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The map label for this gene is hisI

Identifier: 39996631

GI number: 39996631

Start: 1679191

End: 1679568

Strand: Reverse

Name: hisI

Synonym: GSU1531

Alternate gene names: 39996631

Gene position: 1679568-1679191 (Counterclockwise)

Preceding gene: 39996636

Following gene: 39996630

Centisome position: 44.04

GC content: 59.26

Gene sequence:

>378_bases
ATGATAACGATCGATTTCCAGAAGATGGGAGGGCTCATCCCGGCCATTATCCAGGACCACGCCACCAACGAGGTTCTCAT
GGTGGCCTTCATGGATGAAAAAACCCTCAACCTCACCCTTGAGAGCGGCAAGACCTGGTTCTTCAGCCGCAGCCGCAACA
AGTACTGGATGAAGGGCGAGGAGTCGGGCAACACCCAGGAGGTGGTCGAGGTGCTCACCGACTGTGATGCCGACGCCGTG
GTCATCAAGGTGAAGCAGAACGGTCCGGCAGCCTGCCACACGGGCAACCGGAGCTGCTTCTACGTCCGATGGGAGGACGG
CCAGTGGGTCGAGCACTCCGAGCCCCTGTTCGATCCGGCGGAGGTGTACAAGAAATGA

Upstream 100 bases:

>100_bases
ATGAGCCTGGTATTACTGAAAGAGACCGTCGGCACGACTGCAGGCAGTGTTCAACTGCTGAAATCTGGTTCATTCCCGCA
AAGGAGGAGAGACACCCGGC

Downstream 100 bases:

>100_bases
GCGGCCTTCTCAATTTCGGCGTGCCCAAGGGCAGCCTCGAAAACGCAACGGTCGAGCTGTTCCGCAAGGCCGGCTGGCAG
ATCAGCATCTCCTCCCGCAG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 125; Mature: 125

Protein sequence:

>125_residues
MITIDFQKMGGLIPAIIQDHATNEVLMVAFMDEKTLNLTLESGKTWFFSRSRNKYWMKGEESGNTQEVVEVLTDCDADAV
VIKVKQNGPAACHTGNRSCFYVRWEDGQWVEHSEPLFDPAEVYKK

Sequences:

>Translated_125_residues
MITIDFQKMGGLIPAIIQDHATNEVLMVAFMDEKTLNLTLESGKTWFFSRSRNKYWMKGEESGNTQEVVEVLTDCDADAV
VIKVKQNGPAACHTGNRSCFYVRWEDGQWVEHSEPLFDPAEVYKK
>Mature_125_residues
MITIDFQKMGGLIPAIIQDHATNEVLMVAFMDEKTLNLTLESGKTWFFSRSRNKYWMKGEESGNTQEVVEVLTDCDADAV
VIKVKQNGPAACHTGNRSCFYVRWEDGQWVEHSEPLFDPAEVYKK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=97, Percent_Identity=45.360824742268, Blast_Score=97, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=75, Percent_Identity=38.6666666666667, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_GEOSL (P60542)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952582.1
- ProteinModelPortal:   P60542
- SMR:   P60542
- GeneID:   2687351
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1531
- NMPDR:   fig|243231.1.peg.1520
- TIGR:   GSU1531
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- BioCyc:   GSUL243231:GSU_1531-MONOMER
- BRENDA:   3.5.4.19
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14263; Mature: 14263

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIDFQKMGGLIPAIIQDHATNEVLMVAFMDEKTLNLTLESGKTWFFSRSRNKYWMKGE
CEEEEHHHHCCCCHHHHCCCCCCCEEEEEEECCCEEEEEEECCCEEEEECCCCEEEECCC
ESGNTQEVVEVLTDCDADAVVIKVKQNGPAACHTGNRSCFYVRWEDGQWVEHSEPLFDPA
CCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCEEEEEECCCCEECCCCCCCCHH
EVYKK
HHHCC
>Mature Secondary Structure
MITIDFQKMGGLIPAIIQDHATNEVLMVAFMDEKTLNLTLESGKTWFFSRSRNKYWMKGE
CEEEEHHHHCCCCHHHHCCCCCCCEEEEEEECCCEEEEEEECCCEEEEECCCCEEEECCC
ESGNTQEVVEVLTDCDADAVVIKVKQNGPAACHTGNRSCFYVRWEDGQWVEHSEPLFDPA
CCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCEEEEEECCCCEECCCCCCCCHH
EVYKK
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA