Following gene: 39996658

Centisome position: 44.87

GC content: 60.24

Gene sequence:

>825_bases
ATGGACACCATGGGACAGTATCAGCAGCTGGTTGTCACGTATGCAACGGTAATCGGGACAAAGATCATCGCCGCCATTTT
GTTCTGGGTTGTCGGCCGCTGGCTGATCCACCTGGTGCAGCGGATGCTTCATCAGGTTCTGGAGAAGCAGAAAGTCGATC
CCAGTCTGATGCGGTATCTGGGCAACTTCCTCGGAGTGGCTCTGAACATCGTGCTGGTGGTGGCGATACTCGGCTACTTC
GGGGTGCAGACCACCACCTTCGCCGCATTGGTGGCCGGCGTCGGCATTGCCATTGGCGCTGCCTGGGGTGGGCTCCTTTC
CAACCTGGCGGCCGGGGCGTTCCTTCTGGTGTTGCGCCCCTTCAAGGTGGGGGATTTCGTCACCGCCGGAGGCATCACCG
GCACCGTAAACGAGATAGGCCTCTTCGTGACCGCCATCAATACCCCTGACAATGTCATGACCATGGTGGGCAACGCCAAA
ATCTTCAACGATACGATCCAGAACTTTACCATCAATGACTATCGCCGAGTGGAACTGAAGTGCCAGCTGGCCGGAAGCGC
CGATCACGTGGCAGCGATGGCGCTGCTGCGCGAGAAGCTCGCGACGGTGCCGAATGTGCTGACAACGCCTGCGGTCGATG
TGGAGATCCTCGACTTCACCCTGGTGGGTCCGGTGCTCGCCGTGCGCCCTTACTGTCACAACGACCATTACTGGCAAGTC
TATTTCGACGGCAACCGGACGATACGCGAAGCCCTCGCCGCGGCGGGATTCCCTGCTCCCATGCCGGCCCAGGTGGTGCT
GGTCCAGAGTCCGCAGGGGGGATGA

Upstream 100 bases:

>100_bases
CAAACTGCGGCTTCACTGGACGGTGGCAGCCGGAGGGGATGGCATTTGCAGGGAATGACGATAGACTTGATTGGAATGGC
TAACTTCAAGGAGGAATGGC

Downstream 100 bases:

>100_bases
CCGGTCATGGTGCCTGGATAGACCGTTCATTGCCTCGGTGCGATTACTGCCCGACCAGGCTGCCTTGCGATCCGGCAATC
CATCGCTATACTCACTGAAG

Product: mechanosensitive ion channel family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MDTMGQYQQLVVTYATVIGTKIIAAILFWVVGRWLIHLVQRMLHQVLEKQKVDPSLMRYLGNFLGVALNIVLVVAILGYF
GVQTTTFAALVAGVGIAIGAAWGGLLSNLAAGAFLLVLRPFKVGDFVTAGGITGTVNEIGLFVTAINTPDNVMTMVGNAK
IFNDTIQNFTINDYRRVELKCQLAGSADHVAAMALLREKLATVPNVLTTPAVDVEILDFTLVGPVLAVRPYCHNDHYWQV
YFDGNRTIREALAAAGFPAPMPAQVVLVQSPQGG

Sequences:

>Translated_274_residues
MDTMGQYQQLVVTYATVIGTKIIAAILFWVVGRWLIHLVQRMLHQVLEKQKVDPSLMRYLGNFLGVALNIVLVVAILGYF
GVQTTTFAALVAGVGIAIGAAWGGLLSNLAAGAFLLVLRPFKVGDFVTAGGITGTVNEIGLFVTAINTPDNVMTMVGNAK
IFNDTIQNFTINDYRRVELKCQLAGSADHVAAMALLREKLATVPNVLTTPAVDVEILDFTLVGPVLAVRPYCHNDHYWQV
YFDGNRTIREALAAAGFPAPMPAQVVLVQSPQGG
>Mature_274_residues
MDTMGQYQQLVVTYATVIGTKIIAAILFWVVGRWLIHLVQRMLHQVLEKQKVDPSLMRYLGNFLGVALNIVLVVAILGYF
GVQTTTFAALVAGVGIAIGAAWGGLLSNLAAGAFLLVLRPFKVGDFVTAGGITGTVNEIGLFVTAINTPDNVMTMVGNAK
IFNDTIQNFTINDYRRVELKCQLAGSADHVAAMALLREKLATVPNVLTTPAVDVEILDFTLVGPVLAVRPYCHNDHYWQV
YFDGNRTIREALAAAGFPAPMPAQVVLVQSPQGG

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=255, Percent_Identity=28.2352941176471, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 29542; Mature: 29542

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTMGQYQQLVVTYATVIGTKIIAAILFWVVGRWLIHLVQRMLHQVLEKQKVDPSLMRYL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GNFLGVALNIVLVVAILGYFGVQTTTFAALVAGVGIAIGAAWGGLLSNLAAGAFLLVLRP
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FKVGDFVTAGGITGTVNEIGLFVTAINTPDNVMTMVGNAKIFNDTIQNFTINDYRRVELK
CCCCCEEECCCCCCCHHHHEEEEEEECCCCHHHHHHCCCHHHHHHHHCCCCCCEEEEEEE
CQLAGSADHVAAMALLREKLATVPNVLTTPAVDVEILDFTLVGPVLAVRPYCHNDHYWQV
EEECCCHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEHHHHHHHHHHHCCCCCCCCEEEE
YFDGNRTIREALAAAGFPAPMPAQVVLVQSPQGG
EECCCHHHHHHHHHCCCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MDTMGQYQQLVVTYATVIGTKIIAAILFWVVGRWLIHLVQRMLHQVLEKQKVDPSLMRYL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GNFLGVALNIVLVVAILGYFGVQTTTFAALVAGVGIAIGAAWGGLLSNLAAGAFLLVLRP
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FKVGDFVTAGGITGTVNEIGLFVTAINTPDNVMTMVGNAKIFNDTIQNFTINDYRRVELK
CCCCCEEECCCCCCCHHHHEEEEEEECCCCHHHHHHCCCHHHHHHHHCCCCCCEEEEEEE
CQLAGSADHVAAMALLREKLATVPNVLTTPAVDVEILDFTLVGPVLAVRPYCHNDHYWQV
EEECCCHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEHHHHHHHHHHHCCCCCCCCEEEE
YFDGNRTIREALAAAGFPAPMPAQVVLVQSPQGG
EECCCHHHHHHHHHCCCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]